Acvr1 (activin A receptor type 1) - Rat Genome Database

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Gene: Acvr1 (activin A receptor type 1) Rattus norvegicus
Analyze
Symbol: Acvr1
Name: activin A receptor type 1
RGD ID: 620200
Description: Enables activin receptor activity, type I. Involved in cellular response to glucocorticoid stimulus; regulation of skeletal muscle tissue development; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within urogenital system development. Part of activin receptor complex. Human ortholog(s) of this gene implicated in exfoliation syndrome; fibrodysplasia ossificans progressiva; primary angle-closure glaucoma; and primary open angle glaucoma. Orthologous to human ACVR1 (activin A receptor type 1); PARTICIPATES IN activin signaling pathway; cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activin A receptor, type 1; activin A receptor, type I; activin receptor type I; activin receptor type-1; activin type I receptor; ACTR-I; ALK2-B; serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8363,387,378 - 63,506,980 (-)NCBIGRCr8
mRatBN7.2342,978,558 - 43,097,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl342,978,561 - 43,098,241 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx346,318,305 - 46,385,863 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0354,907,442 - 54,974,813 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0352,686,046 - 52,753,663 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0344,432,476 - 44,539,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl344,432,471 - 44,522,930 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0349,551,411 - 49,641,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4340,191,727 - 40,260,488 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1340,088,098 - 40,156,860 (-)NCBI
Celera341,046,965 - 41,113,654 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Acvr1Ratbicuspid aortic valve disease  ISORGD:734161329337340 RGD 
Acvr1RatCarotid Artery Injuries  IEP 329845558mRNA:increased expression:carotic artery (rat)RGD 
Acvr1Ratcataract  ISORGD:7341618547757 RGD 
Acvr1Ratcongenital heart disease  ISORGD:734161329328929 RGD 
Acvr1RatDiabetic Nephropathies  IEP 2313802associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:kidneyRGD 
Acvr1Ratexfoliation syndrome disease_progressionISORGD:1344480329845517DNA:missense mutation:SNP:rs12997 (human)RGD 
Acvr1RatEye Neoplasms  ISORGD:7341618547757 RGD 
Acvr1Ratfibrodysplasia ossificans progressiva  ISORGD:134448011341914DNA:mutation:CDS:c.772A>G, R258GRGD 
Acvr1Ratfibrodysplasia ossificans progressiva  ISORGD:1344480329337363DNA:mutation:cds:R206HRGD 
Acvr1Ratmiddle cerebral artery infarction  ISORGD:734161329845521 RGD 
Acvr1Ratpancreatic cancer  ISORGD:13444802317217 RGD 
Acvr1Ratprimary angle-closure glaucoma sexual_dimorphismISORGD:1344480329845517DNA:missense mutation:SNP:rs12997 (human)RGD 
Acvr1Ratprimary open angle glaucoma  ISORGD:1344480329328928DNA:SNP:3'utr: (rs12997)RGD 
Acvr1Ratsevere pre-eclampsia severityISORGD:1344480329845529mRNA:increased expression:decidua basalis (human)RGD 
Acvr1Ratventricular septal defect  ISORGD:734161329337340 RGD 
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Acvr1Ratautism spectrum disorder  ISORGD:13444808554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868|PMID:27569545
Acvr1Ratfibrodysplasia ossificans progressiva  ISORGD:13444808554872ClinVar Annotator: match by term: ACVR1-related condition | ClinVar Annotator: match by term: Progressive myositis more ...ClinVarPMID:10441661|PMID:16642017|PMID:17077940|PMID:17272450|PMID:17351709|PMID:17576681|PMID:18203193|PMID:18684712|PMID:18830232|PMID:18952055|PMID:19085907|PMID:19330033|PMID:21044902|PMID:21377447|PMID:21525719|PMID:21567927|PMID:22351757|PMID:22508565|PMID:22977237|PMID:23302548|PMID:23653868|PMID:24051199|PMID:24259422|PMID:24705251|PMID:25326637|PMID:25741868|PMID:26058333|PMID:28492532|PMID:29307777|PMID:29482508|PMID:30379592|PMID:31012264|PMID:33973349|PMID:35511419|PMID:5033743|PMID:7068725|PMID:818090|PMID:9536098
Acvr1Ratgenetic disease  ISORGD:13444808554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:16642017|PMID:17077940|PMID:17272450|PMID:17351709|PMID:18684712|PMID:18830232|PMID:19085907|PMID:19330033|PMID:21525719|PMID:22351757|PMID:22508565|PMID:22977237|PMID:23302548|PMID:23653868|PMID:25741868|PMID:28492532|PMID:29307777|PMID:29482508|PMID:30379592|PMID:31012264|PMID:33973349|PMID:35511419|PMID:5033743|PMID:7068725|PMID:818090
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Acvr1RatAcute Lung Injury  ISORGD:134448011554173CTD Direct Evidence: marker/mechanismCTDPMID:21297076
Acvr1RatBreast Neoplasms  ISORGD:134448011554173CTD Direct Evidence: marker/mechanismCTDPMID:23180569
Acvr1Rathigh grade glioma  ISORGD:134448011554173CTD Direct Evidence: marker/mechanismCTDPMID:24705251|PMID:24705252|PMID:24705254
Acvr1Ratmalignant astrocytoma  ISORGD:134448011554173CTD Direct Evidence: marker/mechanismCTDPMID:24705250
Acvr1Ratmyositis ossificans  ISORGD:134448011554173CTD Direct Evidence: marker/mechanismCTD 
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Acvr1Ratfibrodysplasia ossificans progressiva  ISSRGD:73416113592920OMIM:135100MouseDO 
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Acvr1Ratfibrodysplasia ossificans progressiva  ISORGD:13444807240710 OMIM 

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Acvr1Rat2,2'-Methylenebis(4-methyl-6-tert-butylphenol) multiple interactionsISORGD:13444806480464[CYP3A4 protein affects the susceptibility to 2,2'-methylenebis(4-methyl-6-tert-butylphenol)] which affects the expression of ACVR1 mRNACTDPMID:38160208
Acvr1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:7341616480464Tetrachlorodibenzodioxin affects the expression of ACVR1 mRNACTDPMID:21570461
Acvr1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ACVR1 mRNACTDPMID:20959002|PMID:33387578
Acvr1Rat2-hydroxypropanoic acid increases expressionISORGD:13444806480464Lactic Acid results in increased expression of ACVR1 mRNACTDPMID:30851411
Acvr1Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ACVR1 mRNACTDPMID:23196670
Acvr1Rat4,4'-diaminodiphenylmethane increases expressionISORGD:73416164804644,4'-diaminodiphenylmethane results in increased expression of ACVR1 mRNACTDPMID:18648102
Acvr1Rat4,4'-sulfonyldiphenol affects methylationISORGD:7341616480464bisphenol S affects the methylation of ACVR1 geneCTDPMID:31683443
Acvr1Rat4-hydroxyphenyl retinamide decreases expressionISORGD:7341616480464Fenretinide results in decreased expression of ACVR1 mRNACTDPMID:28973697
Acvr1Rat5-aza-2'-deoxycytidine decreases expressionISORGD:7341616480464Decitabine results in decreased expression of ACVR1 mRNACTDPMID:27915011
Acvr1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of ACVR1 mRNACTDPMID:30047161
Acvr1Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of ACVR1 mRNACTDPMID:31881176
Acvr1Rataflatoxin B1 increases expressionISORGD:7341616480464Aflatoxin B1 results in increased expression of ACVR1 mRNACTDPMID:19770486
Acvr1Rataflatoxin B1 decreases methylationISORGD:13444806480464Aflatoxin B1 results in decreased methylation of ACVR1 geneCTDPMID:27153756
Acvr1Rataristolochic acid A decreases expressionISORGD:13444806480464aristolochic acid I results in decreased expression of ACVR1 mRNACTDPMID:33212167
Acvr1Ratarsenite(3-) multiple interactionsISORGD:13444806480464arsenite inhibits the reaction [G3BP1 protein binds to ACVR1 mRNA]CTDPMID:32406909
Acvr1RatAzoxymethane multiple interactionsISORGD:7341616480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of ACVR1 more ...CTDPMID:29950665
Acvr1Ratbenzo[a]pyrene increases expressionISORGD:13444806480464Benzo(a)pyrene results in increased expression of ACVR1 mRNACTDPMID:26238291
Acvr1Ratbenzo[a]pyrene increases methylationISORGD:13444806480464Benzo(a)pyrene results in increased methylation of ACVR1 promoterCTDPMID:27901495
Acvr1Ratbenzo[a]pyrene affects methylationISORGD:13444806480464Benzo(a)pyrene affects the methylation of ACVR1 5' UTR; Benzo(a)pyrene affects the methylation of ACVR1 intronCTDPMID:27901495|PMID:30157460
Acvr1Ratbenzo[a]pyrene decreases methylationISORGD:7341616480464Benzo(a)pyrene results in decreased methylation of ACVR1 exon; Benzo(a)pyrene results in decreased methylation of ACVR1 more ...CTDPMID:27901495

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Biological Process
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Acvr1Ratactivin receptor signaling pathway involved_inIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratactivin receptor signaling pathway involved_inISORGD:13444801624291 PMID:18326817, PMID:19506109RGDPMID:18326817|PMID:19506109
Acvr1Ratacute inflammatory response involved_inIEAUniProtKB:P37172|ensembl:ENSMUSP000000884531600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratacute inflammatory response involved_inISORGD:7341611624291 PMID:12151307RGDPMID:12151307
Acvr1Ratatrial septum primum morphogenesis involved_inISORGD:7341611624291 PMID:16140292RGDPMID:16140292
Acvr1Ratatrial septum primum morphogenesis involved_inIEAUniProtKB:P37172|ensembl:ENSMUSP000000884531600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratatrial septum primum morphogenesis involved_inISORGD:13444801624291 PMID:19506109RGDPMID:19506109
Acvr1Ratatrial septum primum morphogenesis involved_inIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratatrioventricular valve morphogenesis involved_inISORGD:7341611624291 PMID:16140292RGDPMID:16140292
Acvr1Ratatrioventricular valve morphogenesis involved_inIEAUniProtKB:P37172|ensembl:ENSMUSP000000884531600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1RatBMP signaling pathway involved_inIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1RatBMP signaling pathway involved_inIEAUniProtKB:P37172|ensembl:ENSMUSP000000884531600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1RatBMP signaling pathway involved_inIBAFB:FBgn0003317|MGI:1338946|MGI:87911|PANTHER:PTN000583833|UniProtKB:P37023|UniProtKB:Q04771|ZFIN:ZDB-GENE-990415-91600115GO_REF:0000033GO_CentralGO_REF:0000033
Acvr1RatBMP signaling pathway involved_inISORGD:13444801624291 PMID:12065756, PMID:18436533, PMID:26598555RGDPMID:12065756|PMID:18436533|PMID:26598555
Acvr1RatBMP signaling pathway involved_inISORGD:7341611624291 PMID:16140292RGDPMID:16140292
Acvr1Ratbranching involved in blood vessel morphogenesis acts_upstream_of_or_withinISORGD:7341611624291MGI:2386570|MGI:2651395 PMID:17078885RGDPMID:17078885
Acvr1Ratbranching involved in blood vessel morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P37172|ensembl:ENSMUSP000000884531600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratcardiac muscle cell fate commitment involved_inIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratcardiac muscle cell fate commitment involved_inISORGD:13444801624291 PMID:19506109RGDPMID:19506109
Acvr1Ratcell differentiation involved_inIBAFB:FBgn0003317|MGI:1338946|MGI:87911|PANTHER:PTN000583833|UniProtKB:P37023|UniProtKB:Q04771|UniProtKB:Q90ZK6|ZFIN:ZDB-GENE-990415-91600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component
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Acvr1Ratactivin receptor complex  IDA 724761 RGD 
Acvr1Ratactivin receptor complex part_ofIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratactivin receptor complex part_ofISORGD:13444801624291 PMID:8242742RGDPMID:8242742
Acvr1Ratapical part of cell located_inIEAUniProtKB:P37172|ensembl:ENSMUSP000000884531600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratapical part of cell located_inISORGD:7341611624291 PMID:10704880, PMID:11290335RGDPMID:10704880|PMID:11290335
Acvr1RatBMP receptor complex part_ofIBAFB:FBgn0003317|PANTHER:PTN000583833|ZFIN:ZDB-GENE-990415-91600115GO_REF:0000033GO_CentralGO_REF:0000033
Acvr1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Acvr1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Acvr1Ratmembrane located_inIEAInterPro:IPR000333|InterPro:IPR000472|InterPro:IPR0036051600115GO_REF:0000002InterProGO_REF:0000002
Acvr1Ratplasma membrane is_active_inIBAFB:FBgn0003169|FB:FBgn0003317|FB:FBgn0003716|FB:FBgn0011300|FB:FBgn0024179|MGI:102806|MGI:107191|MGI:1095407|MGI:87911|MGI:98729|PANTHER:PTN002758232|RGD:3852|RGD:620200|RGD:621789|RGD:69651|RGD:70964|RGD:71082|UniProtKB:P27037|UniProtKB:P36894|UniProtKB:P36896|UniProtKB:P36897|UniProtKB:P37023|UniProtKB:P37173|UniProtKB:Q04771|UniProtKB:Q13705|UniProtKB:Q13873|UniProtKB:Q16671|UniProtKB:Q8NER5|WB:WBGene00000900|ZFIN:ZDB-GENE-000502-1|ZFIN:ZDB-GENE-990415-91600115GO_REF:0000033GO_CentralGO_REF:0000033
Acvr1Ratplasma membrane located_inIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratplasma membrane located_inISORGD:7341611624291 PMID:11376112RGDPMID:11376112
Acvr1Ratplasma membrane located_inIEAUniProtKB:P37172|ensembl:ENSMUSP000000884531600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratplasma membrane located_inISORGD:13444801624291 PMID:8242742RGDPMID:8242742
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Molecular Function
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Acvr1Ratactivin binding enablesIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratactivin binding enablesISORGD:7341611624291PR:P27038|PR:Q04998 PMID:1646080, PMID:7577669RGDPMID:1646080|PMID:7577669
Acvr1Ratactivin binding enablesIEAUniProtKB:P37172|ensembl:ENSMUSP000000884531600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratactivin binding enablesISORGD:13444801624291 PMID:8242742RGDPMID:8242742
Acvr1Ratactivin receptor activity, type I  IDA 724761 RGD 
Acvr1Ratactivin receptor activity, type I enablesIEAUniProtKB:P37172|ensembl:ENSMUSP000000884531600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratactivin receptor activity, type I contributes_toIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratactivin receptor activity, type I enablesISORGD:7341611624291 PMID:11376112RGDPMID:11376112
Acvr1Ratactivin receptor activity, type I contributes_toISORGD:13444801624291 PMID:8242742RGDPMID:8242742
Acvr1RatATP binding enablesIEAUniRule:UR000135868|UniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Acvr1RatATP binding enablesIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1RatATP binding enablesIEAInterPro:IPR000333|InterPro:IPR000719|InterPro:IPR003605|InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Acvr1RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Acvr1RatATP binding enablesISORGD:13444801624291 PMID:12065756RGDPMID:12065756
Acvr1RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Acvr1RatBMP receptor activity enablesIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1RatBMP receptor activity enablesISORGD:13444801624291 PMID:12065756RGDPMID:12065756
Acvr1Ratcadherin binding enablesIEAUniProtKB:Q04771|ensembl:ENSP000004050041600115GO_REF:0000107EnsemblGO_REF:0000107
Acvr1Ratcadherin binding enablesISORGD:13444801624291UniProtKB:P33151 PMID:26598555RGDPMID:26598555
Acvr1Ratgrowth factor binding enablesISORGD:7341611624291 PMID:8388127RGDPMID:8388127
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RGD Manual Annotations


  
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Acvr1Ratactivin signaling pathway  TAS 1559169 RGD 

Imported Annotations - KEGG (archival)

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Acvr1Ratcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060
Acvr1Rattransforming growth factor-beta superfamily mediated signaling pathway  IEA 6907045 KEGGrno:04350

Imported Annotations - PID (archival)

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Acvr1Ratactivin signaling pathway  ISORGD:13444806484113 PIDPID:200029

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#
Reference Title
Reference Citation
1. The transforming growth factor-beta superfamily of receptors. de Caestecker M Cytokine Growth Factor Rev. 2004 Feb;15(1):1-11.
2. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Regulatory roles of bone morphogenetic proteins and glucocorticoids in catecholamine production by rat pheochromocytoma cells. Kano Y, etal., Endocrinology. 2005 Dec;146(12):5332-40. Epub 2005 Sep 8.
6. Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients. Kaplan FS, etal., Am J Med Genet A. 2015 Oct;167A(10):2265-71. doi: 10.1002/ajmg.a.37205. Epub 2015 Jun 11.
7. Concomitant over-expression of activin/inhibin beta subunits and their receptors in human pancreatic cancer. Kleeff J, etal., Int J Cancer. 1998 Sep 11;77(6):860-8.
8. Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin. Kondkar AA, etal., BMC Med Genet. 2020 Jul 8;21(1):145. doi: 10.1186/s12881-020-01076-0.
9. Association of rs12997 variant in the ACVR1 gene: a member of bone morphogenic protein signaling pathway with primary open-angle glaucoma in a Saudi cohort. Kondkar AA, etal., J Investig Med. 2021 Feb;69(2):402-407. doi: 10.1136/jim-2020-001596. Epub 2020 Dec 21.
10. Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva. Kou S, etal., Orphanet J Rare Dis. 2020 Jul 29;15(1):193. doi: 10.1186/s13023-020-01465-x.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity. Thomas PS, etal., Dev Biol. 2014 Jun 15;390(2):191-207. doi: 10.1016/j.ydbio.2014.03.008. Epub 2014 Mar 27.
20. Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development. Thomas PS, etal., PLoS One. 2012;7(4):e35539. doi: 10.1371/journal.pone.0035539. Epub 2012 Apr 19.
1 to 20 of 29 rows
PMID:1646080   PMID:7577669   PMID:8242742   PMID:8388127   PMID:8395914   PMID:9884026   PMID:10226013   PMID:10479450   PMID:10704880   PMID:11290335   PMID:12054694   PMID:12065756  
PMID:12151307   PMID:12477932   PMID:14729481   PMID:14993131   PMID:15037318   PMID:15226263   PMID:15289457   PMID:15531373   PMID:16140292   PMID:16420278   PMID:16642017   PMID:17078885  
PMID:17117439   PMID:18326817   PMID:18436533   PMID:19506109   PMID:19736306   PMID:22871113   PMID:26598555   PMID:26873969  



Acvr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8363,387,378 - 63,506,980 (-)NCBIGRCr8
mRatBN7.2342,978,558 - 43,097,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl342,978,561 - 43,098,241 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx346,318,305 - 46,385,863 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0354,907,442 - 54,974,813 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0352,686,046 - 52,753,663 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0344,432,476 - 44,539,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl344,432,471 - 44,522,930 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0349,551,411 - 49,641,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4340,191,727 - 40,260,488 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1340,088,098 - 40,156,860 (-)NCBI
Celera341,046,965 - 41,113,654 (-)NCBICelera
Cytogenetic Map3q21NCBI
ACVR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382157,736,446 - 157,876,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2157,736,251 - 157,876,330 (-)EnsemblGRCh38hg38GRCh38
GRCh372158,592,958 - 158,732,842 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362158,301,207 - 158,403,036 (-)NCBINCBI36Build 36hg18NCBI36
Build 342158,418,468 - 158,520,298NCBI
Celera2152,206,070 - 152,344,336 (-)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2150,478,249 - 150,616,526 (-)NCBIHuRef
CHM1_12158,598,894 - 158,738,243 (-)NCBICHM1_1
T2T-CHM13v2.02158,189,880 - 158,329,404 (-)NCBIT2T-CHM13v2.0
Acvr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39258,336,450 - 58,456,840 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl258,278,656 - 58,457,169 (-)EnsemblGRCm39 Ensembl
GRCm38258,446,438 - 58,566,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl258,388,644 - 58,567,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv37258,298,849 - 58,419,239 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36258,261,824 - 58,331,545 (-)NCBIMGSCv36mm8
Celera260,202,316 - 60,294,260 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map233.05NCBI
Acvr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544915,640,230 - 15,708,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544915,587,958 - 15,706,432 (+)NCBIChiLan1.0ChiLan1.0
ACVR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21360,399,806 - 60,481,894 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B60,414,781 - 60,553,730 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B44,994,175 - 45,133,490 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B162,234,823 - 162,372,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B162,234,823 - 162,297,805 (-)Ensemblpanpan1.1panPan2
ACVR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1363,743,257 - 3,818,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl363,744,163 - 3,818,652 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,880,162 - 4,006,562 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0363,865,484 - 3,991,973 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl363,865,493 - 3,946,584 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1363,867,397 - 3,993,826 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0363,927,214 - 4,053,637 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0363,965,356 - 4,091,837 (-)NCBIUU_Cfam_GSD_1.0
Acvr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303120,806,153 - 120,874,529 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646920,743,213 - 20,811,569 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646920,743,195 - 20,811,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1564,750,796 - 64,891,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11564,749,478 - 64,891,653 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21571,681,467 - 71,823,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACVR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11043,139,396 - 43,281,024 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1043,139,528 - 43,281,177 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040156,293,920 - 156,435,319 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acvr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247327,929,583 - 8,005,072 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247327,929,997 - 8,004,235 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Acvr1
606 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir130arno-miR-130a-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:701
Count of miRNA genes:261
Interacting mature miRNAs:322
Transcripts:ENSRNOT00000006963
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 58 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat

1 to 10 of 58 rows
BF401349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2343,037,901 - 43,038,048 (+)MAPPERmRatBN7.2
Rnor_6.0344,491,716 - 44,491,862NCBIRnor6.0
Rnor_5.0349,610,697 - 49,610,843UniSTSRnor5.0
RGSC_v3.4340,250,254 - 40,250,400UniSTSRGSC3.4
Celera341,104,894 - 41,105,040UniSTS
RH 3.4 Map16742.8UniSTS
Cytogenetic Map3q21UniSTS
RH138112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2342,982,660 - 42,982,786 (+)MAPPERmRatBN7.2
Rnor_6.0344,436,580 - 44,436,705NCBIRnor6.0
Rnor_5.0349,555,515 - 49,555,640UniSTSRnor5.0
RGSC_v3.4340,194,784 - 40,194,909UniSTSRGSC3.4
Celera341,050,022 - 41,050,147UniSTS
RH 3.4 Map3554.0UniSTS
Cytogenetic Map3q21UniSTS
Acvr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8363,388,629 - 63,389,369 (+)Marker Load Pipeline
mRatBN7.2342,979,809 - 42,980,549 (+)MAPPERmRatBN7.2
Rnor_6.0344,433,728 - 44,434,467NCBIRnor6.0
Rnor_5.0349,552,663 - 49,553,402UniSTSRnor5.0
RGSC_v3.4340,191,932 - 40,192,671UniSTSRGSC3.4
Celera341,047,170 - 41,047,909UniSTS
Cytogenetic Map3q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 21 of 21 rows
RefSeq Transcripts NM_001431445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY693390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC167754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB745997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

Ensembl Acc Id: ENSRNOT00000006963   ⟹   ENSRNOP00000006963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl342,978,561 - 43,054,154 (-)Ensembl
Rnor_6.0 Ensembl344,432,479 - 44,522,930 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087071   ⟹   ENSRNOP00000072326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl342,978,561 - 43,098,241 (-)Ensembl
Rnor_6.0 Ensembl344,432,471 - 44,501,115 (-)Ensembl
RefSeq Acc Id: NM_024486   ⟹   NP_077812
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,388,425 - 63,456,016 (-)NCBI
mRatBN7.2342,979,605 - 43,047,200 (-)NCBI
Rnor_6.0344,433,523 - 44,500,986 (-)NCBI
Rnor_5.0349,551,411 - 49,641,517 (-)NCBI
RGSC_v3.4340,191,727 - 40,260,488 (-)RGD
Celera341,046,965 - 41,113,654 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761867   ⟹   XP_008760089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
Rnor_6.0344,432,476 - 44,478,216 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105896   ⟹   XP_038961824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
RefSeq Acc Id: XM_039105898   ⟹   XP_038961826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,493,149 (-)NCBI
mRatBN7.2342,978,558 - 43,082,359 (-)NCBI
RefSeq Acc Id: XM_039105899   ⟹   XP_038961827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
RefSeq Acc Id: XM_039105902   ⟹   XP_038961830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,493,149 (-)NCBI
mRatBN7.2342,978,558 - 43,082,359 (-)NCBI
RefSeq Acc Id: XM_039105904   ⟹   XP_038961832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
RefSeq Acc Id: XM_039105906   ⟹   XP_038961834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
RefSeq Acc Id: XM_063284608   ⟹   XP_063140678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
RefSeq Acc Id: XM_063284609   ⟹   XP_063140679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
RefSeq Acc Id: XM_063284610   ⟹   XP_063140680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
1 to 5 of 13 rows
1 to 5 of 13 rows
RefSeq Acc Id: NP_077812   ⟸   NM_024486
- Peptide Label: precursor
- UniProtKB: P80201 (UniProtKB/Swiss-Prot),   B3DM96 (UniProtKB/TrEMBL),   A6JF58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760089   ⟸   XM_008761867
- Peptide Label: isoform X2
- UniProtKB: A6JF58 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072326   ⟸   ENSRNOT00000087071
Ensembl Acc Id: ENSRNOP00000006963   ⟸   ENSRNOT00000006963
RefSeq Acc Id: XP_038961832   ⟸   XM_039105904
- Peptide Label: isoform X3
GS   Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P80201-F1-model_v2 AlphaFold P80201 1-509 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 44 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-49657 BioCyc
Ensembl Genes ENSRNOG00000005033 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006963 ENTREZGENE
  ENSRNOT00000087071 ENTREZGENE
  ENSRNOT00000137840 ENTREZGENE
  ENSRNOT00000160344 ENTREZGENE
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9089038 IMAGE-MGC_LOAD
InterPro Activin_recp UniProtKB/Swiss-Prot
  GS_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Snake_toxin-like_sf UniProtKB/Swiss-Prot
  TGFB_receptor UniProtKB/Swiss-Prot
KEGG Report rno:79558 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187367 IMAGE-MGC_LOAD
NCBI Gene 79558 ENTREZGENE
PANTHER ACTIVIN RECEPTOR TYPE-1 UniProtKB/Swiss-Prot
  PTHR23255 UniProtKB/Swiss-Prot
Pfam Activin_recp UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  TGF_beta_GS UniProtKB/Swiss-Prot
PhenoGen Acvr1 PhenoGen
PRINTS ACTIVIN2R UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS51256 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005033 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
  SM00467 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
  SSF57302 UniProtKB/Swiss-Prot
UniProt A0A0G2K2P7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q2G6_RAT UniProtKB/TrEMBL
1 to 40 of 44 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Acvr1  activin A receptor type 1  Acvr1  activin A receptor, type I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Acvr1  activin A receptor, type I  Acvr1  activin A receptor, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Acvr1  activin A receptor, type 1    activin type I receptor  Name updated 1299863 APPROVED
2002-08-07 Acvr1  activin type I receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_function receptor for activin 724707
gene_physical_interaction may form a complex with type II activin receptors 724761