Aldh6a1 (aldehyde dehydrogenase 6 family, member A1) - Rat Genome Database

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Gene: Aldh6a1 (aldehyde dehydrogenase 6 family, member A1) Rattus norvegicus
Analyze
Symbol: Aldh6a1
Name: aldehyde dehydrogenase 6 family, member A1
RGD ID: 621556
Description: Enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity and thiolester hydrolase activity. Involved in beta-alanine catabolic process; thymine catabolic process; and valine catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde dehydrogenase family 6 member A1; aldehyde dehydrogenase family 6, subfamily A1; malonate-semialdehyde dehydrogenase; methylmalonate semialdehyde dehydrogenase; methylmalonate semialdehyde dehydrogenase gene; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial; Mmsdh
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,809,092 - 109,829,725 (-)NCBIGRCr8
mRatBN7.26104,077,975 - 104,098,636 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,077,979 - 104,098,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,239,731 - 104,260,583 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,538,815 - 104,559,667 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06103,908,399 - 103,929,251 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,146,552 - 108,167,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,146,582 - 108,167,185 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,379,212 - 117,399,845 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,495,781 - 108,516,414 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16108,500,592 - 108,736,789 (-)NCBI
Celera6101,905,993 - 101,926,661 (-)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
antimony(0)  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycidyl methacrylate  (ISO)
Heliotrine  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methylisothiazolinone  (ISO)
motexafin gadolinium  (ISO)
Muraglitazar  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfasalazine  (EXP)
sulindac  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Purification and characterization of methylmalonate-semialdehyde dehydrogenase from rat liver. Identity to malonate-semialdehyde dehydrogenase. Goodwin GW, etal., J Biol Chem. 1989 Sep 5;264(25):14965-71.
4. CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distribution. Kedishvili NY, etal., J Biol Chem 1992 Sep 25;267(27):19724-9.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Coenzyme A- and NADH-dependent esterase activity of methylmalonate semialdehyde dehydrogenase. Popov KM, etal., Biochim Biophys Acta. 1992 Feb 13;1119(1):69-73.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:1898092   PMID:8889548   PMID:14651853   PMID:18492766   PMID:18614015   PMID:22207704   PMID:22658674   PMID:23376485   PMID:23835272   PMID:26316108  


Genomics

Comparative Map Data
Aldh6a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,809,092 - 109,829,725 (-)NCBIGRCr8
mRatBN7.26104,077,975 - 104,098,636 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,077,979 - 104,098,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,239,731 - 104,260,583 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,538,815 - 104,559,667 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06103,908,399 - 103,929,251 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,146,552 - 108,167,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,146,582 - 108,167,185 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,379,212 - 117,399,845 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,495,781 - 108,516,414 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16108,500,592 - 108,736,789 (-)NCBI
Celera6101,905,993 - 101,926,661 (-)NCBICelera
Cytogenetic Map6q31NCBI
ALDH6A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,056,847 - 74,084,453 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,056,847 - 74,084,492 (-)EnsemblGRCh38hg38GRCh38
GRCh371474,523,550 - 74,551,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361473,596,622 - 73,620,949 (-)NCBINCBI36Build 36hg18NCBI36
Build 341473,596,625 - 73,620,949NCBI
Celera1454,563,821 - 54,588,152 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1454,691,070 - 54,717,914 (-)NCBIHuRef
CHM1_11474,463,827 - 74,490,670 (-)NCBICHM1_1
T2T-CHM13v2.01468,264,517 - 68,292,135 (-)NCBIT2T-CHM13v2.0
Aldh6a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,477,491 - 84,497,798 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,477,491 - 84,497,778 (-)EnsemblGRCm39 Ensembl
GRCm381284,430,717 - 84,451,024 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,430,717 - 84,451,004 (-)EnsemblGRCm38mm10GRCm38
MGSCv371285,771,667 - 85,791,900 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361285,320,465 - 85,340,698 (-)NCBIMGSCv36mm8
Celera1285,886,230 - 85,906,463 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.21NCBI
Aldh6a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555231,343,545 - 1,369,073 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555231,343,545 - 1,369,080 (+)NCBIChiLan1.0ChiLan1.0
ALDH6A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21575,147,212 - 75,174,139 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11474,364,771 - 74,390,647 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01454,616,531 - 54,643,346 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11473,472,248 - 73,495,734 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,472,255 - 73,495,734 (-)Ensemblpanpan1.1panPan2
ALDH6A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1847,280,872 - 47,304,460 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl847,282,235 - 47,304,283 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha846,965,176 - 46,988,785 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0847,508,633 - 47,532,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl847,508,638 - 47,532,005 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,177,814 - 47,201,402 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,195,555 - 47,219,148 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,586,417 - 47,609,987 (-)NCBIUU_Cfam_GSD_1.0
Aldh6a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864028,728,491 - 28,749,256 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364883,318,422 - 3,340,626 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364883,320,357 - 3,340,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH6A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,360,610 - 97,381,830 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1797,360,583 - 97,381,885 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,115,079 - 103,136,362 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH6A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12451,273,257 - 51,296,661 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2451,269,272 - 51,288,826 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605339,498,437 - 39,523,387 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh6a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473427,499,411 - 27,524,419 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473427,499,376 - 27,525,783 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh6a1
163 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:119
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000015545
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat

Markers in Region
D6Mgh4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,085,867 - 104,086,014 (+)MAPPERmRatBN7.2
Rnor_6.06108,154,445 - 108,154,591NCBIRnor6.0
Rnor_5.06117,391,806 - 117,391,952UniSTSRnor5.0
RGSC_v3.46108,503,674 - 108,503,820UniSTSRGSC3.4
RGSC_v3.16108,507,129 - 108,507,276RGD
Celera6101,913,886 - 101,914,031UniSTS
RH 3.4 Map6741.3RGD
RH 3.4 Map6741.3UniSTS
RH 2.0 Map6977.5RGD
SHRSP x BN Map662.3498RGD
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015545   ⟹   ENSRNOP00000015545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,077,994 - 104,098,656 (-)Ensembl
Rnor_6.0 Ensembl6108,146,582 - 108,167,185 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102519   ⟹   ENSRNOP00000078147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,077,979 - 104,095,299 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116902   ⟹   ENSRNOP00000097349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,079,005 - 104,098,656 (-)Ensembl
RefSeq Acc Id: NM_031057   ⟹   NP_112319
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86109,809,092 - 109,829,725 (-)NCBI
mRatBN7.26104,077,975 - 104,098,636 (-)NCBI
Rnor_6.06108,146,552 - 108,167,185 (-)NCBI
Rnor_5.06117,379,212 - 117,399,845 (+)NCBI
RGSC_v3.46108,495,781 - 108,516,414 (-)RGD
Celera6101,905,993 - 101,926,661 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112319 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81512 (Get FASTA)   NCBI Sequence Viewer  
  EDL81513 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015545.3
  ENSRNOP00000078147.1
  ENSRNOP00000097349.1
  ENSRNOP00055036995
  ENSRNOP00060036124
  ENSRNOP00065039195
GenBank Protein Q02253 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112319   ⟸   NM_031057
- Peptide Label: precursor
- UniProtKB: Q02253 (UniProtKB/Swiss-Prot),   G3V7J0 (UniProtKB/TrEMBL),   A6JDW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015545   ⟸   ENSRNOT00000015545
Ensembl Acc Id: ENSRNOP00000097349   ⟸   ENSRNOT00000116902
Ensembl Acc Id: ENSRNOP00000078147   ⟸   ENSRNOT00000102519
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02253-F1-model_v2 AlphaFold Q02253 1-535 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694726
Promoter ID:EPDNEW_R5251
Type:initiation region
Name:Aldh6a1_1
Description:aldehyde dehydrogenase 6 family, member A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06108,167,156 - 108,167,216EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621556 AgrOrtholog
BioCyc Gene G2FUF-36818 BioCyc
BioCyc Pathway VALDEG-PWY [L-valine degradation I] BioCyc
BioCyc Pathway Image VALDEG-PWY BioCyc
Ensembl Genes ENSRNOG00000011419 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055026126 UniProtKB/Swiss-Prot
  ENSRNOG00060025142 UniProtKB/Swiss-Prot
  ENSRNOG00065027727 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015545.5 UniProtKB/TrEMBL
  ENSRNOT00000102519.1 UniProtKB/TrEMBL
  ENSRNOT00000116902.1 UniProtKB/TrEMBL
  ENSRNOT00055045106 UniProtKB/Swiss-Prot
  ENSRNOT00060043577 UniProtKB/Swiss-Prot
  ENSRNOT00065047785 UniProtKB/Swiss-Prot
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MeMal-semiAld_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81708 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81708 ENTREZGENE
PANTHER METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43866 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldedh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aldh6a1 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011419 RatGTEx
  ENSRNOG00055026126 RatGTEx
  ENSRNOG00060025142 RatGTEx
  ENSRNOG00065027727 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5YC72_RAT UniProtKB/TrEMBL
  A0A8I6ASH9_RAT UniProtKB/TrEMBL
  A6JDW8 ENTREZGENE, UniProtKB/TrEMBL
  A6JDW9_RAT UniProtKB/TrEMBL
  G3V7J0 ENTREZGENE, UniProtKB/TrEMBL
  MMSA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aldh6a1  aldehyde dehydrogenase 6 family, member A1  Aldh6a1  aldehyde dehydrogenase family 6, subfamily A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Aldh6a1  aldehyde dehydrogenase family 6, subfamily A1  Mmsdh  methylmalonate semialdehyde dehydrogenase gene  Symbol and Name updated 1299863 APPROVED
2002-08-07 Mmsdh  methylmalonate semialdehyde dehydrogenase gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology closely related to betaine aldehyde dehydrogenase 633220
gene_product member of aldehyde dehydrogenases superfamily 633220
gene_protein 503 amino acids; 55.3 kDa 633220