Me3 (malic enzyme 3) - Rat Genome Database

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Gene: Me3 (malic enzyme 3) Rattus norvegicus
Analyze
Symbol: Me3
Name: malic enzyme 3
RGD ID: 1311070
Description: Predicted to enable NADP+ binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process. Predicted to be active in mitochondrial matrix. Orthologous to human ME3 (malic enzyme 3); PARTICIPATES IN pyruvate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361602; malic enzyme 3, NADP(+)-dependent, mitochondrial; mitochondrial malic enzyme 3; NADP-dependent malic enzyme, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81152,946,595 - 153,148,026 (+)NCBIGRCr8
mRatBN7.21143,534,024 - 143,735,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,534,139 - 143,733,132 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,479,136 - 151,672,663 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,655,512 - 158,849,041 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01151,529,440 - 151,722,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01153,861,535 - 154,058,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,861,569 - 154,056,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,166,289 - 160,361,740 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41146,220,504 - 146,422,659 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,297,071 - 146,500,992 (+)NCBI
Celera1141,786,200 - 141,975,029 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Me3Ratexudative vitreoretinopathy 1  ISORGD:13223328554872ClinVar Annotator: match by term: Exudative vitreoretinopathy 1ClinVarPMID:21097938|PMID:21681106
Me3Ratintellectual disability  ISORGD:13223328554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 

1 to 20 of 116 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Me3Rat(+)-catechin multiple interactionsISORGD:13223326480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ME3 mRNACTDPMID:24763279
Me3Rat1,1-dichloroethene decreases expressionISORGD:15536536480464vinylidene chloride results in decreased expression of ME3 mRNACTDPMID:26682919
Me3Rat1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsISORGD:15536536480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Me3Rat17alpha-ethynylestradiol multiple interactionsISORGD:15536536480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ME3 mRNACTDPMID:17942748
Me3Rat17beta-estradiol multiple interactionsISORGD:13223326480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ME3 mRNACTDPMID:19619570
Me3Rat17beta-estradiol increases expressionISORGD:13223326480464Estradiol results in increased expression of ME3 mRNACTDPMID:19619570
Me3Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISORGD:15536536480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Me3Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISORGD:15536536480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Me3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:13223326480464Tetrachlorodibenzodioxin results in increased expression of ME3 mRNACTDPMID:19619570
Me3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ME3 mRNACTDPMID:21215274
Me3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of ME3 mRNACTDPMID:22298810
Me3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:15536536480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ME3 mRNACTDPMID:17942748
Me3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:13223326480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ME3 mRNACTDPMID:19619570
Me3Rat2,4,4'-trichlorobiphenyl multiple interactionsISORGD:15536536480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Me3Rat2,6-dinitrotoluene affects expressionEXP 64804642,6-dinitrotoluene affects the expression of ME3 mRNACTDPMID:21346803
Me3Rat2-hydroxypropanoic acid decreases expressionISORGD:13223326480464Lactic Acid results in decreased expression of ME3 mRNACTDPMID:30851411
Me3Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionISORGD:132233264804643,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ME3 mRNACTDPMID:23146750
Me3Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of ME3 mRNACTDPMID:31881176
Me3Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of ME3 mRNACTDPMID:28959563
Me3Ratacrylamide decreases expressionISORGD:13223326480464Acrylamide results in decreased expression of ME3 mRNACTDPMID:32763439

1 to 20 of 116 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Me3Ratmalate metabolic process involved_inISORGD:13223321624291 PMID:7818469RGDPMID:7818469
Me3Ratmalate metabolic process involved_inIBAFB:FBgn0002719|PANTHER:PTN000601050|PomBase:SPCC794.12c|TAIR:locus:2017854|TAIR:locus:2052045|TAIR:locus:2054085|TAIR:locus:2127038|TAIR:locus:2180547|TAIR:locus:2181980|UniProtKB:P48163|UniProtKB:Q167981600115GO_REF:0000033GO_CentralGO_REF:0000033
Me3Ratmalate metabolic process involved_inIEAUniProtKB:Q16798|ensembl:ENSP000004402461600115GO_REF:0000107EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Me3Ratmitochondrial matrix is_active_inIEAUniProtKB:Q8BMF3|ensembl:ENSMUSP000000328561600115GO_REF:0000107EnsemblGO_REF:0000107
Me3Ratmitochondrial matrix is_active_inISORGD:15536531624291 PMID:25711RGDPMID:25711
Me3Ratmitochondrion located_inISORGD:13223329068941 PMID:34800366FlyBasePMID:34800366
Me3Ratmitochondrion is_active_inIBAMGI:1916679|MGI:2147351|PANTHER:PTN001157886|RGD:3074|UniProtKB:P233681600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Me3Ratmalate dehydrogenase (decarboxylating) (NADP+) activity enablesISORGD:13223321624291 PMID:7818469RGDPMID:7818469
Me3Ratmalate dehydrogenase (decarboxylating) (NADP+) activity enablesIEAUniProtKB:Q8BMF3|ensembl:ENSMUSP000000328561600115GO_REF:0000107EnsemblGO_REF:0000107
Me3Ratmalate dehydrogenase (decarboxylating) (NADP+) activity enablesISORGD:15536531624291 PMID:25711RGDPMID:25711
Me3Ratmalate dehydrogenase (decarboxylating) (NADP+) activity enablesIBAFB:FBgn0002719|MGI:1916679|MGI:97043|PANTHER:PTN000601052|RGD:3074|TAIR:locus:2017854|TAIR:locus:2052045|TAIR:locus:2180547|TAIR:locus:2181980|UniProtKB:P48163|UniProtKB:Q167981600115GO_REF:0000033GO_CentralGO_REF:0000033
Me3Ratmalate dehydrogenase (decarboxylating) (NADP+) activity enablesIEAUniProtKB:Q16798|ensembl:ENSP000004402461600115GO_REF:0000107EnsemblGO_REF:0000107
Me3Ratmalic enzyme activity enablesISORGD:13223321624291 PMID:7818469RGDPMID:7818469
Me3Ratmalic enzyme activity enablesIEAInterPro:IPR001891|InterPro:IPR012301|InterPro:IPR0370621600115GO_REF:0000002InterProGO_REF:0000002
Me3Ratmalic enzyme activity enablesIEAUniProtKB:Q16798|ensembl:ENSP000004402461600115GO_REF:0000107EnsemblGO_REF:0000107
Me3Ratmalic enzyme activity enablesIEAARBA:ARBA000286331600115GO_REF:0000117UniProtGO_REF:0000117
Me3Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Me3RatNAD binding enablesIEAInterPro:IPR0123021600115GO_REF:0000002InterProGO_REF:0000002
Me3RatNADP+ binding enablesISORGD:13223321624291 PMID:7818469RGDPMID:7818469
Me3RatNADP+ binding enablesIEAUniProtKB:Q16798|ensembl:ENSP000004402461600115GO_REF:0000107EnsemblGO_REF:0000107
Me3Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Me3Ratoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor enablesIEAARBA:ARBA000284421600115GO_REF:0000117UniProtGO_REF:0000117
Me3Ratoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor enablesIEAInterPro:IPR001891|InterPro:IPR012301|InterPro:IPR0370621600115GO_REF:0000002InterProGO_REF:0000002
1 to 16 of 16 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Me3Ratpyruvate metabolic pathway   IEA 6907045 KEGGrno:00620

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:7818469   PMID:18614015   PMID:25594249   PMID:34800366  



Me3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81152,946,595 - 153,148,026 (+)NCBIGRCr8
mRatBN7.21143,534,024 - 143,735,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,534,139 - 143,733,132 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,479,136 - 151,672,663 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,655,512 - 158,849,041 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01151,529,440 - 151,722,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01153,861,535 - 154,058,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,861,569 - 154,056,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,166,289 - 160,361,740 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41146,220,504 - 146,422,659 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,297,071 - 146,500,992 (+)NCBI
Celera1141,786,200 - 141,975,029 (+)NCBICelera
Cytogenetic Map1q32NCBI
ME3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,434,930 - 86,672,616 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,441,108 - 86,672,636 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,145,972 - 86,383,658 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,829,798 - 86,061,075 (-)NCBINCBI36Build 36hg18NCBI36
Build 341185,829,885 - 86,061,004NCBI
Celera1183,462,760 - 83,694,235 (-)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1182,440,697 - 82,672,413 (-)NCBIHuRef
CHM1_11186,037,902 - 86,269,349 (-)NCBICHM1_1
T2T-CHM13v2.01186,377,442 - 86,612,763 (-)NCBIT2T-CHM13v2.0
Me3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39789,281,492 - 89,503,423 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl789,281,600 - 89,503,567 (+)EnsemblGRCm39 Ensembl
GRCm38789,632,284 - 89,854,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl789,632,392 - 89,854,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv37796,781,328 - 97,002,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36789,508,010 - 89,729,551 (+)NCBIMGSCv36mm8
Celera786,981,993 - 87,178,718 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map750.27NCBI
Me3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554146,343,476 - 6,557,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554146,335,411 - 6,555,494 (+)NCBIChiLan1.0ChiLan1.0
ME3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2987,349,049 - 87,595,198 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,407,386 - 88,646,956 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,490,947 - 81,728,589 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,104,477 - 85,336,683 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,104,477 - 85,222,822 (-)Ensemblpanpan1.1panPan2
ME3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12112,813,052 - 13,105,805 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2112,813,047 - 13,105,804 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2112,678,922 - 12,971,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02112,995,770 - 13,288,435 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2113,101,638 - 13,288,430 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12112,781,982 - 13,074,486 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02112,853,629 - 13,146,550 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02112,909,897 - 13,203,162 (+)NCBIUU_Cfam_GSD_1.0
Me3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494772,614,105 - 72,823,300 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649814,216,513 - 14,423,031 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649814,216,510 - 14,422,936 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ME3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl920,294,908 - 20,583,584 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1920,294,871 - 20,613,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2922,589,632 - 22,780,615 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ME3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1177,712,748 - 77,934,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl177,712,838 - 77,933,727 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604347,792,396 - 48,016,415 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Me3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248453,307,568 - 3,546,631 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248453,307,610 - 3,546,539 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Me3
1680 total Variants

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:48
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000023329
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 63 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat

1 to 10 of 63 rows
BI301980  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,568,830 - 143,569,020 (+)MAPPERmRatBN7.2
Rnor_6.01153,895,885 - 153,896,074NCBIRnor6.0
Rnor_5.01160,200,232 - 160,200,421UniSTSRnor5.0
RGSC_v3.41146,255,789 - 146,255,978UniSTSRGSC3.4
Celera1141,820,906 - 141,821,095UniSTS
RH 3.4 Map11116.4UniSTS
Cytogenetic Map1q32UniSTS
RH129606  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81152,946,456 - 152,946,755 (+)Marker Load Pipeline
mRatBN7.21143,533,885 - 143,534,184 (+)MAPPERmRatBN7.2
Rnor_6.01153,861,316 - 153,861,614NCBIRnor6.0
Rnor_5.01160,166,036 - 160,166,334UniSTSRnor5.0
RGSC_v3.41146,220,251 - 146,220,549UniSTSRGSC3.4
Celera1141,785,947 - 141,786,245UniSTS
RH 3.4 Map11115.9UniSTS
Cytogenetic Map1q32UniSTS
RH133219  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1141,973,432 - 141,974,926UniSTS
RH 3.4 Map11121.0UniSTS
Cytogenetic Map1q32UniSTS
BF405328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,535,926 - 143,536,019 (+)MAPPERmRatBN7.2
Rnor_6.01153,863,357 - 153,863,449NCBIRnor6.0
Rnor_5.01160,168,077 - 160,168,169UniSTSRnor5.0
RGSC_v3.41146,222,292 - 146,222,384UniSTSRGSC3.4
Celera1141,787,988 - 141,788,080UniSTS
RH 3.4 Map11116.4UniSTS
Cytogenetic Map1q32UniSTS
BE118196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,532,538 - 143,532,716 (+)MAPPERmRatBN7.2
Rnor_6.01153,859,969 - 153,860,146NCBIRnor6.0
Rnor_5.01160,164,689 - 160,164,866UniSTSRnor5.0
RGSC_v3.41146,218,904 - 146,219,081UniSTSRGSC3.4
Celera1141,784,600 - 141,784,777UniSTS
RH 3.4 Map11114.6UniSTS
Cytogenetic Map1q32UniSTS
MARC_13809-13810:1046871162:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81153,140,608 - 153,141,337 (+)Marker Load Pipeline
mRatBN7.21143,728,048 - 143,728,777 (+)MAPPERmRatBN7.2
Rnor_6.01154,052,701 - 154,053,429NCBIRnor6.0
Rnor_5.01160,357,081 - 160,357,809UniSTSRnor5.0
RGSC_v3.41146,418,037 - 146,418,543UniSTSRGSC3.4
Celera1141,971,160 - 141,971,889UniSTS
Cytogenetic Map1q32UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 89 88 57 25 57 6 216 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000023329   ⟹   ENSRNOP00000023329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1143,534,139 - 143,731,927 (+)Ensembl
Rnor_6.0 Ensembl1153,861,569 - 154,056,587 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087067   ⟹   ENSRNOP00000072989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1143,534,139 - 143,733,132 (+)Ensembl
Rnor_6.0 Ensembl1153,861,948 - 154,056,654 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095307   ⟹   ENSRNOP00000089037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1143,534,139 - 143,733,132 (+)Ensembl
RefSeq Acc Id: NM_001415972   ⟹   NP_001402901
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,946,628 - 153,148,026 (+)NCBI
mRatBN7.21143,534,057 - 143,735,466 (+)NCBI
RefSeq Acc Id: XM_006229666   ⟹   XP_006229728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,946,595 - 153,144,494 (+)NCBI
mRatBN7.21143,534,024 - 143,735,551 (+)NCBI
Rnor_6.01153,861,535 - 154,058,608 (+)NCBI
Rnor_5.01160,166,289 - 160,361,740 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063266979   ⟹   XP_063123049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,946,595 - 153,142,135 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001402901 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229728 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123049 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18573 (Get FASTA)   NCBI Sequence Viewer  
  EDM18574 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023329
  ENSRNOP00000023329.6
  ENSRNOP00000072989.1
  ENSRNOP00000089037
  ENSRNOP00000089037.1
1 to 10 of 10 rows
RefSeq Acc Id: XP_006229728   ⟸   XM_006229666
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4C6 (UniProtKB/TrEMBL),   F1M5N4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072989   ⟸   ENSRNOT00000087067
Ensembl Acc Id: ENSRNOP00000023329   ⟸   ENSRNOT00000023329
Ensembl Acc Id: ENSRNOP00000089037   ⟸   ENSRNOT00000095307
RefSeq Acc Id: NP_001402901   ⟸   NM_001415972
- UniProtKB: F1M5N4 (UniProtKB/TrEMBL),   A0A8I6AK15 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-F1M5N4-F1-model_v2 AlphaFold F1M5N4 1-605 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690183
Promoter ID:EPDNEW_R707
Type:single initiation site
Name:Me3_1
Description:malic enzyme 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01153,861,552 - 153,861,612EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58554 BioCyc
Ensembl Genes ENSRNOG00000017311 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023329 ENTREZGENE
  ENSRNOT00000023329.8 UniProtKB/TrEMBL
  ENSRNOT00000087067.2 UniProtKB/TrEMBL
  ENSRNOT00000095307 ENTREZGENE
  ENSRNOT00000095307.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10380 UniProtKB/TrEMBL
  6.20.310.10 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Aminiacid_DH-like_N_sf UniProtKB/TrEMBL
  Malic_enzyme_CS UniProtKB/TrEMBL
  Malic_N UniProtKB/TrEMBL
  Malic_N_dom_sf UniProtKB/TrEMBL
  Malic_NAD-bd UniProtKB/TrEMBL
  Malic_OxRdtase UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene 361602 ENTREZGENE
PANTHER MALIC ENZYME-RELATED UniProtKB/TrEMBL
  NADP-DEPENDENT MALIC ENZYME, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam malic UniProtKB/TrEMBL
  Malic_M UniProtKB/TrEMBL
PhenoGen Me3 PhenoGen
PIRSF PIRSF000106 UniProtKB/TrEMBL
PRINTS MALOXRDTASE UniProtKB/TrEMBL
PROSITE MALIC_ENZYMES UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017311 RatGTEx
SMART malic UniProtKB/TrEMBL
  Malic_M UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF53223 UniProtKB/TrEMBL
UniProt A0A0G2K4C6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AK15 ENTREZGENE, UniProtKB/TrEMBL
  F1M5N4 ENTREZGENE, UniProtKB/TrEMBL
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Me3  malic enzyme 3  Me3  malic enzyme 3, NADP(+)-dependent, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Me3  malic enzyme 3, NADP(+)-dependent, mitochondrial   Me3_predicted  malic enzyme 3, NADP(+)-dependent, mitochondrial (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Me3_predicted  malic enzyme 3, NADP(+)-dependent, mitochondrial (predicted)      Symbol and Name status set to approved 70820 APPROVED