Tnfsf14 (TNF superfamily member 14) - Rat Genome Database

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Gene: Tnfsf14 (TNF superfamily member 14) Rattus norvegicus
Analyze
Symbol: Tnfsf14
Name: TNF superfamily member 14
RGD ID: 1588572
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytokine activity; and identical protein binding activity. Predicted to be involved in cell surface receptor signaling pathway; cellular response to mechanical stimulus; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including T cell costimulation; positive regulation of T cell chemotaxis; and positive regulation of myoblast fusion. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human TNFSF14 (TNF superfamily member 14); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH amphetamine; bisphenol A; doxorubicin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC301133; similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen); Tnlg1d; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand 1d; tumor necrosis factor ligand superfamily member 14; tumor necrosis factor superfamily member 14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,155,270 - 2,160,100 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl92,155,270 - 2,160,191 (-)EnsemblGRCr8
mRatBN7.292,068,295 - 2,073,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,069,104 - 2,073,216 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,497,352 - 2,501,003 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,846,726 - 7,850,377 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,802,581 - 6,806,232 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,761,363 - 9,765,461 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,761,536 - 9,765,186 (+)Ensemblrn6Rnor6.0
Rnor_5.098,768,631 - 8,772,649 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,447,405 - 6,451,055 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-D  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
fructose  (ISO)
genistein  (ISO)
glucose  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
isoflurane  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
monosodium L-glutamate  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentobarbital  (EXP)
perfluorononanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
PF-3758309  (ISO)
pinostrobin  (ISO)
propanal  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IEA)
membrane  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10754304   PMID:12393901   PMID:15568026   PMID:19593445   PMID:21236258   PMID:23844157   PMID:25087510   PMID:26646413  


Genomics

Comparative Map Data
Tnfsf14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,155,270 - 2,160,100 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl92,155,270 - 2,160,191 (-)EnsemblGRCr8
mRatBN7.292,068,295 - 2,073,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,069,104 - 2,073,216 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,497,352 - 2,501,003 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,846,726 - 7,850,377 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,802,581 - 6,806,232 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,761,363 - 9,765,461 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,761,536 - 9,765,186 (+)Ensemblrn6Rnor6.0
Rnor_5.098,768,631 - 8,772,649 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,447,405 - 6,451,055 (+)NCBICelera
Cytogenetic Map9q11NCBI
TNFSF14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,661,253 - 6,670,588 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,658,085 - 6,670,588 (-)Ensemblhg38GRCh38
GRCh37196,661,264 - 6,670,599 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,615,560 - 6,621,599 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34196,615,565 - 6,621,599NCBI
Celera196,604,701 - 6,612,155 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,425,122 - 6,432,649 (-)NCBIHuRef
CHM1_1196,663,409 - 6,670,848 (-)NCBICHM1_1
T2T-CHM13v2.0196,650,888 - 6,660,217 (-)NCBIT2T-CHM13v2.0
Tnfsf14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,496,437 - 57,501,182 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,496,492 - 57,501,177 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381757,189,474 - 57,194,181 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,189,492 - 57,194,177 (-)Ensemblmm10GRCm38
MGSCv371757,328,915 - 57,333,612 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,874,827 - 56,889,591 (-)NCBIMGSCv36mm8
Celera1761,538,038 - 61,542,735 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.71NCBI
Tnfsf14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,829,402 - 2,835,335 (+)Ensembl
ChiLan1.0NW_0049554952,829,314 - 2,834,826 (+)NCBIChiLan1.0ChiLan1.0
TNFSF14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22011,074,535 - 11,081,518 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11910,299,977 - 10,306,862 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,691,648 - 5,700,935 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,614,372 - 6,621,763 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,614,378 - 6,621,763 (-)EnsemblpanPan2panpan1.1
TNFSF14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,604,101 - 53,607,522 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,603,709 - 53,607,522 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2053,351,781 - 53,355,064 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02054,258,226 - 54,261,513 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,258,091 - 54,261,536 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,325,114 - 53,328,394 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,773,591 - 53,776,865 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,002,586 - 54,005,871 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tnfsf14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,854,848 - 213,859,307 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,976,492 - 3,979,825 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,976,492 - 3,979,825 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFSF14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,473,477 - 72,483,989 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1272,478,178 - 72,483,885 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,993,336 - 72,998,023 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNFSF14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,235,641 - 6,241,706 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,236,193 - 6,241,311 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660811,755,097 - 1,764,021 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfsf14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248283,763,849 - 3,770,500 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnfsf14
39 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000074247
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 8 34 65 76 79 49 92 49 6 280 153 11 40 57 62 30 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000074247   ⟹   ENSRNOP00000067356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl92,155,270 - 2,160,191 (-)Ensembl
mRatBN7.2 Ensembl92,069,104 - 2,073,216 (-)Ensembl
Rnor_6.0 Ensembl99,761,536 - 9,765,186 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107320   ⟹   ENSRNOP00000078327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl92,069,104 - 2,073,216 (-)Ensembl
RefSeq Acc Id: NM_001191803   ⟹   NP_001178732
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr892,155,270 - 2,160,086 (-)NCBI
mRatBN7.292,068,295 - 2,073,111 (-)NCBI
Rnor_6.099,761,536 - 9,765,186 (+)NCBI
Rnor_5.098,768,631 - 8,772,649 (+)NCBI
Celera96,447,405 - 6,451,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083146   ⟹   XP_038939074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr892,156,050 - 2,160,100 (-)NCBI
mRatBN7.292,069,075 - 2,073,128 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178732 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939074 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CTQ86172 (Get FASTA)   NCBI Sequence Viewer  
  EDL83572 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067356.2
  ENSRNOP00000078327.1
RefSeq Acc Id: NP_001178732   ⟸   NM_001191803
- UniProtKB: A6KQR4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067356   ⟸   ENSRNOT00000074247
RefSeq Acc Id: XP_038939074   ⟸   XM_039083146
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000078327   ⟸   ENSRNOT00000107320
Protein Domains
THD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RCN2-F1-model_v2 AlphaFold M0RCN2 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588572 AgrOrtholog
BioCyc Gene G2FUF-28484 BioCyc
Ensembl Genes ENSRNOG00000047730 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074247.2 UniProtKB/TrEMBL
  ENSRNOT00000107320.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro TNF UniProtKB/TrEMBL
  TNF UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/TrEMBL
KEGG Report rno:301133 UniProtKB/TrEMBL
NCBI Gene 301133 ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR FAMILY MEMBER UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 UniProtKB/TrEMBL
Pfam TNF UniProtKB/TrEMBL
PhenoGen Tnfsf14 PhenoGen
PRINTS TNECROSISFCT UniProtKB/TrEMBL
PROSITE TNF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047730 RatGTEx
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt A0A8I5ZKN8_RAT UniProtKB/TrEMBL
  A6KQR4 ENTREZGENE, UniProtKB/TrEMBL
  M0RCN2_RAT UniProtKB/TrEMBL
UniProt Secondary A0A0U5J7G4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Tnfsf14  TNF superfamily member 14  Tnfsf14  tumor necrosis factor superfamily member 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-25 Tnfsf14  tumor necrosis factor superfamily member 14  Tnfsf14  tumor necrosis factor (ligand) superfamily, member 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Tnfsf14  tumor necrosis factor (ligand) superfamily, member 14  LOC301133  similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301133  similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen)      Symbol and Name status set to provisional 70820 PROVISIONAL