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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619871
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclm
Name: glutamate cysteine ligase, modifier subunit
Acc ID: CHEBI:28777
Term: liquiritigenin
Definition: A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.
Chemical ID: MESH:C083152
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclmincreases expressionEXP 6480464CTDliquiritigenin results in increased expression of GCLM protein

PMID:29908794
Gclmmultiple interactionsEXP 6480464CTDliquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]

PMID:29908794
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