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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:28230
Term: hesperetin
Definition: A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
Chemical ID: MESH:C013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:107176480464CTDhesperetin results in increased expression of HMOX1 protein

PMID:15316927
increases expressionISORGD:7309016480464CTDhesperetin results in increased expression of HMOX1 protein

PMID:31153982
multiple interactionsISORGD:107176480464CTDhesperetin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein], hesperetin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]

PMID:15316927, PMID:31153982
multiple interactionsISORGD:7309016480464CTD[Cisplatin co-treated with hesperetin] results in increased expression of HMOX1 protein

PMID:31153982
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.