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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:28230
Term: hesperetin
Definition: A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
Chemical ID: MESH:C013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDhesperetin analog results in increased expression of BAX mRNAPMID:20564462
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDhesperetin affects the expression of BAX proteinPMID:15975156
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDhesperetin analog results in increased expression of BAX protein; hesperetin results in increased expression of BAX mRNA; hesperetin results in increased expression of BAX proteinPMID:22142698 PMID:25345581 PMID:37487865
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDhesperetin promotes the reaction [Cisplatin results in increased expression of BAX protein]PMID:31153982
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Cisplatin co-treated with hesperetin] results in decreased expression of BAX proteinPMID:31153982
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