Atp6ap1 (ATPase H+ transporting accessory protein 1)

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Gene: Atp6ap1 (ATPase H+ transporting accessory protein 1) Rattus norvegicus

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Symbol:

Atp6ap1

Name:

ATPase H+ transporting accessory protein 1

RGD ID:

620423

Description:

Predicted to enable ATPase activator activity; small GTPase binding activity; and transporter activator activity. Predicted to be involved in several processes, including endosome to plasma membrane protein transport; intracellular monoatomic cation homeostasis; and synaptic vesicle lumen acidification. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1); PARTICIPATES IN oxidative phosphorylation pathway; phagocytosis pathway; rheumatoid arthritis pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Atp6s1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; C7-1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit S1; V-type proton ATPase subunit S1; vacuolar proton pump subunit S1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	157,231,243 - 157,238,323 (+)	NCBI		GRCr8
mRatBN7.2	X	152,079,954 - 152,087,034 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	152,079,865 - 152,087,034 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	154,221,080 - 154,228,160 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,784,313 - 157,791,393 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	155,456,112 - 155,463,192 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	156,407,973 - 156,415,053 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	156,407,937 - 156,415,145 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,148,120 - 152,155,200 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	160,306,354 - 160,313,434 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	160,382,734 - 160,389,815 (-)	NCBI
Celera	1	135,809,720 - 135,816,800 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

Barth syndrome (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

favism (ISO)

follicular lymphoma (ISO)

genetic disease (ISO)

immunodeficiency 33 (ISO)

immunodeficiency 47 (ISO)

neutropenia (ISO)

non-syndromic X-linked intellectual disability (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

severe congenital encephalopathy due to MECP2 mutation (ISO)

Splenomegaly (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

cadmium dichloride (ISO)

capsaicin (EXP)

carbon nanotube (ISO)

chlordecone (ISO)

cobalt dichloride (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

ethanol (EXP,ISO)

fenthion (ISO)

folic acid (ISO)

genistein (EXP)

gentamycin (EXP)

hydralazine (ISO)

indometacin (EXP,ISO)

inulin (ISO)

methidathion (ISO)

methimazole (EXP)

N,N-diethyl-m-toluamide (EXP)

niclosamide (ISO)

Nonylphenol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

phenylpropanolamine (ISO)

potassium chromate (ISO)

Pyridostigmine bromide (EXP)

rotenone (EXP,ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

undecane (EXP)

valproic acid (ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

Yessotoxin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to increased oxygen levels (ISO,ISS)

endosome to plasma membrane protein transport (ISO,ISS)

intracellular iron ion homeostasis (ISO,ISS)

osteoclast development (ISO,ISS)

proton-transporting V-type ATPase complex assembly (ISO)

regulation of cellular pH (IBA)

synaptic vesicle lumen acidification (ISO)

Cellular Component

clathrin-coated vesicle membrane (IEA)

endoplasmic reticulum membrane (IEA)

endoplasmic reticulum-Golgi intermediate compartment membrane (IEA)

endosome membrane (ISO)

membrane (IEA,ISO)

proton-transporting V-type ATPase complex (IBA)

synaptic vesicle membrane (EXP,IDA,IEP)

Molecular Function

ATPase activator activity (IBA,ISO)

protein binding (ISO)

small GTPase binding (ISO,ISS)

transporter activator activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

oxidative phosphorylation pathway (IEA)

phagocytosis pathway (IEA)

rheumatoid arthritis pathway (IEA)

tuberculosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Structure of V-ATPase from the mammalian brain.	Abbas YM, etal., Science. 2020 Mar 13;367(6483):1240-1246. doi: 10.1126/science.aaz2924.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction.	Hodi FS, etal., Proc Natl Acad Sci U S A 2002 May 14;99(10):6919-24.
5.	Age-dependent increase in C7-1 gene expression in rat frontal cortex.	Hung H, etal., Brain Res Mol Brain Res. 2000 Feb 22;75(2):330-6.
6.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:19056867	PMID:22467241	PMID:23376485	PMID:28296633	PMID:29476059

Genomics

Comparative Map Data

Atp6ap1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	157,231,243 - 157,238,323 (+)	NCBI		GRCr8
mRatBN7.2	X	152,079,954 - 152,087,034 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	152,079,865 - 152,087,034 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	154,221,080 - 154,228,160 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,784,313 - 157,791,393 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	155,456,112 - 155,463,192 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	156,407,973 - 156,415,053 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	156,407,937 - 156,415,145 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,148,120 - 152,155,200 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	160,306,354 - 160,313,434 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	160,382,734 - 160,389,815 (-)	NCBI
Celera	1	135,809,720 - 135,816,800 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

ATP6AP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	154,428,677 - 154,436,516 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	154,428,633 - 154,436,516 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	153,657,023 - 153,664,862 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	153,310,172 - 153,318,056 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	153,177,867 - 153,183,641	NCBI
Celera	X	153,818,024 - 153,825,908 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	142,234,564 - 142,269,596 (+)	NCBI		HuRef
CHM1_1	X	153,568,616 - 153,576,500 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	152,665,185 - 152,673,024 (+)	NCBI		T2T-CHM13v2.0

Atp6ap1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	73,340,753 - 73,348,297 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	73,340,703 - 73,348,327 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	74,297,097 - 74,304,721 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	74,297,097 - 74,304,721 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	71,542,436 - 71,550,060 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	70,549,866 - 70,557,411 (+)	NCBI		MGSCv36	mm8
Celera	X	65,550,888 - 65,558,512 (+)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.96	NCBI

Atp6ap1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	927,114 - 934,734 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	927,546 - 934,633 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATP6AP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	154,402,930 - 154,410,908 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	154,406,616 - 154,414,513 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	143,870,421 - 143,878,288 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	153,740,751 - 153,748,621 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	153,740,751 - 153,748,621 (+)	Ensembl	panpan1.1		panPan2

ATP6AP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	122,133,314 - 122,140,949 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	122,133,325 - 122,140,447 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	125,274,997 - 125,282,640 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	125,275,036 - 125,282,639 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	121,044,023 - 121,051,666 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	123,559,169 - 123,566,812 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	123,320,845 - 123,328,488 (+)	NCBI		UU_Cfam_GSD_1.0

Atp6ap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	119,441,750 - 119,450,401 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	1,179,464 - 1,188,283 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	1,179,507 - 1,188,172 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP6AP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	124,952,500 - 124,960,343 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	124,952,532 - 124,960,344 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	143,693,025 - 143,696,039 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP6AP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666065	66,657,080 - 66,664,908 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp6ap1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624946	884,685 - 902,365 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624946	885,400 - 902,082 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Atp6ap1
6 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	102
Count of miRNA genes:	79
Interacting mature miRNAs:	95
Transcripts:	ENSRNOT00000056294
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634346	Insul4	Insulin level QTL 4	0		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	X	126975089	152453651	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat

Markers in Region

RH128191

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	152,086,738 - 152,086,948 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	156,408,059 - 156,408,268	NCBI	Rnor6.0
Rnor_5.0	1	152,148,206 - 152,148,415	UniSTS	Rnor5.0
RGSC_v3.4	X	160,306,440 - 160,306,649	UniSTS	RGSC3.4
Celera	1	135,809,806 - 135,810,015	UniSTS
Cytogenetic Map	X	q37	UniSTS
Cytogenetic Map	X	q37.1-q37.2	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF035387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC070937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000081914 ⟹ ENSRNOP00000069530

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	152,079,874 - 152,087,034 (+)	Ensembl
Rnor_6.0 Ensembl	X	156,407,937 - 156,415,145 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113494 ⟹ ENSRNOP00000090467

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	152,079,865 - 152,087,034 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117428 ⟹ ENSRNOP00000091970

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	152,079,917 - 152,087,034 (+)	Ensembl

RefSeq Acc Id:

NM_031785 ⟹ NP_113973

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	157,231,243 - 157,238,323 (+)	NCBI
mRatBN7.2	X	152,079,954 - 152,087,034 (+)	NCBI
Rnor_6.0	X	156,407,973 - 156,415,053 (-)	NCBI
Rnor_5.0	1	152,148,120 - 152,155,200 (-)	NCBI
RGSC_v3.4	X	160,306,354 - 160,313,434 (-)	RGD
Celera	1	135,809,720 - 135,816,800 (-)	NCBI

Sequence:

show sequence

CTATGATGGCGGCAACAGTGGTATCTCGGATACGAACCGGGACACGGTGGGCTCCAGTCCTGTG
GCTGCTTCTGTCGTTGGTGGCAGTGGCGGCAGCAGTGGCTGCGGAGCAGCAGGTGCCACTGGTA
CTGTGGTCGAGTGACCGGGACCTCTGGGCTCCTGTGGCCGACACACATGAGGGTCATATTACCA
GCGATATGCAGCTTTCTACCTACTTAGACCCTGCCCTGGAGCTGGGCCCCCGCAATGTATTGCT
GTTCCTGCAGGACAAGCTGAGCATTGAGGATTTCACAGCATACGGTGGTGTGTTTGGAAATAAA
CAGGACAGTGCCTTTTCTAACCTGGAGAATGCCCTGGACTTGGCCCCCTCCTCACTGGTACTTC
CTGCTGTGGACTGGTATGCAATCAGCACTCTGACCACCTACCTACAGGAGAAGCTTGGAGCTAG
TCCCTTGCATGTGGATCTAGCTACCCTAAAGGAGCTGAAGCTCAATGCCAGCCTTCCTGCCCTG
CTGCTCATCCGTCTGCCCTACACAGCCAGCTCCGGTCTGATGGCGCCCAGGGAGGTCCTTACAG
GTAATGATGAGGTCATCGGACAGGTACTGAGCACACTTGAGTCTGAAGATGTTCCTTACACCGC
GGCTCTTACTGCAGTCCGCCCTTCTAGAGTGGCCCGTGATGTAGCCATGGTGGCTGGGGGTCTA
GGTCGCCAGCTGCTTCAGACTCAGGTGGCATCACCTGCGATCCATCCTCCTGTGAGTTACAATG
ACACTGCCCCAAGGATCCTGTTTTGGGCACAAAACTTCTCTGTGGCATACAAAGACGAATGGAA
AGACTTGACCTCCCTCACCTTTGGTGTGGAGAATCTTAACTTGACCGGCTCCTTCTGGAATGAC
TCCTTTGCCATGCTTTCACTGACCTATGAACCACTCTTTGGTGCAACAGTGACATTCAAGTTCA
TTCTGGCTAGTCGCTTCTACCCAGTATCTGCCCGATATTGGTTTACCATGGAACGACTTGAAAT
CCACAGCAATGGCTCGGTTGCCCATTTCAATGTTTCCCAAGTCACAGGACCTAGTATCTATTCT
TTCCACTGTGAGTACGTCAGCAGTCTGAGCAAGAAAGGCAGTCTCCTTGTGACCAACGTGCCCT
CCCTCTGGCAGATGACTCTTCATAACTTCCAGATCCAAGCCTTCAATGTGACTGGTGAACAGTT
CTCCTATGCTAGCGACTGTGCTGGCTTCTTCTCTCCGGGCATCTGGATGGGGCTGCTCACCACC
CTCTTCATGCTTTTCATATTCACCTATGGTCTGCACATGATACTCAGCCTAAAGACCATGGATC
GCTTTGATGACCGCAAGGGCCCCACCATCACTTTGACCCAGATTGTGTGACATATACCAGAGAG
GGATTGAGGGAGTATTGGTGTCTAGGTTTCCATTTTGTGACACAGTGGATGGAAAGGTTTGTCC
TCTTCCTACTATAGCATGAACCCTACATACACCACCCTCAGCCTGTCTTGCTTCCTCTTTCCTG
GACAGGGACTTCCCTGAGGCTATCCCCCACTTCTACCAACAAAGTGTATTATTCTTCATAGATA
AATCTTCCAGGCTTCATCAAGAGGGGAAGGGACCTTAATTCTAGGGTGCCCCCCTTTCCCTTTC
TCCTTATTTATTCTTGCCCCTCTGCTATTATTTCGTGCTGTTTATAGTGCTTTTGTGTAGTAAA
TACTCACTCCCCAAGCTTTATGGAGCTTTCCAGCAATAGCCATGAACTTGAGGTCCCTTGAATT
TGAGAGGTGTGGAAAGGCTAGTTAACTGTCCAGCTTAGCCTTTATGGGTTTTTTTTTTTTGGCG
GGTGGGGGTTAAGAATGAGCGGTACACTGGGGTTTATTTCTGTGACCTGAGAAGGAAGAAATCA
CCACGAGAACTGGAGAAACAAAGTGTACTCATTGGGTTTCTGGTTTGTTCTCACAAGGATTGCC
TGTCAAGAAGCCAGAAGTATGTGTGTGTGTGTGTGGGGGGGGTGTGCTCTGTTGTTTCATTCCT
AATAAAATAAAGACGTGTTGCCATGAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_113973	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB88008	(Get FASTA)	NCBI Sequence Viewer
	AAH70937	(Get FASTA)	NCBI Sequence Viewer
	EDL84979	(Get FASTA)	NCBI Sequence Viewer
	EDL84980	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069530.1
	ENSRNOP00000090467.1
	ENSRNOP00000091970.1
GenBank Protein	O54715	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_113973 ⟸ NM_031785
- Peptide Label:	precursor
- UniProtKB:	O54715 (UniProtKB/Swiss-Prot), Q6IRF8 (UniProtKB/TrEMBL), A6KRR4 (UniProtKB/TrEMBL), A0A0G2JVL4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMAATVVSRIRTGTRWAPVLWLLLSLVAVAAAVAAEQQVPLVLWSSDRDLWAPVADTHEGHITS DMQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNLENALDLAPSSLVLP AVDWYAISTLTTYLQEKLGASPLHVDLATLKELKLNASLPALLLIRLPYTASSGLMAPREVLTG NDEVIGQVLSTLESEDVPYTAALTAVRPSRVARDVAMVAGGLGRQLLQTQVASPAIHPPVSYND TAPRILFWAQNFSVAYKDEWKDLTSLTFGVENLNLTGSFWNDSFAMLSLTYEPLFGATVTFKFI LASRFYPVSARYWFTMERLEIHSNGSVAHFNVSQVTGPSIYSFHCEYVSSLSKKGSLLVTNVPS LWQMTLHNFQIQAFNVTGEQFSYASDCAGFFSPGIWMGLLTTLFMLFIFTYGLHMILSLKTMDR FDDRKGPTITLTQIV hide sequence

Ensembl Acc Id:

ENSRNOP00000069530 ⟸ ENSRNOT00000081914

Ensembl Acc Id:

ENSRNOP00000090467 ⟸ ENSRNOT00000113494

Ensembl Acc Id:

ENSRNOP00000091970 ⟸ ENSRNOT00000117428

Protein Domains

V-type proton ATPase subunit S1 luminal V-type proton ATPase subunit S1/VOA1 transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O54715-F1-model_v2	AlphaFold	O54715	1-463	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13702045

Promoter ID:

EPDNEW_R12569

Type:

multiple initiation site

Name:

Atp6ap1_1

Description:

ATPase H+ transporting accessory protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	156,415,067 - 156,415,127	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620423	AgrOrtholog
BioCyc Gene	G2FUF-630	BioCyc
Ensembl Genes	ENSRNOG00000054352	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000081914.2	UniProtKB/TrEMBL
	ENSRNOT00000113494.1	UniProtKB/TrEMBL
	ENSRNOT00000117428.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.160.110	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7099117	IMAGE-MGC_LOAD
InterPro	ATPase_V1-cplx_s1su	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VAS1/VOA1_TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VAS1_LD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:83615	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:91619	IMAGE-MGC_LOAD
NCBI Gene	83615	ENTREZGENE
PANTHER	PTHR12471	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	V-TYPE PROTON ATPASE SUBUNIT S1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ac45-VOA1_TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-synt_S1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Atp6ap1	PhenoGen
RatGTEx	ENSRNOG00000054352	RatGTEx
UniProt	A0A0G2JVL4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AD46_RAT	UniProtKB/TrEMBL
	A0A8I6ADV4_RAT	UniProtKB/TrEMBL
	A6KRR3_RAT	UniProtKB/TrEMBL
	A6KRR4	ENTREZGENE, UniProtKB/TrEMBL
	O54715	ENTREZGENE
	Q6IRF8	ENTREZGENE
	VAS1_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q6IRF8	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Atp6ap1	ATPase H+ transporting accessory protein 1	Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1		ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1	Name updated	1299863	APPROVED
2004-09-10	Atp6ap1	ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1	Atp6s1		Symbol and Name updated	1299863	APPROVED
2002-08-07	Atp6s1	ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_disease	increased antibody response to human homolog is associated with immune mediated response to tumors and tumor destruction	634610

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)