Cd70 (Cd70 molecule) - Rat Genome Database

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Gene: Cd70 (Cd70 molecule) Rattus norvegicus
Analyze
Symbol: Cd70
Name: Cd70 molecule
RGD ID: 1588573
Description: Predicted to enable cytokine activity and protease binding activity. Predicted to be involved in several processes, including B cell proliferation; T cell mediated immunity; and extrinsic apoptotic signaling pathway. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome. Orthologous to human CD70 (CD70 molecule); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; arsenous acid; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD70 antigen; LOC301132; similar to Tumor necrosis factor ligand superfamily member 7 (CD27 ligand) (CD27-L) (CD70 antigen)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.292,006,563 - 2,009,715 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,006,563 - 2,009,715 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,440,782 - 2,443,934 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.097,790,156 - 7,793,308 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.096,746,009 - 6,749,161 (-)NCBIRnor_WKY
Rnor_6.099,842,585 - 9,845,728 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,842,585 - 9,845,728 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,844,883 - 8,848,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,508,540 - 6,511,692 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9177220   PMID:11920585   PMID:12777399   PMID:20458337   PMID:28011863   PMID:28011864  


Genomics

Comparative Map Data
Cd70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.292,006,563 - 2,009,715 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,006,563 - 2,009,715 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,440,782 - 2,443,934 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.097,790,156 - 7,793,308 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.096,746,009 - 6,749,161 (-)NCBIRnor_WKY
Rnor_6.099,842,585 - 9,845,728 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,842,585 - 9,845,728 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,844,883 - 8,848,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,508,540 - 6,511,692 (+)NCBICelera
Cytogenetic Map9q12NCBI
CD70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,581,648 - 6,591,150 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl196,583,183 - 6,604,103 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,581,659 - 6,591,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,536,850 - 6,542,163 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,536,850 - 6,542,163NCBI
Celera196,525,685 - 6,531,003 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,346,587 - 6,351,902 (-)NCBIHuRef
CHM1_1196,585,772 - 6,591,088 (-)NCBICHM1_1
T2T-CHM13v2.0196,571,316 - 6,580,807 (-)NCBIT2T-CHM13v2.0
Cd70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,452,997 - 57,456,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,452,997 - 57,456,777 (-)EnsemblGRCm39 Ensembl
GRCm381757,145,997 - 57,149,777 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,145,997 - 57,149,777 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,285,420 - 57,289,200 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,831,330 - 56,835,110 (-)NCBIMGSCv36mm8
Celera1761,495,459 - 61,499,239 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.69NCBI
CD70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1196,535,559 - 6,542,310 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,535,559 - 6,542,310 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0195,615,056 - 5,621,055 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CD70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,639,315 - 53,642,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,639,436 - 53,642,319 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,386,663 - 53,389,596 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,293,471 - 54,296,448 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,293,040 - 54,296,476 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,360,273 - 53,363,248 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,808,582 - 53,811,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,037,542 - 54,040,520 (+)NCBIUU_Cfam_GSD_1.0
Cd70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,913,063 - 213,916,307 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365883,918,944 - 3,921,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,528,400 - 72,532,951 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,528,988 - 72,531,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,154,180 - 73,157,142 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,188,720 - 6,202,212 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,188,897 - 6,193,652 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660811,796,679 - 1,810,205 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248283,720,808 - 3,724,337 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd70
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:56
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000070806
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 6 6 26 12
Below cutoff 8 7 5 10 5 1 1 28 1 22 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000070806   ⟹   ENSRNOP00000064850
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl92,006,563 - 2,009,715 (-)Ensembl
Rnor_6.0 Ensembl99,842,585 - 9,845,728 (+)Ensembl
RefSeq Acc Id: NM_001106878   ⟹   NP_001100348
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.292,006,563 - 2,009,715 (-)NCBI
Rnor_6.099,842,585 - 9,845,728 (+)NCBI
Rnor_5.098,844,883 - 8,848,026 (+)NCBI
Celera96,508,540 - 6,511,692 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100348 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83573 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100348   ⟸   NM_001106878
- Sequence:
RefSeq Acc Id: ENSRNOP00000064850   ⟸   ENSRNOT00000070806
Protein Domains
TNF_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R613-F1-model_v2 AlphaFold M0R613 1-195 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588573 AgrOrtholog
BioCyc Gene G2FUF-28485 BioCyc
Ensembl Genes ENSRNOG00000051015 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064850 ENTREZGENE
  ENSRNOP00000064850.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070806 ENTREZGENE
  ENSRNOT00000070806.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro CD70 UniProtKB/TrEMBL
  TNF UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/TrEMBL
NCBI Gene 301132 ENTREZGENE
PANTHER PTHR15152 UniProtKB/TrEMBL
Pfam TNF UniProtKB/TrEMBL
PhenoGen Cd70 PhenoGen
PROSITE TNF_2 UniProtKB/TrEMBL
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt M0R613_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-29 Cd70  Cd70 molecule  Cd70  CD70 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Cd70  CD70 antigen  LOC301132  similar to Tumor necrosis factor ligand superfamily member 7 (CD27 ligand) (CD27-L) (CD70 antigen)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301132  similar to Tumor necrosis factor ligand superfamily member 7 (CD27 ligand) (CD27-L) (CD70 antigen)      Symbol and Name status set to provisional 70820 PROVISIONAL