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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619871
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclm
Name: glutamate cysteine ligase, modifier subunit
Acc ID: CHEBI:80845
Term: liquiritin
Definition: A flavanone glycoside that is liquiritigenin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage.
Chemical ID: MESH:C512196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclmincreases expressionEXP 6480464CTDliquiritin results in increased expression of GCLM protein

PMID:29908794
Gclmmultiple interactionsEXP 6480464CTDliquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]

PMID:29908794
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.