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Gene: Aldh6a1 (aldehyde dehydrogenase 6 family, member A1) Rattus norvegicus
Symbol: Aldh6a1
Name: aldehyde dehydrogenase 6 family, member A1
RGD ID: 621556
Description: Exhibits malonate-semialdehyde dehydrogenase (acetylating) activity; methylmalonate-semialdehyde dehydrogenase (acylating) activity; and thiolester hydrolase activity. Involved in beta-alanine catabolic process; thymine catabolic process; and valine catabolic process. Predicted to localize to mitochondrion and nucleoplasm. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aldehyde dehydrogenase family 6 member A1; aldehyde dehydrogenase family 6, subfamily A1; malonate-semialdehyde dehydrogenase; methylmalonate semialdehyde dehydrogenase; methylmalonate semialdehyde dehydrogenase gene; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Mmsdh
Homo sapiens (human) : ALDH6A1 (aldehyde dehydrogenase 6 family member A1)  HGNC  Alliance
Mus musculus (house mouse) : Aldh6a1 (aldehyde dehydrogenase family 6, subfamily A1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldh6a1 (aldehyde dehydrogenase 6 family member A1)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDH6A1 (aldehyde dehydrogenase 6 family member A1)
Canis lupus familiaris (dog) : ALDH6A1 (aldehyde dehydrogenase 6 family member A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aldh6a1 (aldehyde dehydrogenase 6 family member A1)
Sus scrofa (pig) : ALDH6A1 (aldehyde dehydrogenase 6 family member A1)
Chlorocebus sabaeus (African green monkey) : ALDH6A1 (aldehyde dehydrogenase 6 family member A1)
Heterocephalus glaber (naked mole-rat) : Aldh6a1 (aldehyde dehydrogenase 6 family member A1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06108,146,552 - 108,167,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,146,582 - 108,167,185 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,379,212 - 117,399,845 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,495,781 - 108,516,414 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16108,500,592 - 108,736,789 (-)NCBI
Celera6101,905,993 - 101,926,661 (-)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Aldh6a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621556
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.