Me3 (malic enzyme 3) - Rat Genome Database

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Gene: Me3 (malic enzyme 3) Heterocephalus glaber
Analyze
Symbol: Me3
Name: malic enzyme 3
RGD ID: 18899769
Description: ENCODES a protein that exhibits NADP+ binding (ortholog); INVOLVED IN malate metabolic process (inferred); pyruvate metabolic process (inferred); ASSOCIATED WITH exudative vitreoretinopathy 1 (ortholog); intellectual disability (ortholog); FOUND IN mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NADP-dependent malic enzyme, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248453,307,568 - 3,546,631 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248453,307,610 - 3,546,539 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Me3Naked Mole-Ratexudative vitreoretinopathy 1  ISOME3 (Homo sapiens)8554872ClinVar Annotator: match by term: Exudative vitreoretinopathy 1ClinVarPMID:21097938 and PMID:21681106
Me3Naked Mole-Ratintellectual disability  ISOME3 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Me3Naked Mole-Ratmalate metabolic process involved_inIEAPANTHER:PTN000601118150520179 TreeGrafterGO_REF:0000118
Me3Naked Mole-Ratpyruvate metabolic process involved_inIEAPANTHER:PTN000601118150520179 TreeGrafterGO_REF:0000118

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Me3Naked Mole-Ratmitochondrial matrix is_active_inISOMe3 (Mus musculus)9068941 PMID:25711MGIPMID:25711
Me3Naked Mole-Ratmitochondrion located_inIEAPANTHER:PTN000601118150520179 TreeGrafterGO_REF:0000118

Molecular Function
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Me3Naked Mole-Ratmalate dehydrogenase (decarboxylating) (NADP+) activity enablesIEAPANTHER:PTN000601118150520179 TreeGrafterGO_REF:0000118
Me3Naked Mole-Ratmalic enzyme activity enablesIEAInterPro:IPR001891 more ...150520179 InterProGO_REF:0000002
Me3Naked Mole-Ratmalic enzyme activity enablesIEAARBA:ARBA00028633150520179 UniProtGO_REF:0000117
Me3Naked Mole-Ratmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
Me3Naked Mole-RatNAD binding enablesIEAInterPro:IPR012302150520179 InterProGO_REF:0000002
Me3Naked Mole-RatNADP+ binding enablesISOME3 (Homo sapiens)9068941 PMID:7818469UniProtPMID:7818469
Me3Naked Mole-Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-0560150520179 UniProtGO_REF:0000043
Me3Naked Mole-Ratoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor enablesIEAInterPro:IPR001891 more ...150520179 InterProGO_REF:0000002
Me3Naked Mole-Ratoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor enablesIEAARBA:ARBA00028442150520179 UniProtGO_REF:0000117
1 to 9 of 9 rows

PMID:22301074   PMID:30032202  



Me3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248453,307,568 - 3,546,631 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248453,307,610 - 3,546,539 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ME3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,434,930 - 86,672,616 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,441,108 - 86,672,636 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,145,972 - 86,383,658 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,829,798 - 86,061,075 (-)NCBINCBI36Build 36hg18NCBI36
Build 341185,829,885 - 86,061,004NCBI
Celera1183,462,760 - 83,694,235 (-)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1182,440,697 - 82,672,413 (-)NCBIHuRef
CHM1_11186,037,902 - 86,269,349 (-)NCBICHM1_1
T2T-CHM13v2.01186,377,442 - 86,612,763 (-)NCBIT2T-CHM13v2.0
Me3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39789,281,492 - 89,503,423 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl789,281,600 - 89,503,567 (+)EnsemblGRCm39 Ensembl
GRCm38789,632,284 - 89,854,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl789,632,392 - 89,854,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv37796,781,328 - 97,002,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36789,508,010 - 89,729,551 (+)NCBIMGSCv36mm8
Celera786,981,993 - 87,178,718 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map750.27NCBI
Me3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81152,946,595 - 153,148,026 (+)NCBIGRCr8
mRatBN7.21143,534,024 - 143,735,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,534,139 - 143,733,132 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,479,136 - 151,672,663 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,655,512 - 158,849,041 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01151,529,440 - 151,722,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01153,861,535 - 154,058,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,861,569 - 154,056,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,166,289 - 160,361,740 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41146,220,504 - 146,422,659 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,297,071 - 146,500,992 (+)NCBI
Celera1141,786,200 - 141,975,029 (+)NCBICelera
Cytogenetic Map1q32NCBI
Me3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554146,343,476 - 6,557,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554146,335,411 - 6,555,494 (+)NCBIChiLan1.0ChiLan1.0
ME3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2987,349,049 - 87,595,198 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,407,386 - 88,646,956 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,490,947 - 81,728,589 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,104,477 - 85,336,683 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,104,477 - 85,222,822 (-)Ensemblpanpan1.1panPan2
ME3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12112,813,052 - 13,105,805 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2112,813,047 - 13,105,804 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2112,678,922 - 12,971,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02112,995,770 - 13,288,435 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2113,101,638 - 13,288,430 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12112,781,982 - 13,074,486 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02112,853,629 - 13,146,550 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02112,909,897 - 13,203,162 (+)NCBIUU_Cfam_GSD_1.0
Me3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494772,614,105 - 72,823,300 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649814,216,513 - 14,423,031 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649814,216,510 - 14,422,936 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ME3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl920,294,908 - 20,583,584 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1920,294,871 - 20,613,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2922,589,632 - 22,780,615 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ME3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1177,712,748 - 77,934,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl177,712,838 - 77,933,727 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604347,792,396 - 48,016,415 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000001382   ⟹   ENSHGLP00000001340
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248453,307,568 - 3,546,631 (+)Ensembl
RefSeq Acc Id: XM_004868220   ⟹   XP_004868277
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248453,307,615 - 3,546,539 (+)NCBI
RefSeq Acc Id: XM_004868221   ⟹   XP_004868278
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248453,307,615 - 3,546,539 (+)NCBI
RefSeq Acc Id: XM_013066859   ⟹   XP_012922313
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248453,307,614 - 3,546,539 (+)NCBI
RefSeq Acc Id: XM_021247150   ⟹   XP_021102809
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248453,307,610 - 3,546,539 (+)NCBI
Protein RefSeqs XP_004868277 (Get FASTA)   NCBI Sequence Viewer  
  XP_004868278 (Get FASTA)   NCBI Sequence Viewer  
  XP_012922313 (Get FASTA)   NCBI Sequence Viewer  
  XP_021102809 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001340
RefSeq Acc Id: XP_021102809   ⟸   XM_021247150
- Peptide Label: isoform X3
- UniProtKB: A0AAX6S2Y1 (UniProtKB/TrEMBL),   G5B521 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012922313   ⟸   XM_013066859
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QPF1 (UniProtKB/TrEMBL),   G5B521 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004868278   ⟸   XM_004868221
- Peptide Label: isoform X1
- UniProtKB: A0AAX6Q9T4 (UniProtKB/TrEMBL),   G5B521 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004868277   ⟸   XM_004868220
- Peptide Label: isoform X1
- UniProtKB: A0AAX6Q9T4 (UniProtKB/TrEMBL),   G5B521 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000001340   ⟸   ENSHGLT00000001382



1 to 27 of 27 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000001044 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000001382 ENTREZGENE
Gene3D-CATH Malic enzyme, N-terminal domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Aminoacid_DH-like_N_sf UniProtKB/TrEMBL
  Malic_enzyme_CS UniProtKB/TrEMBL
  Malic_N_dom UniProtKB/TrEMBL
  Malic_N_dom_sf UniProtKB/TrEMBL
  Malic_NAD-bd UniProtKB/TrEMBL
  Malic_OxRdtase UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene Me3 ENTREZGENE
PANTHER MALIC ENZYME-RELATED UniProtKB/TrEMBL
  NADP-DEPENDENT MALIC ENZYME, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam malic UniProtKB/TrEMBL
  Malic_M UniProtKB/TrEMBL
PIRSF PIRSF000106 UniProtKB/TrEMBL
PRINTS MALOXRDTASE UniProtKB/TrEMBL
PROSITE MALIC_ENZYMES UniProtKB/TrEMBL
SMART malic UniProtKB/TrEMBL
  Malic_M UniProtKB/TrEMBL
Superfamily-SCOP Aminoacid dehydrogenase-like, N-terminal domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL
UniProt A0AAX6Q9T4 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QPF1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S2Y1 ENTREZGENE, UniProtKB/TrEMBL
  G5B521 ENTREZGENE, UniProtKB/TrEMBL
1 to 27 of 27 rows