CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: niclosamide
Accession: CHEBI:7553
browse the term
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Synonyms: exact_synonym: 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
related_synonym: 2',5-dichloro-2-hydroxy-4'-nitrobenzanilide; 2',5-dichloro-4'-nitrosalicylanilide; 2-chloro-4-nitrophenylamide-6-chlorosalicylic acid; 2-hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide; 5-chloro-2'-chloro-4'-nitrosalicylanilide; 5-chloro-N-(2'-chloro-4'-nitrophenyl)salicylamide; Atenase; B 2353; BAY 2353; Bayer 2353; Bayer 73; Bayluscide; Cestocid; Devermin; Devermine; Fedal-Telmin; Fenasal; Formula=C13H8Cl2N2O4; HL 2447; Helmiantin; InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19); InChIKey=RJMUSRYZPJIFPJ-UHFFFAOYSA-N; Iomesan; Lintex; Mansonil; Mato; N-(2-chloro-4-nitrophenyl)-5-chlorosalicylamide; Nasemo; Phenasal; Radeverm; SMILES=OC1=CC=C(Cl)C=C1C(=O)NC1=C(Cl)C=C(C=C1)[N+]([O-])=O; Sagimid; Sulqui; Tredemine; Utosamide; Vermitid; Vermitin; WR 46234; Yomesan; Zestocarp; clonitralide; niclocide; niclosamida; niclosamidum
alt_id: CHEBI:92630
xref: CAS:50-65-7; Chemspider:4322; DrugBank:DB06803; Drug_Central:1912; HMDB:HMDB0015679; KEGG:D00436; LINCS:LSM-2787
xref_mesh: MESH:D009534
xref: PMCID:PMC8308039; PMCID:PMC8508655; PMID:24900231; PMID:33325188; PMID:33772737; PMID:33855343; PMID:33860549; PMID:33870260; PMID:34038481; PMID:34209118; PMID:34332199; PMID:34386088; PMID:34429248; PMID:34482191; PMID:34483712; PMID:34512959; PMID:34517104; PMID:34572856; PMID:34638761; PPDB:1929; Pesticides:niclosamide; Reaxys:2820605; VSDB:1929; Wikipedia:Niclosamide
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A1bg
alpha-1-B glycoprotein
increases expression
ISO
Niclosamide results in increased expression of A1BG mRNA
CTD
PMID:36318118
NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097
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Abca12
ATP binding cassette subfamily A member 12
decreases expression
ISO
Niclosamide results in decreased expression of ABCA12 mRNA
CTD
PMID:36318118
NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049
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Abcc9
ATP binding cassette subfamily C member 9
decreases expression
ISO
Niclosamide results in decreased expression of ABCC9 mRNA
CTD
PMID:36318118
NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
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Abcg4
ATP binding cassette subfamily G member 4
increases expression
ISO
Niclosamide results in increased expression of ABCG4 mRNA
CTD
PMID:36318118
NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881
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Abhd1
abhydrolase domain containing 1
increases expression
ISO
Niclosamide results in increased expression of ABHD1 mRNA
CTD
PMID:36318118
NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514
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Abhd14b
abhydrolase domain containing 14b
increases expression
ISO
Niclosamide results in increased expression of ABHD14B mRNA
CTD
PMID:36318118
NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119
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Acaca
acetyl-CoA carboxylase alpha
decreases expression
ISO
Niclosamide results in decreased expression of ACACA mRNA
CTD
PMID:22576131
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Acp5
acid phosphatase 5, tartrate resistant
multiple interactions
ISO
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]
CTD
PMID:26792726 PMID:28824321
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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Acsl1
acyl-CoA synthetase long-chain family member 1
decreases expression
ISO
Niclosamide results in decreased expression of ACSL1 mRNA
CTD
PMID:22576131
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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Acta2
actin alpha 2, smooth muscle
multiple interactions decreases expression
ISO
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein] CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of ACTA2 protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of ACTA2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of ACTA2 protein] Niclosamide results in decreased expression of ACTA2 mRNA; Niclosamide results in decreased expression of ACTA2 protein
CTD
PMID:26643609 PMID:28318631 PMID:34118929 PMID:35115509 PMID:36870549
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
decreases expression
ISO
Niclosamide results in decreased expression of ADAMTS17 mRNA
CTD
PMID:36318118
NCBI chr 1:120,445,800...120,768,204
Ensembl chr 1:120,445,749...120,768,202
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Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
decreases expression
ISO
Niclosamide results in decreased expression of ADH4 mRNA
CTD
PMID:28284560
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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Adm2
adrenomedullin 2
increases expression
ISO
Niclosamide results in increased expression of ADM2 mRNA
CTD
PMID:36318118
NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331
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Adra2a
adrenoceptor alpha 2A
decreases expression
ISO
Niclosamide results in decreased expression of ADRA2A mRNA
CTD
PMID:36318118
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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Afp
alpha-fetoprotein
multiple interactions
EXP
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]
CTD
PMID:32961231
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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Agbl3
AGBL carboxypeptidase 3
decreases expression
ISO
Niclosamide results in decreased expression of AGBL3 mRNA
CTD
PMID:36318118
NCBI chr 4:63,448,789...63,535,538
Ensembl chr 4:63,453,940...63,531,188
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Aifm1
apoptosis inducing factor, mitochondria associated 1
increases cleavage
ISO
Niclosamide results in increased cleavage of AIFM1 protein
CTD
PMID:22576131
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Akna
AT-hook transcription factor
increases expression
ISO
Niclosamide results in increased expression of AKNA mRNA
CTD
PMID:36318118
NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
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Akt1
AKT serine/threonine kinase 1
increases expression multiple interactions
ISO
Niclosamide results in increased expression of AKT1 mRNA Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]
CTD
PMID:20215516 PMID:26792726 PMID:29843133
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
decreases expression
ISO
Niclosamide results in decreased expression of ALDH1A1 protein
CTD
PMID:24736023
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh6a1
aldehyde dehydrogenase 6 family, member A1
increases expression
ISO
Niclosamide results in increased expression of ALDH6A1 mRNA
CTD
PMID:36318118
NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
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Aldob
aldolase, fructose-bisphosphate B
increases expression
ISO
Niclosamide results in increased expression of ALDOB mRNA
CTD
PMID:22576131
NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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Aldoc
aldolase, fructose-bisphosphate C
decreases expression increases expression
ISO
Niclosamide results in decreased expression of ALDOC mRNA Niclosamide results in increased expression of ALDOC mRNA
CTD
PMID:22576131 PMID:36318118
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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Alkbh7
alkB homolog 7
increases expression
ISO
Niclosamide results in increased expression of ALKBH7 mRNA
CTD
PMID:36318118
NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044
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Alox12b
arachidonate 12-lipoxygenase, 12R type
increases expression decreases response to substance multiple interactions
ISO
Niclosamide results in increased expression of ALOX12B mRNA ALOX12B protein results in decreased susceptibility to Niclosamide TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]
CTD
PMID:30258081
NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938
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Alox5
arachidonate 5-lipoxygenase
multiple interactions increases expression decreases response to substance
ISO
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA] ALOX5 protein results in decreased susceptibility to Niclosamide
CTD
PMID:30258081
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Alpl
alkaline phosphatase, biomineralization associated
decreases expression
ISO
Niclosamide results in decreased expression of ALPL mRNA
CTD
PMID:28824321
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Amhr2
anti-Mullerian hormone receptor type 2
increases expression
ISO
Niclosamide results in increased expression of AMHR2 mRNA
CTD
PMID:36318118
NCBI chr 7:133,579,152...133,588,874
Ensembl chr 7:133,579,393...133,588,258
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Amot
angiomotin
increases expression
ISO
Niclosamide results in increased expression of AMOT mRNA
CTD
PMID:36318118
NCBI chr X:108,982,399...109,041,265
Ensembl chr X:108,984,022...109,041,272
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Ank3
ankyrin 3
increases expression
ISO
Niclosamide results in increased expression of ANK3 mRNA
CTD
PMID:36318118
NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
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Ankmy2
ankyrin repeat and MYND domain containing 2
increases expression
ISO
Niclosamide results in increased expression of ANKMY2 mRNA
CTD
PMID:36318118
NCBI chr 6:52,888,959...52,930,343
Ensembl chr 6:52,888,963...52,930,394
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Ankrd12
ankyrin repeat domain 12
increases expression
ISO
Niclosamide results in increased expression of ANKRD12 mRNA
CTD
PMID:36318118
NCBI chr 9:105,583,273...105,687,957
Ensembl chr 9:105,584,065...105,687,911
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Ankrd34a
ankyrin repeat domain 34A
increases expression
ISO
Niclosamide results in increased expression of ANKRD34A mRNA
CTD
PMID:36318118
NCBI chr 2:184,129,830...184,135,075
Ensembl chr 2:184,129,238...184,135,116
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Anxa4
annexin A4
increases expression
ISO
Niclosamide results in increased expression of ANXA4 mRNA
CTD
PMID:36318118
NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
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Ap1s3
adaptor related protein complex 1 subunit sigma 3
decreases expression
ISO
Niclosamide results in decreased expression of AP1S3 mRNA
CTD
PMID:36318118
NCBI chr 9:80,950,402...81,009,889
Ensembl chr 9:80,950,715...81,009,798
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Aplnr
apelin receptor
decreases expression
ISO
Niclosamide results in decreased expression of APLNR mRNA
CTD
PMID:36318118
NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050
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Apof
apolipoprotein F
decreases expression
ISO
Niclosamide results in decreased expression of APOF mRNA
CTD
PMID:28284560
NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
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Ar
androgen receptor
multiple interactions decreases expression
ISO
[enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form Niclosamide results in decreased expression of AR protein; Niclosamide results in decreased expression of AR protein alternative form
CTD
PMID:24740322 PMID:25970160 PMID:28500234
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Araf
A-Raf proto-oncogene, serine/threonine kinase
decreases expression
ISO
Niclosamide analog results in decreased expression of ARAF protein; Niclosamide results in decreased expression of ARAF protein
CTD
PMID:28284560
NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073
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Arhgdib
Rho GDP dissociation inhibitor beta
increases expression
ISO
Niclosamide results in increased expression of ARHGDIB mRNA
CTD
PMID:36318118
NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
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Armcx1
armadillo repeat containing, X-linked 1
increases expression
ISO
Niclosamide results in increased expression of ARMCX1 mRNA
CTD
PMID:36318118
NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299
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Arrdc2
arrestin domain containing 2
increases expression
ISO
Niclosamide results in increased expression of ARRDC2 mRNA
CTD
PMID:36318118
NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029
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Asf1b
anti-silencing function 1B histone chaperone
decreases expression
ISO
Niclosamide results in decreased expression of ASF1B mRNA
CTD
PMID:28284560
NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
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Atcay
ATCAY kinesin light chain interacting caytaxin
increases expression
ISO
Niclosamide results in increased expression of ATCAY mRNA
CTD
PMID:36318118
NCBI chr 7:8,487,763...8,511,527
Ensembl chr 7:8,487,763...8,512,663
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Atf3
activating transcription factor 3
increases expression multiple interactions
ISO
Niclosamide results in increased expression of ATF3 mRNA; Niclosamide results in increased expression of ATF3 protein ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]; ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]
CTD
PMID:26917416
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atf4
activating transcription factor 4
increases expression
ISO
Niclosamide results in increased expression of ATF4 mRNA; Niclosamide results in increased expression of ATF4 protein
CTD
PMID:26917416
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Atosb
atos homolog B
increases expression
ISO
Niclosamide results in increased expression of ATOSB mRNA
CTD
PMID:36318118
NCBI chr 5:57,260,839...57,274,524
Ensembl chr 5:57,260,841...57,268,892
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Atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
increases expression
ISO
Niclosamide results in increased expression of ATP2A3 mRNA
CTD
PMID:36318118
NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
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Atp5f1a
ATP synthase F1 subunit alpha
increases expression
ISO
Niclosamide results in increased expression of ATP5F1A mRNA
CTD
PMID:22576131
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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Atp5f1d
ATP synthase F1 subunit delta
increases expression
ISO
Niclosamide results in increased expression of ATP5F1D mRNA
CTD
PMID:22576131
NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
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Atp5mc3
ATP synthase membrane subunit c locus 3
decreases expression
ISO
Niclosamide results in decreased expression of ATP5MC3 mRNA
CTD
PMID:22576131
NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
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Atp5mf
ATP synthase membrane subunit f
decreases expression
ISO
Niclosamide results in decreased expression of ATP5MF mRNA
CTD
PMID:22576131
NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
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Atp5mg
ATP synthase membrane subunit G
decreases expression
ISO
Niclosamide results in decreased expression of ATP5MG mRNA
CTD
PMID:22576131
NCBI chr 8:45,225,680...45,233,630
Ensembl chr 8:45,225,686...45,233,559
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Atp5pb
ATP synthase peripheral stalk-membrane subunit b
decreases expression
ISO
Niclosamide results in decreased expression of ATP5PB mRNA
CTD
PMID:22576131
NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418
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Atp6ap1
ATPase H+ transporting accessory protein 1
decreases expression
ISO
Niclosamide results in decreased expression of ATP6AP1 mRNA
CTD
PMID:22576131
NCBI chr X:152,079,954...152,087,034
Ensembl chr X:152,079,865...152,087,034
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Atp6v0d2
ATPase H+ transporting V0 subunit D2
multiple interactions
ISO
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]
CTD
PMID:26792726
NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
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Atpsckmt
ATP synthase c subunit lysine N-methyltransferase
decreases expression
ISO
Niclosamide results in decreased expression of ATPSCKMT mRNA
CTD
PMID:36318118
NCBI chr 2:82,603,086...82,618,325
Ensembl chr 2:82,603,009...82,618,308
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Aurkb
aurora kinase B
decreases expression
ISO
Niclosamide results in decreased expression of AURKB mRNA
CTD
PMID:28284560
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Avpi1
arginine vasopressin-induced 1
increases expression
ISO
Niclosamide results in increased expression of AVPI1 mRNA
CTD
PMID:36318118
NCBI chr 1:240,930,236...240,936,154
Ensembl chr 1:240,930,236...240,936,154
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Axin2
axin 2
multiple interactions decreases expression
ISO
Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA] Niclosamide results in decreased expression of AXIN2 mRNA; Niclosamide results in decreased expression of AXIN2 protein
CTD
PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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B3gnt7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
increases expression
ISO
Niclosamide results in increased expression of B3GNT7 mRNA
CTD
PMID:36318118
NCBI chr 9:86,956,220...86,960,171
Ensembl chr 9:86,956,220...86,960,170
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B3gnt9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
increases expression
ISO
Niclosamide results in increased expression of B3GNT9 mRNA
CTD
PMID:36318118
NCBI chr19:33,129,740...33,134,048
Ensembl chr19:33,128,142...33,132,344
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Bad
BCL2-associated agonist of cell death
multiple interactions
ISO
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAD mRNA
CTD
PMID:25988281
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bak1
BCL2-antagonist/killer 1
multiple interactions
ISO
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA
CTD
PMID:25988281
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
increases expression decreases expression multiple interactions
ISO
Niclosamide results in increased expression of BAX protein Niclosamide results in decreased expression of BAX protein [Niclosamide binds to Polyethyleneimine] which results in increased expression of BAX mRNA; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]
CTD
PMID:25634333 PMID:25988281 PMID:26703449 PMID:28500234 PMID:35115509
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bbc3
Bcl-2 binding component 3
multiple interactions increases expression
ISO
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA]
CTD
PMID:30258081 PMID:36318118
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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Bbs2
Bardet-Biedl syndrome 2
increases expression
ISO
Niclosamide results in increased expression of BBS2 mRNA
CTD
PMID:36318118
NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO
Niclosamide analog results in decreased expression of BCL2 protein; Niclosamide results in decreased expression of BCL2 protein [Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein]
CTD
PMID:20215516 PMID:23894143 PMID:25634333 PMID:25988281 PMID:26116531 PMID:26703449 PMID:28284560 PMID:28500234 PMID:35115509 More...
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions decreases expression
ISO
[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2L1 mRNA; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein] Niclosamide analog results in decreased expression of BCL2L1 protein; Niclosamide results in decreased expression of BCL2L1 protein
CTD
PMID:20215516 PMID:25988281 PMID:26116531 PMID:28284560 PMID:28500234
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bcl2l2
Bcl2-like 2
decreases expression multiple interactions
ISO
Niclosamide results in decreased expression of BCL2L2 protein [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]
CTD
PMID:23894143
NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
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Bcl3
BCL3, transcription coactivator
increases expression
ISO
Niclosamide results in increased expression of BCL3 mRNA
CTD
PMID:36318118
NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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Bcl6
BCL6, transcription repressor
multiple interactions increases expression
ISO
Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein] Niclosamide results in increased expression of BCL6 mRNA
CTD
PMID:33632240 PMID:36318118
NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
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Bcl6b
BCL6B, transcription repressor
increases expression
ISO
Niclosamide results in increased expression of BCL6B mRNA
CTD
PMID:36318118
NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974
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Bcl9
BCL9, transcription coactivator
decreases expression
EXP
Niclosamide results in decreased expression of BCL9 mRNA
CTD
PMID:27338550
NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435
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Bcorl1
BCL6 co-repressor-like 1
increases expression
ISO
Niclosamide results in increased expression of BCORL1 mRNA
CTD
PMID:36318118
NCBI chr X:127,516,504...127,584,529
Ensembl chr X:127,537,538...127,584,087
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Bet1l
Bet1 golgi vesicular membrane trafficking protein-like
increases expression
ISO
Niclosamide results in increased expression of BET1L mRNA
CTD
PMID:36318118
NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040
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Bgn
biglycan
increases expression
ISO
Niclosamide results in increased expression of BGN mRNA
CTD
PMID:36318118
NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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Bhlhe40
basic helix-loop-helix family, member e40
increases expression
ISO
Niclosamide results in increased expression of BHLHE40 mRNA
CTD
PMID:36318118
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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Birc5
baculoviral IAP repeat-containing 5
multiple interactions decreases expression affects expression
ISO
enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein] Niclosamide analog results in decreased expression of BIRC5 protein; Niclosamide results in decreased expression of BIRC5 mRNA; Niclosamide results in decreased expression of BIRC5 protein Niclosamide affects the expression of BIRC5 protein
CTD
PMID:24552774 PMID:24736023 PMID:25970160 PMID:28284560 PMID:28500234 PMID:36318118 More...
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Bmf
Bcl2 modifying factor
increases expression
ISO
Niclosamide results in increased expression of BMF mRNA
CTD
PMID:36318118
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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Borcs6
BLOC-1 related complex subunit 6
increases expression
ISO
Niclosamide results in increased expression of BORCS6 mRNA
CTD
PMID:36318118
NCBI chr10:53,760,504...53,762,358
Ensembl chr10:53,758,093...53,762,632
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Braf
B-Raf proto-oncogene, serine/threonine kinase
decreases expression decreases phosphorylation
ISO
Niclosamide analog results in decreased expression of BRAF protein; Niclosamide results in decreased expression of BRAF protein Niclosamide analog results in decreased phosphorylation of BRAF protein
CTD
PMID:28284560
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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Btbd7
BTB domain containing 7
decreases expression
ISO
Niclosamide results in decreased expression of BTBD7 mRNA
CTD
PMID:36318118
NCBI chr 6:121,920,365...122,010,114
Ensembl chr 6:121,923,023...121,972,405
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
Niclosamide results in increased expression of BTG2 mRNA
CTD
PMID:36318118
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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C13h1orf105
similar to human chromosome 1 open reading frame 105
decreases expression
ISO
Niclosamide results in decreased expression of C1ORF105 mRNA
CTD
PMID:36318118
NCBI chr13:74,313,320...74,356,322
Ensembl chr13:74,313,322...74,356,322
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C16h8orf48
similar to human chromosome 8 open reading frame 48
decreases expression
ISO
Niclosamide results in decreased expression of C8ORF48 mRNA
CTD
PMID:36318118
NCBI chr16:55,244,744...55,246,642
Ensembl chr16:55,236,322...55,246,650
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C19h16orf86
similar to human chromosome 16 open reading frame 86
increases expression
ISO
Niclosamide results in increased expression of C16ORF86 mRNA
CTD
PMID:36318118
NCBI chr19:33,596,591...33,598,703
Ensembl chr19:33,595,995...33,598,521
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C1ql4
complement C1q like 4
increases expression
ISO
Niclosamide results in increased expression of C1QL4 mRNA
CTD
PMID:36318118
NCBI chr 7:130,243,606...130,246,678
Ensembl chr 7:130,243,606...130,246,678
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Cables2
Cdk5 and Abl enzyme substrate 2
decreases expression
ISO
Niclosamide results in decreased expression of CABLES2 mRNA
CTD
PMID:36318118
NCBI chr 3:167,347,527...167,362,274
Ensembl chr 3:167,347,461...167,362,279
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Cacna1e
calcium voltage-gated channel subunit alpha1 E
increases expression
ISO
Niclosamide results in increased expression of CACNA1E mRNA
CTD
PMID:36318118
NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
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Cacna1h
calcium voltage-gated channel subunit alpha1 H
increases expression
ISO
Niclosamide results in increased expression of CACNA1H mRNA
CTD
PMID:36318118
NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
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Cacng1
calcium voltage-gated channel auxiliary subunit gamma 1
increases expression
ISO
Niclosamide results in increased expression of CACNG1 mRNA
CTD
PMID:36318118
NCBI chr10:92,652,924...92,665,612
Ensembl chr10:92,652,614...92,665,783
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
increases expression
ISO
Niclosamide results in increased expression of CAMK2A mRNA
CTD
PMID:36318118
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Camsap3
calmodulin regulated spectrin-associated protein family, member 3
increases expression
ISO
Niclosamide results in increased expression of CAMSAP3 mRNA
CTD
PMID:36318118
NCBI chr12:1,643,062...1,666,685
Ensembl chr12:1,643,251...1,666,685
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Caps
calcyphosine
increases expression
ISO
Niclosamide results in increased expression of CAPS mRNA
CTD
PMID:36318118
NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647
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Casp1
caspase 1
multiple interactions
ISO
[Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]
CTD
PMID:33524445
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
increases cleavage multiple interactions decreases expression increases expression
ISO EXP
Niclosamide results in increased cleavage of CASP3 protein 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; [Niclosamide binds to Polyethyleneimine] which results in increased expression of CASP3 mRNA; ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein] Niclosamide results in decreased expression of CASP3 protein Niclosamide results in increased expression of CASP3 protein modified form [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form] Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]
CTD
PMID:20215516 PMID:21871175 PMID:24750999 PMID:25174399 PMID:25634333 PMID:25988281 PMID:26116531 PMID:26703449 PMID:26917416 PMID:28824321 PMID:29031202 PMID:30258081 PMID:30329025 PMID:32961231 PMID:35115509 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
multiple interactions increases expression
ISO
bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form]
CTD
PMID:26116531 PMID:28500234
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8
caspase 8
increases cleavage
ISO
Niclosamide results in increased cleavage of CASP8 protein
CTD
PMID:35115509
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
multiple interactions increases cleavage increases expression
ISO
TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein] Niclosamide results in increased expression of CASP9 mRNA; Niclosamide results in increased expression of CASP9 protein modified form
CTD
PMID:26116531 PMID:26703449 PMID:30258081 PMID:36318118
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cbx4
chromobox 4
increases expression
ISO
Niclosamide results in increased expression of CBX4 mRNA
CTD
PMID:36318118
NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706
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Ccdc113
coiled-coil domain containing 113
increases expression
ISO
Niclosamide results in increased expression of CFAP263 mRNA
CTD
PMID:36318118
NCBI chr19:9,497,000...9,516,917
Ensembl chr19:9,496,886...9,516,923
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Ccdc188
coiled-coil domain containing 188
increases expression
ISO
Niclosamide results in increased expression of CCDC188 mRNA
CTD
PMID:36318118
NCBI chr11:82,769,735...82,772,062
Ensembl chr11:82,769,473...82,772,114
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Ccdc68
coiled-coil domain containing 68
decreases expression
ISO
Niclosamide results in decreased expression of CCDC68 mRNA
CTD
PMID:36318118
NCBI chr18:63,541,828...63,584,122
Ensembl chr18:63,541,896...63,584,119
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]
CTD
PMID:24561310 PMID:28318631
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl20
C-C motif chemokine ligand 20
multiple interactions
ISO EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]
CTD
PMID:28318631
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ccl3
C-C motif chemokine ligand 3
multiple interactions
ISO
Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]
CTD
PMID:24561310
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL5 protein]
CTD
PMID:24561310
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccnb1
cyclin B1
decreases expression
ISO
Niclosamide results in decreased expression of CCNB1 mRNA
CTD
PMID:28284560
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnb3
cyclin B3
decreases expression
ISO
Niclosamide results in decreased expression of CCNB3 mRNA
CTD
PMID:36318118
NCBI chr X:15,478,050...15,543,292
Ensembl chr X:15,478,065...15,542,885
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Ccnd1
cyclin D1
multiple interactions decreases expression
EXP ISO
Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]] Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein] Niclosamide analog results in decreased expression of CCND1 protein; Niclosamide results in decreased expression of CCND1 mRNA; Niclosamide results in decreased expression of CCND1 protein
CTD
PMID:19160421 PMID:20215516 PMID:24552774 PMID:24736023 PMID:26297436 PMID:26964897 PMID:27338550 PMID:28284560 PMID:28500234 PMID:30143678 PMID:32961231 PMID:36318118 More...
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd2
cyclin D2
decreases expression increases expression
ISO
Niclosamide results in decreased expression of CCND2 mRNA Niclosamide results in increased expression of CCND2 mRNA
CTD
PMID:22576131 PMID:27226553 PMID:36318118
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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Ccnd3
cyclin D3
decreases expression
ISO
Niclosamide results in decreased expression of CCND3 mRNA
CTD
PMID:22576131 PMID:27226553
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccne1
cyclin E1
decreases expression
ISO
Niclosamide results in decreased expression of CCNE1 mRNA
CTD
PMID:36318118
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Ccne2
cyclin E2
multiple interactions decreases expression
ISO
Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA] Niclosamide results in decreased expression of CCNE2 mRNA
CTD
PMID:27542212 PMID:36318118
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Ccng2
cyclin G2
multiple interactions increases expression
ISO
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA] Niclosamide results in increased expression of CCNG2 mRNA
CTD
PMID:27542212 PMID:36318118
NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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Ccr10
C-C motif chemokine receptor 10
increases expression
ISO
Niclosamide results in increased expression of CCR10 mRNA
CTD
PMID:36318118
NCBI chr10:86,108,551...86,110,988
Ensembl chr10:86,108,551...86,110,988
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Cd27
CD27 molecule
increases expression
ISO
Niclosamide results in increased expression of CD27 mRNA
CTD
PMID:36318118
NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592
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Cd274
CD274 molecule
decreases expression
ISO
Niclosamide results in decreased expression of CD274 mRNA; Niclosamide results in decreased expression of CD274 protein
CTD
PMID:35115509
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd40
CD40 molecule
multiple interactions
ISO
Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein]
CTD
PMID:24561310
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Cd55
CD55 molecule (Cromer blood group)
increases expression
ISO
Niclosamide results in increased expression of CD55 mRNA
CTD
PMID:36318118
NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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Cd68
Cd68 molecule
increases expression
ISO
Niclosamide results in increased expression of CD68 mRNA
CTD
PMID:36318118
NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
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Cd80
Cd80 molecule
multiple interactions
ISO
Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein]
CTD
PMID:24561310
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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Cd86
CD86 molecule
multiple interactions
ISO
Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein]
CTD
PMID:24561310
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Cdc37
cell division cycle 37, HSP90 cochaperone
multiple interactions
ISO
CDC37 protein binds to and results in increased susceptibility to Niclosamide analog
CTD
PMID:28284560
NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
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Cdc42
cell division cycle 42
decreases expression decreases phosphorylation
ISO
Niclosamide results in decreased expression of CDC42 mRNA Niclosamide results in decreased phosphorylation of CDC42 protein
CTD
PMID:29251334
NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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Cdc42ep1
CDC42 effector protein 1
increases expression
ISO
Niclosamide results in increased expression of CDC42EP1 mRNA
CTD
PMID:36318118
NCBI chr 7:110,395,287...110,403,203
Ensembl chr 7:110,395,332...110,403,200
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Cdc6
cell division cycle 6
decreases expression
ISO
Niclosamide results in decreased expression of CDC6 mRNA
CTD
PMID:28284560 PMID:36318118
NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
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Cdca2
cell division cycle associated 2
decreases expression
ISO
Niclosamide results in decreased expression of CDCA2 mRNA
CTD
PMID:28284560
NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
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Cdca5
cell division cycle associated 5
decreases expression
ISO
Niclosamide results in decreased expression of CDCA5 mRNA
CTD
PMID:28284560
NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023
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Cdca8
cell division cycle associated 8
decreases expression
ISO
Niclosamide results in decreased expression of CDCA8 mRNA
CTD
PMID:28284560
NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
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Cdh1
cadherin 1
multiple interactions increases expression
ISO
CTNNB1 protein inhibits the reaction [Niclosamide results in increased expression of CDH1 protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein] Niclosamide results in increased expression of CDH1 mRNA; Niclosamide results in increased expression of CDH1 protein
CTD
PMID:25174399 PMID:26643609 PMID:30143678 PMID:35115509
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdh11
cadherin 11
decreases expression
ISO
Niclosamide results in decreased expression of CDH11 mRNA
CTD
PMID:36318118
NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
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Cdh12
cadherin 12
multiple interactions
ISO
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CDH12 protein]
CTD
PMID:36870549
NCBI chr 2:70,474,679...71,705,369
Ensembl chr 2:70,475,043...71,700,572
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Cdh2
cadherin 2
multiple interactions decreases expression
ISO
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein] Niclosamide results in decreased expression of CDH2 protein
CTD
PMID:26643609 PMID:34118929
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Cdh4
cadherin 4
increases expression
ISO
Niclosamide results in increased expression of CDH4 mRNA
CTD
PMID:36318118
NCBI chr 3:166,525,092...167,003,380
Ensembl chr 3:166,525,099...167,003,371
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Cdh6
cadherin 6
decreases expression
ISO
Niclosamide results in decreased expression of CDH6 mRNA
CTD
PMID:36318118
NCBI chr 2:62,079,139...62,225,298
Ensembl chr 2:62,079,137...62,225,228
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Cdhr1
cadherin-related family member 1
increases expression
ISO
Niclosamide results in increased expression of CDHR1 mRNA
CTD
PMID:36318118
NCBI chr16:12,843,436...12,863,321
Ensembl chr16:12,843,437...12,863,396
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Cdhr2
cadherin-related family member 2
decreases expression
ISO
Niclosamide results in decreased expression of CDHR2 mRNA
CTD
PMID:36318118
NCBI chr17:9,876,853...9,913,356
Ensembl chr17:9,876,860...9,912,575
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Cdk15
cyclin-dependent kinase 15
decreases expression
ISO
Niclosamide results in decreased expression of CDK15 mRNA
CTD
PMID:36318118
NCBI chr 9:60,710,787...60,803,638
Ensembl chr 9:60,711,715...60,802,777
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
Niclosamide results in decreased expression of CDK2 protein
CTD
PMID:29031202
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
Niclosamide results in decreased expression of CDK4 protein
CTD
PMID:29031202
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdkl3
cyclin-dependent kinase-like 3
increases expression
ISO
Niclosamide results in increased expression of CDKL3 mRNA
CTD
PMID:36318118
NCBI chr10:36,263,212...36,349,268
Ensembl chr10:36,266,977...36,349,268
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]
CTD
PMID:30258081
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn3
cyclin-dependent kinase inhibitor 3
decreases expression
ISO
Niclosamide results in decreased expression of CDKN3 mRNA
CTD
PMID:28284560
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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Cebpb
CCAAT/enhancer binding protein beta
increases expression
ISO
Niclosamide results in increased expression of CEBPB mRNA
CTD
PMID:36318118
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Celf6
CUGBP, Elav-like family member 6
increases expression
ISO
Niclosamide results in increased expression of CELF6 mRNA
CTD
PMID:36318118
NCBI chr 8:59,975,095...60,006,060
Ensembl chr 8:59,975,088...60,005,041
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Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
increases expression
ISO
Niclosamide results in increased expression of CELSR3 mRNA
CTD
PMID:28284560
NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354
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Cenpa
centromere protein A
decreases expression
ISO
Niclosamide results in decreased expression of CENPA mRNA
CTD
PMID:28284560
NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
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Cenpo
centromere protein O
decreases expression
ISO
Niclosamide results in decreased expression of CENPO mRNA
CTD
PMID:36318118
NCBI chr 6:27,203,642...27,218,394
Ensembl chr 6:27,188,537...27,218,314
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Cenpu
centromere protein U
decreases expression
ISO
Niclosamide results in decreased expression of CENPU mRNA
CTD
PMID:36318118
NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823
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Cfap70
cilia and flagella associated protein 70
increases expression
ISO
Niclosamide results in increased expression of CFAP70 mRNA
CTD
PMID:36318118
NCBI chr15:3,852,381...3,918,036
Ensembl chr15:3,852,509...3,918,014
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Cfp
complement factor properdin
increases expression
ISO
Niclosamide results in increased expression of CFP mRNA
CTD
PMID:28284560
NCBI chr X:1,162,014...1,167,576
Ensembl chr X:1,161,979...1,167,573
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Chac1
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
increases expression
ISO
Niclosamide results in increased expression of CHAC1 mRNA
CTD
PMID:36318118
NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
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Chac2
ChaC glutathione specific gamma-glutamylcyclotransferase 2
decreases expression
ISO
Niclosamide results in decreased expression of CHAC2 mRNA
CTD
PMID:36318118
NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301
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Chaf1a
chromatin assembly factor 1 subunit A
decreases expression
ISO
Niclosamide results in decreased expression of CHAF1A mRNA
CTD
PMID:36318118
NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
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Chrnb1
cholinergic receptor nicotinic beta 1 subunit
increases expression
ISO
Niclosamide results in increased expression of CHRNB1 mRNA
CTD
PMID:36318118
NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345
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Chst8
carbohydrate sulfotransferase 8
increases expression
ISO
Niclosamide results in increased expression of CHST8 mRNA
CTD
PMID:36318118
NCBI chr 1:87,294,144...87,435,900
Ensembl chr 1:87,294,540...87,435,900
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
multiple interactions
ISO
Niclosamide results in decreased phosphorylation of and affects the localization of CHUK protein
CTD
PMID:26116531
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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Cish
cytokine inducible SH2-containing protein
increases expression
ISO
Niclosamide results in increased expression of CISH mRNA
CTD
PMID:36318118
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
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Clec11a
C-type lectin domain containing 11A
increases expression
ISO
Niclosamide results in increased expression of CLEC11A mRNA
CTD
PMID:36318118
NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633
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Clip2
CAP-GLY domain containing linker protein 2
increases expression
ISO
Niclosamide results in increased expression of CLIP2 mRNA
CTD
PMID:36318118
NCBI chr12:22,163,044...22,227,023
Ensembl chr12:22,163,218...22,227,023
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Clip3
CAP-GLY domain containing linker protein 3
increases expression
ISO
Niclosamide results in increased expression of CLIP3 mRNA
CTD
PMID:36318118
NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184
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Clspn
claspin
decreases expression
ISO
Niclosamide results in decreased expression of CLSPN mRNA
CTD
PMID:36318118
NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
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Clstn3
calsyntenin 3
increases expression
ISO
Niclosamide results in increased expression of CLSTN3 mRNA
CTD
PMID:36318118
NCBI chr 4:157,331,494...157,364,769
Ensembl chr 4:157,331,494...157,364,769
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Cmklr1
chemerin chemokine-like receptor 1
decreases expression
ISO
Niclosamide results in decreased expression of CMKLR1 mRNA
CTD
PMID:36318118
NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129
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Cmpk2
cytidine/uridine monophosphate kinase 2
decreases expression
ISO
Niclosamide results in decreased expression of CMPK2 mRNA
CTD
PMID:36318118
NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183
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Cnbd2
cyclic nucleotide binding domain containing 2
increases expression
ISO
Niclosamide results in increased expression of CNBD2 mRNA
CTD
PMID:36318118
NCBI chr 3:144,819,166...144,884,825
Ensembl chr 3:144,819,195...144,901,583
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Cnn1
calponin 1
increases expression
ISO
Niclosamide results in increased expression of CNN1 mRNA
CTD
PMID:36318118
NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098
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Cnn2
calponin 2
increases expression
ISO
Niclosamide results in increased expression of CNN2 mRNA
CTD
PMID:36318118
NCBI chr 7:9,712,505...9,719,678
Ensembl chr 7:9,712,516...9,719,656
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Col1a1
collagen type I alpha 1 chain
decreases expression multiple interactions
ISO
Niclosamide results in decreased expression of COL1A1 mRNA Niclosamide results in decreased expression of COL1A1 protein CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Gemcitabine inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Niclosamide inhibits the reaction [Gemcitabine results in decreased expression of COL1A1 protein]
CTD
PMID:28824321 PMID:35115509
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col6a2
collagen type VI alpha 2 chain
increases expression
ISO
Niclosamide results in increased expression of COL6A2 mRNA
CTD
PMID:36318118
NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564
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Colec10
collectin subfamily member 10
increases expression
ISO
Niclosamide results in increased expression of COLEC10 mRNA
CTD
PMID:28284560
NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675
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Cox8c
cytochrome c oxidase subunit 8C
increases expression
ISO
Niclosamide results in increased expression of COX8C mRNA
CTD
PMID:36318118
NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889
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Crb2
crumbs cell polarity complex component 2
increases expression
ISO
Niclosamide results in increased expression of CRB2 mRNA
CTD
PMID:36318118
NCBI chr 3:21,542,138...21,564,876
Ensembl chr 3:21,542,221...21,563,294
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Crebbp
CREB binding protein
increases expression
ISO
Niclosamide results in increased expression of CREBBP mRNA
CTD
PMID:22576131
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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Crebrf
CREB3 regulatory factor
increases expression
ISO
Niclosamide results in increased expression of CREBRF mRNA
CTD
PMID:36318118
NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999
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Crlf1
cytokine receptor-like factor 1
decreases expression
ISO
Niclosamide results in decreased expression of CRLF1 mRNA
CTD
PMID:36318118
NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997
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Crot
carnitine O-octanoyltransferase
decreases expression
ISO
Niclosamide results in decreased expression of CROT mRNA
CTD
PMID:36318118
NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
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Crybb1
crystallin, beta B1
increases expression
ISO
Niclosamide results in increased expression of CRYBB1 mRNA
CTD
PMID:36318118
NCBI chr12:44,369,734...44,383,344
Ensembl chr12:44,369,735...44,383,344
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Cryl1
crystallin, lambda 1
increases expression
ISO
Niclosamide results in increased expression of CRYL1 mRNA
CTD
PMID:36318118
NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997
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Csf1
colony stimulating factor 1
multiple interactions
ISO
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]
CTD
PMID:28824321
NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
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Csgalnact1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
multiple interactions
ISO
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]
CTD
PMID:27542212
NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
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Csnk1e
casein kinase 1, epsilon
increases expression
ISO
Niclosamide results in increased expression of CSNK1E mRNA
CTD
PMID:22576131
NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
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Csrnp1
cysteine and serine rich nuclear protein 1
increases expression
ISO
Niclosamide results in increased expression of CSRNP1 mRNA
CTD
PMID:28284560
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
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Ctbp1
C-terminal binding protein 1
increases expression
ISO
Niclosamide results in increased expression of CTBP1 mRNA
CTD
PMID:22576131
NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821
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Ctnnb1
catenin beta 1
increases expression multiple interactions decreases expression decreases activity increases ubiquitination affects localization
ISO EXP
Niclosamide results in increased expression of CTNNB1 mRNA CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of ACTA2 protein]; CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; CTNNB1 protein inhibits the reaction [Niclosamide results in increased expression of CDH1 protein]; Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein]; Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein]; Niclosamide results in decreased expression of and results in increased phosphorylation of CTNNB1 protein Niclosamide analog results in decreased expression of CTNNB1 protein; Niclosamide results in decreased expression of CTNNB1 protein Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]] Niclosamide results in decreased activity of CTNNB1 protein Niclosamide results in increased ubiquitination of CTNNB1 protein Niclosamide results in decreased expression of CTNNB1 mRNA Niclosamide affects the localization of CTNNB1 protein
CTD
PMID:19772353 PMID:21531761 PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023 PMID:25174399 PMID:26964897 PMID:27226553 PMID:27492973 PMID:28284560 PMID:30143678 PMID:32961231 PMID:35115509 PMID:36318118 More...
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Ctnnbip1
catenin, beta-interacting protein 1
multiple interactions increases expression
ISO
Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein] Niclosamide results in increased expression of CTNNBIP1 mRNA
CTD
PMID:24534281 PMID:36318118
NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939
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Ctsc
cathepsin C
decreases expression
ISO
Niclosamide results in decreased expression of CTSC protein
CTD
PMID:29480568
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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Ctsd
cathepsin D
decreases expression
ISO
Niclosamide results in decreased expression of CTSD protein
CTD
PMID:29480568
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Ctsk
cathepsin K
multiple interactions
ISO
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]
CTD
PMID:26792726
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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Cxcl12
C-X-C motif chemokine ligand 12
decreases expression
ISO
Niclosamide results in decreased expression of CXCL12 mRNA
CTD
PMID:36318118
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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Cxcr5
C-X-C motif chemokine receptor 5
multiple interactions
ISO
Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]
CTD
PMID:33632240
NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893
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Cyb561
cytochrome b-561
decreases expression
ISO
Niclosamide results in decreased expression of CYB561 mRNA
CTD
PMID:36318118
NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787
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Cycs
cytochrome c, somatic
increases expression
ISO
Niclosamide results in increased expression of CYCS protein
CTD
PMID:26703449
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases activity
ISO
Niclosamide results in increased activity of CYP1A1 protein
CTD
PMID:12451431
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity increases expression
ISO
Niclosamide results in decreased activity of CYP1A2 protein Niclosamide results in increased expression of CYP1A2 mRNA
CTD
PMID:11124226 PMID:28284560
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
increases expression
ISO
Niclosamide results in increased expression of CYP27A1 mRNA
CTD
PMID:36318118
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
Niclosamide results in decreased activity of CYP2D6 protein
CTD
PMID:11124226
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp39a1
cytochrome P450, family 39, subfamily a, polypeptide 1
increases expression
ISO
Niclosamide results in increased expression of CYP39A1 mRNA
CTD
PMID:28284560
NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
Niclosamide results in decreased activity of CYP3A4 protein
CTD
PMID:11124226
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Dact3
dishevelled-binding antagonist of beta-catenin 3
increases expression
ISO
Niclosamide results in increased expression of DACT3 mRNA
CTD
PMID:36318118
NCBI chr 1:77,546,900...77,558,631
Ensembl chr 1:77,546,900...77,558,630
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Dbp
D-box binding PAR bZIP transcription factor
increases expression
ISO
Niclosamide results in increased expression of DBP mRNA
CTD
PMID:36318118
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
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Ddah2
DDAH family member 2, ADMA-independent
increases expression
ISO
Niclosamide results in increased expression of DDAH2 mRNA
CTD
PMID:36318118
NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
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Ddias
DNA damage-induced apoptosis suppressor
decreases expression
ISO
Niclosamide results in decreased expression of DDIAS mRNA
CTD
PMID:36318118
NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462
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Ddit3
DNA-damage inducible transcript 3
increases expression multiple interactions
ISO
Niclosamide results in increased expression of DDIT3 mRNA; Niclosamide results in increased expression of DDIT3 protein ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]
CTD
PMID:26917416 PMID:36318118
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Ddit4
DNA-damage-inducible transcript 4
increases expression
ISO
Niclosamide results in increased expression of DDIT4 mRNA
CTD
PMID:36318118
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Ddr1
discoidin domain receptor tyrosine kinase 1
increases expression
ISO
Niclosamide results in increased expression of DDR1 mRNA
CTD
PMID:36318118
NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
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Decr1
2,4-dienoyl-CoA reductase 1
decreases expression
ISO
Niclosamide results in decreased expression of DECR1 mRNA
CTD
PMID:22576131
NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
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Dgcr8
DGCR8 microprocessor complex subunit
decreases expression
ISO
Niclosamide results in decreased expression of DGCR8 mRNA
CTD
PMID:36318118
NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242
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Dgkb
diacylglycerol kinase, beta
increases expression
ISO
Niclosamide results in increased expression of DGKB mRNA
CTD
PMID:36318118
NCBI chr 6:54,640,948...55,397,210
Ensembl chr 6:54,641,614...55,397,043
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Dhfr
dihydrofolate reductase
decreases expression
ISO
Niclosamide results in decreased expression of DHFR mRNA
CTD
PMID:36318118
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
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Dhrs3
dehydrogenase/reductase 3
increases expression
ISO
Niclosamide results in increased expression of DHRS3 mRNA
CTD
PMID:36318118
NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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Dkk1
dickkopf WNT signaling pathway inhibitor 1
decreases expression
ISO
Niclosamide results in decreased expression of DKK1 mRNA
CTD
PMID:36318118
NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
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Dlg4
discs large MAGUK scaffold protein 4
increases expression
ISO
Niclosamide results in increased expression of DLG4 mRNA
CTD
PMID:36318118
NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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Dmac2l
distal membrane arm assembly component 2 like
decreases expression
ISO
Niclosamide results in decreased expression of DMAC2L mRNA
CTD
PMID:22576131
NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
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Dnaja1
DnaJ heat shock protein family (Hsp40) member A1
decreases expression
ISO
Niclosamide results in decreased expression of DNAJA1 mRNA
CTD
PMID:36318118
NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
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Dnaja4
DnaJ heat shock protein family (Hsp40) member A4
decreases expression
ISO
Niclosamide results in decreased expression of DNAJA4 mRNA
CTD
PMID:36318118
NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207
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Dnajc22
DnaJ heat shock protein family (Hsp40) member C22
increases expression
ISO
Niclosamide results in increased expression of DNAJC22 mRNA
CTD
PMID:36318118
NCBI chr 7:130,257,504...130,262,880
Ensembl chr 7:130,257,851...130,263,230
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Dnajc9
DnaJ heat shock protein family (Hsp40) member C9
decreases expression
ISO
Niclosamide results in decreased expression of DNAJC9 mRNA
CTD
PMID:36318118
NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118
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Dock5
dedicator of cytokinesis 5
decreases expression
ISO
Niclosamide results in decreased expression of DOCK5 mRNA
CTD
PMID:36318118
NCBI chr15:41,979,728...42,158,733
Ensembl chr15:41,979,729...42,158,649
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Dqx1
DEAQ box RNA-dependent ATPase 1
increases expression
ISO
Niclosamide results in increased expression of DQX1 mRNA
CTD
PMID:36318118
NCBI chr 4:115,563,497...115,572,598
Ensembl chr 4:115,563,752...115,572,590
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Drd4
dopamine receptor D4
increases expression
ISO
Niclosamide results in increased expression of DRD4 mRNA
CTD
PMID:36318118
NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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Dscc1
DNA replication and sister chromatid cohesion 1
multiple interactions
ISO
Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]
CTD
PMID:27542212
NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212
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Dtl
denticleless E3 ubiquitin protein ligase homolog
decreases expression
ISO
Niclosamide results in decreased expression of DTL mRNA
CTD
PMID:36318118
NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
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Dusp4
dual specificity phosphatase 4
increases expression
ISO
Niclosamide results in increased expression of DUSP4 mRNA
CTD
PMID:36318118
NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
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Dusp8
dual specificity phosphatase 8
increases expression
ISO
Niclosamide results in increased expression of DUSP8 mRNA
CTD
PMID:36318118
NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
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Dusp9
dual specificity phosphatase 9
increases expression
ISO
Niclosamide results in increased expression of DUSP9 mRNA
CTD
PMID:36318118
NCBI chr X:151,351,897...151,355,822
Ensembl chr X:151,351,897...151,355,821
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Dvl1
dishevelled segment polarity protein 1
increases expression
ISO
Niclosamide results in increased expression of DVL1 mRNA
CTD
PMID:22576131
NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
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Dvl2
dishevelled segment polarity protein 2
decreases expression multiple interactions
ISO EXP
Niclosamide results in decreased expression of DVL2 protein Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]]
CTD
PMID:19772353 PMID:21531761 PMID:30143678 PMID:32961231
NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820
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Dvl3
dishevelled segment polarity protein 3
increases expression
ISO
Niclosamide results in increased expression of DVL3 mRNA
CTD
PMID:22576131
NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462
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Dyrk1b
dual specificity tyrosine phosphorylation regulated kinase 1B
increases expression
ISO
Niclosamide results in increased expression of DYRK1B mRNA
CTD
PMID:36318118
NCBI chr 1:83,479,168...83,497,011
Ensembl chr 1:83,479,147...83,487,169
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E2f1
E2F transcription factor 1
decreases expression
ISO
Niclosamide results in decreased expression of E2F1 mRNA
CTD
PMID:29843133
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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E2f2
E2F transcription factor 2
decreases expression
ISO
Niclosamide results in decreased expression of E2F2 mRNA
CTD
PMID:36318118
NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
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E2f7
E2F transcription factor 7
decreases expression
ISO
Niclosamide results in decreased expression of E2F7 mRNA
CTD
PMID:36318118
NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
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E2f8
E2F transcription factor 8
decreases expression
ISO
Niclosamide results in decreased expression of E2F8 mRNA
CTD
PMID:28284560 PMID:36318118
NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
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Eaf2
ELL associated factor 2
decreases expression
ISO
Niclosamide results in decreased expression of EAF2 mRNA
CTD
PMID:36318118
NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610
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Ebf1
EBF transcription factor 1
decreases expression
ISO
Niclosamide results in decreased expression of EBF1 mRNA
CTD
PMID:27226553
NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665
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Ebf4
EBF family member 4
increases expression
ISO
Niclosamide results in increased expression of EBF4 mRNA
CTD
PMID:36318118
NCBI chr 3:117,498,186...117,566,566
Ensembl chr 3:117,498,319...117,566,566
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Echdc1
ethylmalonyl-CoA decarboxylase 1
decreases expression
ISO
Niclosamide results in decreased expression of ECHDC1 mRNA
CTD
PMID:22576131
NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319
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Echdc2
enoyl CoA hydratase domain containing 2
decreases expression
ISO
Niclosamide results in decreased expression of ECHDC2 mRNA
CTD
PMID:36318118
NCBI chr 5:122,915,874...122,934,860
Ensembl chr 5:122,916,134...122,934,859
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Echs1
enoyl-CoA hydratase, short chain 1
decreases expression
ISO
Niclosamide results in decreased expression of ECHS1 mRNA
CTD
PMID:22576131
NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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Efna1
ephrin A1
increases expression
ISO
Niclosamide results in increased expression of EFNA1 mRNA
CTD
PMID:36318118
NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
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Efna3
ephrin A3
increases expression
ISO
Niclosamide results in increased expression of EFNA3 mRNA
CTD
PMID:36318118
NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736
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Efnb3
ephrin B3
increases expression
ISO
Niclosamide results in increased expression of EFNB3 mRNA
CTD
PMID:36318118
NCBI chr10:54,274,506...54,281,951
Ensembl chr10:54,274,506...54,280,471
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Egf
epidermal growth factor
decreases expression multiple interactions
ISO
Niclosamide results in decreased expression of EGF mRNA; Niclosamide results in decreased expression of EGF protein [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein binds to EGFR protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Niclosamide inhibits the reaction [EGF protein binds to EGFR protein]; Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]
CTD
PMID:30779072 PMID:38185387
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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Egfr
epidermal growth factor receptor
decreases expression decreases phosphorylation multiple interactions
ISO
Niclosamide analog results in decreased expression of EGFR protein; Niclosamide results in decreased expression of EGFR mRNA; Niclosamide results in decreased expression of EGFR protein Niclosamide results in decreased phosphorylation of EGFR protein [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein binds to EGFR protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Niclosamide inhibits the reaction [EGF protein binds to EGFR protein]
CTD
PMID:28284560 PMID:28426875 PMID:30779072 PMID:38185387
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Egr1
early growth response 1
increases expression decreases expression
ISO
Niclosamide results in increased expression of EGR1 mRNA Niclosamide results in decreased expression of EGR1 mRNA
CTD
PMID:28284560 PMID:36318118
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases expression multiple interactions
ISO
Niclosamide results in increased expression of EIF2AK3 mRNA ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]; Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein
CTD
PMID:26917416
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
increases phosphorylation
ISO
Niclosamide results in increased phosphorylation of EIF2S1 protein
CTD
PMID:26917416
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Eif4a2
eukaryotic translation initiation factor 4A2
increases expression
ISO
Niclosamide results in increased expression of EIF4A2 mRNA
CTD
PMID:36318118
NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
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Eif4e
eukaryotic translation initiation factor 4E
multiple interactions
ISO
Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
CTD
PMID:19771169
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
decreases expression decreases phosphorylation multiple interactions
ISO
Niclosamide analog results in decreased expression of EIF4EBP1 protein modified form; Niclosamide results in decreased expression of EIF4EBP1 protein modified form Niclosamide results in decreased phosphorylation of EIF4EBP1 protein Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
CTD
PMID:19771169 PMID:28284560 PMID:30258081
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Elf1
E74 like ETS transcription factor 1
increases expression
ISO
Niclosamide results in increased expression of ELF1 mRNA
CTD
PMID:36318118
NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699
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Elfn1
extracellular leucine-rich repeat and fibronectin type III domain containing 1
increases expression
ISO
Niclosamide results in increased expression of ELFN1 mRNA
CTD
PMID:36318118
NCBI chr12:14,660,049...14,725,709
Ensembl chr12:14,660,083...14,724,580
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Eml2
EMAP like 2
increases expression
ISO
Niclosamide results in increased expression of EML2 mRNA
CTD
PMID:36318118
NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341
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Endod1
endonuclease domain containing 1
multiple interactions
ISO
Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]
CTD
PMID:27542212
NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:11,211,110...11,238,892
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Eng
endoglin
increases expression
ISO
Niclosamide results in increased expression of ENG mRNA
CTD
PMID:36318118
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
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Eno2
enolase 2
increases expression
ISO
Niclosamide results in increased expression of ENO2 mRNA
CTD
PMID:22576131
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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Eno3
enolase 3
decreases expression
ISO
Niclosamide results in decreased expression of ENO3 mRNA
CTD
PMID:22576131
NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
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Ep300
E1A binding protein p300
increases expression
ISO
Niclosamide results in increased expression of EP300 mRNA
CTD
PMID:22576131
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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Epas1
endothelial PAS domain protein 1
multiple interactions
ISO
Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]
CTD
PMID:36318118
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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Epha8
Eph receptor A8
increases expression
ISO
Niclosamide results in increased expression of EPHA8 mRNA
CTD
PMID:36318118
NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399
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Eps8l3
EPS8 like 3
increases expression
ISO
Niclosamide results in increased expression of EPS8L3 mRNA
CTD
PMID:28284560
NCBI chr 2:195,514,692...195,528,085
Ensembl chr 2:195,514,692...195,528,085
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Ethe1
ETHE1, persulfide dioxygenase
increases expression
ISO
Niclosamide results in increased expression of ETHE1 mRNA
CTD
PMID:36318118
NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052
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Eva1b
eva-1 homolog B
increases expression
ISO
Niclosamide results in increased expression of EVA1B mRNA
CTD
PMID:36318118
NCBI chr 5:138,427,088...138,429,602
Ensembl chr 5:138,427,151...138,432,433
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Exo5
exonuclease 5
decreases expression
ISO
Niclosamide results in decreased expression of EXO5 mRNA
CTD
PMID:36318118
NCBI chr 5:134,494,440...134,497,757
Ensembl chr 5:134,493,829...134,497,772
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Exog
exo/endonuclease G
decreases expression
ISO
Niclosamide results in decreased expression of EXOG mRNA
CTD
PMID:36318118
NCBI chr 8:119,184,974...119,204,819
Ensembl chr 8:119,185,136...119,204,672
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F10
coagulation factor X
increases expression
ISO
Niclosamide results in increased expression of F10 mRNA
CTD
PMID:36318118
NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
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F12
coagulation factor XII
increases expression
ISO
Niclosamide results in increased expression of F12 mRNA
CTD
PMID:36318118
NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
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Fam131c
family with sequence similarity 131, member C
increases expression
ISO
Niclosamide results in increased expression of FAM131C mRNA
CTD
PMID:36318118
NCBI chr 5:153,674,459...153,690,791
Ensembl chr 5:153,671,772...153,690,800
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Fam135b
family with sequence similarity 135, member B
increases expression
ISO
Niclosamide results in increased expression of FAM135B mRNA
CTD
PMID:36318118
NCBI chr 7:103,380,981...103,649,802
Ensembl chr 7:103,386,915...103,649,708
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Fam13b
family with sequence similarity 13, member B
decreases expression
ISO
Niclosamide results in decreased expression of FAM13B mRNA
CTD
PMID:36318118
NCBI chr18:26,040,285...26,107,112
Ensembl chr18:26,040,285...26,106,587
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Fam221a
family with sequence similarity 221, member A
increases expression
ISO
Niclosamide results in increased expression of FAM221A mRNA
CTD
PMID:36318118
NCBI chr 4:78,337,296...78,358,918
Ensembl chr 4:78,337,296...78,358,909
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Fam43a
family with sequence similarity 43, member A
increases expression
ISO
Niclosamide results in increased expression of FAM43A mRNA
CTD
PMID:36318118
NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401
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Fam43b
family with sequence similarity 43, member B
increases expression
ISO
Niclosamide results in increased expression of FAM43B mRNA
CTD
PMID:36318118
NCBI chr 5:150,610,656...150,613,054
Ensembl chr 5:150,611,609...150,612,601
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Fam83d
family with sequence similarity 83, member D
decreases expression
ISO
Niclosamide results in decreased expression of FAM83D mRNA
CTD
PMID:28284560
NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
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Fancb
FA complementation group B
decreases expression
ISO
Niclosamide results in decreased expression of FANCB mRNA
CTD
PMID:36318118
NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192
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Fas
Fas cell surface death receptor
multiple interactions
ISO EXP
Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]
CTD
PMID:28318631 PMID:33632240
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fastkd3
FAST kinase domains 3
decreases expression
ISO
Niclosamide results in decreased expression of FASTKD3 mRNA
CTD
PMID:36318118
NCBI chr 1:34,858,342...34,866,988
Ensembl chr 1:34,858,219...34,866,973
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Fbxo2
F-box protein 2
increases expression
ISO
Niclosamide results in increased expression of FBXO2 mRNA
CTD
PMID:36318118
NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355
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Fbxo48
F-box protein 48
increases expression
ISO
Niclosamide results in increased expression of FBXO48 mRNA
CTD
PMID:36318118
NCBI chr14:91,380,857...91,382,314
Ensembl chr14:91,380,857...91,382,314
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Fcho1
FCH and mu domain containing endocytic adaptor 1
increases expression
ISO
Niclosamide results in increased expression of FCHO1 mRNA
CTD
PMID:36318118
NCBI chr16:18,413,452...18,430,795
Ensembl chr16:18,413,363...18,435,104
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Fcrlb
Fc receptor-like B
increases expression
ISO
Niclosamide results in increased expression of FCRLB mRNA
CTD
PMID:36318118
NCBI chr13:83,148,685...83,157,157
Ensembl chr13:83,149,751...83,155,957
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Fen1
flap structure-specific endonuclease 1
decreases expression
ISO
Niclosamide results in decreased expression of FEN1 mRNA
CTD
PMID:36318118
NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
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Fgd1
FYVE, RhoGEF and PH domain containing 1
increases expression
ISO
Niclosamide results in increased expression of FGD1 mRNA
CTD
PMID:36318118
NCBI chr X:20,023,746...20,066,734
Ensembl chr X:20,023,746...20,066,566
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Fgf1
fibroblast growth factor 1
decreases expression
ISO
Niclosamide results in decreased expression of FGF1 mRNA; Niclosamide results in decreased expression of FGF1 protein
CTD
PMID:25174399
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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Fgf19
fibroblast growth factor 19
increases expression
ISO
Niclosamide results in increased expression of FGF19 mRNA
CTD
PMID:36318118
NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
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Fgfr4
fibroblast growth factor receptor 4
increases expression
ISO
Niclosamide results in increased expression of FGFR4 mRNA
CTD
PMID:36318118
NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242
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Fignl1
fidgetin-like 1
decreases expression
ISO
Niclosamide results in decreased expression of FIGNL1 mRNA
CTD
PMID:36318118
NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455
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Fkbp5
FKBP prolyl isomerase 5
multiple interactions decreases expression
ISO
[Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA Niclosamide results in decreased expression of FKBP5 mRNA
CTD
PMID:28500234
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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Flrt3
fibronectin leucine rich transmembrane protein 3
decreases expression
ISO
Niclosamide results in decreased expression of FLRT3 mRNA
CTD
PMID:36318118
NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841
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Fmn1
formin 1
increases expression
ISO
Niclosamide results in increased expression of FMN1 mRNA
CTD
PMID:36318118
NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220
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Fn1
fibronectin 1
multiple interactions
ISO
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]
CTD
PMID:28318631
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fndc10
fibronectin type III domain containing 10
increases expression
ISO
Niclosamide results in increased expression of FNDC10 mRNA
CTD
PMID:36318118
NCBI chr 5:166,299,587...166,311,477
Ensembl chr 5:166,300,122...166,310,326
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Niclosamide results in increased expression of FNDC4 mRNA
CTD
PMID:36318118
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA] Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]
CTD
PMID:26792726 PMID:28824321
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Niclosamide results in increased expression of FOSB mRNA
CTD
PMID:28284560
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
G
Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
ISO
Niclosamide results in increased expression of FOSL1 mRNA
CTD
PMID:22576131
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
G
Foxl1
forkhead box L1
increases expression
ISO
Niclosamide results in increased expression of FOXL1 mRNA
CTD
PMID:36318118
NCBI chr19:49,197,269...49,200,682
Ensembl chr19:49,197,400...49,198,425
G
Foxm1
forkhead box M1
multiple interactions decreases expression
ISO
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of FOXM1 protein]
CTD
PMID:27492973
NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
G
Foxo4
forkhead box O4
increases expression
ISO
Niclosamide results in increased expression of FOXO4 mRNA
CTD
PMID:36318118
NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115
G
Foxo6
forkhead box O6
increases expression
ISO
Niclosamide results in increased expression of FOXO6 mRNA
CTD
PMID:36318118
NCBI chr 5:133,856,087...133,876,387
Ensembl chr 5:133,856,072...133,876,573
G
Frat2
FRAT regulator of WNT signaling pathway 2
increases expression
ISO
Niclosamide results in increased expression of FRAT2 mRNA
CTD
PMID:36318118
NCBI chr 1:240,654,120...240,656,449
Ensembl chr 1:240,654,137...240,656,517
G
Frzb
frizzled-related protein
increases expression
ISO
Niclosamide results in increased expression of FRZB mRNA
CTD
PMID:36318118
NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208
G
Fscn1
fascin actin-bundling protein 1
multiple interactions
ISO
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA]
CTD
PMID:29733962
NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
G
Fstl3
follistatin like 3
increases expression
ISO
Niclosamide results in increased expression of FSTL3 mRNA
CTD
PMID:36318118
NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639
G
Fzd1
frizzled class receptor 1
affects localization
ISO
Niclosamide affects the localization of FZD1 protein
CTD
PMID:19772353
NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643 Ensembl chr 4:29,310,091...29,312,643
G
Fzd2
frizzled class receptor 2
decreases expression increases expression
ISO
Niclosamide results in decreased expression of FZD2 mRNA Niclosamide results in increased expression of FZD2 mRNA
CTD
PMID:22576131 PMID:36318118
NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
G
Fzd5
frizzled class receptor 5
increases expression
ISO
Niclosamide results in increased expression of FZD5 mRNA
CTD
PMID:22576131
NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457
G
Fzd9
frizzled class receptor 9
decreases expression
ISO
Niclosamide results in decreased expression of FZD9 mRNA
CTD
PMID:22576131
NCBI chr12:21,427,084...21,429,398
Ensembl chr12:21,427,084...21,429,398
G
G4
G4 protein
affects expression
ISO
Niclosamide affects the expression of C6ORF47 mRNA
CTD
PMID:36318118
NCBI chr20:3,693,691...3,696,194
Ensembl chr20:3,693,649...3,696,088
G
Gab2
GRB2-associated binding protein 2
increases expression
ISO
Niclosamide results in increased expression of GAB2 mRNA
CTD
PMID:36318118
NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
G
Gabarapl1
GABA type A receptor associated protein like 1
increases expression
ISO
Niclosamide results in increased expression of GABARAPL1 mRNA
CTD
PMID:36318118
NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
G
Gabra4
gamma-aminobutyric acid type A receptor subunit alpha 4
increases expression
ISO
Niclosamide results in increased expression of GABRA4 mRNA
CTD
PMID:36318118
NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
G
Gabrb1
gamma-aminobutyric acid type A receptor subunit beta1
increases expression
ISO
Niclosamide results in increased expression of GABRB1 mRNA
CTD
PMID:36318118
NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
G
Gadd45b
growth arrest and DNA-damage-inducible, beta
increases expression
ISO
Niclosamide results in increased expression of GADD45B mRNA
CTD
PMID:36318118
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
G
Garin1a
golgi associated RAB2 interactor 1A
increases expression
ISO
Niclosamide results in increased expression of GARIN1A mRNA
CTD
PMID:36318118
NCBI chr 4:57,880,019...57,890,824
Ensembl chr 4:57,880,019...57,890,820
G
Gata5
GATA binding protein 5
increases expression
ISO
Niclosamide results in increased expression of GATA5 mRNA
CTD
PMID:36318118
NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751
G
Gcg
glucagon
multiple interactions
EXP
Niclosamide inhibits the reaction [GCG protein results in increased abundance of Cyclic AMP]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]
CTD
PMID:26964897
NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929
G
Gclm
glutamate cysteine ligase, modifier subunit
decreases expression
ISO
Niclosamide results in decreased expression of GCLM mRNA
CTD
PMID:36318118
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gdf15
growth differentiation factor 15
increases expression
ISO
Niclosamide results in increased expression of GDF15 mRNA
CTD
PMID:36318118
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
G
Gdpd5
glycerophosphodiester phosphodiesterase domain containing 5
increases expression
ISO
Niclosamide results in increased expression of GDPD5 mRNA
CTD
PMID:36318118
NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446
G
Gdpgp1
GDP-D-glucose phosphorylase 1
decreases expression
ISO
Niclosamide results in decreased expression of GDPGP1 mRNA
CTD
PMID:36318118
NCBI chr 1:134,184,119...134,193,281
Ensembl chr 1:134,183,696...134,219,783
G
Gfap
glial fibrillary acidic protein
decreases expression
ISO
Niclosamide results in decreased expression of GFAP protein
CTD
PMID:34118929
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Gid4
GID complex subunit 4
increases expression
ISO
Niclosamide results in increased expression of GID4 mRNA
CTD
PMID:36318118
NCBI chr10:45,221,556...45,247,627
Ensembl chr10:45,245,754...45,247,621 Ensembl chr10:45,245,754...45,247,621
G
Gins1
GINS complex subunit 1
decreases expression
ISO
Niclosamide results in decreased expression of GINS1 mRNA
CTD
PMID:36318118
NCBI chr 3:139,724,513...139,745,930
Ensembl chr 3:139,724,490...139,745,936
G
Gins2
GINS complex subunit 2
decreases expression
ISO
Niclosamide results in decreased expression of GINS2 mRNA
CTD
PMID:36318118
NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339
G
Gins3
GINS complex subunit 3
decreases expression
ISO
Niclosamide results in decreased expression of GINS3 mRNA
CTD
PMID:36318118
NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687
G
Gins4
GINS complex subunit 4
decreases expression
ISO
Niclosamide results in decreased expression of GINS4 mRNA
CTD
PMID:36318118
NCBI chr16:68,787,572...68,799,938
Ensembl chr16:68,767,339...68,802,273
G
Glb1l3
galactosidase, beta 1-like 3
decreases expression
ISO
Niclosamide results in decreased expression of GLB1L3 mRNA
CTD
PMID:36318118
NCBI chr 8:25,179,165...25,220,904
Ensembl chr 8:25,179,165...25,220,904
G
Glis1
GLIS family zinc finger 1
increases expression
ISO
Niclosamide results in increased expression of GLIS1 mRNA
CTD
PMID:36318118
NCBI chr 5:122,222,155...122,412,141
Ensembl chr 5:122,222,128...122,412,141
G
Glis2
GLIS family zinc finger 2
increases expression
ISO
Niclosamide results in increased expression of GLIS2 mRNA
CTD
PMID:36318118
NCBI chr10:10,951,157...10,978,524
Ensembl chr10:10,951,371...10,971,578
G
Gng7
G protein subunit gamma 7
increases expression
ISO
Niclosamide results in increased expression of GNG7 mRNA
CTD
PMID:36318118
NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
G
Golga2
golgin A2
increases expression
ISO
Niclosamide results in increased expression of GOLGA2 mRNA
CTD
PMID:36318118
NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279
G
Gosr2
golgi SNAP receptor complex member 2
decreases expression
ISO
Niclosamide results in decreased expression of GOSR2 mRNA
CTD
PMID:36318118
NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625
G
Got2
glutamic-oxaloacetic transaminase 2
increases expression
ISO
Niclosamide results in increased expression of GOT2 mRNA
CTD
PMID:22576131
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
G
Gp1bb
glycoprotein Ib platelet subunit beta
increases expression
ISO
Niclosamide results in increased expression of GP1BB mRNA
CTD
PMID:36318118
NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392
G
Gpc2
glypican 2
increases expression
ISO
Niclosamide results in increased expression of GPC2 mRNA
CTD
PMID:36318118
NCBI chr12:17,277,875...17,284,297
Ensembl chr12:17,277,875...17,284,208
G
Gpr153
G protein-coupled receptor 153
increases expression
ISO
Niclosamide results in increased expression of GPR153 mRNA
CTD
PMID:36318118
NCBI chr 5:162,781,587...162,792,975
Ensembl chr 5:162,781,587...162,792,971
G
Gpr75
G protein-coupled receptor 75
decreases expression
ISO
Niclosamide results in decreased expression of GPR75 mRNA
CTD
PMID:36318118
NCBI chr14:104,609,542...104,618,885
Ensembl chr14:104,611,089...104,620,370
G
Gprc5c
G protein-coupled receptor, class C, group 5, member C
increases expression
ISO
Niclosamide results in increased expression of GPRC5C mRNA
CTD
PMID:36318118
NCBI chr10:99,886,900...99,908,928
Ensembl chr10:99,887,077...99,908,926
G
Grem2
gremlin 2, DAN family BMP antagonist
decreases expression
ISO
Niclosamide results in decreased expression of GREM2 mRNA
CTD
PMID:36318118
NCBI chr13:86,778,543...86,871,509
Ensembl chr13:86,778,500...86,871,615
G
Grik5
glutamate ionotropic receptor kainate type subunit 5
increases expression
ISO
Niclosamide results in increased expression of GRIK5 mRNA
CTD
PMID:36318118
NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125
G
Grin2d
glutamate ionotropic receptor NMDA type subunit 2D
increases expression
ISO
Niclosamide results in increased expression of GRIN2D mRNA
CTD
PMID:36318118
NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
G
Grip2
glutamate receptor interacting protein 2
increases expression
ISO
Niclosamide results in increased expression of GRIP2 mRNA
CTD
PMID:36318118
NCBI chr 4:124,271,456...124,356,538
Ensembl chr 4:124,271,456...124,321,268
G
Gsk3b
glycogen synthase kinase 3 beta
decreases expression decreases phosphorylation increases phosphorylation
ISO
Niclosamide results in decreased expression of GSK3B mRNA Niclosamide results in decreased phosphorylation of GSK3B protein Niclosamide results in increased phosphorylation of GSK3B protein
CTD
PMID:22576131 PMID:30143678 PMID:35115509
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gstt2
glutathione S-transferase theta 2
decreases expression
ISO
Niclosamide results in decreased expression of GSTT2 mRNA
CTD
PMID:36318118
NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
G
Gtf2h4
general transcription factor 2H subunit 4
decreases expression increases expression
ISO
Niclosamide results in decreased expression of GTF2H4 mRNA Niclosamide results in increased expression of GTF2H4 mRNA
CTD
PMID:36318118
NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984
G
Gtse1
G-2 and S-phase expressed 1
decreases expression
ISO
Niclosamide results in decreased expression of GTSE1 mRNA
CTD
PMID:28284560
NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806
G
Gxylt2
glucoside xylosyltransferase 2
increases expression
ISO
Niclosamide results in increased expression of GXYLT2 mRNA
CTD
PMID:36318118
NCBI chr 4:133,347,230...133,449,708
Ensembl chr 4:133,347,499...133,449,454
G
Hadh
hydroxyacyl-CoA dehydrogenase
decreases expression
ISO
Niclosamide results in decreased expression of HADH mRNA
CTD
PMID:22576131
NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
G
Hamp
hepcidin antimicrobial peptide
decreases expression increases expression
ISO
Niclosamide results in decreased expression of HAMP mRNA Niclosamide results in increased expression of HAMP mRNA
CTD
PMID:25633564 PMID:28284560
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
G
Hbp1
HMG-box transcription factor 1
multiple interactions increases expression
ISO
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA] Niclosamide results in increased expression of HBP1 mRNA
CTD
PMID:27542212 PMID:36318118
NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
G
Hdac5
histone deacetylase 5
increases expression
ISO
Niclosamide results in increased expression of HDAC5 mRNA
CTD
PMID:36318118
NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
G
Helz2
helicase with zinc finger 2
increases expression
ISO
Niclosamide results in increased expression of HELZ2 mRNA
CTD
PMID:36318118
NCBI chr 3:168,338,813...168,353,219
Ensembl chr 3:168,338,813...168,353,159
G
Hes1
hes family bHLH transcription factor 1
decreases expression multiple interactions
ISO EXP
Niclosamide results in decreased expression of HES1 protein Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]] Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HES1 mRNA]
CTD
PMID:19160421 PMID:28318631 PMID:32961231
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
G
Hey1
hes-related family bHLH transcription factor with YRPW motif 1
multiple interactions
ISO EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY1 mRNA] Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]
CTD
PMID:27542212 PMID:28318631
NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312
G
Hey2
hes-related family bHLH transcription factor with YRPW motif 2
multiple interactions increases expression
EXP ISO
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA] Niclosamide results in increased expression of HEY2 mRNA N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA] Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY2 mRNA]
CTD
PMID:19160421 PMID:28318631
NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
G
Hhipl1
HHIP-like 1
increases expression
ISO
Niclosamide results in increased expression of HHIPL1 mRNA
CTD
PMID:36318118
NCBI chr 6:127,219,616...127,243,839
Ensembl chr 6:127,220,014...127,242,564
G
Hid1
HID1 domain containing
increases expression
ISO
Niclosamide results in increased expression of HID1 mRNA
CTD
PMID:36318118
NCBI chr10:100,589,555...100,610,050
Ensembl chr10:100,589,555...100,610,041
G
Hif1a
hypoxia inducible factor 1 subunit alpha
decreases expression multiple interactions
ISO
Niclosamide results in decreased expression of HIF1A mRNA; Niclosamide results in decreased expression of HIF1A protein Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD
PMID:30779072 PMID:36318118
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Hipk2
homeodomain interacting protein kinase 2
multiple interactions
ISO EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 protein] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein] HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]
CTD
PMID:28318631
NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
G
Hist1h2bc
histone cluster 1, H2bc
increases expression
ISO
Niclosamide results in increased expression of H2BC21 mRNA
CTD
PMID:36318118
NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642
G
Hivep2
HIVEP zinc finger 2
increases expression
ISO
Niclosamide results in increased expression of HIVEP2 mRNA
CTD
PMID:36318118
NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993
G
Hk3
hexokinase 3
decreases expression
ISO
Niclosamide results in decreased expression of HK3 mRNA
CTD
PMID:36318118
NCBI chr17:9,596,950...9,614,847
Ensembl chr17:9,599,865...9,614,863
G
Hmgcl
3-hydroxy-3-methylglutaryl-CoA lyase
increases expression
ISO
Niclosamide results in increased expression of HMGCL mRNA
CTD
PMID:36318118
NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068
G
Hmmr
hyaluronan-mediated motility receptor
decreases expression
ISO
Niclosamide results in decreased expression of HMMR mRNA
CTD
PMID:28284560
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
G
Hmx2
H6 family homeobox 2
increases expression
ISO
Niclosamide results in increased expression of HMX2 mRNA
CTD
PMID:36318118
NCBI chr 1:186,319,110...186,326,771
Ensembl chr 1:186,319,110...186,326,771
G
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
increases expression
ISO
Niclosamide results in increased expression of HOGA1 mRNA
CTD
PMID:36318118
NCBI chr 1:240,856,991...240,884,243
Ensembl chr 1:240,857,126...240,884,568
G
Homer1
homer scaffold protein 1
decreases expression
ISO
Niclosamide results in decreased expression of HOMER1 mRNA
CTD
PMID:36318118
NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
G
Homer3
homer scaffold protein 3
increases expression
ISO
Niclosamide results in increased expression of HOMER3 mRNA
CTD
PMID:36318118
NCBI chr16:19,132,177...19,142,739
Ensembl chr16:19,132,162...19,142,680
G
Hoxa1
homeobox A1
increases expression
ISO
Niclosamide results in increased expression of HOXA1
CTD
PMID:26820057
NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504
G
Hr
HR, lysine demethylase and nuclear receptor corepressor
increases expression
ISO
Niclosamide results in increased expression of HR mRNA
CTD
PMID:36318118
NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313
G
Hrh1
histamine receptor H 1
increases expression
ISO
Niclosamide results in increased expression of HRH1 mRNA
CTD
PMID:36318118
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
G
Hs6st1
heparan sulfate 6-O-sulfotransferase 1
decreases expression
ISO
Niclosamide results in decreased expression of HS6ST1 mRNA
CTD
PMID:36318118
NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683
G
Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
increases expression
ISO
Niclosamide results in increased expression of HSD17B14 mRNA
CTD
PMID:36318118
NCBI chr 1:96,029,224...96,039,577
Ensembl chr 1:96,029,284...96,039,883
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
increases expression
ISO
Niclosamide results in increased expression of HSD3B1 mRNA
CTD
PMID:36318118
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
increases expression
ISO
Niclosamide results in increased expression of HSD3B2 mRNA
CTD
PMID:36318118
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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Hspa6l-ps1
heat shock protein family A (Hsp70) member 6 like, pseudogene 1
increases expression
ISO
Niclosamide results in increased expression of HSPA6 mRNA
CTD
PMID:36318118
NCBI chr13:83,273,176...83,274,317
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Hspb7
heat shock protein family B (small) member 7
increases expression
ISO
Niclosamide results in increased expression of HSPB7 mRNA
CTD
PMID:36318118
NCBI chr 5:153,727,782...153,731,268
Ensembl chr 5:153,727,588...153,731,266
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Hvcn1
hydrogen voltage-gated channel 1
increases expression
ISO
Niclosamide results in increased expression of HVCN1 mRNA
CTD
PMID:36318118
NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ICAM1 mRNA] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]
CTD
PMID:28318631
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Icam5
intercellular adhesion molecule 5
increases expression
ISO
Niclosamide results in increased expression of ICAM5 mRNA
CTD
PMID:36318118
NCBI chr 8:19,567,390...19,575,588
Ensembl chr 8:19,568,600...19,575,588
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Id1
inhibitor of DNA binding 1
increases expression
ISO
Niclosamide results in increased expression of ID1 mRNA
CTD
PMID:36318118
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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Ier5l
immediate early response 5-like
increases expression
ISO
Niclosamide results in increased expression of IER5L mRNA
CTD
PMID:36318118
NCBI chr 3:13,744,056...13,745,647
Ensembl chr 3:13,744,078...13,745,647
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Igf1r
insulin-like growth factor 1 receptor
affects response to substance
ISO
IGF1R protein affects the susceptibility to Niclosamide
CTD
PMID:27497986
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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Igfbp4
insulin-like growth factor binding protein 4
increases expression
ISO
Niclosamide results in increased expression of IGFBP4 mRNA
CTD
PMID:36318118
NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
affects localization
ISO
Niclosamide affects the localization of IKBKB protein
CTD
PMID:26116531
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
affects localization
ISO
Niclosamide affects the localization of IKBKG protein
CTD
PMID:26116531
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
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Ikzf2
IKAROS family zinc finger 2
increases expression
ISO
Niclosamide results in increased expression of IKZF2 mRNA
CTD
PMID:36318118
NCBI chr 9:71,046,038...71,191,296
Ensembl chr 9:71,042,440...71,190,867
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Il12a
interleukin 12A
multiple interactions
ISO
Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]
CTD
PMID:26297436
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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Il17re
interleukin 17 receptor E
increases expression
ISO
Niclosamide results in increased expression of IL17RE mRNA
CTD
PMID:36318118
NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206
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Il1b
interleukin 1 beta
multiple interactions
ISO
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]
CTD
PMID:33524445
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il21
interleukin 21
multiple interactions
ISO
Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL21 protein]
CTD
PMID:33632240
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
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Il6
interleukin 6
multiple interactions
ISO
Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL6 protein] Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of SOCS1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]
CTD
PMID:24561310 PMID:25970160 PMID:26297436 PMID:28318631 PMID:33632240
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Inafm1
InaF-motif containing 1
increases expression
ISO
Niclosamide results in increased expression of INAFM1 mRNA
CTD
PMID:36318118
NCBI chr 1:76,976,808...76,978,292
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Inca1
inhibitor of CDK, cyclin A1 interacting protein 1
increases expression
ISO
Niclosamide results in increased expression of INCA1 mRNA
CTD
PMID:36318118
NCBI chr10:55,401,989...55,414,364
Ensembl chr10:55,401,982...55,414,114
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Inhbe
inhibin subunit beta E
increases expression
ISO
Niclosamide results in increased expression of INHBE mRNA
CTD
PMID:36318118
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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Inpp5j
inositol polyphosphate-5-phosphatase J
increases expression
ISO
Niclosamide results in increased expression of INPP5J mRNA
CTD
PMID:36318118
NCBI chr14:78,374,161...78,385,305
Ensembl chr14:78,374,161...78,385,326
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Insrr
insulin receptor-related receptor
decreases expression
ISO
Niclosamide results in decreased expression of INSRR mRNA
CTD
PMID:36318118
NCBI chr 2:173,255,335...173,274,800
Ensembl chr 2:173,255,414...173,274,800
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Iqsec3
IQ motif and Sec7 domain ArfGEF 3
increases expression
ISO
Niclosamide results in increased expression of IQSEC3 mRNA
CTD
PMID:36318118
NCBI chr 4:154,610,933...154,707,310
Ensembl chr 4:154,610,934...154,707,310
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Irak2
interleukin-1 receptor-associated kinase 2
increases expression
ISO
Niclosamide results in increased expression of IRAK2 mRNA
CTD
PMID:36318118
NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
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Irf2bp2
interferon regulatory factor 2 binding protein 2
increases expression
ISO
Niclosamide results in increased expression of IRF2BP2 mRNA
CTD
PMID:36318118
NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642
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Itgav
integrin subunit alpha V
multiple interactions
ISO
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]
CTD
PMID:26792726
NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
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Itgb3
integrin subunit beta 3
multiple interactions
ISO
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA] Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]
CTD
PMID:26792726 PMID:28824321
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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Jade2
jade family PHD finger 2
increases expression
ISO
Niclosamide results in increased expression of JADE2 mRNA
CTD
PMID:36318118
NCBI chr10:36,075,239...36,124,210
Ensembl chr10:36,078,917...36,116,984
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Jak3
Janus kinase 3
increases expression
ISO
Niclosamide results in increased expression of JAK3 mRNA
CTD
PMID:36318118
NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
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Jakmip3
janus kinase and microtubule interacting protein 3
increases expression
ISO
Niclosamide results in increased expression of JAKMIP3 mRNA
CTD
PMID:36318118
NCBI chr 1:193,753,134...193,881,105
Ensembl chr 1:193,811,513...193,881,104
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Jdp2
Jun dimerization protein 2
increases expression
ISO
Niclosamide results in increased expression of JDP2 mRNA
CTD
PMID:36318118
NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485
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Jph3
junctophilin 3
increases expression
ISO
Niclosamide results in increased expression of JPH3 mRNA
CTD
PMID:36318118
NCBI chr19:49,793,967...49,855,338
Ensembl chr19:49,793,092...49,855,338
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Jph4
junctophilin 4
increases expression
ISO
Niclosamide results in increased expression of JPH4 mRNA
CTD
PMID:36318118
NCBI chr15:28,579,579...28,588,903
Ensembl chr15:28,571,568...28,587,573
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
affects localization increases expression increases phosphorylation multiple interactions
EXP ISO
Niclosamide affects the localization of JUN protein Niclosamide results in increased expression of JUN mRNA Niclosamide results in increased phosphorylation of JUN protein Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]
CTD
PMID:24750999 PMID:27338550
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Kbtbd11
kelch repeat and BTB domain containing 11
increases expression
ISO
Niclosamide results in increased expression of KBTBD11 mRNA
CTD
PMID:36318118
NCBI chr16:74,618,291...74,638,010
Ensembl chr16:74,615,792...74,637,736
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Kcnf1
potassium voltage-gated channel modifier subfamily F member 1
increases expression
ISO
Niclosamide results in increased expression of KCNF1 mRNA
CTD
PMID:36318118
NCBI chr 6:39,962,301...39,964,979
Ensembl chr 6:39,962,307...39,964,979
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Kcnk13
potassium two pore domain channel subfamily K member 13
decreases expression
ISO
Niclosamide results in decreased expression of KCNK13 mRNA
CTD
PMID:36318118
NCBI chr 6:119,240,825...119,345,292
Ensembl chr 6:119,242,188...119,345,240
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Kcnn3
potassium calcium-activated channel subfamily N member 3
increases expression
ISO
Niclosamide results in increased expression of KCNN3 mRNA
CTD
PMID:36318118
NCBI chr 2:174,929,846...175,088,910
Ensembl chr 2:174,936,629...175,081,145
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Kcnv1
potassium voltage-gated channel modifier subfamily V member 1
decreases expression
ISO
Niclosamide results in decreased expression of KCNV1 mRNA
CTD
PMID:36318118
NCBI chr 7:76,260,695...76,269,170
Ensembl chr 7:76,260,695...76,269,170
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Kctd11
potassium channel tetramerization domain containing 11
increases expression
ISO
Niclosamide results in increased expression of KCTD11 mRNA
CTD
PMID:36318118
NCBI chr10:54,602,575...54,604,738
Ensembl chr10:54,599,754...54,604,760
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Kdelr3
KDEL endoplasmic reticulum protein retention receptor 3
increases expression
ISO
Niclosamide results in increased expression of KDELR3 mRNA
CTD
PMID:36318118
NCBI chr 7:111,079,236...111,089,463
Ensembl chr 7:111,079,218...111,101,600
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Kdm5b
lysine demethylase 5B
increases expression
ISO
Niclosamide results in increased expression of KDM5B mRNA
CTD
PMID:36318118
NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872
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Kdm6b
lysine demethylase 6B
increases expression
ISO
Niclosamide results in increased expression of KDM6B mRNA
CTD
PMID:36318118
NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
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Kdm7a
lysine demethylase 7A
increases expression
ISO
Niclosamide results in increased expression of KDM7A mRNA
CTD
PMID:36318118
NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998
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Khnyn
KH and NYN domain containing
increases expression
ISO
Niclosamide results in increased expression of KHNYN mRNA
CTD
PMID:36318118
NCBI chr15:29,365,399...29,379,650
Ensembl chr15:29,365,260...29,376,967
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Kiaa1614
KIAA1614 homolog
decreases expression
ISO
Niclosamide results in decreased expression of KIAA1614 mRNA
CTD
PMID:36318118
NCBI chr13:67,388,916...67,427,392
Ensembl chr13:67,389,044...67,421,272
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Kif11
kinesin family member 11
decreases expression
ISO
Niclosamide results in decreased expression of KIF11 mRNA
CTD
PMID:28284560
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
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Kif20a
kinesin family member 20A
decreases expression
ISO
Niclosamide results in decreased expression of KIF20A mRNA
CTD
PMID:28284560
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
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Kifc1
kinesin family member C1
decreases expression
ISO
Niclosamide results in decreased expression of KIFC1 mRNA
CTD
PMID:28284560
NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
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Kirrel2
kirre like nephrin family adhesion molecule 2
increases expression
ISO
Niclosamide results in increased expression of KIRREL2 mRNA
CTD
PMID:36318118
NCBI chr 1:85,708,793...85,718,670
Ensembl chr 1:85,708,793...85,718,670
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Kiz
kizuna centrosomal protein
increases expression
ISO
Niclosamide results in increased expression of KIZ mRNA
CTD
PMID:36318118
NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190
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Klc4
kinesin light chain 4
increases expression
ISO
Niclosamide results in increased expression of KLC4 mRNA
CTD
PMID:36318118
NCBI chr 9:14,337,164...14,351,075
Ensembl chr 9:14,337,534...14,351,066
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Klf15
KLF transcription factor 15
increases expression
ISO
Niclosamide results in increased expression of KLF15 mRNA
CTD
PMID:36318118
NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
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Klf9
KLF transcription factor 9
increases expression
ISO
Niclosamide results in increased expression of KLF9 mRNA
CTD
PMID:36318118
NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037
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Klhdc8a
kelch domain containing 8A
increases expression
ISO
Niclosamide results in increased expression of KLHDC8A mRNA
CTD
PMID:36318118
NCBI chr13:43,735,702...43,744,277
Ensembl chr13:43,736,192...43,744,277
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Klhdc8b
kelch domain containing 8B
increases expression
ISO
Niclosamide results in increased expression of KLHDC8B mRNA
CTD
PMID:36318118
NCBI chr 8:109,141,594...109,146,584
Ensembl chr 8:109,141,594...109,146,918
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Klhl24
kelch-like family member 24
increases expression
ISO
Niclosamide results in increased expression of KLHL24 mRNA
CTD
PMID:36318118
NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636
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Klhl30
kelch-like family member 30
increases expression
ISO
Niclosamide results in increased expression of KLHL30 mRNA
CTD
PMID:36318118
NCBI chr 9:91,942,475...91,952,756
Ensembl chr 9:91,942,504...91,952,730
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Klhl34
kelch-like family member 34
decreases expression
ISO
Niclosamide results in decreased expression of KLHL34 mRNA
CTD
PMID:36318118
NCBI chr X:37,151,298...37,154,053
Ensembl chr X:37,151,592...37,153,529
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Klk1c10
kallikrein 1-related peptidase C10
decreases expression multiple interactions
ISO
Niclosamide results in decreased expression of KLK3 mRNA; Niclosamide results in decreased expression of KLK3 protein [Niclosamide co-treated with bicalutamide] results in decreased expression of KLK3 mRNA; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; enzalutamide promotes the reaction [Niclosamide results in decreased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]
CTD
PMID:24740322 PMID:25970160 PMID:28500234
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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Larp6
La ribonucleoprotein 6, translational regulator
increases expression
ISO
Niclosamide results in increased expression of LARP6 mRNA
CTD
PMID:36318118
NCBI chr 8:61,183,744...61,205,548
Ensembl chr 8:61,184,116...61,205,535
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Lbh
LBH regulator of WNT signaling pathway
increases expression
ISO
Niclosamide results in increased expression of LBH mRNA
CTD
PMID:36318118
NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079
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Lbx2
ladybird homeobox 2
increases expression
ISO
Niclosamide results in increased expression of LBX2 mRNA
CTD
PMID:36318118
NCBI chr 4:115,591,974...115,593,859
Ensembl chr 4:115,591,974...115,594,132
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Lcat
lecithin cholesterol acyltransferase
increases expression
ISO
Niclosamide results in increased expression of LCAT mRNA
CTD
PMID:28284560
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
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Lcmt2
leucine carboxyl methyltransferase 2
decreases expression
ISO
Niclosamide results in decreased expression of LCMT2 mRNA
CTD
PMID:36318118
NCBI chr 3:108,099,960...108,102,084
Ensembl chr 3:108,099,961...108,102,084
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Lcorl
ligand dependent nuclear receptor corepressor-like
increases expression
ISO
Niclosamide results in increased expression of LCORL mRNA
CTD
PMID:36318118
NCBI chr14:65,271,339...65,407,732
Ensembl chr14:65,271,135...65,404,174
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Ldha
lactate dehydrogenase A
increases expression multiple interactions decreases expression
ISO
Niclosamide results in increased expression of LDHA mRNA Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of LDHA mRNA] Niclosamide results in decreased expression of LDHA mRNA
CTD
PMID:22576131 PMID:36318118
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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Leng9
leukocyte receptor cluster member 9
increases expression
ISO
Niclosamide results in increased expression of LENG9 mRNA
CTD
PMID:36318118
NCBI chr 1:70,039,099...70,041,559
Ensembl chr 1:70,035,791...70,044,509
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Lgals3
galectin 3
increases expression
ISO
Niclosamide results in increased expression of LGALS3 mRNA
CTD
PMID:36318118
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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Lgals8
galectin 8
decreases expression
ISO
Niclosamide results in decreased expression of LGALS8 mRNA
CTD
PMID:36318118
NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764
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Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
increases expression
ISO
Niclosamide results in increased expression of LHPP mRNA
CTD
PMID:36318118
NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578
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Lhx6
LIM homeobox 6
increases expression
ISO
Niclosamide results in increased expression of LHX6 mRNA
CTD
PMID:36318118
NCBI chr 3:19,432,439...19,456,268
Ensembl chr 3:19,433,494...19,456,061
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Lingo1
leucine rich repeat and Ig domain containing 1
increases expression
ISO
Niclosamide results in increased expression of LINGO1 mRNA
CTD
PMID:36318118
NCBI chr 8:57,011,272...57,193,496
Ensembl chr 8:57,010,007...57,196,544
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Lipg
lipase G, endothelial type
decreases expression
ISO
Niclosamide results in decreased expression of LIPG mRNA
CTD
PMID:36318118
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
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Lix1
limb and CNS expressed 1
decreases expression
ISO
Niclosamide results in decreased expression of LIX1 mRNA
CTD
PMID:36318118
NCBI chr 1:58,128,961...58,187,554
Ensembl chr 1:58,128,961...58,185,964
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Lmtk3
lemur tyrosine kinase 3
increases expression
ISO
Niclosamide results in increased expression of LMTK3 mRNA
CTD
PMID:36318118
NCBI chr 1:96,261,058...96,280,362
Ensembl chr 1:96,260,977...96,280,672
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Lonrf1
LON peptidase N-terminal domain and ring finger 1
increases expression
ISO
Niclosamide results in increased expression of LONRF1 mRNA
CTD
PMID:36318118
NCBI chr16:55,984,572...56,015,156
Ensembl chr16:55,984,463...56,015,156
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Loxl3
lysyl oxidase-like 3
increases expression
ISO
Niclosamide results in increased expression of LOXL3 mRNA
CTD
PMID:36318118
NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466
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Lpin3
lipin 3
increases expression
ISO
Niclosamide results in increased expression of LPIN3 mRNA
CTD
PMID:36318118
NCBI chr 3:149,533,719...149,558,494
Ensembl chr 3:149,534,051...149,558,327
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Lrp1
LDL receptor related protein 1
increases expression
ISO
Niclosamide results in increased expression of LRP1 mRNA
CTD
PMID:36318118
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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Lrp10
LDL receptor related protein 10
increases expression
ISO
Niclosamide results in increased expression of LRP10 mRNA
CTD
PMID:36318118
NCBI chr15:27,921,335...27,927,507
Ensembl chr15:27,920,259...27,927,505
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Lrp5
LDL receptor related protein 5
multiple interactions
EXP
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]]
CTD
PMID:32961231
NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
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Lrp6
LDL receptor related protein 6
decreases expression multiple interactions
ISO EXP
Niclosamide analog results in decreased expression of LRP6 protein; Niclosamide results in decreased expression of LRP6 protein Niclosamide results in decreased expression of and results in decreased phosphorylation of LRP6 protein Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]]
CTD
PMID:24552774 PMID:24736023 PMID:28284560 PMID:32961231
NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497
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Lrrc2
leucine rich repeat containing 2
increases expression
ISO
Niclosamide results in increased expression of LRRC2 mRNA
CTD
PMID:36318118
NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185
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Lrrc55
leucine rich repeat containing 55
decreases expression
ISO
Niclosamide results in decreased expression of LRRC55 mRNA
CTD
PMID:36318118
NCBI chr 3:70,269,908...70,280,651
Ensembl chr 3:70,265,936...70,278,639
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Lrrc73
leucine rich repeat containing 73
increases expression
ISO
Niclosamide results in increased expression of LRRC73 mRNA
CTD
PMID:36318118
NCBI chr 9:14,726,157...14,730,144
Ensembl chr 9:14,726,158...14,729,158
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Lrrc75b
leucine rich repeat containing 75B
increases expression
ISO
Niclosamide results in increased expression of LRRC75B mRNA
CTD
PMID:36318118
NCBI chr20:13,100,302...13,106,503
Ensembl chr20:13,100,302...13,106,503
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Lsp1
lymphocyte-specific protein 1
decreases expression
ISO
Niclosamide results in decreased expression of LSP1 mRNA
CTD
PMID:36318118
NCBI chr 1:197,614,677...197,648,414
Ensembl chr 1:197,614,687...197,648,416
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Ltbp4
latent transforming growth factor beta binding protein 4
increases expression
ISO
Niclosamide results in increased expression of LTBP4 mRNA
CTD
PMID:36318118
NCBI chr 1:82,600,136...82,634,346
Ensembl chr 1:82,600,136...82,632,178
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Ly6g5b
lymphocyte antigen 6 family member G5B
decreases expression
ISO
Niclosamide results in decreased expression of LY6G5B mRNA
CTD
PMID:36318118
NCBI chr20:3,705,464...3,707,830
Ensembl chr20:3,706,124...3,707,133
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Lyrm9
LYR motif containing 9
increases expression
ISO
Niclosamide results in increased expression of LYRM9 mRNA
CTD
PMID:36318118
NCBI chr10:63,725,718...63,739,772
Ensembl chr10:63,725,743...63,739,772
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Macc1
MET transcriptional regulator MACC1
multiple interactions
ISO
Niclosamide inhibits the reaction [MACC1 protein results in increased expression of S100A4 protein]
CTD
PMID:36008464
NCBI chr 6:140,352,690...140,430,255
Ensembl chr 6:140,352,755...140,430,255
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Mad2l1
mitotic arrest deficient 2 like 1
decreases expression
ISO
Niclosamide results in decreased expression of MAD2L1 mRNA
CTD
PMID:28284560
NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
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Magix
MAGI family member, X-linked
increases expression
ISO
Niclosamide results in increased expression of MAGIX mRNA
CTD
PMID:36318118
NCBI chr X:14,824,114...14,832,466
Ensembl chr X:14,824,188...14,831,045
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
increases expression
ISO
Niclosamide results in increased expression of MAP1LC3B protein modified form
CTD
PMID:30258081
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation multiple interactions
ISO
Niclosamide results in decreased phosphorylation of MAPK1 protein Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD
PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions decreases phosphorylation
ISO
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] Niclosamide results in decreased phosphorylation of MAPK3 protein
CTD
PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]
CTD
PMID:28824321
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
multiple interactions
ISO
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]
CTD
PMID:28824321
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mapt
microtubule-associated protein tau
increases expression
ISO
Niclosamide results in increased expression of MAPT mRNA
CTD
PMID:36318118
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Masp1
MBL associated serine protease 1
increases expression
ISO
Niclosamide results in increased expression of MASP1 mRNA
CTD
PMID:36318118
NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
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MAST1
microtubule associated serine/threonine kinase 1
increases expression
ISO
Niclosamide results in increased expression of MAST1 mRNA
CTD
PMID:36318118
NCBI chr19:23,216,418...23,244,224
Ensembl chr19:23,207,991...23,244,235
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Mat2a
methionine adenosyltransferase 2A
decreases expression
ISO
Niclosamide results in decreased expression of MAT2A mRNA
CTD
PMID:36318118
NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
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Matn1
matrilin 1
increases expression
ISO
Niclosamide results in increased expression of MATN1 mRNA
CTD
PMID:36318118
NCBI chr 5:143,117,198...143,127,140
Ensembl chr 5:143,117,504...143,127,059
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Mboat7
membrane bound O-acyltransferase domain containing 7
increases expression
ISO
Niclosamide results in increased expression of MBOAT7 mRNA
CTD
PMID:36318118
NCBI chr 1:65,525,206...65,539,538
Ensembl chr 1:65,525,213...65,539,538
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
Niclosamide results in decreased expression of MCL1 protein
CTD
PMID:20215516 PMID:26116531
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Mcm10
minichromosome maintenance 10 replication initiation factor
decreases expression
ISO
Niclosamide results in decreased expression of MCM10 mRNA
CTD
PMID:36318118
NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
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Mcm2
minichromosome maintenance complex component 2
decreases expression
ISO
Niclosamide results in decreased expression of MCM2 mRNA; Niclosamide results in decreased expression of MCM2 protein
CTD
PMID:28284560 PMID:29031202
NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
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Mcm5
minichromosome maintenance complex component 5
decreases expression
ISO
Niclosamide results in decreased expression of MCM5 mRNA
CTD
PMID:36318118
NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
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Mcm6
minichromosome maintenance complex component 6
decreases expression
ISO
Niclosamide results in decreased expression of MCM6 mRNA
CTD
PMID:36318118
NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
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Mcm7
minichromosome maintenance complex component 7
decreases expression
ISO
Niclosamide results in decreased expression of MCM7 protein
CTD
PMID:29031202
NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
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Me3
malic enzyme 3
decreases expression
ISO
Niclosamide results in decreased expression of ME3 mRNA
CTD
PMID:36318118
NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132
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Med31
mediator complex subunit 31
decreases expression
ISO
Niclosamide results in decreased expression of MED31 mRNA
CTD
PMID:36318118
NCBI chr10:56,836,944...56,840,326
Ensembl chr10:56,836,944...56,840,326
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Mef2d
myocyte enhancer factor 2D
increases expression
ISO
Niclosamide results in increased expression of MEF2D mRNA
CTD
PMID:36318118
NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457
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Meis3
Meis homeobox 3
increases expression
ISO
Niclosamide results in increased expression of MEIS3 mRNA
CTD
PMID:36318118
NCBI chr 1:76,861,267...76,872,691
Ensembl chr 1:76,861,924...76,872,691
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Mesp1
mesoderm posterior bHLH transcription factor 1
increases expression
ISO
Niclosamide results in increased expression of MESP1 mRNA
CTD
PMID:36318118
NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
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Met
MET proto-oncogene, receptor tyrosine kinase
decreases expression
EXP
Niclosamide results in decreased expression of MET mRNA
CTD
PMID:27338550
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Metrnl
meteorin-like, glial cell differentiation regulator
increases expression
ISO
Niclosamide results in increased expression of METRNL mRNA
CTD
PMID:36318118
NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869
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Mgll
monoglyceride lipase
increases expression
ISO
Niclosamide results in increased expression of MGLL mRNA
CTD
PMID:36318118
NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179
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Minar2
membrane integral NOTCH2 associated receptor 2
decreases expression
ISO
Niclosamide results in decreased expression of MINAR2 mRNA
CTD
PMID:36318118
NCBI chr18:52,539,714...52,554,465
Ensembl chr18:52,539,917...52,554,461
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Niclosamide results in decreased expression of MKI67 mRNA; Niclosamide results in decreased expression of MKI67 protein
CTD
PMID:28284560 PMID:35115509
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mknk2
MAPK interacting serine/threonine kinase 2
increases expression
ISO
Niclosamide results in increased expression of MKNK2 mRNA
CTD
PMID:36318118
NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827
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Mme
membrane metallo-endopeptidase
decreases expression
ISO
Niclosamide results in decreased expression of MME mRNA; Niclosamide results in decreased expression of MME protein
CTD
PMID:29480568
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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Mmp11
matrix metallopeptidase 11
increases expression
ISO
Niclosamide results in increased expression of MMP11 mRNA
CTD
PMID:36318118
NCBI chr20:12,730,846...12,739,629
Ensembl chr20:12,730,836...12,739,628
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Mmp15
matrix metallopeptidase 15
increases expression
ISO
Niclosamide results in increased expression of MMP15 mRNA
CTD
PMID:36318118
NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
Niclosamide results in decreased expression of MMP2 mRNA; Niclosamide results in decreased expression of MMP2 protein
CTD
PMID:29251334 PMID:30143678
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp7
matrix metallopeptidase 7
multiple interactions decreases expression
EXP ISO
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA] Niclosamide results in decreased expression of MMP7 mRNA Niclosamide inhibits the reaction [Doxorubicin results in increased expression of MMP7 mRNA]
CTD
PMID:27338550 PMID:28318631
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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Mmp9
matrix metallopeptidase 9
decreases expression multiple interactions
ISO
Niclosamide results in decreased expression of MMP9 mRNA; Niclosamide results in decreased expression of MMP9 protein Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]
CTD
PMID:28824321 PMID:29480568 PMID:30143678
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mrc2
mannose receptor, C type 2
increases expression
ISO
Niclosamide results in increased expression of MRC2 mRNA
CTD
PMID:36318118
NCBI chr10:90,261,986...90,323,187
Ensembl chr10:90,261,394...90,322,856
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Mrm2
mitochondrial rRNA methyltransferase 2
decreases expression
ISO
Niclosamide results in decreased expression of MRM2 mRNA
CTD
PMID:36318118
NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118
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Mrpl30
mitochondrial ribosomal protein L30
decreases expression
ISO
Niclosamide results in decreased expression of MRPL30 mRNA
CTD
PMID:36318118
NCBI chr 9:40,125,352...40,136,189
Ensembl chr 9:40,125,430...40,137,257
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Msantd7
Myb/SANT DNA binding domain containing 7
decreases expression
ISO
Niclosamide results in decreased expression of MSANTD7 mRNA
CTD
PMID:36318118
NCBI chr17:74,728,927...74,735,527
Ensembl chr17:74,728,811...74,736,094
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Mt1-ps3
metallothionein 1, pseudogene 3
increases expression
ISO
Niclosamide results in increased expression of MT1E mRNA
CTD
PMID:28284560
NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
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Mt2A
metallothionein 2A
increases expression
ISO
Niclosamide results in increased expression of MT2A mRNA
CTD
PMID:28284560
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation increases expression multiple interactions
ISO
Niclosamide analog results in decreased phosphorylation of MTOR protein; Niclosamide results in decreased phosphorylation of MTOR protein Niclosamide results in increased expression of MTOR mRNA Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of MTOR protein]; Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
CTD
PMID:19771169 PMID:26643609 PMID:26703449 PMID:28284560 PMID:29843133 PMID:34118929 More...
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Mvp
major vault protein
increases expression
ISO
Niclosamide results in increased expression of MVP mRNA
CTD
PMID:36318118
NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380
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Mxi1
MAX interactor 1, dimerization protein
increases expression
ISO
Niclosamide results in increased expression of MXI1 mRNA
CTD
PMID:36318118
NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions decreases expression
EXP ISO
Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA] [Niclosamide binds to Polyethyleneimine] which results in increased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC protein; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; Niclosamide inhibits the reaction [bicalutamide results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA] Niclosamide results in decreased expression of MYC mRNA; Niclosamide results in decreased expression of MYC protein
CTD
PMID:19160421 PMID:20215516 PMID:22576131 PMID:25970160 PMID:25988281 PMID:26964897 PMID:28500234 PMID:29843133 More...
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Mycl
MYCL proto-oncogene, bHLH transcription factor
increases expression
ISO
Niclosamide results in increased expression of MYCL mRNA
CTD
PMID:36318118
NCBI chr 5:135,274,713...135,281,584
Ensembl chr 5:135,274,748...135,281,582
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Mycn
MYCN proto-oncogene, bHLH transcription factor
decreases expression
ISO
Niclosamide results in decreased expression of MYCN mRNA; Niclosamide results in decreased expression of MYCN protein
CTD
PMID:36318118
NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
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Myh3
myosin heavy chain 3
increases expression
ISO
Niclosamide results in increased expression of MYH3 mRNA
CTD
PMID:34118929
NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
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Myo18b
myosin XVIIIb
increases expression
ISO
Niclosamide results in increased expression of MYO18B mRNA
CTD
PMID:36318118
NCBI chr12:43,747,003...43,953,694
Ensembl chr12:43,747,010...43,953,695
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Myod1
myogenic differentiation 1
increases expression
ISO
Niclosamide results in increased expression of MYOD1 mRNA
CTD
PMID:34118929
NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
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Myog
myogenin
increases expression
ISO
Niclosamide results in increased expression of MYOG protein
CTD
PMID:34118929
NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
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Myom3
myomesin 3
increases expression
ISO
Niclosamide results in increased expression of MYOM3 mRNA
CTD
PMID:36318118
NCBI chr 5:147,992,737...148,043,282
Ensembl chr 5:147,992,737...148,043,274
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Myrf
myelin regulatory factor
increases expression
ISO
Niclosamide results in increased expression of MYRF mRNA
CTD
PMID:36318118
NCBI chr 1:206,854,175...206,886,276
Ensembl chr 1:206,854,175...206,886,157
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N4bp2l1
NEDD4 binding protein 2-like 1
increases expression
ISO
Niclosamide results in increased expression of N4BP2L1 mRNA
CTD
PMID:36318118
NCBI chr12:102,572...128,352
Ensembl chr12:102,573...127,257
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Naa80
N(alpha)-acetyltransferase 80, NatH catalytic subunit
increases expression
ISO
Niclosamide results in increased expression of NAA80 mRNA
CTD
PMID:36318118
NCBI chr 8:108,254,314...108,257,564
Ensembl chr 8:108,253,302...108,257,563
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Nat1
N-acetyltransferase 1
decreases expression
ISO
Niclosamide results in decreased expression of NAT1 mRNA
CTD
PMID:36318118
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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Natd1
N-acetyltransferase domain containing 1
increases expression
ISO
Niclosamide results in increased expression of NATD1 mRNA
CTD
PMID:36318118
NCBI chr10:45,580,154...45,590,333
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Nbr1
NBR1, autophagy cargo receptor
increases expression
ISO
Niclosamide results in increased expression of NBR1 mRNA
CTD
PMID:36318118
NCBI chr10:86,477,775...86,506,418
Ensembl chr10:86,478,290...86,506,412
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Ncoa5
nuclear receptor coactivator 5
decreases expression
ISO
Niclosamide results in decreased expression of NCOA5 mRNA
CTD
PMID:36318118
NCBI chr 3:153,736,420...153,769,838
Ensembl chr 3:153,736,420...153,769,553
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Ndor1
NADPH dependent diflavin oxidoreductase 1
decreases expression
ISO
Niclosamide results in decreased expression of NDOR1 mRNA
CTD
PMID:36318118
NCBI chr 3:8,062,629...8,070,873
Ensembl chr 3:8,062,630...8,070,860
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Ndrg1
N-myc downstream regulated 1
increases expression
ISO
Niclosamide results in increased expression of NDRG1 mRNA
CTD
PMID:36318118
NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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Ndufa10
NADH:ubiquinone oxidoreductase subunit A10
decreases expression
ISO
Niclosamide results in decreased expression of NDUFA10 mRNA
CTD
PMID:22576131
NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560
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Ndufa4l2
NDUFA4, mitochondrial complex associated like 2
increases expression
ISO
Niclosamide results in increased expression of NDUFA4L2 mRNA
CTD
PMID:22576131 PMID:36318118
NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010
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Ndufa7
NADH:ubiquinone oxidoreductase subunit A7
decreases expression
ISO
Niclosamide results in decreased expression of NDUFA7 mRNA
CTD
PMID:22576131
NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976
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Ndufa8
NADH:ubiquinone oxidoreductase subunit A8
decreases expression
ISO
Niclosamide results in decreased expression of NDUFA8 mRNA
CTD
PMID:22576131
NCBI chr 3:19,386,062...19,402,090
Ensembl chr 3:19,386,065...19,402,071
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Ndufb10
NADH:ubiquinone oxidoreductase subunit B10
decreases expression
ISO
Niclosamide results in decreased expression of NDUFB10 mRNA
CTD
PMID:22576131
NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442
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Ndufb6
NADH:ubiquinone oxidoreductase subunit B6
decreases expression
ISO
Niclosamide results in decreased expression of NDUFB6 mRNA
CTD
PMID:22576131
NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
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Ndufc1
NADH:ubiquinone oxidoreductase subunit C1
increases expression
ISO
Niclosamide results in increased expression of NDUFC1 mRNA
CTD
PMID:22576131
NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874
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Ndufs2
NADH:ubiquinone oxidoreductase core subunit S2
decreases expression
ISO
Niclosamide results in decreased expression of NDUFS2 mRNA
CTD
PMID:22576131
NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
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Ndufs3
NADH:ubiquinone oxidoreductase core subunit S3
decreases expression
ISO
Niclosamide results in decreased expression of NDUFS3 mRNA
CTD
PMID:22576131
NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824
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Ndufs7
NADH:ubiquinone oxidoreductase core subunit S7
decreases expression
ISO
Niclosamide results in decreased expression of NDUFS7 mRNA
CTD
PMID:22576131
NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
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Ndufs8
NADH:ubiquinone oxidoreductase core subunit S8
decreases expression
ISO
Niclosamide results in decreased expression of NDUFS8 mRNA
CTD
PMID:22576131
NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
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Ndufv3
NADH:ubiquinone oxidoreductase subunit V3
increases expression
ISO
Niclosamide results in increased expression of NDUFV3 mRNA
CTD
PMID:22576131
NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074 Ensembl chr13:9,612,431...9,623,074
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Nectin3
nectin cell adhesion molecule 3
decreases expression
ISO
Niclosamide results in decreased expression of NECTIN3 mRNA
CTD
PMID:36318118
NCBI chr11:54,362,712...54,469,351
Ensembl chr11:54,364,487...54,462,519
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Nfatc1
nuclear factor of activated T-cells 1
multiple interactions
ISO
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]
CTD
PMID:26792726 PMID:28824321
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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Nfatc2ip
nuclear factor of activated T-cells 2 interacting protein
decreases expression
ISO
Niclosamide results in decreased expression of NFATC2IP mRNA
CTD
PMID:36318118
NCBI chr 1:180,954,834...180,971,847
Ensembl chr 1:180,955,043...180,971,747
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Nfix
nuclear factor I X
increases expression
ISO
Niclosamide results in increased expression of NFIX mRNA
CTD
PMID:36318118
NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265
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Nfkb1
nuclear factor kappa B subunit 1
affects localization
ISO
Niclosamide affects the localization of NFKB1 protein
CTD
PMID:26116531
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkb2
nuclear factor kappa B subunit 2
increases expression
ISO
Niclosamide results in increased expression of NFKB2 mRNA
CTD
PMID:36318118
NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
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Nfkbia
NFKB inhibitor alpha
decreases phosphorylation multiple interactions
ISO
Niclosamide results in decreased phosphorylation of NFKBIA protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein] Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
CTD
PMID:20215516 PMID:26116531 PMID:27492973 PMID:28824321 PMID:33524445
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nfkbil1
NFKB inhibitor like 1
increases expression
ISO
Niclosamide results in increased expression of NFKBIL1 mRNA
CTD
PMID:36318118
NCBI chr20:3,589,974...3,608,348
Ensembl chr20:3,590,642...3,605,616
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Nkd1
NKD inhibitor of WNT signaling pathway 1
multiple interactions increases expression
ISO
Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of NKD1 mRNA] Niclosamide results in increased expression of NKD1 mRNA
CTD
PMID:22576131 PMID:24534281
NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380
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Nkx3-1
NK3 homeobox 1
multiple interactions decreases expression
ISO
[Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNA Niclosamide results in decreased expression of NKX3-1 mRNA
CTD
PMID:28500234
NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein]
CTD
PMID:33524445
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nmrk1
nicotinamide riboside kinase 1
increases expression
ISO
Niclosamide results in increased expression of NMRK1 mRNA
CTD
PMID:36318118
NCBI chr 1:216,049,350...216,076,792
Ensembl chr 1:216,049,437...216,076,791
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Nnat
neuronatin
decreases expression
ISO
Niclosamide results in decreased expression of NNAT mRNA
CTD
PMID:36318118
NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834
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Nostrin
nitric oxide synthase trafficking
decreases expression
ISO
Niclosamide results in decreased expression of NOSTRIN mRNA
CTD
PMID:36318118
NCBI chr 3:53,904,746...53,970,995
Ensembl chr 3:53,904,827...53,970,988
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Notch1
notch receptor 1
decreases activity multiple interactions
ISO EXP
Niclosamide results in decreased activity of NOTCH1 protein Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]]
CTD
PMID:19160421 PMID:32961231
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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Notum
NOTUM, palmitoleoyl-protein carboxylesterase
increases expression
ISO
Niclosamide results in increased expression of NOTUM mRNA
CTD
PMID:36318118
NCBI chr10:105,933,245...105,940,327
Ensembl chr10:105,933,249...105,940,315
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Nova2
NOVA alternative splicing regulator 2
increases expression
ISO
Niclosamide results in increased expression of NOVA2 mRNA
CTD
PMID:36318118
NCBI chr 1:78,572,253...78,613,703
Ensembl chr 1:78,572,279...78,608,021
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Nox1
NADPH oxidase 1
decreases expression
ISO
Niclosamide results in decreased expression of NOX1 mRNA
CTD
PMID:36318118
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Npas4
neuronal PAS domain protein 4
increases expression
ISO
Niclosamide results in increased expression of NPAS4 mRNA
CTD
PMID:36318118
NCBI chr 1:202,281,260...202,298,681
Ensembl chr 1:202,281,958...202,286,724
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Npr1
natriuretic peptide receptor 1
increases expression
ISO
Niclosamide results in increased expression of NPR1 mRNA
CTD
PMID:36318118
NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
increases expression
ISO
Niclosamide results in increased expression of NR1D1 mRNA
CTD
PMID:36318118
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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Nr1d2
nuclear receptor subfamily 1, group D, member 2
increases expression
ISO
Niclosamide results in increased expression of NR1D2 mRNA
CTD
PMID:36318118
NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
ISO
Niclosamide binds to and results in increased activity of NR1I3 protein alternative form
CTD
PMID:31312845
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression
ISO
Niclosamide results in increased expression of NR4A1 mRNA
CTD
PMID:36318118
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nrxn2
neurexin 2
increases expression
ISO
Niclosamide results in increased expression of NRXN2 mRNA
CTD
PMID:36318118
NCBI chr 1:203,726,420...203,842,301
Ensembl chr 1:203,735,753...203,842,297
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Nt5m
5',3'-nucleotidase, mitochondrial
increases expression
ISO
Niclosamide results in increased expression of NT5M mRNA
CTD
PMID:36318118
NCBI chr10:44,652,845...44,680,549
Ensembl chr10:44,652,975...44,679,150
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Ntng2
netrin G2
increases expression
ISO
Niclosamide results in increased expression of NTNG2 mRNA
CTD
PMID:36318118
NCBI chr 3:12,492,574...12,551,104
Ensembl chr 3:12,492,639...12,545,890
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Nudt18
nudix hydrolase 18
increases expression
ISO
Niclosamide results in increased expression of NUDT18 mRNA
CTD
PMID:36318118
NCBI chr15:45,650,597...45,653,985
Ensembl chr15:45,650,664...45,653,963
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Nupr2
nuclear protein 2, transcriptional regulator
increases expression
ISO
Niclosamide results in increased expression of NUPR2 mRNA
CTD
PMID:36318118
NCBI chr12:26,800,123...26,803,228
Ensembl chr12:26,799,800...26,803,304
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Nxph1
neurexophilin 1
decreases expression
ISO
Niclosamide results in decreased expression of NXPH1 mRNA
CTD
PMID:36318118
NCBI chr 4:36,998,068...37,311,135
Ensembl chr 4:36,997,669...37,311,132
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Nxph2
neurexophilin 2
decreases expression
ISO
Niclosamide results in decreased expression of NXPH2 mRNA
CTD
PMID:36318118
NCBI chr 3:5,986,175...5,988,525
Ensembl chr 3:5,756,621...5,987,008
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Nxph4
neurexophilin 4
increases expression
ISO
Niclosamide results in increased expression of NXPH4 mRNA
CTD
PMID:36318118
NCBI chr 7:63,367,758...63,376,579
Ensembl chr 7:63,367,761...63,376,579
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Nyap1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
increases expression
ISO
Niclosamide results in increased expression of NYAP1 mRNA
CTD
PMID:36318118
NCBI chr12:18,956,192...18,967,624
Ensembl chr12:18,956,268...18,967,543
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Oas1a
2'-5' oligoadenylate synthetase 1A
decreases expression
ISO
Niclosamide results in decreased expression of OAS1 mRNA
CTD
PMID:36318118
NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
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Oaz3
ornithine decarboxylase antizyme 3
increases expression
ISO
Niclosamide results in increased expression of OAZ3 mRNA
CTD
PMID:36318118
NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399
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Oca2
OCA2 melanosomal transmembrane protein
increases expression
ISO
Niclosamide results in increased expression of OCA2 mRNA
CTD
PMID:36318118
NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074
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Ocstamp
osteoclast stimulatory transmembrane protein
multiple interactions
ISO
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]
CTD
PMID:28824321
NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991
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Olr765
olfactory receptor 765
decreases expression
ISO
Niclosamide results in decreased expression of OR4F17 mRNA
CTD
PMID:36318118
NCBI chr 3:98,118,744...98,121,011
Ensembl chr 3:98,097,957...98,101,421
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Opcml
opioid binding protein/cell adhesion molecule-like
increases expression
ISO
Niclosamide results in increased expression of OPCML mRNA
CTD
PMID:36318118
NCBI chr 8:26,788,988...27,304,551
Ensembl chr 8:26,192,841...27,300,620
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Opn3
opsin 3
increases expression
ISO
Niclosamide results in increased expression of OPN3 mRNA
CTD
PMID:36318118
NCBI chr13:87,589,333...87,619,847
Ensembl chr13:87,589,333...87,619,847
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Orai3
ORAI calcium release-activated calcium modulator 3
increases expression
ISO
Niclosamide results in increased expression of ORAI3 mRNA
CTD
PMID:36318118
NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052
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Orc1
origin recognition complex, subunit 1
decreases expression
ISO
Niclosamide results in decreased expression of ORC1 mRNA
CTD
PMID:28284560 PMID:36318118
NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
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Oscar
osteoclast associated Ig-like receptor
multiple interactions
ISO
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA] Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]
CTD
PMID:26792726 PMID:28824321
NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758
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Otud1
OTU deubiquitinase 1
increases expression
ISO
Niclosamide results in increased expression of OTUD1 mRNA
CTD
PMID:36318118
NCBI chr17:82,259,920...82,262,770
Ensembl chr17:82,259,840...82,262,995
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Otulinl
OTU deubiquitinase with linear linkage specificity like
decreases expression
ISO
Niclosamide results in decreased expression of OTULINL mRNA
CTD
PMID:36318118
NCBI chr 2:78,405,994...78,433,860
Ensembl chr 2:78,408,593...78,433,838
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P2ry6
pyrimidinergic receptor P2Y6
decreases expression
ISO
Niclosamide results in decreased expression of P2RY6 mRNA
CTD
PMID:36318118
NCBI chr 1:155,295,110...155,330,610
Ensembl chr 1:155,295,111...155,330,808
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Paip2b
poly(A) binding protein interacting protein 2B
increases expression
ISO
Niclosamide results in increased expression of PAIP2B mRNA
CTD
PMID:36318118
NCBI chr 4:116,292,001...116,323,387
Ensembl chr 4:116,292,020...116,323,379
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Palm
paralemmin
increases expression
ISO
Niclosamide results in increased expression of PALM mRNA
CTD
PMID:36318118
NCBI chr 7:9,886,634...9,912,389
Ensembl chr 7:9,886,643...9,912,555
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Pard3b
par-3 family cell polarity regulator beta
increases expression
ISO
Niclosamide results in increased expression of PARD3B mRNA
CTD
PMID:36318118
NCBI chr 9:63,038,435...64,067,178
Ensembl chr 9:63,038,436...64,068,053
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases cleavage increases expression decreases expression
ISO
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide results in increased cleavage of PARP1 protein]; bicalutamide promotes the reaction [Niclosamide results in increased expression of PARP1 protein modified form]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein] Niclosamide results in decreased expression of PARP1 protein
CTD
PMID:24750999 PMID:25174399 PMID:26917416 PMID:28500234 PMID:30258081 PMID:30329025 More...
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pax7
paired box 7
increases expression
ISO
Niclosamide results in increased expression of PAX7 mRNA
CTD
PMID:34118929
NCBI chr 5:151,996,368...152,098,023
Ensembl chr 5:151,999,092...152,097,979
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Pbx1
PBX homeobox 1
increases expression
ISO
Niclosamide results in increased expression of PBX1 mRNA
CTD
PMID:36318118
NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594
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Pbx2
PBX homeobox 2
increases expression
ISO
Niclosamide results in increased expression of PBX2 mRNA
CTD
PMID:36318118
NCBI chr20:4,151,500...4,156,425
Ensembl chr20:4,151,500...4,156,425
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Pbxip1
PBX homeobox interacting protein 1
increases expression
ISO
Niclosamide results in increased expression of PBXIP1 mRNA
CTD
PMID:36318118
NCBI chr 2:174,856,339...174,868,922
Ensembl chr 2:174,856,397...174,868,919
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Pc
pyruvate carboxylase
increases expression
ISO
Niclosamide results in increased expression of PC mRNA
CTD
PMID:22576131
NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
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Pcdh19
protocadherin 19
decreases expression
ISO
Niclosamide results in decreased expression of PCDH19 mRNA
CTD
PMID:36318118
NCBI chr X:96,767,686...96,873,477
Ensembl chr X:96,771,947...96,873,524
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Pcdh20
protocadherin 20
decreases expression
ISO
Niclosamide results in decreased expression of PCDH20 mRNA
CTD
PMID:36318118
NCBI chr15:64,425,534...64,431,790
Ensembl chr15:64,425,534...64,431,790
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Pcgf1
polycomb group ring finger 1
increases expression
ISO
Niclosamide results in increased expression of PCGF1 mRNA
CTD
PMID:36318118
NCBI chr 4:115,576,165...115,587,019
Ensembl chr 4:115,583,867...115,587,008
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Pcna
proliferating cell nuclear antigen
decreases expression
ISO
Niclosamide results in decreased expression of PCNA mRNA
CTD
PMID:36318118
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pdcd4
programmed cell death 4
increases expression
ISO
Niclosamide results in increased expression of PDCD4 mRNA
CTD
PMID:36318118
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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Pde4b
phosphodiesterase 4B
increases expression
ISO
Niclosamide results in increased expression of PDE4B mRNA
CTD
PMID:36318118
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
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Pdgfrb
platelet derived growth factor receptor beta
increases expression decreases expression
ISO
Niclosamide results in increased expression of PDGFRB mRNA Niclosamide results in decreased expression of PDGFRB protein
CTD
PMID:34118929 PMID:36318118
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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Pdk1
pyruvate dehydrogenase kinase 1
multiple interactions
ISO
Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of PDK1 mRNA]
CTD
PMID:36318118
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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Pdk3
pyruvate dehydrogenase kinase 3
decreases expression multiple interactions
ISO
Niclosamide results in decreased expression of PDK3 mRNA Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of PDK3 mRNA]
CTD
PMID:36318118
NCBI chr X:58,486,699...58,553,533
Ensembl chr X:58,486,554...58,553,557
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Pdlim4
PDZ and LIM domain 4
increases expression
ISO
Niclosamide results in increased expression of PDLIM4 mRNA
CTD
PMID:36318118
NCBI chr10:38,198,686...38,212,935
Ensembl chr10:38,198,689...38,212,938
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Pdzd7
PDZ domain containing 7
increases expression
ISO
Niclosamide results in increased expression of PDZD7 mRNA
CTD
PMID:36318118
NCBI chr 1:243,888,295...243,907,778
Ensembl chr 1:243,888,281...243,906,839
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Percc1
proline and glutamate rich with coiled coil 1
increases expression
ISO
Niclosamide results in increased expression of PERCC1 mRNA
CTD
PMID:36318118
NCBI chr10:14,187,858...14,190,634
Ensembl chr10:14,188,216...14,189,040 Ensembl chr10:14,188,216...14,189,040
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Pfkm
phosphofructokinase, muscle
decreases expression
ISO
Niclosamide results in decreased expression of PFKM mRNA
CTD
PMID:22576131
NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
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Pgk1
phosphoglycerate kinase 1
multiple interactions
ISO
Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of PGK1 mRNA]
CTD
PMID:36318118
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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Pgr
progesterone receptor
decreases expression
ISO
Niclosamide results in decreased expression of PGR mRNA
CTD
PMID:36318118
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Phf24
PHD finger protein 24
increases expression
ISO
Niclosamide results in increased expression of PHF24 mRNA
CTD
PMID:36318118
NCBI chr 5:57,143,428...57,171,054
Ensembl chr 5:57,142,632...57,168,497
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Phka2
phosphorylase kinase regulatory subunit alpha 2
decreases expression
ISO
Niclosamide results in decreased expression of PHKA2 mRNA
CTD
PMID:36318118
NCBI chr X:34,170,959...34,293,498
Ensembl chr X:34,171,323...34,293,466
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Phlda1
pleckstrin homology-like domain, family A, member 1
increases expression
ISO
Niclosamide results in increased expression of PHLDA1 mRNA
CTD
PMID:28284560
NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
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Phldb3
pleckstrin homology-like domain, family B, member 3
increases expression
ISO
Niclosamide results in increased expression of PHLDB3 mRNA
CTD
PMID:36318118
NCBI chr 1:80,201,083...80,219,541
Ensembl chr 1:80,201,578...80,219,534
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Phyhip
phytanoyl-CoA 2-hydroxylase interacting protein
increases expression
ISO
Niclosamide results in increased expression of PHYHIP mRNA
CTD
PMID:36318118
NCBI chr15:45,533,974...45,545,223
Ensembl chr15:45,533,974...45,545,221
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Pi15
peptidase inhibitor 15
decreases expression
ISO
Niclosamide results in decreased expression of PI15 mRNA
CTD
PMID:36318118
NCBI chr 5:1,395,094...1,423,213
Ensembl chr 5:1,395,094...1,423,213
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Pigw
phosphatidylinositol glycan anchor biosynthesis, class W
decreases expression
ISO
Niclosamide results in decreased expression of PIGW mRNA
CTD
PMID:36318118
NCBI chr10:69,746,996...69,782,656
Ensembl chr10:69,748,789...69,790,475
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
increases expression multiple interactions
ISO
Niclosamide results in increased expression of PIK3CA mRNA Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]
CTD
PMID:27542212 PMID:29843133
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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Pik3ip1
phosphoinositide-3-kinase interacting protein 1
increases expression
ISO
Niclosamide results in increased expression of PIK3IP1 mRNA
CTD
PMID:36318118
NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608
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Pim1
Pim-1 proto-oncogene, serine/threonine kinase
increases expression
ISO
Niclosamide results in increased expression of PIM1 mRNA
CTD
PMID:36318118
NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
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Pkm
pyruvate kinase M1/2
increases expression
ISO
Niclosamide results in increased expression of PKM mRNA
CTD
PMID:22576131
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Pla2g4c
phospholipase A2 group IVC
increases expression
ISO
Niclosamide results in increased expression of PLA2G4C mRNA
CTD
PMID:36318118
NCBI chr 1:74,237,714...74,275,757
Ensembl chr 1:74,236,211...74,274,656
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Plec
plectin
increases expression
ISO
Niclosamide results in increased expression of PLEC mRNA
CTD
PMID:36318118
NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467
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Plekha2
pleckstrin homology domain containing A2
increases expression
ISO
Niclosamide results in increased expression of PLEKHA2 mRNA
CTD
PMID:36318118
NCBI chr16:66,938,684...67,000,661
Ensembl chr16:66,939,109...66,999,395
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Plekhg4
pleckstrin homology and RhoGEF domain containing G4
increases expression
ISO
Niclosamide results in increased expression of PLEKHG4 mRNA
CTD
PMID:36318118
NCBI chr19:33,251,788...33,266,490
Ensembl chr19:33,249,706...33,266,357
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Pnrc1
proline-rich nuclear receptor coactivator 1
increases expression
ISO
Niclosamide results in increased expression of PNRC1 mRNA
CTD
PMID:36318118
NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161
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Pold4
DNA polymerase delta 4, accessory subunit
increases expression
ISO
Niclosamide results in increased expression of POLD4 mRNA
CTD
PMID:36318118
NCBI chr 1:201,526,591...201,528,406
Ensembl chr 1:201,526,665...201,528,401
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Pou3f1
POU class 3 homeobox 1
increases expression
ISO
Niclosamide results in increased expression of POU3F1 mRNA
CTD
PMID:36318118
NCBI chr 5:136,910,391...136,913,371
Ensembl chr 5:136,910,391...136,913,371
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Pou5f1
POU class 5 homeobox 1
decreases phosphorylation
ISO
Niclosamide results in decreased phosphorylation of POU5F1 protein
CTD
PMID:23333246
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Ppard
peroxisome proliferator-activated receptor delta
increases expression
ISO
Niclosamide results in increased expression of PPARD mRNA
CTD
PMID:22576131
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
Niclosamide results in increased expression of PPARG mRNA
CTD
PMID:36318118
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppef2
protein phosphatase with EF-hand domain 2
decreases expression
ISO
Niclosamide results in decreased expression of PPEF2 mRNA
CTD
PMID:36318118
NCBI chr14:15,797,414...15,831,620
Ensembl chr14:15,797,435...15,831,491
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Ppfia3
PTPRF interacting protein alpha 3
increases expression
ISO
Niclosamide results in increased expression of PPFIA3 mRNA
CTD
PMID:36318118
NCBI chr 1:95,817,110...95,845,950
Ensembl chr 1:95,817,110...95,845,798
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Ppil6
peptidylprolyl isomerase like 6
increases expression
ISO
Niclosamide results in increased expression of PPIL6 mRNA
CTD
PMID:36318118
NCBI chr20:44,989,509...45,017,833
Ensembl chr20:44,988,943...45,018,340
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Ppp1r12b
protein phosphatase 1, regulatory subunit 12B
increases expression
ISO
Niclosamide results in increased expression of PPP1R12B mRNA
CTD
PMID:36318118
NCBI chr13:46,199,418...46,397,108
Ensembl chr13:46,201,251...46,397,108
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
ISO
Niclosamide results in increased expression of PPP1R15A mRNA
CTD
PMID:36318118
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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Ppp1r3b
protein phosphatase 1, regulatory subunit 3B
decreases expression
ISO
Niclosamide results in decreased expression of PPP1R3B mRNA
CTD
PMID:36318118
NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406
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Ppp2cb
protein phosphatase 2 catalytic subunit beta
decreases expression
ISO
Niclosamide results in decreased expression of PPP2CB mRNA
CTD
PMID:22576131
NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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Ppp2r1a
protein phosphatase 2 scaffold subunit A alpha
increases expression
ISO
Niclosamide results in increased expression of PPP2R1A mRNA
CTD
PMID:22576131
NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
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Ppp2r1b
protein phosphatase 2 scaffold subunit A beta
multiple interactions
ISO
Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]
CTD
PMID:27542212
NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485
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Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
decreases expression
ISO
Niclosamide results in decreased expression of PPP2R2B mRNA
CTD
PMID:22576131
NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
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Ppp2r2c
protein phosphatase 2, regulatory subunit B, gamma
decreases expression
ISO
Niclosamide results in decreased expression of PPP2R2C mRNA
CTD
PMID:22576131
NCBI chr14:73,846,547...73,931,489
Ensembl chr14:73,846,547...73,931,864
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Prdm1
PR/SET domain 1
multiple interactions
ISO
Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]
CTD
PMID:33632240
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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Prkcd
protein kinase C, delta
increases expression
ISO
Niclosamide results in increased expression of PRKCD mRNA
CTD
PMID:36318118
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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Prkcq
protein kinase C, theta
increases expression
ISO
Niclosamide results in increased expression of PRKCQ mRNA
CTD
PMID:22576131
NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
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Prpf8
pre-mRNA processing factor 8
decreases expression
ISO
Niclosamide results in decreased expression of PRPF8 mRNA
CTD
PMID:36318118
NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,331,494...60,354,606
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Prr29
proline rich 29
decreases expression
ISO
Niclosamide results in decreased expression of PRR29 mRNA
CTD
PMID:36318118
NCBI chr10:91,305,820...91,320,661
Ensembl chr10:91,305,723...91,310,439
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Prr36
proline rich 36
increases expression
ISO
Niclosamide results in increased expression of PRR36 mRNA
CTD
PMID:36318118
NCBI chr12:2,560,533...2,567,766
Ensembl chr12:2,560,536...2,567,742
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Psen2
presenilin 2
decreases expression
ISO
Niclosamide results in decreased expression of PSEN2 mRNA
CTD
PMID:36318118
NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
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Psmc3ip
PSMC3 interacting protein
decreases expression
ISO
Niclosamide results in decreased expression of PSMC3IP mRNA
CTD
PMID:36318118
NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423
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Pten
phosphatase and tensin homolog
increases expression
ISO
Niclosamide results in increased expression of PTEN mRNA
CTD
PMID:29843133
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Ptger4
prostaglandin E receptor 4
decreases expression
ISO
Niclosamide results in decreased expression of PTGER4 mRNA
CTD
PMID:36318118
NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
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Ptges
prostaglandin E synthase
increases expression
ISO
Niclosamide results in increased expression of PTGES mRNA
CTD
PMID:36318118
NCBI chr 3:14,177,892...14,189,236
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Ptk2b
protein tyrosine kinase 2 beta
increases expression
ISO
Niclosamide results in increased expression of PTK2B mRNA
CTD
PMID:36318118
NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
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Ptprg
protein tyrosine phosphatase, receptor type, G
decreases expression
ISO
Niclosamide results in decreased expression of PTPRG mRNA
CTD
PMID:36318118
NCBI chr15:12,871,706...13,552,186
Ensembl chr15:12,871,721...13,554,094
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Ptprh
protein tyrosine phosphatase, receptor type, H
increases expression
ISO
Niclosamide results in increased expression of PTPRH mRNA
CTD
PMID:36318118
NCBI chr 1:69,243,704...69,276,294
Ensembl chr 1:69,242,321...69,285,077
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Ptprt
protein tyrosine phosphatase, receptor type, T
decreases expression
ISO
Niclosamide results in decreased expression of PTPRT mRNA
CTD
PMID:36318118
NCBI chr 3:150,189,343...151,288,145
Ensembl chr 3:150,194,859...151,288,124
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R3hdm2
R3H domain containing 2
increases expression
ISO
Niclosamide results in increased expression of R3HDM2 mRNA
CTD
PMID:36318118
NCBI chr 7:63,212,519...63,340,574
Ensembl chr 7:63,232,346...63,340,540
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Rab26
RAB26, member RAS oncogene family
increases expression
ISO
Niclosamide results in increased expression of RAB26 mRNA
CTD
PMID:36318118
NCBI chr10:13,553,395...13,558,063
Ensembl chr10:13,553,395...13,558,030
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Rab3a
RAB3A, member RAS oncogene family
increases expression
ISO
Niclosamide results in increased expression of RAB3A mRNA
CTD
PMID:36318118
NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
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Rab3il1
RAB3A interacting protein-like 1
increases expression
ISO
Niclosamide results in increased expression of RAB3IL1 mRNA
CTD
PMID:36318118
NCBI chr 1:206,646,168...206,682,718
Ensembl chr 1:206,646,155...206,679,972
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Rab7b
Rab7b, member RAS oncogene family
increases expression
ISO
Niclosamide results in increased expression of RAB7B mRNA
CTD
PMID:36318118
NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581
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Rac2
Rac family small GTPase 2
increases expression
ISO
Niclosamide results in increased expression of RAC2 mRNA
CTD
PMID:36318118
NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
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Rad54l
RAD54 like
increases expression
ISO
Niclosamide results in increased expression of RAD54L mRNA
CTD
PMID:28284560
NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
decreases phosphorylation decreases expression
ISO
Niclosamide analog results in decreased phosphorylation of RAF1 protein Niclosamide analog results in decreased expression of RAF1 protein; Niclosamide results in decreased expression of RAF1 protein
CTD
PMID:28284560
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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Rasa4
RAS p21 protein activator 4
increases expression
ISO
Niclosamide results in increased expression of RASA4B mRNA
CTD
PMID:36318118
NCBI chr12:20,552,805...20,580,177
Ensembl chr12:20,552,806...20,580,147
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Rassf10
Ras association domain family member 10
decreases expression
ISO
Niclosamide results in decreased expression of RASSF10 mRNA
CTD
PMID:36318118
NCBI chr 1:167,058,277...167,063,591
Ensembl chr 1:167,058,099...167,063,572
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Rbm45
RNA binding motif protein 45
decreases expression
ISO
Niclosamide results in decreased expression of RBM45 mRNA
CTD
PMID:36318118
NCBI chr 3:61,305,973...61,320,950
Ensembl chr 3:61,305,924...61,320,952
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Rcn3
reticulocalbin 3
increases expression
ISO
Niclosamide results in increased expression of RCN3 mRNA
CTD
PMID:36318118
NCBI chr 1:95,564,503...95,573,762
Ensembl chr 1:95,564,380...95,573,725
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Rcor2
REST corepressor 2
increases expression
ISO
Niclosamide results in increased expression of RCOR2 mRNA
CTD
PMID:36318118
NCBI chr 1:204,453,403...204,461,403
Ensembl chr 1:204,454,360...204,460,838
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Reep6
receptor accessory protein 6
increases expression
ISO
Niclosamide results in increased expression of REEP6 mRNA
CTD
PMID:36318118
NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions decreases expression
ISO EXP
Niclosamide affects the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of and results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of RELA protein modified form] Niclosamide results in decreased expression of RELA protein Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of RELA protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of RELA protein]; Niclosamide results in decreased phosphorylation of and affects the localization of RELA protein Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]
CTD
PMID:20215516 PMID:26116531 PMID:26643609 PMID:27492973 PMID:28318631 PMID:28824321 PMID:33524445 More...
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Relb
RELB proto-oncogene, NF-kB subunit
increases expression
ISO
Niclosamide results in increased expression of RELB mRNA
CTD
PMID:36318118
NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507
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Rep15
RAB15 effector protein
decreases expression
ISO
Niclosamide results in decreased expression of REP15 mRNA
CTD
PMID:36318118
NCBI chr 4:179,951,935...179,953,008
Ensembl chr 4:179,951,935...179,953,008
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Rgma
repulsive guidance molecule BMP co-receptor a
decreases expression
ISO
Niclosamide results in decreased expression of RGMA mRNA
CTD
PMID:36318118
NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918
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Rgs10
regulator of G-protein signaling 10
increases expression
ISO
Niclosamide results in increased expression of RGS10 mRNA
CTD
PMID:36318118
NCBI chr 1:182,946,334...182,987,729
Ensembl chr 1:182,946,336...182,987,697
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Rgs13
regulator of G-protein signaling 13
decreases expression
ISO
Niclosamide results in decreased expression of RGS13 mRNA
CTD
PMID:36318118
NCBI chr13:55,922,290...55,955,753
Ensembl chr13:55,922,395...55,955,648
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Rgs14
regulator of G-protein signaling 14
increases expression
ISO
Niclosamide results in increased expression of RGS14 mRNA
CTD
PMID:36318118
NCBI chr17:9,248,982...9,263,104
Ensembl chr17:9,249,019...9,263,104
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Rgs8
regulator of G-protein signaling 8
decreases expression
ISO
Niclosamide results in decreased expression of RGS8 mRNA
CTD
PMID:36318118
NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807
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Rhobtb1
Rho-related BTB domain containing 1
increases expression
ISO
Niclosamide results in increased expression of RHOBTB1 mRNA
CTD
PMID:36318118
NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012
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Rhof
ras homolog family member F, filopodia associated
multiple interactions
ISO
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA]
CTD
PMID:29733962
NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703
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Rilpl1
Rab interacting lysosomal protein-like 1
increases expression
ISO
Niclosamide results in increased expression of RILPL1 mRNA
CTD
PMID:36318118
NCBI chr12:32,071,870...32,109,687
Ensembl chr12:32,071,693...32,109,938
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Rin1
Ras and Rab interactor 1
increases expression
ISO
Niclosamide results in increased expression of RIN1 mRNA
CTD
PMID:36318118
NCBI chr 1:202,355,729...202,362,731
Ensembl chr 1:202,355,890...202,362,729
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Ripor3
RIPOR family member 3
increases expression
ISO
Niclosamide results in increased expression of FAM65C mRNA
CTD
PMID:28284560
NCBI chr 3:156,687,253...156,760,524
Ensembl chr 3:156,687,517...156,715,061
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Rnf122
ring finger protein 122
increases expression
ISO
Niclosamide results in increased expression of RNF122 mRNA
CTD
PMID:36318118
NCBI chr16:61,009,879...61,027,429
Ensembl chr16:61,009,879...61,027,448
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Rnf215
ring finger protein 215
increases expression
ISO
Niclosamide results in increased expression of RNF215 mRNA
CTD
PMID:36318118
NCBI chr14:79,006,659...79,013,091
Ensembl chr14:79,006,688...79,013,091
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Rnf227
ring finger protein 227
increases expression
ISO
Niclosamide results in increased expression of RNF227 mRNA
CTD
PMID:36318118
NCBI chr10:54,061,054...54,063,015
Ensembl chr10:54,059,947...54,063,010
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Rock1
Rho-associated coiled-coil containing protein kinase 1
decreases expression
ISO
Niclosamide results in decreased expression of ROCK1 mRNA; Niclosamide results in decreased expression of ROCK1 protein
CTD
PMID:29251334
NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
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Rps6
ribosomal protein S6
affects phosphorylation
ISO
Niclosamide affects the phosphorylation of RPS6 protein
CTD
PMID:27542212
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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Rps6ka5
ribosomal protein S6 kinase A5
increases expression
ISO
Niclosamide results in increased expression of RPS6KA5 mRNA
CTD
PMID:36318118
NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224
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Rps6kb1
ribosomal protein S6 kinase B1
decreases phosphorylation
ISO
Niclosamide results in decreased phosphorylation of RPS6KB1 protein
CTD
PMID:27542212 PMID:30258081
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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Rrm2
ribonucleotide reductase regulatory subunit M2
decreases expression
ISO
Niclosamide results in decreased expression of RRM2 mRNA
CTD
PMID:28284560
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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Rsl1
regulator of sex limited protein 1
decreases expression
ISO
Niclosamide results in decreased expression of ZNF66 mRNA
CTD
PMID:36318118
NCBI chr 2:84,739,694...84,763,617
Ensembl chr 2:84,718,530...84,762,596
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Rsph4a
radial spoke head component 4A
decreases expression
ISO
Niclosamide results in decreased expression of RSPH4A mRNA
CTD
PMID:36318118
NCBI chr20:30,764,409...30,780,574
Ensembl chr20:30,764,409...30,780,574
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Rtn4r
reticulon 4 receptor
increases expression
ISO
Niclosamide results in increased expression of RTN4R mRNA
CTD
PMID:36318118
NCBI chr11:82,844,309...82,869,251
Ensembl chr11:82,844,309...82,869,466
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Rtn4rl1
reticulon 4 receptor-like 1
increases expression
ISO
Niclosamide results in increased expression of RTN4RL1 mRNA
CTD
PMID:36318118
NCBI chr10:60,043,246...60,116,977
Ensembl chr10:60,043,002...60,116,978
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Runx2
RUNX family transcription factor 2
decreases expression
ISO
Niclosamide results in decreased expression of RUNX2 mRNA
CTD
PMID:28824321
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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Rwdd3
RWD domain containing 3
decreases expression
ISO
Niclosamide results in decreased expression of RWDD3 mRNA
CTD
PMID:36318118
NCBI chr 2:209,233,622...209,254,842
Ensembl chr 2:209,233,622...209,248,853
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S100a4
S100 calcium-binding protein A4
decreases expression multiple interactions
ISO
Niclosamide results in decreased expression of S100A4 mRNA; Niclosamide results in decreased expression of S100A4 protein Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein] Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein]; Niclosamide inhibits the reaction [MACC1 protein results in increased expression of S100A4 protein]
CTD
PMID:21685359 PMID:29733962 PMID:34118929 PMID:36008464
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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Samd11
sterile alpha motif domain containing 11
increases expression
ISO
Niclosamide results in increased expression of SAMD11 mRNA
CTD
PMID:36318118
NCBI chr 5:166,831,681...166,859,805
Ensembl chr 5:166,831,663...166,850,009
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Satb1
SATB homeobox 1
increases expression
ISO
Niclosamide results in increased expression of SATB1 mRNA
CTD
PMID:36318118
NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251
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Saxo5
stabilizer of axonemal microtubules 5
increases expression
ISO
Niclosamide results in increased expression of SAXO5 mRNA
CTD
PMID:36318118
NCBI chr12:1,520,983...1,538,127
Ensembl chr12:1,521,014...1,538,118
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Scaper
S-phase cyclin A-associated protein in the ER
increases expression
ISO
Niclosamide results in increased expression of SCAPER mRNA
CTD
PMID:36318118
NCBI chr 8:55,932,717...56,332,222
Ensembl chr 8:55,933,306...56,332,122
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Scn7a
sodium voltage-gated channel alpha subunit 7
decreases expression
ISO
Niclosamide results in decreased expression of SCN7A mRNA
CTD
PMID:36318118
NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256
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Scrt1
scratch family transcriptional repressor 1
increases expression
ISO
Niclosamide results in increased expression of SCRT1 mRNA
CTD
PMID:36318118
NCBI chr 7:108,240,986...108,244,636
Ensembl chr 7:108,240,986...108,244,636
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Scrt2
scratch family transcriptional repressor 2
increases expression
ISO
Niclosamide results in increased expression of SCRT2 mRNA
CTD
PMID:36318118
NCBI chr 3:140,581,336...140,595,273
Ensembl chr 3:140,581,593...140,593,299
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Sdhaf4
succinate dehydrogenase complex assembly factor 4
increases expression
ISO
Niclosamide results in increased expression of SDHAF4 mRNA
CTD
PMID:36318118
NCBI chr 9:26,408,332...26,416,478
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Sema3f
semaphorin 3F
increases expression
ISO
Niclosamide results in increased expression of SEMA3F mRNA
CTD
PMID:36318118
NCBI chr 8:108,357,629...108,386,569
Ensembl chr 8:108,357,629...108,387,083
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Sema4a
semaphorin 4A
increases expression
ISO
Niclosamide results in increased expression of SEMA4A mRNA
CTD
PMID:36318118
NCBI chr 2:173,896,432...173,917,903
Ensembl chr 2:173,896,439...173,914,442
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Sema6b
semaphorin 6B
increases expression
ISO
Niclosamide results in increased expression of SEMA6B mRNA
CTD
PMID:36318118
NCBI chr 9:950,939...967,905
Ensembl chr 9:950,939...961,521
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Septin5
septin 5
increases expression
ISO
Niclosamide results in increased expression of SEPTIN5 mRNA
CTD
PMID:36318118
NCBI chr11:82,373,601...82,379,393
Ensembl chr11:82,369,754...82,379,393
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Serpine1
serpin family E member 1
multiple interactions
ISO
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SERPINE1 mRNA]
CTD
PMID:28318631
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serpine2
serpin family E member 2
multiple interactions
EXP
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA]
CTD
PMID:28318631
NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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Sertad4
SERTA domain containing 4
decreases expression
ISO
Niclosamide results in decreased expression of SERTAD4 mRNA
CTD
PMID:36318118
NCBI chr13:104,360,307...104,371,064
Ensembl chr13:104,360,307...104,370,546
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Sestd1
SEC14 and spectrin domain containing 1
decreases expression
ISO
Niclosamide results in decreased expression of SESTD1 mRNA
CTD
PMID:36318118
NCBI chr 3:62,123,590...62,220,759
Ensembl chr 3:62,129,887...62,220,546
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Setdb2
SET domain bifurcated histone lysine methyltransferase 2
increases expression
ISO
Niclosamide results in increased expression of SETDB2 mRNA
CTD
PMID:36318118
NCBI chr15:33,553,657...33,606,586
Ensembl chr15:33,453,952...33,606,470
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Sfxn2
sideroflexin 2
decreases expression
ISO
Niclosamide results in decreased expression of SFXN2 mRNA
CTD
PMID:36318118
NCBI chr 1:245,447,014...245,459,312
Ensembl chr 1:245,447,015...245,468,411 Ensembl chr 1:245,447,015...245,468,411
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Sgpp2
sphingosine-1-phosphate phosphatase 2
decreases expression
ISO
Niclosamide results in decreased expression of SGPP2 mRNA
CTD
PMID:36318118
NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457
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Sh2b2
SH2B adaptor protein 2
increases expression
ISO
Niclosamide results in increased expression of SH2B2 mRNA
CTD
PMID:36318118
NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844
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Sh3tc2
SH3 domain and tetratricopeptide repeats 2
decreases expression
ISO
Niclosamide results in decreased expression of SH3TC2 mRNA
CTD
PMID:36318118
NCBI chr18:55,416,383...55,477,419
Ensembl chr18:55,416,413...55,483,083
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Shank3
SH3 and multiple ankyrin repeat domains 3
increases expression
ISO
Niclosamide results in increased expression of SHANK3 mRNA
CTD
PMID:36318118
NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374
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Shfl
shiftless antiviral inhibitor of ribosomal frameshifting
increases expression
ISO
Niclosamide results in increased expression of SHFL mRNA
CTD
PMID:36318118
NCBI chr 8:19,408,298...19,414,084
Ensembl chr 8:19,408,333...19,413,971
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Shisa4
shisa family member 4
increases expression
ISO
Niclosamide results in increased expression of SHISA4 mRNA
CTD
PMID:36318118
NCBI chr13:46,799,735...46,803,816
Ensembl chr13:46,799,772...46,803,998
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Six5
SIX homeobox 5
increases expression
ISO
Niclosamide results in increased expression of SIX5 mRNA
CTD
PMID:36318118
NCBI chr 1:78,740,812...78,745,890
Ensembl chr 1:78,741,367...78,745,890
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Slc16a14
solute carrier family 16, member 14
increases expression
ISO
Niclosamide results in increased expression of SLC16A14 mRNA
CTD
PMID:36318118
NCBI chr 9:86,110,066...86,137,546
Ensembl chr 9:86,112,894...86,137,318
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Slc16a2
solute carrier family 16 member 2
increases expression
ISO
Niclosamide results in increased expression of SLC16A2 mRNA
CTD
PMID:36318118
NCBI chr X:68,725,365...68,848,572
Ensembl chr X:68,723,261...68,848,771
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Slc16a9
solute carrier family 16, member 9
increases expression
ISO
Niclosamide results in increased expression of SLC16A9 mRNA
CTD
PMID:36318118
NCBI chr20:18,335,862...18,377,125
Ensembl chr20:18,335,862...18,377,022
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Slc17a7
solute carrier family 17 member 7
increases expression
ISO
Niclosamide results in increased expression of SLC17A7 mRNA
CTD
PMID:36318118
NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
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Slc22a18
solute carrier family 22, member 18
increases expression
ISO
Niclosamide results in increased expression of SLC22A18 mRNA
CTD
PMID:36318118
NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975
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Slc29a4
solute carrier family 29 member 4
increases expression
ISO
Niclosamide results in increased expression of SLC29A4 mRNA
CTD
PMID:36318118
NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834
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Slc2a1
solute carrier family 2 member 1
decreases expression
ISO
Niclosamide results in decreased expression of SLC2A1 mRNA
CTD
PMID:22576131
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc2a12
solute carrier family 2 member 12
increases expression
ISO
Niclosamide results in increased expression of SLC2A12 mRNA
CTD
PMID:36318118
NCBI chr 1:22,803,068...22,862,204
Ensembl chr 1:22,804,418...22,860,971
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Slc2a3
solute carrier family 2 member 3
decreases expression increases expression
ISO
Niclosamide results in decreased expression of SLC2A3 mRNA Niclosamide results in increased expression of SLC2A3 mRNA
CTD
PMID:22576131 PMID:36318118
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Slc35d3
solute carrier family 35, member D3
decreases expression
ISO
Niclosamide results in decreased expression of SLC35D3 mRNA
CTD
PMID:36318118
NCBI chr 1:14,565,482...14,573,581
Ensembl chr 1:14,569,687...14,573,159
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Slc43a1
solute carrier family 43 member 1
increases expression
ISO
Niclosamide results in increased expression of SLC43A1 mRNA
CTD
PMID:36318118
NCBI chr 3:69,920,586...69,946,768
Ensembl chr 3:69,920,649...69,946,768
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Slc4a3
solute carrier family 4 member 3
increases expression
ISO
Niclosamide results in increased expression of SLC4A3 mRNA
CTD
PMID:36318118
NCBI chr 9:77,036,243...77,053,940
Ensembl chr 9:77,037,016...77,049,105
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Slc6a19
solute carrier family 6 member 19
decreases expression
ISO
Niclosamide results in decreased expression of SLC6A19 mRNA
CTD
PMID:36318118
NCBI chr 1:29,586,191...29,604,964
Ensembl chr 1:29,586,195...29,604,962
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Slco5a1
solute carrier organic anion transporter family, member 5A1
increases expression
ISO
Niclosamide results in increased expression of SLCO5A1 mRNA
CTD
PMID:36318118
NCBI chr 5:6,228,938...6,358,124
Ensembl chr 5:6,228,973...6,352,913
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Smad2
SMAD family member 2
multiple interactions
ISO
Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
CTD
PMID:36870549
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Smad3
SMAD family member 3
multiple interactions
ISO EXP
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein]
CTD
PMID:28318631 PMID:36870549
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Smc1b
structural maintenance of chromosomes 1B
decreases expression
ISO
Niclosamide results in decreased expression of SMC1B mRNA
CTD
PMID:36318118
NCBI chr 7:116,180,987...116,242,778
Ensembl chr 7:116,180,987...116,242,744
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Smim10l2a
small integral membrane protein 10 like 2A
increases expression
ISO
Niclosamide results in increased expression of SMIM10L2A mRNA
CTD
PMID:36318118
NCBI chr X:134,151,325...134,154,647
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Smim14
small integral membrane protein 14
increases expression
ISO
Niclosamide results in increased expression of SMIM14 mRNA
CTD
PMID:36318118
NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760
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Smim45
small integral membrane protein 45
increases expression
ISO
Niclosamide results in increased expression of SMIM45 mRNA
CTD
PMID:36318118
NCBI chr 7:113,769,175...113,773,952
Ensembl chr 7:113,765,468...113,773,339
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Smn1
survival of motor neuron 1, telomeric
decreases expression
ISO
Niclosamide results in decreased expression of SMN1 mRNA
CTD
PMID:36318118
NCBI chr 2:31,490,018...31,501,065
Ensembl chr 2:31,490,015...31,501,060
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Smox
spermine oxidase
increases expression
ISO
Niclosamide results in increased expression of SMOX mRNA
CTD
PMID:36318118
NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710
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Snai1
snail family transcriptional repressor 1
multiple interactions decreases expression increases expression
ISO EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SNAI1 mRNA] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA] Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of SNAI1 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SNAI1 protein] Niclosamide results in decreased expression of SNAI1 mRNA; Niclosamide results in decreased expression of SNAI1 protein Niclosamide results in increased expression of SNAI1 mRNA
CTD
PMID:26643609 PMID:28318631 PMID:30143678 PMID:36318118 PMID:36870549
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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Snai2
snail family transcriptional repressor 2
multiple interactions decreases expression
ISO
Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SNAI2 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein] Niclosamide results in decreased expression of SNAI2 protein
CTD
PMID:25174399 PMID:36870549
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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Snca
synuclein alpha
increases expression
ISO
Niclosamide results in increased expression of SNCA mRNA
CTD
PMID:36318118
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Snorc
secondary ossification center associated regulator of chondrocyte maturation
increases expression
ISO
Niclosamide results in increased expression of SNORC mRNA
CTD
PMID:36318118
NCBI chr 9:88,140,510...88,145,527
Ensembl chr 9:88,140,419...88,145,891
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Socs2
suppressor of cytokine signaling 2
increases expression
ISO
Niclosamide results in increased expression of SOCS2 mRNA
CTD
PMID:36318118
NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
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Socs3
suppressor of cytokine signaling 3
increases expression
ISO
Niclosamide results in increased expression of SOCS3 mRNA
CTD
PMID:36318118
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Sox8
SRY-box transcription factor 8
increases expression
ISO
Niclosamide results in increased expression of SOX8 mRNA
CTD
PMID:36318118
NCBI chr10:14,584,829...14,589,818
Ensembl chr10:14,584,829...14,589,818
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Sptbn4
spectrin, beta, non-erythrocytic 4
increases expression
ISO
Niclosamide results in increased expression of SPTBN4 mRNA
CTD
PMID:36318118
NCBI chr 1:82,650,750...82,738,345
Ensembl chr 1:82,650,751...82,737,228
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Sqstm1
sequestosome 1
decreases expression
ISO
Niclosamide results in decreased expression of SQSTM1 protein
CTD
PMID:34118929
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
multiple interactions
ISO
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of SRC protein]
CTD
PMID:26643609
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Srsf2
serine and arginine rich splicing factor 2
decreases expression
ISO
Niclosamide results in decreased expression of SRSF2 mRNA
CTD
PMID:36318118
NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
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Srsf6
serine and arginine rich splicing factor 6
decreases expression
ISO
Niclosamide results in decreased expression of SRSF6 mRNA
CTD
PMID:36318118
NCBI chr 3:151,589,546...151,594,869
Ensembl chr 3:151,589,535...151,594,860
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St8sia4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
increases expression
ISO
Niclosamide results in increased expression of ST8SIA4 mRNA
CTD
PMID:36318118
NCBI chr 9:95,990,131...96,084,661
Ensembl chr 9:95,993,503...96,084,653
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Stac2
SH3 and cysteine rich domain 2
increases expression
ISO
Niclosamide results in increased expression of STAC2 mRNA
CTD
PMID:36318118
NCBI chr10:83,032,418...83,048,260
Ensembl chr10:83,032,417...83,048,260
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Stat3
signal transducer and activator of transcription 3
decreases phosphorylation decreases expression multiple interactions
ISO
Niclosamide analog results in decreased phosphorylation of STAT3 protein; Niclosamide results in decreased phosphorylation of STAT3 protein Niclosamide analog results in decreased expression of STAT3 protein; Niclosamide results in decreased expression of STAT3 protein [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]; Niclosamide results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of STAT3 protein; Niclosamide results in decreased expression of and results in decreased phosphorylation of STAT3 protein Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]
CTD
PMID:23333246 PMID:23894143 PMID:24552774 PMID:25970160 PMID:26116531 PMID:26792726 PMID:28284560 PMID:29031202 PMID:29251334 PMID:30329025 PMID:30779072 PMID:33632240 PMID:34118929 More...
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stat5a
signal transducer and activator of transcription 5A
increases expression
ISO
Niclosamide results in increased expression of STAT5A mRNA
CTD
PMID:36318118
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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Stc2
stanniocalcin 2
increases expression
ISO
Niclosamide results in increased expression of STC2 mRNA
CTD
PMID:36318118
NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
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Stmn4
stathmin 4
increases expression
ISO
Niclosamide results in increased expression of STMN4 mRNA
CTD
PMID:36318118
NCBI chr15:40,541,305...40,559,253
Ensembl chr15:40,541,357...40,559,253
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Strc
stereocilin
increases expression
ISO
Niclosamide results in increased expression of STRC mRNA
CTD
PMID:36318118
NCBI chr 3:108,335,920...108,355,114
Ensembl chr 3:108,335,747...108,354,134
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Stx3
syntaxin 3
increases expression
ISO
Niclosamide results in increased expression of STX3 mRNA
CTD
PMID:36318118
NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
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Supt3h
SPT3 homolog, SAGA and STAGA complex component
increases expression
ISO
Niclosamide results in increased expression of SUPT3H mRNA
CTD
PMID:36318118
NCBI chr 9:15,878,296...16,206,768
Ensembl chr 9:15,868,287...16,206,706
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Syt17
synaptotagmin 17
increases expression
ISO
Niclosamide results in increased expression of SYT17 mRNA
CTD
PMID:36318118
NCBI chr 1:172,695,275...172,761,906
Ensembl chr 1:172,696,120...172,761,960
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Syt3
synaptotagmin 3
increases expression
ISO
Niclosamide results in increased expression of SYT3 mRNA
CTD
PMID:36318118
NCBI chr 1:94,880,835...94,895,518
Ensembl chr 1:94,881,247...94,895,246
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Syt5
synaptotagmin 5
increases expression
ISO
Niclosamide results in increased expression of SYT5 mRNA
CTD
PMID:36318118
NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
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Syt9
synaptotagmin 9
decreases expression
ISO
Niclosamide results in decreased expression of SYT9 mRNA
CTD
PMID:36318118
NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007
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Tacc3
transforming, acidic coiled-coil containing protein 3
decreases expression
ISO
Niclosamide results in decreased expression of TACC3 mRNA
CTD
PMID:28284560
NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219
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Tamalin
trafficking regulator and scaffold protein tamalin
increases expression
ISO
Niclosamide results in increased expression of TAMALIN mRNA
CTD
PMID:36318118
NCBI chr 7:132,338,900...132,359,519
Ensembl chr 7:132,338,900...132,346,666
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Tbc1d10a
TBC1 domain family, member 10a
increases expression
ISO
Niclosamide results in increased expression of TBC1D10A mRNA
CTD
PMID:36318118
NCBI chr14:79,051,822...79,083,603
Ensembl chr14:79,055,432...79,083,600
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Tbc1d17
TBC1 domain family, member 17
increases expression
ISO
Niclosamide results in increased expression of TBC1D17 mRNA
CTD
PMID:36318118
NCBI chr 1:95,324,770...95,333,156
Ensembl chr 1:95,322,737...95,333,005
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Tbx6
T-box transcription factor 6
increases expression
ISO
Niclosamide results in increased expression of TBX6 mRNA
CTD
PMID:36318118
NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593
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Tcf7
transcription factor 7
multiple interactions decreases expression
ISO
Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein] Niclosamide results in decreased expression of TCF7 mRNA
CTD
PMID:33632240 PMID:36318118
NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
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Tcim
transcriptional and immune response regulator
increases expression
ISO
Niclosamide results in increased expression of TCIM mRNA
CTD
PMID:28284560
NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581
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Tcp11l2
t-complex 11 like 2
increases expression
ISO
Niclosamide results in increased expression of TCP11L2 mRNA
CTD
PMID:36318118
NCBI chr 7:19,150,241...19,185,135
Ensembl chr 7:19,150,252...19,185,095
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Tdrp
testis development related protein
increases expression
ISO
Niclosamide results in increased expression of TDRP mRNA
CTD
PMID:36318118
NCBI chr16:75,624,047...75,652,635
Ensembl chr16:75,624,907...75,652,420
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Tead3
TEA domain transcription factor 3
increases expression
ISO
Niclosamide results in increased expression of TEAD3 mRNA
CTD
PMID:36318118
NCBI chr20:6,392,053...6,411,446
Ensembl chr20:6,392,053...6,411,446
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Tent5a
terminal nucleotidyltransferase 5A
decreases expression
ISO
Niclosamide results in decreased expression of TENT5A mRNA
CTD
PMID:36318118
NCBI chr 8:86,222,294...86,229,045
Ensembl chr 8:86,225,357...86,229,045
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Tent5b
terminal nucleotidyltransferase 5B
increases expression
ISO
Niclosamide results in increased expression of TENT5B mRNA
CTD
PMID:36318118
NCBI chr 5:145,695,358...145,702,668
Ensembl chr 5:145,695,362...145,706,073
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Tesmin
testis expressed metallothionein like protein
increases expression
ISO
Niclosamide results in increased expression of TESMIN mRNA
CTD
PMID:36318118
NCBI chr 1:200,629,688...200,648,434
Ensembl chr 1:200,630,144...200,648,433
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO EXP
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CDH12 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of ACTA2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SNAI1 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SNAI2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of VIM protein] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
CTD
PMID:28318631 PMID:36870549
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgfb1i1
transforming growth factor beta 1 induced transcript 1
increases expression
ISO
Niclosamide results in increased expression of TGFB1I1 mRNA
CTD
PMID:36318118
NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080
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Tgfbr3
transforming growth factor beta receptor 3
decreases expression
ISO
Niclosamide results in decreased expression of TGFBR3 mRNA
CTD
PMID:36318118
NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
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Thbs4
thrombospondin 4
increases expression
ISO
Niclosamide results in increased expression of THBS4 mRNA
CTD
PMID:36318118
NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
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Tigar
TP53 induced glycolysis regulatory phosphatase
decreases expression
ISO
Niclosamide results in decreased expression of TIGAR mRNA
CTD
PMID:36318118
NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029
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Tigd3
tigger transposable element derived 3
decreases expression
ISO
Niclosamide results in decreased expression of TIGD3 mRNA
CTD
PMID:36318118
NCBI chr 1:203,178,456...203,182,775
Ensembl chr 1:203,178,460...203,181,272
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Timp2
TIMP metallopeptidase inhibitor 2
increases expression
ISO
Niclosamide results in increased expression of TIMP2 mRNA
CTD
PMID:30143678
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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Tk1
thymidine kinase 1
decreases expression
ISO
Niclosamide results in decreased expression of TK1 mRNA
CTD
PMID:28284560 PMID:36318118
NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
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Tle4
TLE family member 4, transcriptional corepressor
decreases expression
ISO
Niclosamide results in decreased expression of TLE4 mRNA
CTD
PMID:36318118
NCBI chr 1:211,661,738...211,798,458
Ensembl chr 1:211,661,746...211,797,862
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Tmc6
transmembrane channel like 6
increases expression
ISO
Niclosamide results in increased expression of TMC6 mRNA
CTD
PMID:36318118
NCBI chr10:102,982,059...102,999,509
Ensembl chr10:102,971,229...102,998,960
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Tmem151b
transmembrane protein 151B
increases expression
ISO
Niclosamide results in increased expression of TMEM151B mRNA
CTD
PMID:36318118
NCBI chr 9:15,456,446...15,464,289
Ensembl chr 9:15,455,801...15,464,302
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Tmem231
transmembrane protein 231
increases expression
ISO
Niclosamide results in increased expression of TMEM231 mRNA
CTD
PMID:36318118
NCBI chr19:39,883,077...39,904,296
Ensembl chr19:39,883,077...39,904,269
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Tmem256
transmembrane protein 256
increases expression
ISO
Niclosamide results in increased expression of TMEM256 mRNA
CTD
PMID:36318118
NCBI chr10:54,559,030...54,560,146
Ensembl chr10:54,555,360...54,560,120
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Tmem42
transmembrane protein 42
increases expression
ISO
Niclosamide results in increased expression of TMEM42 mRNA
CTD
PMID:36318118
NCBI chr 8:122,674,793...122,677,290
Ensembl chr 8:122,674,070...122,677,276
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Tmem45a
transmembrane protein 45A
increases expression
ISO
Niclosamide results in increased expression of TMEM45A mRNA
CTD
PMID:36318118
NCBI chr11:43,713,309...43,799,526
Ensembl chr11:43,713,782...43,799,526
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Tmem50b
transmembrane protein 50B
decreases expression
ISO
Niclosamide results in decreased expression of TMEM50B mRNA
CTD
PMID:36318118
NCBI chr11:30,804,835...30,837,675
Ensembl chr11:30,804,837...30,837,661
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Tmem52
transmembrane protein 52
increases expression
ISO
Niclosamide results in increased expression of TMEM52 mRNA
CTD
PMID:36318118
NCBI chr 5:166,048,669...166,050,423
Ensembl chr 5:166,046,565...166,050,433
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Tmem53
transmembrane protein 53
increases expression
ISO
Niclosamide results in increased expression of TMEM53 mRNA
CTD
PMID:36318118
NCBI chr 5:130,721,780...130,737,692
Ensembl chr 5:130,721,659...130,737,692
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Tmem63c
transmembrane protein 63c
increases expression
ISO
Niclosamide results in increased expression of TMEM63C mRNA
CTD
PMID:36318118
NCBI chr 6:106,667,389...106,738,778
Ensembl chr 6:106,672,934...106,736,990
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Tmem8b
transmembrane protein 8B
increases expression
ISO
Niclosamide results in increased expression of TMEM8B mRNA
CTD
PMID:36318118
NCBI chr 5:57,919,473...57,948,419
Ensembl chr 5:57,919,804...57,946,772
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Tnf
tumor necrosis factor
multiple interactions decreases activity
ISO
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Niclosamide results in decreased activity of TNF protein Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
CTD
PMID:20215516 PMID:24561310 PMID:27492973 PMID:28318631 PMID:33524445
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfsf11
TNF superfamily member 11
multiple interactions
ISO
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein] Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]
CTD
PMID:26792726 PMID:28824321
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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Tnfsf4
TNF superfamily member 4
increases expression
ISO
Niclosamide results in increased expression of TNFSF4 mRNA
CTD
PMID:36318118
NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
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Top2a
DNA topoisomerase II alpha
affects binding
ISO
Niclosamide binds to TOP2A protein
CTD
PMID:36870549
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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Tp53
tumor protein p53
multiple interactions increases expression increases response to substance decreases response to substance
ISO
[Niclosamide binds to Polyethyleneimine] which results in increased expression of TP53 mRNA; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA] Niclosamide results in increased expression of TRP53 protein TP53 gene mutant form results in increased susceptibility to Niclosamide; TP53 protein mutant form results in increased susceptibility to Niclosamide TP53 protein results in decreased susceptibility to Niclosamide Niclosamide results in increased expression of TP53 mRNA; Niclosamide results in increased expression of TP53 protein [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of adrenic acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Arachidonic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Docosahexaenoic Acids; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Eicosapentaenoic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Lysophosphatidylcholines; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of lysophosphatidylethanolamine; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form
CTD
PMID:22576131 PMID:25988281 PMID:29031202 PMID:30258081 PMID:36318118
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpi1
triosephosphate isomerase 1
increases expression
ISO
Niclosamide results in increased expression of TPI1 mRNA
CTD
PMID:22576131
NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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Tppp
tubulin polymerization promoting protein
increases expression
ISO
Niclosamide results in increased expression of TPPP mRNA
CTD
PMID:36318118
NCBI chr 1:29,257,111...29,281,134
Ensembl chr 1:29,261,255...29,281,134
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Tpx2
TPX2, microtubule nucleation factor
decreases expression
ISO
Niclosamide results in decreased expression of TPX2 mRNA
CTD
PMID:28284560
NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
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Traf6
TNF receptor associated factor 6
multiple interactions
ISO
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]
CTD
PMID:28824321
NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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Trappc9
trafficking protein particle complex subunit 9
increases expression
ISO
Niclosamide results in increased expression of TRAPPC9 mRNA
CTD
PMID:36318118
NCBI chr 7:104,521,593...104,998,352
Ensembl chr 7:104,521,593...104,998,352
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Trib3
tribbles pseudokinase 3
increases expression
ISO
Niclosamide results in increased expression of TRIB3 mRNA
CTD
PMID:36318118
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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Trim67
tripartite motif-containing 67
increases expression
ISO
Niclosamide results in increased expression of TRIM67 mRNA
CTD
PMID:36318118
NCBI chr19:52,763,991...52,805,906
Ensembl chr19:52,764,387...52,800,422
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Trip10
thyroid hormone receptor interactor 10
increases expression
ISO
Niclosamide results in increased expression of TRIP10 mRNA
CTD
PMID:36318118
NCBI chr 9:2,133,085...2,147,795
Ensembl chr 9:2,133,671...2,147,799
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Trip13
thyroid hormone receptor interactor 13
decreases expression
ISO
Niclosamide results in decreased expression of TRIP13 mRNA
CTD
PMID:28284560
NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
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Trpm4
transient receptor potential cation channel, subfamily M, member 4
increases expression
ISO
Niclosamide results in increased expression of TRPM4 mRNA
CTD
PMID:36318118
NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
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Tsc22d3
TSC22 domain family, member 3
increases expression
ISO
Niclosamide results in increased expression of TSC22D3 mRNA
CTD
PMID:36318118
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
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Ttc9b
tetratricopeptide repeat domain 9B
increases expression
ISO
Niclosamide results in increased expression of TTC9B mRNA
CTD
PMID:36318118
NCBI chr 1:82,953,434...82,955,659
Ensembl chr 1:82,953,434...82,955,616
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Ttll1
TTL family tubulin polyglutamylase complex subunit L1
increases expression
ISO
Niclosamide results in increased expression of TTLL1 mRNA
CTD
PMID:36318118
NCBI chr 7:114,619,509...114,648,850
Ensembl chr 7:114,619,508...114,648,761
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Ttll3
tubulin tyrosine ligase like 3
increases expression
ISO
Niclosamide results in increased expression of TTLL3 mRNA
CTD
PMID:36318118
NCBI chr 4:146,532,958...146,558,425
Ensembl chr 4:146,533,953...146,557,889
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Tubb1
tubulin, beta 1 class VI
decreases expression
ISO
Niclosamide results in decreased expression of TUBB1 mRNA
CTD
PMID:36318118
NCBI chr 3:163,247,990...163,257,460
Ensembl chr 3:163,247,967...163,256,063
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Tubb3
tubulin, beta 3 class III
increases expression
ISO
Niclosamide results in increased expression of TUBB3 protein
CTD
PMID:34118929
NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
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Twist1
twist family bHLH transcription factor 1
decreases expression increases expression
ISO
Niclosamide results in decreased expression of TWIST1 protein Niclosamide results in increased expression of TWIST1 mRNA
CTD
PMID:29480568 PMID:36318118
NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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Ubald2
UBA-like domain containing 2
increases expression
ISO
Niclosamide results in increased expression of UBALD2 mRNA
CTD
PMID:36318118
NCBI chr10:101,662,507...101,667,089
Ensembl chr10:101,658,127...101,667,061
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Ube2c
ubiquitin-conjugating enzyme E2C
multiple interactions decreases expression
ISO
[Niclosamide co-treated with bicalutamide] results in decreased expression of UBE2C mRNA Niclosamide results in decreased expression of UBE2C mRNA
CTD
PMID:28500234
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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Uhrf1
ubiquitin-like with PHD and ring finger domains 1
decreases expression
ISO
Niclosamide results in decreased expression of UHRF1 mRNA
CTD
PMID:28284560 PMID:36318118
NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
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Unc93b1
unc-93 homolog B1, TLR signaling regulator
increases expression
ISO
Niclosamide results in increased expression of UNC93B1 mRNA
CTD
PMID:36318118
NCBI chr 1:201,167,388...201,178,343
Ensembl chr 1:201,152,693...201,178,338
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Utp3
UTP3, small subunit processome component
decreases expression
ISO
Niclosamide results in decreased expression of UTP3 mRNA
CTD
PMID:27226553
NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396
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Vamp4
vesicle-associated membrane protein 4
increases expression
ISO
Niclosamide results in increased expression of VAMP4 mRNA
CTD
PMID:36318118
NCBI chr13:74,919,872...74,942,791
Ensembl chr13:74,919,880...74,933,686
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Vasn
vasorin
affects expression
ISO
Niclosamide affects the expression of VASN mRNA
CTD
PMID:36318118
NCBI chr10:10,917,750...10,928,259
Ensembl chr10:10,917,605...10,928,357
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Vat1
vesicle amine transport 1
increases expression
ISO
Niclosamide results in increased expression of VAT1 mRNA
CTD
PMID:36318118
NCBI chr10:86,389,549...86,397,167
Ensembl chr10:86,389,545...86,397,224
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
Niclosamide results in decreased expression of VEGFA mRNA; Niclosamide results in decreased expression of VEGFA protein
CTD
PMID:29251334
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vgf
VGF nerve growth factor inducible
increases expression
ISO
Niclosamide results in increased expression of VGF mRNA
CTD
PMID:36318118
NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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Vim
vimentin
multiple interactions decreases expression
ISO
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of VIM protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of VIM protein] Niclosamide results in decreased expression of VIM mRNA; Niclosamide results in decreased expression of VIM protein
CTD
PMID:26643609 PMID:28318631 PMID:30143678 PMID:35115509 PMID:36870549
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Vpreb1a
V-set pre-B cell surrogate light chain 1A
decreases expression
ISO
Niclosamide results in decreased expression of VPREB1 mRNA
CTD
PMID:27226553
NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846
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Vps37d
VPS37D subunit of ESCRT-I
increases expression
ISO
Niclosamide results in increased expression of VPS37D mRNA
CTD
PMID:36318118
NCBI chr12:21,609,210...21,614,669
Ensembl chr12:21,609,182...21,614,659
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Vsig10l
V-set and immunoglobulin domain containing 10 like
increases expression
ISO
Niclosamide results in increased expression of VSIG10L mRNA
CTD
PMID:36318118
NCBI chr 1:93,871,487...93,880,157
Ensembl chr 1:93,851,774...93,879,566
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Niclosamide results in increased expression of WIPI1 mRNA
CTD
PMID:36318118
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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Wnt1
Wnt family member 1
decreases expression
ISO
Niclosamide results in decreased expression of WNT1 protein
CTD
PMID:35115509
NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
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Wnt10a
Wnt family member 10A
increases expression
ISO
Niclosamide results in increased expression of WNT10A mRNA
CTD
PMID:36318118
NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400
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Wnt2b
Wnt family member 2B
decreases expression
ISO
Niclosamide results in decreased expression of WNT2B mRNA
CTD
PMID:22576131
NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308
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Wnt3
Wnt family member 3
decreases expression
ISO
Niclosamide results in decreased expression of WNT3 mRNA
CTD
PMID:22576131
NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099
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Wnt3a
Wnt family member 3A
multiple interactions decreases expression
ISO EXP
Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein] Niclosamide results in decreased expression of WNT3A mRNA Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]]
CTD
PMID:19772353 PMID:22576131 PMID:27492973 PMID:32961231
NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324
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Wnt7a
Wnt family member 7A
increases response to substance decreases activity multiple interactions
ISO
WNT7A protein results in increased susceptibility to Niclosamide Niclosamide results in decreased activity of WNT7A protein WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]
CTD
PMID:25174399
NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
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Wnt8b
Wnt family member 8B
increases expression
ISO
Niclosamide results in increased expression of WNT8B mRNA
CTD
PMID:36318118
NCBI chr 1:243,354,145...243,376,000
Ensembl chr 1:243,354,086...243,374,286
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Wtip
WT1 interacting protein
increases expression
ISO
Niclosamide results in increased expression of WTIP mRNA
CTD
PMID:36318118
NCBI chr 1:86,731,214...86,764,939
Ensembl chr 1:86,731,265...86,765,014
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Xiap
X-linked inhibitor of apoptosis
decreases expression
ISO
Niclosamide results in decreased expression of XIAP protein
CTD
PMID:20215516
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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Xndc1
Xrcc1 N-terminal domain containing 1
decreases expression
ISO
Niclosamide results in decreased expression of XNDC1N mRNA
CTD
PMID:36318118
NCBI chr 1:156,440,284...156,460,609
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Ypel1
yippee-like 1
increases expression
ISO
Niclosamide results in increased expression of YPEL1 mRNA
CTD
PMID:36318118
NCBI chr11:83,921,799...83,936,409
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Ypel5
yippee-like 5
increases expression
ISO
Niclosamide results in increased expression of YPEL5 mRNA
CTD
PMID:36318118
NCBI chr 6:22,656,284...22,671,741
Ensembl chr 6:22,656,285...22,671,691
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Zbtb22
zinc finger and BTB domain containing 22
increases expression
ISO
Niclosamide results in increased expression of ZBTB22 mRNA
CTD
PMID:36318118
NCBI chr20:4,966,331...4,969,853
Ensembl chr20:4,966,271...4,969,498
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Zbtb41
zinc finger and BTB domain containing 41
increases expression
ISO
Niclosamide results in increased expression of ZBTB41 mRNA
CTD
PMID:36318118
NCBI chr13:51,042,948...51,065,768
Ensembl chr13:51,042,948...51,065,768
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Zbtb46
zinc finger and BTB domain containing 46
increases expression
ISO
Niclosamide results in increased expression of ZBTB46 mRNA
CTD
PMID:36318118
NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782
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Zbtb7b
zinc finger and BTB domain containing 7B
increases expression
ISO
Niclosamide results in increased expression of ZBTB7B mRNA
CTD
PMID:36318118
NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
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Zfp157
zinc finger protein 157
increases expression
ISO
Niclosamide results in increased expression of ZNF157 mRNA
CTD
PMID:36318118
NCBI chr12:16,248,230...16,279,459
Ensembl chr12:16,248,230...16,270,698
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Zfp18
zinc finger protein 18
increases expression
ISO
Niclosamide results in increased expression of ZNF18 mRNA
CTD
PMID:36318118
NCBI chr10:50,473,428...50,495,707
Ensembl chr10:50,473,483...50,495,706
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Zfp277
zinc finger protein 277
increases expression
ISO
Niclosamide results in increased expression of ZNF277 mRNA
CTD
PMID:36318118
NCBI chr 6:57,383,454...57,512,785
Ensembl chr 6:57,383,951...57,512,765
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Zfp296
zinc finger protein 296
increases expression
ISO
Niclosamide results in increased expression of ZNF296 mRNA
CTD
PMID:36318118
NCBI chr 1:79,228,649...79,231,866
Ensembl chr 1:79,228,401...79,231,866
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Zfp36
zinc finger protein 36
increases expression
ISO
Niclosamide results in increased expression of ZFP36 mRNA
CTD
PMID:28284560
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Zfp367
zinc finger protein 367
decreases expression
ISO
Niclosamide results in decreased expression of ZNF367 mRNA
CTD
PMID:36318118
NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287
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Zfp458
zinc finger protein 458
decreases expression
ISO
Niclosamide results in decreased expression of ZNF43 mRNA
CTD
PMID:36318118
NCBI chr 2:84,661,150...84,705,631
Ensembl chr 2:84,693,186...84,702,558
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Zfp467
zinc finger protein 467
increases expression
ISO
Niclosamide results in increased expression of ZNF467 mRNA
CTD
PMID:36318118
NCBI chr 4:77,385,752...77,394,709
Ensembl chr 4:77,385,758...77,392,229
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Zfp551
zinc finger protein 551
decreases expression
ISO
Niclosamide results in decreased expression of ZNF551 mRNA
CTD
PMID:36318118
NCBI chr 1:72,543,815...72,554,060
Ensembl chr 1:72,540,108...72,554,071
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Zfp703
zinc finger protein 703
decreases expression
ISO
Niclosamide results in decreased expression of ZNF703 mRNA
CTD
PMID:36318118
NCBI chr16:65,076,507...65,080,677
Ensembl chr16:65,076,507...65,080,677
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Zfp853
zinc finger protein 853
increases expression
ISO
Niclosamide results in increased expression of ZNF853 mRNA
CTD
PMID:36318118
NCBI chr12:11,266,124...11,276,492
Ensembl chr12:11,269,414...11,275,731
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Zfp862
zinc finger protein 862
increases expression
ISO
Niclosamide results in increased expression of ZNF862 mRNA
CTD
PMID:36318118
NCBI chr 4:77,452,930...77,481,981
Ensembl chr 4:77,453,037...77,481,995
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Zfp9
zinc finger protein 9
increases expression
ISO
Niclosamide results in increased expression of ZNF25 mRNA
CTD
PMID:36318118
NCBI chr 4:151,638,724...151,656,740
Ensembl chr 4:151,638,711...151,656,803
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Zhx3
zinc fingers and homeoboxes 3
increases expression
ISO
Niclosamide results in increased expression of ZHX3 mRNA
CTD
PMID:36318118
NCBI chr 3:149,417,787...149,548,671
Ensembl chr 3:149,417,818...149,527,079
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Zic2
Zic family member 2
increases expression
ISO
Niclosamide results in increased expression of ZIC2 mRNA
CTD
PMID:28284560
NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522
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Zswim4
zinc finger, SWIM-type containing 4
increases expression
ISO
Niclosamide results in increased expression of ZSWIM4 mRNA
CTD
PMID:36318118
NCBI chr19:23,927,845...23,952,970
Ensembl chr19:23,927,845...23,952,970
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Zwint
ZW10 interacting kinetochore protein
decreases expression
ISO
Niclosamide results in decreased expression of ZWINT mRNA
CTD
PMID:36318118
NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
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