Me3 (malic enzyme 3) - Rat Genome Database

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Gene: Me3 (malic enzyme 3) Rattus norvegicus
Analyze
Symbol: Me3
Name: malic enzyme 3
RGD ID: 1311070
Description: Predicted to enable NADP+ binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrial matrix. Orthologous to human ME3 (malic enzyme 3); PARTICIPATES IN pyruvate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361602; malic enzyme 3, NADP(+)-dependent, mitochondrial; mitochondrial malic enzyme 3; NADP-dependent malic enzyme, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81152,946,595 - 153,148,026 (+)NCBIGRCr8
mRatBN7.21143,534,024 - 143,735,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,534,139 - 143,733,132 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,479,136 - 151,672,663 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,655,512 - 158,849,041 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01151,529,440 - 151,722,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01153,861,535 - 154,058,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,861,569 - 154,056,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,166,289 - 160,361,740 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41146,220,504 - 146,422,659 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,297,071 - 146,500,992 (+)NCBI
Celera1141,786,200 - 141,975,029 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
flutamide  (EXP)
fonofos  (ISO)
furan  (EXP)
genistein  (ISO)
GW 4064  (ISO)
iron dichloride  (ISO)
kojic acid  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-nitrosodiethylamine  (EXP)
niclosamide  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7818469   PMID:18614015   PMID:25594249   PMID:34800366  


Genomics

Comparative Map Data
Me3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81152,946,595 - 153,148,026 (+)NCBIGRCr8
mRatBN7.21143,534,024 - 143,735,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,534,139 - 143,733,132 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,479,136 - 151,672,663 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,655,512 - 158,849,041 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01151,529,440 - 151,722,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01153,861,535 - 154,058,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,861,569 - 154,056,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,166,289 - 160,361,740 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41146,220,504 - 146,422,659 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,297,071 - 146,500,992 (+)NCBI
Celera1141,786,200 - 141,975,029 (+)NCBICelera
Cytogenetic Map1q32NCBI
ME3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,434,930 - 86,672,616 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,441,108 - 86,672,636 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,145,972 - 86,383,658 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,829,798 - 86,061,075 (-)NCBINCBI36Build 36hg18NCBI36
Build 341185,829,885 - 86,061,004NCBI
Celera1183,462,760 - 83,694,235 (-)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1182,440,697 - 82,672,413 (-)NCBIHuRef
CHM1_11186,037,902 - 86,269,349 (-)NCBICHM1_1
T2T-CHM13v2.01186,377,442 - 86,612,763 (-)NCBIT2T-CHM13v2.0
Me3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39789,281,492 - 89,503,423 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl789,281,600 - 89,503,567 (+)EnsemblGRCm39 Ensembl
GRCm38789,632,284 - 89,854,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl789,632,392 - 89,854,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv37796,781,328 - 97,002,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36789,508,010 - 89,729,551 (+)NCBIMGSCv36mm8
Celera786,981,993 - 87,178,718 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map750.27NCBI
Me3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554146,343,476 - 6,557,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554146,335,411 - 6,555,494 (+)NCBIChiLan1.0ChiLan1.0
ME3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2987,349,049 - 87,595,198 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,407,386 - 88,646,956 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,490,947 - 81,728,589 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,104,477 - 85,336,683 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,104,477 - 85,222,822 (-)Ensemblpanpan1.1panPan2
ME3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12112,813,052 - 13,105,805 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2112,813,047 - 13,105,804 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2112,678,922 - 12,971,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02112,995,770 - 13,288,435 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2113,101,638 - 13,288,430 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12112,781,982 - 13,074,486 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02112,853,629 - 13,146,550 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02112,909,897 - 13,203,162 (+)NCBIUU_Cfam_GSD_1.0
Me3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494772,614,105 - 72,823,300 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649814,216,513 - 14,423,031 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649814,216,510 - 14,422,936 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ME3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl920,294,908 - 20,583,584 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1920,294,871 - 20,613,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2922,589,632 - 22,780,615 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ME3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1177,712,748 - 77,934,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl177,712,838 - 77,933,727 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604347,792,396 - 48,016,415 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Me3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248453,307,568 - 3,546,631 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248453,307,610 - 3,546,539 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:48
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000023329
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
BI301980  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,568,830 - 143,569,020 (+)MAPPERmRatBN7.2
Rnor_6.01153,895,885 - 153,896,074NCBIRnor6.0
Rnor_5.01160,200,232 - 160,200,421UniSTSRnor5.0
RGSC_v3.41146,255,789 - 146,255,978UniSTSRGSC3.4
Celera1141,820,906 - 141,821,095UniSTS
RH 3.4 Map11116.4UniSTS
Cytogenetic Map1q32UniSTS
RH129606  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81152,946,456 - 152,946,755 (+)Marker Load Pipeline
mRatBN7.21143,533,885 - 143,534,184 (+)MAPPERmRatBN7.2
Rnor_6.01153,861,316 - 153,861,614NCBIRnor6.0
Rnor_5.01160,166,036 - 160,166,334UniSTSRnor5.0
RGSC_v3.41146,220,251 - 146,220,549UniSTSRGSC3.4
Celera1141,785,947 - 141,786,245UniSTS
RH 3.4 Map11115.9UniSTS
Cytogenetic Map1q32UniSTS
RH133219  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1141,973,432 - 141,974,926UniSTS
RH 3.4 Map11121.0UniSTS
Cytogenetic Map1q32UniSTS
BF405328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,535,926 - 143,536,019 (+)MAPPERmRatBN7.2
Rnor_6.01153,863,357 - 153,863,449NCBIRnor6.0
Rnor_5.01160,168,077 - 160,168,169UniSTSRnor5.0
RGSC_v3.41146,222,292 - 146,222,384UniSTSRGSC3.4
Celera1141,787,988 - 141,788,080UniSTS
RH 3.4 Map11116.4UniSTS
Cytogenetic Map1q32UniSTS
BE118196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,532,538 - 143,532,716 (+)MAPPERmRatBN7.2
Rnor_6.01153,859,969 - 153,860,146NCBIRnor6.0
Rnor_5.01160,164,689 - 160,164,866UniSTSRnor5.0
RGSC_v3.41146,218,904 - 146,219,081UniSTSRGSC3.4
Celera1141,784,600 - 141,784,777UniSTS
RH 3.4 Map11114.6UniSTS
Cytogenetic Map1q32UniSTS
MARC_13809-13810:1046871162:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81153,140,608 - 153,141,337 (+)Marker Load Pipeline
mRatBN7.21143,728,048 - 143,728,777 (+)MAPPERmRatBN7.2
Rnor_6.01154,052,701 - 154,053,429NCBIRnor6.0
Rnor_5.01160,357,081 - 160,357,809UniSTSRnor5.0
RGSC_v3.41146,418,037 - 146,418,543UniSTSRGSC3.4
Celera1141,971,160 - 141,971,889UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 89 88 57 25 57 6 216 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000023329   ⟹   ENSRNOP00000023329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1143,534,139 - 143,731,927 (+)Ensembl
Rnor_6.0 Ensembl1153,861,569 - 154,056,587 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087067   ⟹   ENSRNOP00000072989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1143,534,139 - 143,733,132 (+)Ensembl
Rnor_6.0 Ensembl1153,861,948 - 154,056,654 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095307   ⟹   ENSRNOP00000089037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1143,534,139 - 143,733,132 (+)Ensembl
RefSeq Acc Id: NM_001415972   ⟹   NP_001402901
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,946,628 - 153,148,026 (+)NCBI
mRatBN7.21143,534,057 - 143,735,466 (+)NCBI
RefSeq Acc Id: XM_006229666   ⟹   XP_006229728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,946,595 - 153,144,494 (+)NCBI
mRatBN7.21143,534,024 - 143,735,551 (+)NCBI
Rnor_6.01153,861,535 - 154,058,608 (+)NCBI
Rnor_5.01160,166,289 - 160,361,740 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063266979   ⟹   XP_063123049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,946,595 - 153,142,135 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001402901 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229728 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123049 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18573 (Get FASTA)   NCBI Sequence Viewer  
  EDM18574 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023329.6
  ENSRNOP00000072989.1
  ENSRNOP00000089037.1
RefSeq Acc Id: XP_006229728   ⟸   XM_006229666
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4C6 (UniProtKB/TrEMBL),   F1M5N4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072989   ⟸   ENSRNOT00000087067
Ensembl Acc Id: ENSRNOP00000023329   ⟸   ENSRNOT00000023329
Ensembl Acc Id: ENSRNOP00000089037   ⟸   ENSRNOT00000095307
RefSeq Acc Id: NP_001402901   ⟸   NM_001415972
- UniProtKB: F1M5N4 (UniProtKB/TrEMBL),   A0A8I6AK15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123049   ⟸   XM_063266979
- Peptide Label: isoform X2
Protein Domains
Malic enzyme N-terminal   Malic enzyme NAD-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M5N4-F1-model_v2 AlphaFold F1M5N4 1-605 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690183
Promoter ID:EPDNEW_R707
Type:single initiation site
Name:Me3_1
Description:malic enzyme 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01153,861,552 - 153,861,612EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311070 AgrOrtholog
BioCyc Gene G2FUF-58554 BioCyc
Ensembl Genes ENSRNOG00000017311 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023329.8 UniProtKB/TrEMBL
  ENSRNOT00000087067.2 UniProtKB/TrEMBL
  ENSRNOT00000095307.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10380 UniProtKB/TrEMBL
  6.20.310.10 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Aminiacid_DH-like_N_sf UniProtKB/TrEMBL
  Malic_enzyme_CS UniProtKB/TrEMBL
  Malic_N UniProtKB/TrEMBL
  Malic_N_dom_sf UniProtKB/TrEMBL
  Malic_NAD-bd UniProtKB/TrEMBL
  Malic_OxRdtase UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene 361602 ENTREZGENE
PANTHER MALIC ENZYME-RELATED UniProtKB/TrEMBL
  NADP-DEPENDENT MALIC ENZYME, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam malic UniProtKB/TrEMBL
  Malic_M UniProtKB/TrEMBL
PhenoGen Me3 PhenoGen
PIRSF PIRSF000106 UniProtKB/TrEMBL
PRINTS MALOXRDTASE UniProtKB/TrEMBL
PROSITE MALIC_ENZYMES UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017311 RatGTEx
SMART malic UniProtKB/TrEMBL
  Malic_M UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF53223 UniProtKB/TrEMBL
UniProt A0A0G2K4C6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AK15 ENTREZGENE, UniProtKB/TrEMBL
  F1M5N4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Me3  malic enzyme 3  Me3  malic enzyme 3, NADP(+)-dependent, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Me3  malic enzyme 3, NADP(+)-dependent, mitochondrial   Me3_predicted  malic enzyme 3, NADP(+)-dependent, mitochondrial (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Me3_predicted  malic enzyme 3, NADP(+)-dependent, mitochondrial (predicted)      Symbol and Name status set to approved 70820 APPROVED