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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methoxyflavanone
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Accession:CHEBI:25240 term browser browse the term
Definition:A member of the class of flavanones that consists of flavanone with one or more methoxy substituents.
Synonyms:related_synonym: methoxyflavanones


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hesperetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:16156793 NCBI chr10:528,961...655,179 JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO hesperetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:16156793 NCBI chr15:95,541,186...95,774,898 JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO hesperetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16156793 NCBI chr11:80,473,809...80,567,257 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] CTD PMID:27818223 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO hesperetin results in decreased expression of ADIPOQ mRNA CTD PMID:25345581 NCBI chr11:77,721,912...77,735,644 JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein] CTD PMID:33522063 NCBI chr20:4,148,150...4,151,361 JBrowse link
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
ISO hesperetin results in increased activity of AHR protein
[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein]
CTD PMID:17869316 PMID:21720915 NCBI chr 6:52,234,089...52,271,568 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP hesperetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] CTD PMID:19222219 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
multiple interactions
increases expression
ISO
EXP
hesperetin affects the expression of BAX protein
[Cisplatin co-treated with hesperetin] results in decreased expression of BAX protein
hesperetin promotes the reaction [Cisplatin results in increased expression of BAX protein]
hesperetin analog results in increased expression of BAX protein; hesperetin results in increased expression of BAX mRNA; hesperetin results in increased expression of BAX protein
hesperetin analog results in increased expression of BAX mRNA
CTD PMID:15975156 PMID:20564462 PMID:22142698 PMID:25345581 PMID:31153982 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions
decreases expression
ISO
EXP
hesperetin affects the expression of BCL2 protein
hesperetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein]
hesperetin analog results in decreased expression of BCL2 protein; hesperetin results in decreased expression of BCL2 protein
hesperetin analog results in decreased expression of BCL2 mRNA
CTD PMID:15975156 PMID:20564462 PMID:22142698 PMID:31153982 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 affects cleavage
multiple interactions
increases expression
increases activity
ISO
EXP
hesperetin affects the cleavage of CASP3 protein
hesperetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
hesperetin metabolite results in increased expression of CASP3 protein modified form; hesperetin results in increased expression of CASP3 protein modified form
hesperetin analog results in increased activity of CASP3 protein
hesperetin analog results in increased expression of CASP3 mRNA
CTD PMID:15975156 PMID:19222219 PMID:20564462 PMID:22142698 PMID:31153982 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Cat catalase increases activity
multiple interactions
decreases activity
ISO
EXP
hesperetin results in increased activity of CAT protein
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]
hesperetin analog results in decreased activity of CAT protein; hesperetin results in decreased activity of CAT protein
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]
CTD PMID:19023542 PMID:19222219 PMID:19497424 PMID:21134734 PMID:22142698 PMID:26546711 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:24707119 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein] CTD PMID:24707119 NCBI chr10:68,322,826...68,327,365 JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO
EXP
hesperetin results in decreased expression of CCND1
hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]
CTD PMID:17927510 PMID:27818223 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO hesperetin results in decreased expression of CDK2 CTD PMID:17927510 NCBI chr 7:1,129,878...1,137,431 JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]
hesperetin results in decreased expression of CDK4
CTD PMID:17927510 NCBI chr 7:62,885,647...62,889,562 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]
hesperetin results in increased expression of CDKN1A; hesperetin results in increased expression of CDKN1A mRNA
CTD PMID:17927510 PMID:25345581 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO hesperetin results in increased expression of CDKN1B CTD PMID:17927510 NCBI chr 4:167,760,067...167,765,177 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO hesperetin results in decreased expression of CEBPA protein CTD PMID:25345581 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:27818223 NCBI chr10:79,883,622...79,900,625 JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein] CTD PMID:24707119 NCBI chr10:83,660,787...83,664,569 JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions EXP hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYB5A protein] CTD PMID:19497424 NCBI chr18:78,213,067...78,245,677 JBrowse link
G Cycs cytochrome c, somatic increases expression ISO hesperetin analog results in increased expression of CYCS protein; hesperetin results in increased expression of CYCS protein CTD PMID:22142698 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO hesperetin results in decreased activity of CYP19A1 protein CTD PMID:10403137 NCBI chr 8:54,553,165...54,580,758 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO [2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
hesperetin results in decreased activity of CYP1A1 protein
hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
CTD PMID:10781868 PMID:21720915 PMID:26546711 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO hesperetin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO hesperetin results in decreased activity of CYP1B1 protein CTD PMID:10781868 NCBI chr 6:15,342,312...15,350,886 JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO hesperetin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:237,938,521...237,976,238 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein] CTD PMID:19497424 NCBI chr 1:195,840,330...195,850,728 JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO hesperetin results in decreased expression of FABP4 mRNA CTD PMID:25345581 NCBI chr 2:91,580,858...91,585,578 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein] CTD PMID:21134734 NCBI chr  X:152,201,081...152,220,863 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO
hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]
CTD PMID:21134734 PMID:26546711 NCBI chr16:58,482,209...58,525,256 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO hesperetin results in increased expression of HMOX1 protein
[Cisplatin co-treated with hesperetin] results in increased expression of HMOX1 protein
hesperetin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; hesperetin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]
CTD PMID:15316927 PMID:31153982 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] CTD PMID:33522063 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Ifng interferon gamma multiple interactions ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] CTD PMID:24707119 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:24707119 NCBI chr 3:116,526,601...116,537,055 JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects expression
ISO
EXP
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]
hesperetin affects the expression of IL1B protein
CTD PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions
affects expression
ISO
EXP
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]
hesperetin affects the expression of IL6 protein
CTD PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 PMID:33522063 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein] CTD PMID:28428136 NCBI chr 5:115,780,248...115,888,841 JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of JAK2 protein] CTD PMID:33522063 NCBI chr 1:226,995,334...227,054,381 JBrowse link
G Lpl lipoprotein lipase decreases expression ISO hesperetin results in decreased expression of LPL mRNA CTD PMID:25345581 NCBI chr16:20,830,055...20,853,855 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:31153982 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] CTD PMID:31153982 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
[Cisplatin co-treated with hesperetin] results in decreased phosphorylation of MAPK8 protein
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]
CTD PMID:19222219 PMID:31153982 NCBI chr16:8,638,897...8,721,960 JBrowse link
G Mir410 microRNA 410 multiple interactions ISO hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of MIR410 mRNA]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] CTD PMID:32762101 NCBI chr 6:128,758,358...128,758,433 JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
hesperetin inhibits the reaction [Cisplatin results in increased expression of MPO protein]
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
CTD PMID:31153982 PMID:33522063 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of MYC protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein] CTD PMID:27818223 NCBI chr 7:93,593,705...93,598,633 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of NFE2L2 protein]; hesperetin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
[Cisplatin co-treated with hesperetin] results in increased expression of NFE2L2 protein
hesperetin results in increased expression of NFE2L2 protein
CTD PMID:26546711 PMID:31153982 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:12512693 PMID:15316927 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nox4 NADPH oxidase 4 decreases expression
multiple interactions
ISO hesperetin results in decreased expression of NOX4 protein
hesperetin inhibits the reaction [Cisplatin results in increased expression of NOX4 protein]
CTD PMID:31153982 NCBI chr 1:140,900,886...141,078,844 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP
ISO
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein]
hesperetin inhibits the reaction [Cisplatin results in decreased expression of NQO1 protein]
[Cisplatin co-treated with hesperetin] results in increased expression of NQO1 protein
hesperetin results in increased expression of NQO1 protein
CTD PMID:19497424 PMID:31153982 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO hesperetin results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665 JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of PCNA protein] CTD PMID:26546711 NCBI chr 3:119,499,039...119,502,911 JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein] CTD PMID:19497424 NCBI chr12:20,951,058...20,999,198 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
ISO hesperetin results in decreased expression of PPARG mRNA; hesperetin results in decreased expression of PPARG protein
[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG protein]
CTD PMID:25345581 PMID:28428136 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] CTD PMID:27818223 NCBI chr 1:230,631,303...230,696,754 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects activity
ISO
EXP
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
hesperetin affects the activity of PTGS2 protein
CTD PMID:15240993 PMID:16101151 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:26546711 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Retn resistin decreases expression ISO hesperetin results in decreased expression of RETN mRNA CTD PMID:25345581 NCBI chr12:1,710,881...1,712,621 JBrowse link
G Shbg sex hormone binding globulin affects binding ISO hesperetin binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409 JBrowse link
G Sirt6 sirtuin 6 multiple interactions
increases expression
ISO [Cisplatin co-treated with hesperetin] results in increased expression of SIRT6 protein
hesperetin results in increased expression of SIRT6 protein
CTD PMID:31153982 NCBI chr 7:8,082,312...8,087,776 JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [hesperetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:192,123,755...192,144,617 JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SOCS3 protein] CTD PMID:33522063 NCBI chr10:103,193,909...103,197,322 JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO hesperetin results in increased expression of SOD1 protein CTD PMID:19023542 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO hesperetin results in increased expression of SOD2 protein CTD PMID:19023542 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Sox18 SRY-box transcription factor 18 multiple interactions ISO hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]] CTD PMID:32762101 NCBI chr 3:168,785,488...168,787,290 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein] CTD PMID:28428136 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein] CTD PMID:33522063 NCBI chr10:85,811,206...85,863,057 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] CTD PMID:27818223 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
decreases expression
ISO
EXP
[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
hesperetin affects the expression of TNF protein
hesperetin results in decreased expression of TNF mRNA
CTD PMID:11123379 PMID:16934226 PMID:24871567 PMID:25345581 PMID:26546711 PMID:28428136 PMID:32762101 PMID:33522063 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein] CTD PMID:15795422 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Utrn utrophin increases expression ISO hesperetin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313 JBrowse link
hesperidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP [2,2-bis(4-glycidyloxyphenyl)propane co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein] CTD PMID:32627286 NCBI chr12:19,407,359...19,413,713 JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:28935427 PMID:30779474 NCBI chr14:17,573,412...17,591,476 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein] CTD PMID:30779474 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Alb albumin multiple interactions
increases expression
ISO [Hesperidin co-treated with Doxorubicin] results in increased expression of ALB protein
Hesperidin results in increased expression of ALB protein
CTD PMID:29481770 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]
Doxorubicin promotes the reaction [Hesperidin results in increased expression of BAX mRNA]
CTD PMID:24954035 PMID:29481770 PMID:32050098 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]
Hesperidin results in decreased expression of BCL2 mRNA
Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA]
CTD PMID:22093918 PMID:24954035 PMID:29481770 PMID:30623541 PMID:32050098 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression EXP Hesperidin results in increased expression of BMP2 mRNA CTD PMID:21820093 NCBI chr 3:120,812,660...120,822,579 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
EXP
ISO
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein]
[Hesperidin co-treated with Doxorubicin] results in increased activity of CASP3 protein; Doxorubicin promotes the reaction [Hesperidin results in increased expression of CASP3 mRNA]
Hesperidin results in increased activity of CASP3 protein
CTD PMID:22093918 PMID:29481770 PMID:30623541 PMID:30779474 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp9 caspase 9 multiple interactions EXP Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 protein] CTD PMID:22093918 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cat catalase multiple interactions
increases activity
EXP
ISO
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]
Hesperidin results in increased activity of CAT protein
Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]
CTD PMID:22093918 PMID:29481770 PMID:30098279 PMID:30623541 PMID:30779474 PMID:31095933 PMID:32050098 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 protein]; Hesperidin inhibits the reaction [Ethanol results in increased expression of CCL3 protein] CTD PMID:30368987 PMID:30811821 NCBI chr10:68,451,388...68,452,938 JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein] CTD PMID:30779474 NCBI chr 7:1,129,878...1,137,431 JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:17400256 NCBI chr14:17,270,146...17,289,458 JBrowse link
G Fabp9 fatty acid binding protein 9 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of FABP9 protein] CTD PMID:32050098 NCBI chr 2:91,591,842...91,595,873 JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein] CTD PMID:16427799 NCBI chr10:106,072,093...106,090,259 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
multiple interactions
ISO Hesperidin results in decreased activity of G6PD protein
Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]
CTD PMID:16427799 PMID:25130191 NCBI chr  X:152,201,081...152,220,863 JBrowse link
G Gck glucokinase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA] CTD PMID:16427799 NCBI chr14:80,785,060...80,829,842 JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity
multiple interactions
ISO
EXP
Hesperidin results in decreased activity of GPT protein
Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]
[Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein
CTD PMID:29481770 PMID:30779474 NCBI chr 7:108,416,646...108,419,495 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22093918 PMID:30098279 NCBI chr16:58,482,209...58,525,256 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein] CTD PMID:22093918 PMID:30098279 NCBI chr10:31,118,667...31,151,730 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein] CTD PMID:16427799 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HMOX1 protein] CTD PMID:28935427 PMID:32050098 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein] CTD PMID:32050098 NCBI chr 2:186,169,864...186,175,984 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:17400256 PMID:22074828 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD PMID:17400256 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il4 interleukin 4 multiple interactions ISO Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein] CTD PMID:17400256 NCBI chr10:37,771,203...37,776,750 JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Hesperidin results in decreased expression of IL6 protein
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]
CTD PMID:17400256 PMID:21820093 PMID:30623541 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Lep leptin decreases expression
multiple interactions
EXP Hesperidin results in decreased expression of LEP protein
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein
CTD PMID:21820093 NCBI chr 4:57,661,127...57,675,262 JBrowse link
G Lepr leptin receptor multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]; Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]; Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]; Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]; Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr 5:116,294,409...116,477,904 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein] CTD PMID:19110045 NCBI chr16:8,638,897...8,721,960 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein] CTD PMID:19110045 NCBI chr10:34,169,661...34,211,138 JBrowse link
G Mir126b microRNA 126b multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MIR126B mRNA] CTD PMID:32050098 NCBI chr 3:9,415,087...9,415,159 JBrowse link
G Mir181a2 microRNA 181a-2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MIR181A2 mRNA] CTD PMID:32050098 NCBI chr 3:22,615,845...22,615,961 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases secretion
ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein]; Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA]; Hesperidin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
Hesperidin results in decreased secretion of MMP9 protein
CTD PMID:19110045 PMID:20138977 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP Hesperidin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]
Hesperidin results in decreased activity of MPO protein
CTD PMID:31095933 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NFE2L2 protein] CTD PMID:28935427 PMID:32050098 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NFKB1 mRNA] CTD PMID:22093918 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:12512693 PMID:22093918 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein] CTD PMID:30368987 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:28935427 NCBI chr 3:119,499,039...119,502,911 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein] CTD PMID:30779474 NCBI chr 2:32,878,942...32,963,611 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]
CTD PMID:16427799 PMID:24954035 PMID:28935427 PMID:30623541 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in decreased expression of PPARGC1A protein]; Hesperidin inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein] CTD PMID:30368987 PMID:30811821 NCBI chr14:58,860,752...59,516,525 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA]
CTD PMID:16101151 PMID:19110045 PMID:30098279 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein] CTD PMID:30623541 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SGPP2 mRNA] CTD PMID:30811821 NCBI chr 9:79,762,658...79,884,665 JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32050098 NCBI chr20:25,307,143...25,329,260 JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein] CTD PMID:16427799 NCBI chr 2:111,609,798...111,639,930 JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr10:54,666,015...54,671,581 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 protein] CTD PMID:32050098 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 NCBI chr10:101,758,567...101,764,240 JBrowse link
G Tfeb transcription factor EB multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in decreased expression of TFEB mRNA] CTD PMID:30368987 NCBI chr 9:13,198,890...13,254,726 JBrowse link
G Tnc tenascin C multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in increased expression of TNC protein] CTD PMID:30368987 NCBI chr 5:77,375,851...77,460,712 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:17400256 PMID:28935427 PMID:30623541 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO Hesperidin results in increased expression of TNFRSF25 mRNA CTD PMID:24633329 NCBI chr 5:162,621,669...162,626,341 JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO Hesperidin results in increased expression of TRADD mRNA CTD PMID:24633329 NCBI chr19:33,136,148...33,142,714 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
ISO Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin results in decreased expression of VCAM1
CTD PMID:17400256 PMID:30991044 NCBI chr 2:204,038,120...204,057,852 JBrowse link
homoeriodictyol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein] CTD PMID:29902531 NCBI chr  X:127,650,223...127,689,356 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:29902531 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein] CTD PMID:29902531 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Casp3 caspase 3 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] CTD PMID:29902531 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp9 caspase 9 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein] CTD PMID:29902531 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] CTD PMID:31850465 NCBI chr 1:242,959,539...242,995,066 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO homoeriodictyol results in decreased activity of CYP1A1 protein CTD PMID:10781868 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO homoeriodictyol results in decreased activity of CYP1B1 protein CTD PMID:10781868 NCBI chr 6:15,342,312...15,350,886 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO homoeriodictyol results in increased expression of GCLM mRNA CTD PMID:29902531 NCBI chr 2:210,347,482...210,367,537 JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO [homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein CTD PMID:28834253 NCBI chr 4:146,865,712...146,869,621 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] CTD PMID:31850465 NCBI chr16:69,319,487...69,373,251 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:31850465 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:31850465 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] CTD PMID:29902531 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:31850465 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:31850465 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO homoeriodictyol results in increased expression of NQO1 mRNA
NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]
CTD PMID:29902531 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:29902531 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31850465 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein] CTD PMID:31850465 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31850465 NCBI chr20:3,622,011...3,624,629 JBrowse link
kurarinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]
CTD PMID:24997323 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO kurarinol results in increased activity of CASP3 protein
STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
CTD PMID:24997323 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO kurarinol results in decreased expression of CCND1 protein CTD PMID:24997323 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein CTD PMID:24997323 NCBI chr 2:183,219,137...183,235,676 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
kurarinol results in decreased phosphorylation of STAT3 protein
CTD PMID:24997323 NCBI chr10:85,811,206...85,863,057 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    chemical entity 19762
      atom 19760
        nonmetal atom 19641
          oxygen atom 19353
            oxygen molecular entity 19353
              organooxygen compound 18894
                ether 16903
                  aromatic ether 16205
                    methoxyflavanone 116
                      2,3-dihydro-2-(4-hydroxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                      2,3-dihydro-2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one 0
                      2,3-dihydro-4',4'''-di-O-methylamentoflavone 0
                      3'-methoxyflavanones + 21
                      4'-methoxyflavanones + 108
                      dimethoxyflavanone + 0
                      monomethoxyflavanone + 116
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19493
                              organic cyclic compound 19322
                                organic heterocyclic compound 18554
                                  oxacycle 17539
                                    benzopyran 10268
                                      1-benzopyran 9991
                                        flavonoid 6513
                                          flavans 3016
                                            flavanones 320
                                              methoxyflavanone 116
                                                2,3-dihydro-2-(4-hydroxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 0
                                                2,3-dihydro-2-(4-hydroxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one 0
                                                2,3-dihydro-4',4'''-di-O-methylamentoflavone 0
                                                3'-methoxyflavanones + 21
                                                4'-methoxyflavanones + 108
                                                dimethoxyflavanone + 0
                                                monomethoxyflavanone + 116
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