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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621120
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk4
Name: cyclin-dependent kinase 4
Acc ID: CHEBI:28230
Term: hesperetin
Definition: A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
Chemical ID: MESH:C013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk4decreases expressionISOCDK4 (Homo sapiens)6480464CTDhesperetin results in decreased expression of CDK4PMID:17927510
Cdk4multiple interactionsISOCDK4 (Homo sapiens)6480464CTDhesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]PMID:17927510
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