Pim2 (Pim-2 proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: Pim2 (Pim-2 proto-oncogene, serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Pim2
Name: Pim-2 proto-oncogene, serine/threonine kinase
RGD ID: 1560759
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of canonical NF-kappaB signal transduction; and protein stabilization. Predicted to act upstream of or within apoptotic mitochondrial changes and positive regulation of macroautophagy. Predicted to be active in cytoplasm; PARTICIPATES IN acute myeloid leukemia pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; aflatoxin B1; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC317366; pim-2 oncogene; RGD1560759; serine/threonine-protein kinase pim-2; similar to serine-threonine protein kinase pim-2 isoform 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,289,509 - 17,294,778 (-)NCBIGRCr8
mRatBN7.2X14,617,582 - 14,622,851 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,617,582 - 14,622,851 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X15,462,621 - 15,467,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,462,016 - 15,467,875 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,243,856 - 16,249,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX14,702,331 - 14,707,600 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Pim2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,289,509 - 17,294,778 (-)NCBIGRCr8
mRatBN7.2X14,617,582 - 14,622,851 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,617,582 - 14,622,851 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X15,462,621 - 15,467,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,462,016 - 15,467,875 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,243,856 - 16,249,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX14,702,331 - 14,707,600 (-)NCBICelera
Cytogenetic MapXq12NCBI
PIM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,913,182 - 48,919,024 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,913,182 - 48,919,024 (-)EnsemblGRCh38hg38GRCh38
GRCh37X48,770,459 - 48,776,301 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,655,403 - 48,661,228 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X48,526,708 - 48,532,532NCBI
CeleraX52,887,115 - 52,893,070 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,426,613 - 46,432,568 (-)NCBIHuRef
CHM1_1X48,801,601 - 48,807,568 (-)NCBICHM1_1
T2T-CHM13v2.0X48,323,658 - 48,329,501 (-)NCBIT2T-CHM13v2.0
Pim2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,744,545 - 7,749,671 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,744,501 - 7,749,671 (+)EnsemblGRCm39 Ensembl
GRCm38X7,878,306 - 7,883,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,878,262 - 7,883,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,455,432 - 7,460,558 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,035,265 - 7,040,391 (+)NCBIMGSCv36mm8
CeleraX3,586,468 - 3,591,566 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.55NCBI
Pim2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543444,314 - 449,201 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955543444,314 - 449,201 (-)NCBIChiLan1.0ChiLan1.0
PIM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,402,317 - 50,408,597 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,405,689 - 50,411,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,210,494 - 41,216,552 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X49,068,721 - 49,074,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX49,068,721 - 49,074,731 (-)Ensemblpanpan1.1panPan2
PIM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,072,495 - 42,077,741 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,073,457 - 42,077,543 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,447,938 - 16,453,190 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,208,734 - 42,213,941 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,208,739 - 42,213,967 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,194,931 - 42,200,181 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,183,224 - 42,188,429 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,277,421 - 42,282,674 (-)NCBIUU_Cfam_GSD_1.0
Pim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,599,487 - 34,604,014 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721839,874 - 844,488 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721839,876 - 844,488 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,993,551 - 42,998,573 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,993,547 - 42,998,575 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,814,362 - 47,819,371 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,032,640 - 46,040,220 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607611,517,954 - 11,525,618 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pim2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893694,928 - 700,062 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893694,944 - 700,068 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pim2
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:245
Count of miRNA genes:164
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000011207
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000011207   ⟹   ENSRNOP00000011207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,617,582 - 14,622,851 (-)Ensembl
Rnor_6.0 EnsemblX15,462,016 - 15,467,875 (-)Ensembl
RefSeq Acc Id: NM_001172103   ⟹   NP_001165574
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,289,509 - 17,294,778 (-)NCBI
mRatBN7.2X14,617,582 - 14,622,851 (-)NCBI
Rnor_6.0X15,462,621 - 15,467,890 (-)NCBI
Rnor_5.0X16,243,856 - 16,249,125 (-)NCBI
CeleraX14,702,331 - 14,707,600 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001165574 (Get FASTA)   NCBI Sequence Viewer  
  XP_228778 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011207.5
RefSeq Acc Id: NP_001165574   ⟸   NM_001172103
- UniProtKB: F1M419 (UniProtKB/TrEMBL),   A6KP72 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011207   ⟸   ENSRNOT00000011207
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M419-F1-model_v2 AlphaFold F1M419 1-311 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701740
Promoter ID:EPDNEW_R12264
Type:single initiation site
Name:Pim2_1
Description:Pim-2 proto-oncogene, serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X15,467,901 - 15,467,961EPDNEW

Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-2926 BioCyc
Ensembl Genes ENSRNOG00000008177 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011207.8 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  PIM1/2/3 UniProtKB/TrEMBL
  PIM_Ser/Thr_kinase UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:317366 UniProtKB/TrEMBL
NCBI Gene Pim2 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE PIM UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE PIM-2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Pim2 PhenoGen
PIRSF STPK_Pim-1 UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008177 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A6KP72 ENTREZGENE, UniProtKB/TrEMBL
  F1M419 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-10 Pim2  Pim-2 proto-oncogene, serine/threonine kinase  Pim2  pim-2 oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 Pim2  pim-2 oncogene  Pim2  pim-2 oncogene  Gene reactivated at release of RGSC5.0 assembly 2298974 REACTIVATED
2008-04-30 Pim2  pim-2 oncogene   Pim2_predicted  pim-2 oncogene (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Pim2_predicted  pim-2 oncogene (predicted)  RGD1560759_predicted  similar to serine-threonine protein kinase pim-2 isoform 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560759_predicted  similar to serine-threonine protein kinase pim-2 isoform 1 (predicted)  LOC317366  similar to serine-threonine protein kinase pim-2 isoform 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317366  similar to serine-threonine protein kinase pim-2 isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL