Acvr1 (activin A receptor type 1) - Rat Genome Database

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Gene: Acvr1 (activin A receptor type 1) Ictidomys tridecemlineatus
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Symbol: Acvr1
Name: activin A receptor type 1
RGD ID: 12669688
Description: ENCODES a protein that exhibits activin binding (ortholog); activin receptor activity, type I (ortholog); ATP binding (ortholog); INVOLVED IN activin receptor signaling pathway (ortholog); acute inflammatory response (ortholog); atrial septum primum morphogenesis (ortholog); PARTICIPATES IN activin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); autism spectrum disorder (ortholog); Breast Neoplasms (ortholog); FOUND IN activin receptor complex (ortholog); apical part of cell (ortholog); integral component of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: activin receptor type-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303120,806,153 - 120,874,529 (-)NCBI
SpeTri2.0NW_00493646920,743,195 - 20,811,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (ISO)
acute inflammatory response  (ISO)
atrial septum primum morphogenesis  (ISO)
atrioventricular valve morphogenesis  (ISO)
BMP signaling pathway  (ISO)
BMP signaling pathway involved in heart development  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
cardiac muscle cell fate commitment  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
determination of left/right symmetry  (ISO)
embryonic heart tube morphogenesis  (ISO)
endocardial cushion cell fate commitment  (ISO)
endocardial cushion fusion  (ISO)
endocardial cushion morphogenesis  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
gastrulation  (ISO)
gastrulation with mouth forming second  (ISO)
germ cell development  (ISO)
heart development  (ISO)
in utero embryonic development  (ISO)
mesoderm development  (ISO)
mesoderm formation  (ISO)
mitral valve morphogenesis  (ISO)
negative regulation of activin receptor signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of signal transduction  (ISO)
neural crest cell migration  (ISO)
outflow tract septum morphogenesis  (ISO)
pathway-restricted SMAD protein phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
pharyngeal system development  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of determination of dorsal identity  (ISO)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein phosphorylation  (ISO)
regulation of ossification  (ISO)
regulation of skeletal muscle tissue development  (ISO)
smooth muscle cell differentiation  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Acvr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303120,806,153 - 120,874,529 (-)NCBI
SpeTri2.0NW_00493646920,743,195 - 20,811,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2157,736,444 - 157,875,862 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2157,736,444 - 157,876,330 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2157,736,251 - 157,876,330 (-)EnsemblGRCh38hg38GRCh38
GRCh382157,736,446 - 157,876,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372158,592,958 - 158,732,842 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362158,301,207 - 158,403,036 (-)NCBINCBI36hg18NCBI36
Build 342158,418,468 - 158,520,298NCBI
Celera2152,206,070 - 152,344,336 (-)NCBI
Cytogenetic Map2q24.1NCBI
HuRef2150,478,249 - 150,616,526 (-)NCBIHuRef
CHM1_12158,598,894 - 158,738,243 (-)NCBICHM1_1
Acvr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39258,336,450 - 58,456,840 (-)NCBIGRCm39mm39
GRCm39 Ensembl258,278,656 - 58,457,169 (-)Ensembl
GRCm38258,446,438 - 58,566,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl258,388,644 - 58,567,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv37258,298,849 - 58,419,239 (-)NCBIGRCm37mm9NCBIm37
MGSCv36258,261,824 - 58,331,545 (-)NCBImm8
Celera260,202,316 - 60,294,260 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
Acvr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
Rnor_6.0 Ensembl344,432,471 - 44,522,930 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0344,432,476 - 44,539,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0349,551,411 - 49,641,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4340,191,727 - 40,260,488 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1340,088,098 - 40,156,860 (-)NCBI
Celera341,046,965 - 41,113,654 (-)NCBICelera
Cytogenetic Map3q21NCBI
Acvr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544915,640,230 - 15,708,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544915,587,958 - 15,706,432 (+)NCBIChiLan1.0ChiLan1.0
ACVR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B162,234,823 - 162,372,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B162,234,823 - 162,297,805 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B44,994,175 - 45,133,490 (-)NCBIMhudiblu_PPA_v0panPan3
ACVR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1363,743,257 - 3,818,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl363,744,163 - 3,818,652 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,880,162 - 4,006,562 (-)NCBI
ROS_Cfam_1.0363,865,484 - 3,991,973 (-)NCBI
UMICH_Zoey_3.1363,867,397 - 3,993,826 (-)NCBI
UNSW_CanFamBas_1.0363,927,214 - 4,053,637 (-)NCBI
UU_Cfam_GSD_1.0363,965,356 - 4,091,837 (-)NCBI
ACVR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1564,748,761 - 64,892,153 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11564,749,478 - 64,891,653 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21571,681,467 - 71,823,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACVR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11043,139,396 - 43,281,024 (-)NCBI
ChlSab1.1 Ensembl1043,139,528 - 43,281,177 (-)Ensembl
Vero_WHO_p1.0NW_023666040156,293,920 - 156,435,319 (+)NCBI
Acvr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247327,929,997 - 8,004,235 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005315779   ⟹   XP_005315836
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303120,806,153 - 120,874,529 (-)NCBI
SpeTri2.0NW_00493646920,743,195 - 20,811,567 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013366593   ⟹   XP_013222047
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303120,806,153 - 120,874,529 (-)NCBI
SpeTri2.0NW_00493646920,743,195 - 20,811,567 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005315836 (Get FASTA)   NCBI Sequence Viewer  
  XP_013222047 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013222047   ⟸   XM_013366593
- UniProtKB: I3M4Q3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005315836   ⟸   XM_005315779
- UniProtKB: I3M4Q3 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
GS   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000004704 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000004216 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000004698 UniProtKB/TrEMBL
InterPro Activin_recp UniProtKB/TrEMBL
  GS_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/TrEMBL
NCBI Gene Acvr1 ENTREZGENE
PANTHER PTHR23255 UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  TGF_beta_GS UniProtKB/TrEMBL
PRINTS ACTIVIN2R UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PS51256 UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  SM00467 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt I3M4Q3 ENTREZGENE, UniProtKB/TrEMBL