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Gene: ME1 (malic enzyme 1) Homo sapiens
Symbol: ME1
Name: malic enzyme 1
Description: Exhibits malate dehydrogenase (decarboxylating) (NADP+) activity and manganese ion binding activity. Involved in malate metabolic process and regulation of NADP metabolic process. Predicted to localize to the cytosol and mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HUMNDME; malate dehydrogenase; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); malic enzyme 1, NADP(+)-dependent, cytosolic; malic enzyme 1, soluble; Malic enzyme, cytoplasmic; MES; NADP-dependent malic enzyme; NADP-ME; pyruvic-malic carboxylase
Mus musculus (house mouse) : Me1 (malic enzyme 1, NADP(+)-dependent, cytosolic)  MGI  Alliance
Rattus norvegicus (Norway rat) : Me1 (malic enzyme 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Me1 (malic enzyme 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ME1 (malic enzyme 1)
Canis lupus familiaris (dog) : ME1 (malic enzyme 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Me1 (malic enzyme 1)
Sus scrofa (pig) : ME1 (malic enzyme 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38683,210,402 - 83,431,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37683,920,108 - 84,140,938 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36683,976,827 - 84,197,498 (-)NCBINCBI36hg18NCBI36
Build 34683,977,975 - 84,197,499NCBI
Celera684,353,414 - 84,574,177 (-)NCBI
Cytogenetic Map6q14.2NCBI
HuRef681,148,328 - 81,370,879 (-)NCBIHuRef
CHM1_1684,017,801 - 84,238,482 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ME1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736133
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.