Aldh6a1 (aldehyde dehydrogenase 6 family, member A1)

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Gene: Aldh6a1 (aldehyde dehydrogenase 6 family, member A1) Rattus norvegicus

Analyze

Symbol:

Aldh6a1

Name:

aldehyde dehydrogenase 6 family, member A1

RGD ID:

621556

Description:

Enables malonate-semialdehyde dehydrogenase (acetylating) activity; methylmalonate-semialdehyde dehydrogenase (acylating) activity; and thiolester hydrolase activity. Involved in beta-alanine catabolic process; thymine catabolic process; and valine catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

aldehyde dehydrogenase family 6 member A1; aldehyde dehydrogenase family 6, subfamily A1; malonate-semialdehyde dehydrogenase; methylmalonate semialdehyde dehydrogenase; methylmalonate semialdehyde dehydrogenase gene; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Mmsdh

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	104,077,975 - 104,098,636 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	104,077,979 - 104,098,656 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	104,239,731 - 104,260,583 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	104,538,815 - 104,559,667 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	103,908,399 - 103,929,251 (-)	NCBI	Rnor_WKY
Rnor_6.0	6	108,146,552 - 108,167,185 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	108,146,582 - 108,167,185 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	117,379,212 - 117,399,845 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	108,495,781 - 108,516,414 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	108,500,592 - 108,736,789 (-)	NCBI
Celera	6	101,905,993 - 101,926,661 (-)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amino acid metabolic disorder (ISO)

intellectual disability (ISO)

Methylmalonate Semialdehyde Dehydrogenase Deficiency (ISO)

Myocardial Ischemia (ISO)

obesity (ISO)

primary ciliary dyskinesia 16 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3-dimethoxynaphthalene-1,4-dione (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

3-chloropropane-1,2-diol (EXP)

4-hydroxynon-2-enal (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

Allylamine (EXP)

amiodarone (EXP)

ammonium chloride (EXP)

antimony(0) (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsenous acid (ISO)

atrazine (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

Brodifacoum (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

clofibric acid (ISO)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

diuron (EXP)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

fenofibrate (ISO)

fenvalerate (EXP)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

glafenine (EXP)

glucose (ISO)

Heliotrine (ISO)

hydrogen peroxide (ISO)

ivermectin (ISO)

menadione (ISO)

mercury atom (ISO)

mercury dichloride (ISO)

mercury(0) (ISO)

methapyrilene (EXP)

methylisothiazolinone (ISO)

motexafin gadolinium (ISO)

Muraglitazar (EXP)

N-nitrosomorpholine (EXP)

nickel atom (ISO)

O-methyleugenol (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

PCB138 (EXP)

pentanal (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

PhIP (EXP)

phlorizin (ISO)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (EXP)

quercetin (ISO)

senecionine (ISO)

Senkirkine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sulindac (EXP)

tert-butyl hydroperoxide (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vitamin E (ISO)

vorinostat (ISO)

zinc acetate (ISO)

zinc atom (EXP,ISO)

zinc(0) (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

beta-alanine catabolic process (IDA)

brown fat cell differentiation (IEA,ISO)

thymine catabolic process (IBA,IDA,IEA,ISO)

thymine metabolic process (IDA)

valine catabolic process (IBA,IDA,IEA,ISO)

valine metabolic process (IDA)

Cellular Component

cellular_component (ND)

mitochondrion (IBA,IEA,ISO)

nucleoplasm (IEA,ISO)

Molecular Function

fatty-acyl-CoA binding (ISS)

malonate-semialdehyde dehydrogenase (acetylating) activity (IBA,IDA,IEA)

malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity (IEA)

methylmalonate-semialdehyde dehydrogenase (acylating) activity (IBA,IDA,IEA,ISO,NAS)

thiolester hydrolase activity (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway (ISO)

3-hydroxyisobutyric aciduria pathway (ISO)

3-methylcrotonyl CoA carboxylase 1 deficiency pathway (ISO)

3-methylglutaconic aciduria type 1 pathway (ISO)

3-methylglutaconic aciduria type 3 pathway (ISO)

beta-alanine metabolic pathway (ISO)

carnosinemia pathway (ISO)

GABA aminotransferase deficiency pathway (ISO)

inositol phosphate metabolic pathway (IEA)

isobutyryl-CoA dehydrogenase deficiency pathway (ISO)

isovaleric acidemia pathway (ISO)

malonic aciduria pathway (ISO)

maple syrup urine disease pathway (ISO)

methylmalonate semialdehyde dehydrogenase deficiency pathway (ISO)

methylmalonic acidemia pathway (ISO)

methylmalonic aciduria, cobalamin-related pathway (ISO)

propanoate metabolic pathway (IEA,ISO)

propionic acidemia pathway (ISO)

valine, leucine and isoleucine degradation pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Purification and characterization of methylmalonate-semialdehyde dehydrogenase from rat liver. Identity to malonate-semialdehyde dehydrogenase.	Goodwin GW, etal., J Biol Chem. 1989 Sep 5;264(25):14965-71.
4.	CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distribution.	Kedishvili NY, etal., J Biol Chem 1992 Sep 25;267(27):19724-9.
5.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	Coenzyme A- and NADH-dependent esterase activity of methylmalonate semialdehyde dehydrogenase.	Popov KM, etal., Biochim Biophys Acta. 1992 Feb 13;1119(1):69-73.
12.	GOA pipeline	RGD automated data pipeline
13.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:1898092	PMID:8889548	PMID:14651853	PMID:18492766	PMID:18614015	PMID:22207704	PMID:22658674	PMID:23376485	PMID:23835272	PMID:26316108

Genomics

Comparative Map Data

Aldh6a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	104,077,975 - 104,098,636 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	104,077,979 - 104,098,656 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	104,239,731 - 104,260,583 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	104,538,815 - 104,559,667 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	103,908,399 - 103,929,251 (-)	NCBI	Rnor_WKY
Rnor_6.0	6	108,146,552 - 108,167,185 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	108,146,582 - 108,167,185 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	117,379,212 - 117,399,845 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	108,495,781 - 108,516,414 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	108,500,592 - 108,736,789 (-)	NCBI
Celera	6	101,905,993 - 101,926,661 (-)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

ALDH6A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	74,056,847 - 74,084,453 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	14	74,056,847 - 74,084,492 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	74,523,550 - 74,551,156 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	73,596,622 - 73,620,949 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	73,596,625 - 73,620,949	NCBI
Celera	14	54,563,821 - 54,588,152 (-)	NCBI		Celera
Cytogenetic Map	14	q24.3	NCBI
HuRef	14	54,691,070 - 54,717,914 (-)	NCBI		HuRef
CHM1_1	14	74,463,827 - 74,490,670 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	68,264,517 - 68,292,135 (-)	NCBI		T2T-CHM13v2.0

Aldh6a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	84,477,491 - 84,497,798 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	84,477,491 - 84,497,778 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	84,430,717 - 84,451,024 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	84,430,717 - 84,451,004 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	85,771,667 - 85,791,900 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	85,320,465 - 85,340,698 (-)	NCBI		MGSCv36	mm8
Celera	12	85,886,230 - 85,906,463 (-)	NCBI		Celera
Cytogenetic Map	12	D1	NCBI
cM Map	12	39.21	NCBI

Aldh6a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955523	1,343,545 - 1,369,073 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955523	1,343,545 - 1,369,080 (+)	NCBI	ChiLan1.0	ChiLan1.0

ALDH6A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	14	73,472,248 - 73,495,734 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	73,472,255 - 73,495,734 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	14	54,616,531 - 54,643,346 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ALDH6A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	47,280,872 - 47,304,460 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	47,282,235 - 47,304,283 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	46,965,176 - 46,988,785 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	47,508,633 - 47,532,183 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	47,508,638 - 47,532,005 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	47,177,814 - 47,201,402 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	47,195,555 - 47,219,148 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	47,586,417 - 47,609,987 (-)	NCBI		UU_Cfam_GSD_1.0

Aldh6a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	28,728,491 - 28,749,256 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	3,318,422 - 3,340,626 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936488	3,320,357 - 3,340,463 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALDH6A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	97,360,610 - 97,381,830 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	97,360,583 - 97,381,885 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	103,115,079 - 103,136,362 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALDH6A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	51,273,257 - 51,296,661 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	51,269,272 - 51,288,826 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	39,498,437 - 39,523,387 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aldh6a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	27,499,411 - 27,524,419 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	27,499,376 - 27,525,783 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Aldh6a1
135 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	179
Count of miRNA genes:	119
Interacting mature miRNAs:	156
Transcripts:	ENSRNOT00000015545
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	45790088	104200226	Rat
6893332	Cm74	Cardiac mass QTL 74	0.4	0.64	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	57730540	104085867	Rat
1558641	Cm47	Cardiac mass QTL 47	2.9	0.001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	6	57730540	104085867	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	61747639	106747639	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	67262953	112262953	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	71201409	116201409	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	72202632	115200186	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72202632	117202632	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	72202632	130729475	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	72202632	130919985	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	72227641	130729205	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	72227641	130729205	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	73463459	109394713	Rat
2293837	Kiddil1	Kidney dilation QTL 1	3.7		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	81132889	104393926	Rat
2293842	Kiddil3	Kidney dilation QTL 3	4.3		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	81132889	104393926	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	82523650	110548006	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	83190345	106747639	Rat
738034	Anxrr5	Anxiety related response QTL 5	5.9		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	6	84130881	129130881	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	85140138	130140138	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	85140138	130140138	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	85311061	133478515	Rat
1300076	Glom8	Glomerulus QTL 8	7	0.000000009	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	6	86894788	131894788	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	88047916	133047916	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	89762877	106752806	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	93701310	128713626	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	94968928	137848904	Rat
12801411	Schws8	Schwannoma susceptibility QTL 8			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	94968928	139968928	Rat
8552796	Vie3	Viral induced encephalitis QTL 3	2.6		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	6	96833997	140994061	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	100364669	140994061	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	100671796	132340886	Rat
1331797	Bp213	Blood pressure QTL 213	3.291		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	104085867	128713626	Rat

Markers in Region

D6Mgh4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	104,085,867 - 104,086,014 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	108,154,445 - 108,154,591	NCBI	Rnor6.0
Rnor_5.0	6	117,391,806 - 117,391,952	UniSTS	Rnor5.0
RGSC_v3.4	6	108,503,674 - 108,503,820	UniSTS	RGSC3.4
RGSC_v3.1	6	108,507,129 - 108,507,276	RGD
Celera	6	101,913,886 - 101,914,031	UniSTS
RH 3.4 Map	6	741.3	RGD
RH 3.4 Map	6	741.3	UniSTS
RH 2.0 Map	6	977.5	RGD
SHRSP x BN Map	6	62.3498	RGD
Cytogenetic Map	6	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA819519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC114437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB760062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK474421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK476335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV797088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DN948946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000015545 ⟹ ENSRNOP00000015545

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	104,077,994 - 104,098,656 (-)	Ensembl
Rnor_6.0 Ensembl	6	108,146,582 - 108,167,185 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102519 ⟹ ENSRNOP00000078147

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	104,077,979 - 104,095,299 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116902 ⟹ ENSRNOP00000097349

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	104,079,005 - 104,098,656 (-)	Ensembl

RefSeq Acc Id:

NM_031057 ⟹ NP_112319

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	104,077,975 - 104,098,636 (-)	NCBI
Rnor_6.0	6	108,146,552 - 108,167,185 (-)	NCBI
Rnor_5.0	6	117,379,212 - 117,399,845 (+)	NCBI
RGSC_v3.4	6	108,495,781 - 108,516,414 (-)	RGD
Celera	6	101,905,993 - 101,926,661 (-)	RGD

Sequence:

show sequence

ACTGGCAGCGGAGGCGCGGGGAGCTGGGCAGAGTCTGGTGAGCCATGGCGGCGGCAGTGGCGGC
AGCAGCAGCAGTGCGGTCCCGGATCCTGCAGGTTTCTTCTAAAGTAAACTCCACATGGTGTCCA
GCATCTTCCTTCTCTTCATCATCAGTGCCAACTGTAAAGCTCTTCATTGATGGGAAATTCGTTG
AATCCAAAAGTGACAAATGGATTGACATCCACAACCCAGCCACCAATGAGGTTGTTGGTCGGGT
TCCTCAGTCCACCAAAGCTGAAATGGAGGCAGCCGTAGCCGCCTGCAAACGTGCTTTCCCTGCG
TGGGCAGACACATCTATTTTAAGCCGGCAGCAGGTCCTGCTTCGTTATCAGCAACTCATTAAAG
AAAACCTGAAAGAAATCGCCAGGTTAATCACATTGGAACAAGGGAAGACTCTGGCTGATGCTGA
AGGAGATGTGTTCCGAGGCCTTCAGGTGGTTGAGCATGCCTGCAGTGTGACGTCCCTCATGCTG
GGAGAGACCATGCCATCTATCACCAAAGACATGGACCTTTATTCCTACCGCCTGCCTCTGGGGG
TGTGTGCAGGCATCGCACCATTTAATTTTCCTGCCATGATCCCCCTTTGGATGTTTCCCATGGC
TATGGTTTGTGGAAATACTTTCCTAATGAAACCATCAGAGCGAGTACCTGGAGCAACCATGCTT
CTTGCTAAGTTGCTTCAGGATTCTGGTGCCCCGGACGGAACACTGAACATCATCCATGGACAAC
ATGAAGCTGTAAATTTTATTTGCGATCATCCAGACATCAAGGCAATCAGCTTTGTGGGATCCAA
CCAGGCGGGAGAGTACATCTTCGAAAGAGGGTCAAGAAATGGCAAGAGGGTTCAAGCCAATATG
GGAGCCAAGAACCATGGGGTAGTCATGCCAGATGCCAATAAGGAAAATACCCTCAACCAGCTGG
TTGGGGCAGCATTTGGAGCTGCTGGGCAGCGCTGCATGGCTCTTTCAACAGCCGTCCTTGTGGG
AGAAGCTAAGAAGTGGCTGCCAGAACTGGTAGAGCGTGCCAAGAATCTCCGCGTCAATGCAGGA
GATCAGCCTGGAGCTGATCTTGGTCCCCTGATCACCCCCCAGGCCAAAGAGAGAGTCTGCAATC
TGATTGATAGTGGAGCAAAAGAGGGGGCTTCCATCCTTCTGGATGGGCGGAAAATTAAAGTTAA
GGGCTACGAAAACGGTAACTTTGTTGGACCAACCATCATCTCCAATGTTAAGCCAAGTATGACT
TGTTACAAAGAGGAGATTTTTGGTCCAGTTCTTGTGGTCTTAGAGACAGAAACCCTGGATGAAG
CCATCAAGATTGTTAATGACAACCCATATGGAAACGGGACTGCTATCTTTACCACCAACGGAGC
CATAGCTCGGAAATACGCTCACATGGTGGATGTGGGACAGGTGGGCGTGAATGTCCCCATTCCA
GTGCCTTTGCCAATGTTTTCCTTCACTGGCTCTCGATCTTCCTTCAGGGGAGACACCAATTTCT
ATGGCAAACAGGGCATCCAGTTTTACACTCAGTTAAAGACTATCACATCTCAGTGGAAGGAAGA
AGATGCTACTCTTTCCTCACCTGCAGTGGTCATGCCTACCATGGGGCGTTAGAACGTTCAAGAC
TCCATCCAGCCTGAGTAACTTCCCACTGTCCTTGGCAATCTTCATCTGCCATCTTTGCTCCAAA
CAGATCCATGAGGATGGAGTATATTGCAATGAAATTCTTTCTCAGAACTCGCAATCCCTTCAAA
GTTATAGGGAGTACAGGATAACACCAACGCCAGGCCTTCACTTGTTCTCCATACTTCTCTACGG
TTTTTGAGGTTAACTGTTGTTAAGTGTGAAGTGTTTGCCTAGAATAAGAGCTTAGAACTGTCTT
CTAACAATTCTTTTCTGATGACTTGGAGGGACAACGTAGGGGCAGATCTTGCAATCACTGAAAC
TGTTCATCCTCTGAGCCTCAATTATAGCCCTCCACCAGTCCCCACACTATCAAACATGTAACCT
AGTTTTACTTATCCCAGCATGGTGATGACTGCTTTTCTGCTCAATACCACTTTCTTCATGGCCA
CTATTTAATTCTATCCATTTCTTGCTTCTTAAAATACTTCTCAAGGTACCTCAGGATGAAGTGA
TAAGTTAGCTTTTTGTTACATGTGCCATTCTTCATGGTTTGCCTCAACAATCATTAAACCAATA
CTCTAGCCATTAATTCAGATACAAATAAATCCTTAGACAAAATATTTCACAAATGGTTTTTGAC
CCAGAAATCAAAGGATCTCCAATCCTGAAAGTGAATAGACTCTTGCCTTAAGTAGCCTTACCTA
TTATTTGCCAAAATATGTTATTCTTTCTTTTGACAGCATTTCTCTTTAGTTGATACTTTTTAAT
GAACAAAACTCTTCATATAGAATAATTGATTAGGCTACTAGAAACTTCAAAGTTTCATGCTTTG
ACAATATTCAGTCACCTTATTCAACTTAGCCAGTTACTCAGCTGCCTTTAAGCTTGCTTCTCTG
ATAATCTGAACCTTAAGTCAGAAGAGGCTGATGTGCTGAACAGAACAGTTTGTCCATCTGACCT
GAAGCCTTGGCTTTCTGAACTAGGCTATGGGTTCTGCTTAGTCTTTAGTGCTTAGTGAGGTGTG
GCGCTGGCCATTTATTTCCCTCTGTTCTGTACAGCCATGTGTGGACAGTGCTGCTCCAGTCCAT
GTGGGCTTTGGTGAGTTGAGATAAAGGTGGTGAAAACCTTGACATTTCCTACTCTTTGGATATA
GATTTTAGAGCAACCGGCTTCGGTAGAATTCAGAGCTTCGGTCACTTTAACAAACCACAACTCT
GATTTCTTTTGTTTTCCACCCTAAAGCAAAGTAGACATTTATACTTCGTGACTGCATAAAATAC
AGTTCATACTTAATTTAATCCAACAATTTTGGGCTGGGTTGAAAAGTGGTTATTATCTAAATTC
CAAATACAATTTAATCTAGACTCCTAATATTTTCCTTAGATATGAAGGAAGTTTCTTTTAAAAA
ATTATGACTAATCAGAATTGTATTGCTTCTAATTATAATCAACAGATACGAGCAGCTACTAGTG
CTCAAAAGAATTTCTTGTTTCTTAGATGAAATTTATATTTGGCTATATTAAGGTTAATATCACT
AAAACAGAAAACCAGCATTTTTCCTTTTTGTTTTTATATGGCCTCATCAAGTTTTTGTGAGCTT
CTATACTGATCATGAATAATAAAATACAAATAAAAAAGCCTTAGGAAAAAATACAAAAAAAAAA
AAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_112319	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL81512	(Get FASTA)	NCBI Sequence Viewer
	EDL81513	(Get FASTA)	NCBI Sequence Viewer
	Q02253	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_112319 ⟸ NM_031057
- Peptide Label:	precursor
- UniProtKB:	Q02253 (UniProtKB/Swiss-Prot), G3V7J0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAVAAAAAVRSRILQVSSKVNSTWCPASSFSSSSVPTVKLFIDGKFVESKSDKWIDIHNPAT NEVVGRVPQSTKAEMEAAVAACKRAFPAWADTSILSRQQVLLRYQQLIKENLKEIARLITLEQG KTLADAEGDVFRGLQVVEHACSVTSLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIP LWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKA ISFVGSNQAGEYIFERGSRNGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMAL STAVLVGEAKKWLPELVERAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGAKEGASILLD GRKIKVKGYENGNFVGPTIISNVKPSMTCYKEEIFGPVLVVLETETLDEAIKIVNDNPYGNGTA IFTTNGAIARKYAHMVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTI TSQWKEEDATLSSPAVVMPTMGR hide sequence

RefSeq Acc Id:

ENSRNOP00000015545 ⟸ ENSRNOT00000015545

RefSeq Acc Id:

ENSRNOP00000097349 ⟸ ENSRNOT00000116902

RefSeq Acc Id:

ENSRNOP00000078147 ⟸ ENSRNOT00000102519

Protein Domains

Aldedh

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q02253-F1-model_v2	AlphaFold	Q02253	1-535	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694726

Promoter ID:

EPDNEW_R5251

Type:

initiation region

Name:

Aldh6a1_1

Description:

aldehyde dehydrogenase 6 family, member A1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	108,167,156 - 108,167,216	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621556	AgrOrtholog
BioCyc Gene	G2FUF-36818	BioCyc
BioCyc Pathway	VALDEG-PWY [L-valine degradation I]	BioCyc
Ensembl Genes	ENSRNOG00000011419	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000015545	ENTREZGENE
	ENSRNOP00000015545.3	UniProtKB/TrEMBL
	ENSRNOP00000078147.1	UniProtKB/TrEMBL
	ENSRNOP00000097349.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015545	ENTREZGENE
	ENSRNOT00000015545.5	UniProtKB/TrEMBL
	ENSRNOT00000102519.1	UniProtKB/TrEMBL
	ENSRNOT00000116902.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.309.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.605.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Ald_DH/histidinol_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_CS_CYS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldehyde_DH_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MeMal-semiAld_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:81708	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	81708	ENTREZGENE
PANTHER	PTHR43866	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Aldedh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Aldh6a1	PhenoGen
PROSITE	ALDEHYDE_DEHYDR_CYS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53720	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	MMSDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5YC72_RAT	UniProtKB/TrEMBL
	A0A8I6ASH9_RAT	UniProtKB/TrEMBL
	G3V7J0	ENTREZGENE, UniProtKB/TrEMBL
	MMSA_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-26	Aldh6a1	aldehyde dehydrogenase 6 family, member A1	Aldh6a1	aldehyde dehydrogenase family 6, subfamily A1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Aldh6a1	aldehyde dehydrogenase family 6, subfamily A1	Mmsdh	methylmalonate semialdehyde dehydrogenase gene	Symbol and Name updated	1299863	APPROVED
2002-08-07	Mmsdh	methylmalonate semialdehyde dehydrogenase gene			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_homology	closely related to betaine aldehyde dehydrogenase	633220
gene_product	member of aldehyde dehydrogenases superfamily	633220
gene_protein	503 amino acids; 55.3 kDa	633220

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)