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| Gene: Acvr1 (activin A receptor type 1) Rattus norvegicus |  Analyze |
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Analyze GeneStrainQTL List
 Functional Annotation unavailable |
 Annotation Distribution unavailable |
 Genomic Variants unavailble Genomic Variants unavailable |
Functional Annotation |
Annotation Distribution |
Genomic Variants |
 Protein-Protein Interactions unavailable |
 Genome Viewer unavailable |
 Damaging Variants unavailble Damaging Variants unavailable |
Protein-Protein Interactions |
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Damaging Variants |
 Annotation Comparison unavailable |
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Annotation Comparison |
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Excel (Download) |
| Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | ADENOCARCINOMA OF STOMACH | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by term: Adenocarcinoma of stomach | ClinVar | PMID:26619011 | ADENOCARCINOMA OF STOMACH | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by term: Adenocarcinoma of stomach | ClinVar | PMID:25326637 PMID:26619011 | Autism Spectrum Disorder | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by term: Autism spectrum disorders | ClinVar | PMID:25741868 PMID:27569545 | glioma | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by term: Brainstem glioma | ClinVar | PMID:26619011 | glioma | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by term: Brainstem glioma | ClinVar | PMID:25326637 PMID:26619011 | glioma | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by term: Brainstem glioma | ClinVar | PMID:19085907 more ... | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by OMIM:135100 | ClinVar | PMID:10441661 PMID:19085907 | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by term: Progressive myositis ossificans | ClinVar | PMID:19085907 more ... | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by term: Progressive myositis ossificans | ClinVar | PMID:25326637 PMID:26619011 | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by term: Progressive myositis ossificans | ClinVar | PMID:25741868 | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by OMIM:135100 | ClinVar | | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by OMIM:135100 | ClinVar | PMID:21044902 more ... | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by OMIM:135100 | ClinVar | PMID:18203193 PMID:19085907 | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by OMIM:135100 | ClinVar | PMID:18830232 | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by OMIM:135100 | ClinVar | PMID:19085907 PMID:7068725 | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by OMIM:135100 | ClinVar | PMID:19330033 PMID:21567927 | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by OMIM:135100 | ClinVar | PMID:19085907 | Myositis Ossificans | | ISO | RGD:1344480 | 8554872 | ClinVar Annotator: match by OMIM:135100 | ClinVar | PMID:16642017 more ... | |
Imported Annotations - CTD
Imported Annotations - OMIM
Gene-Chemical Interaction AnnotationsGene Ontology AnnotationsBiological Process
Cellular Component
Molecular Function
Molecular Pathway AnnotationsRGD Manual Annotations
Imported Annotations - KEGG (archival)
Imported Annotations - PID (archival)
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
Cellular Component
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Molecular Function
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Molecular Pathway AnnotationsReferences - curated| 1. | de Caestecker M Cytokine Growth Factor Rev. 2004 Feb;15(1):1-11. |
| 2. | Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7. |
| 3. | GOA data from the GO Consortium |
| 4. | Kano Y, etal., Endocrinology. 2005 Dec;146(12):5332-40. Epub 2005 Sep 8. |
| 5. | Kleeff J, etal., Int J Cancer. 1998 Sep 11;77(6):860-8. |
| 6. | MGD data from the GO Consortium |
| 7. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 8. | OMIM Disease Annotation Pipeline |
| 9. | Pipeline to import KEGG annotations from KEGG into RGD |
| 10. | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 11. | RGD automated data pipeline |
| 12. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 13. | RGD automated import pipeline for gene-chemical interactions |
| 14. | Tsuchida K, etal., Proc Natl Acad Sci U S A 1993 Dec 1;90(23):11242-6. |
| 15. | Visser JA, etal., Mol Endocrinol. 2001 Jun;15(6):936-45. |
| 16. | Wang EY, etal., J Endocrinol 2003 Jul;178(1):137-48. |
| 17. | Wang SN, etal., J Am Soc Nephrol. 2001 Nov;12(11):2392-9. |
| 18. | Zhang D, etal., J Bone Miner Res. 2003 Sep;18(9):1593-604. |
References - uncurated| PubMed | 1646080 7577669 8242742 8388127 8395914 9884026 10226013 10479450 10704880 11290335 12054694 12065756 12151307 12477932 14729481 14993131 15037318 15226263 15289457 15531373 16140292 16420278 16642017 17078885 17117439 18326817 18436533 19506109 19736306 22871113 26873969 |
RGD Disease Portals| Acvr1 has been annotated in the following RGD Disease Portals. |
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Genomics
Comparative Map Data| Acvr1 (Rattus norvegicus - Norway rat) |
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| ACVR1 (Homo sapiens - human) |
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| Acvr1 (Mus musculus - house mouse) |
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| Acvr1 (Chinchilla lanigera - long-tailed chinchilla) |
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| ACVR1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| ACVR1 (Canis lupus familiaris - dog) |
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| Acvr1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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Position Markers| BF401349 |
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| RH138112 |
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| Acvr1 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Confirmed Target Of
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_024486 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006234214 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008761864 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008761867 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017592054 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR07052276 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07052277 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01022070 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AY693390 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC167754 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473983 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FB745997 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| L19341 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | NM_024486 | ||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
TGTGCTGGGTGTGCCCCAGAGCTGGCTTTGACTGTACGCTGTCAGGCTCTCCCTGGACCTCACGhide sequence |
| RefSeq Acc Id: | XM_006234214 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
TTTCTTTCTTTCTTTCTTTCTTAAATATTGTGAGTAAGTAAGCATTTAGTGACTGAGAAACTCAhide sequence |
| RefSeq Acc Id: | XM_006234212 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
TTATACAATGGTCGATGGAGCAATGATCCTTTCTGTGCTAATGATGATGGCTCTCCCTTCCCCGhide sequence |
| RefSeq Acc Id: | XM_006234215 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
TTATACAATGGTCGATGGAGCAATGATCCTTTCTGTGCTAATGATGATGGCTCTCCCTTCCCCGhide sequence |
| RefSeq Acc Id: | XM_006234213 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
TTATACAATGGTCGATGGAGCAATGATCCTTTCTGTGCTAATGATGATGGCTCTCCCTTCCCCGhide sequence |
| RefSeq Acc Id: | XM_008761866 |
| RefSeq Status: | |
| Type: | CODING |
| Position: | No map positions available. |
| Sequence: |
GCGCCTCCCGCGCCGCCCTGCAGCTCCCGGCCGCCTCGCGCTCTCCGCCTCCCCGGGTTCAGCAhide sequence |
| RefSeq Acc Id: | XM_008761862 |
| RefSeq Status: | |
| Type: | CODING |
| Position: | No map positions available. |
| Sequence: |
TTTCTTTCTTTCTTTCTTTCTTAAATATTGTGAGTAAGTAAGCATTTAGTGACTGAGAAACTCAhide sequence |
| RefSeq Acc Id: | XM_008761864 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
GTTTGCTATTTACCATTTTTTTTAAACTAGGTCAATCTTTGACCTTGACCTGTAGGTCATAGTAhide sequence |
| RefSeq Acc Id: | XM_008761865 |
| RefSeq Status: | |
| Type: | CODING |
| Position: | No map positions available. |
| Sequence: |
GTTTGCTATTTACCATTTTTTTTAAACTAGGTCAATCTTTGACCTTGACCTGTAGGTCATAGTAhide sequence |
| RefSeq Acc Id: | XM_008761863 |
| RefSeq Status: | |
| Type: | CODING |
| Position: | No map positions available. |
| Sequence: |
GTTTGCTATTTACCATTTTTTTTAAACTAGGTCAATCTTTGACCTTGACCTGTAGGTCATAGTAhide sequence |
| RefSeq Acc Id: | XM_008761867 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
GCTGTGCCTTTAGATTAGTTAAAGCTCCTGGTGTTACACAGCCAACCCGGGTGTAATATGAGAAhide sequence |
| RefSeq Acc Id: | XM_017592054 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_077812 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006234276 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_008760086 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_008760089 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017447543 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAA40673 | (Get FASTA) | NCBI Sequence Viewer |
| AAI67754 | (Get FASTA) | NCBI Sequence Viewer | |
| AAU04390 | (Get FASTA) | NCBI Sequence Viewer | |
| CAT04597 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM00402 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM00403 | (Get FASTA) | NCBI Sequence Viewer | |
| P80201 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| Protein Acc Id: | NP_077812 |
| Peptide Label: | precursor |
| Sequence: |
MVDGAMILSVLMMMALPSPSMEDEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGFRhide sequence |
| Protein Acc Id: | XP_006234276 |
| Peptide Label: | isoform X3 |
| Sequence: |
MVDGAMILSVLMMMALPSPSMEDEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGFRhide sequence |
| Protein Acc Id: | XP_006234274 |
| Sequence: |
MVDGAMILSVLMMMALPSPSMEALTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEhide sequence |
| Protein Acc Id: | XP_006234277 |
| Sequence: |
MRNGVYEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGFRVYQKGCFQVYEQGKMTChide sequence |
| Protein Acc Id: | XP_006234275 |
| Sequence: |
MRNGVSLTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGhide sequence |
| Protein Acc Id: | XP_008760088 |
| Peptide Label: | isoform X2 |
| Sequence: |
MVDGAMILSVLMMMALPSPSMEALTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEhide sequence |
| Protein Acc Id: | XP_008760084 |
| Peptide Label: | isoform X2 |
| Sequence: |
MVDGAMILSVLMMMALPSPSMEALTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEhide sequence |
| Protein Acc Id: | XP_008760086 |
| Peptide Label: | isoform X1 |
| Sequence: |
MVDGAMILSVLMMMALPSPSMEALTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEhide sequence |
| Protein Acc Id: | XP_008760087 |
| Peptide Label: | isoform X2 |
| Sequence: |
MVDGAMILSVLMMMALPSPSMEALTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEhide sequence |
| Protein Acc Id: | XP_008760085 |
| Peptide Label: | isoform X2 |
| Sequence: |
MVDGAMILSVLMMMALPSPSMEALTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEhide sequence |
| Protein Acc Id: | XP_008760089 |
| Peptide Label: | isoform X2 |
| Sequence: |
MRNGVSLTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGhide sequence |
| Protein Acc Id: | XP_017447543 |
| Peptide Label: | isoform X1 |
TranscriptomeStrain Variation
Strain Sequence Variants
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Additional Information
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000005033 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000006963 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOP00000072326 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000006963 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOT00000087071 | ENTREZGENE, UniProtKB/TrEMBL | |
| IMAGE_CLONE | IMAGE:9089038 | IMAGE-MGC_LOAD |
| InterPro | Activin_II_recpt | UniProtKB/Swiss-Prot |
| Activin_rcpt | UniProtKB/Swiss-Prot | |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser-Thr/Tyr_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_AS | UniProtKB/Swiss-Prot | |
| TGF_beta_rcpt_GS | UniProtKB/Swiss-Prot | |
| Transform_growth_fac-b_typ-2 | UniProtKB/TrEMBL | |
| KEGG Report | rno:79558 | UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:187367 | IMAGE-MGC_LOAD |
| NCBI Gene | 79558 | ENTREZGENE |
| PANTHER | PTHR23255 | UniProtKB/Swiss-Prot |
| Pfam | Activin_recp | UniProtKB/Swiss-Prot |
| Pkinase_Tyr | UniProtKB/Swiss-Prot | |
| TGF_beta_GS | UniProtKB/Swiss-Prot | |
| PhenoGen | Acvr1 | PhenoGen |
| PIRSF | TGFRII | UniProtKB/TrEMBL |
| PRINTS | ACTIVIN2R | UniProtKB/Swiss-Prot |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| PS51256 | UniProtKB/Swiss-Prot | |
| SMART | S_TKc | UniProtKB/Swiss-Prot |
| SM00467 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.87899 | ENTREZGENE |
| UniProt | A0A0G2K2P7 | ENTREZGENE, UniProtKB/TrEMBL |
| ACVR1_RAT | UniProtKB/Swiss-Prot | |
| B3DM96 | ENTREZGENE, UniProtKB/TrEMBL | |
| P80201 | ENTREZGENE |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2016-03-15 | Acvr1 | activin A receptor type 1 | Acvr1 | activin A receptor, type I | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-09-09 | Acvr1 | activin A receptor, type I | Acvr1 | activin A receptor, type 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2005-01-20 | Acvr1 | activin A receptor, type 1 | activin type I receptor | Name updated | 1299863 | APPROVED | |
| 2002-08-07 | Acvr1 | activin type I receptor | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_function | receptor for activin | 724707 |
| gene_physical_interaction | may form a complex with type II activin receptors | 724761 |
| More on Acvr1 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 620200 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2018-04-10 |
| Status: | ACTIVE |
