Cox8c (cytochrome c oxidase subunit 8C) - Rat Genome Database

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Gene: Cox8c (cytochrome c oxidase subunit 8C) Rattus norvegicus
Analyze
Symbol: Cox8c
Name: cytochrome c oxidase subunit 8C
RGD ID: 727840
Description: Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Orthologous to human COX8C (cytochrome c oxidase subunit 8C); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH acrylamide; bisphenol A; indole-3-methanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: COX VIII-3; COXVIII-3; cytochrome c oxidase polypeptide 8; cytochrome c oxidase polypeptide VIII; cytochrome c oxidase subunit 8-3; cytochrome c oxidase subunit 8C, mitochondrial; cytochrome c oxidase subunit VIII; cytochrome c oxidase subunit VIII isoform 3; cytochrome c oxidase, subunit 8C; cytochrome c oxidase, subunit VIIIc; LOC360229
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,793,379 - 127,794,702 (+)NCBIGRCr8
mRatBN7.26122,028,566 - 122,029,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,028,566 - 122,029,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6122,166,956 - 122,168,278 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06122,462,221 - 122,463,543 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,798,339 - 121,799,672 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,766,967 - 126,768,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,766,967 - 126,768,290 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,972,917 - 135,974,240 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,161,354 - 127,162,677 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16127,165,100 - 127,166,424 (+)NCBI
Celera6119,515,028 - 119,516,351 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12762575   PMID:12909344   PMID:18614015  


Genomics

Comparative Map Data
Cox8c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,793,379 - 127,794,702 (+)NCBIGRCr8
mRatBN7.26122,028,566 - 122,029,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,028,566 - 122,029,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6122,166,956 - 122,168,278 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06122,462,221 - 122,463,543 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,798,339 - 121,799,672 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,766,967 - 126,768,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,766,967 - 126,768,290 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,972,917 - 135,974,240 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,161,354 - 127,162,677 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16127,165,100 - 127,166,424 (+)NCBI
Celera6119,515,028 - 119,516,351 (+)NCBICelera
Cytogenetic Map6q32NCBI
COX8C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381493,347,182 - 93,348,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1493,347,182 - 93,348,356 (+)EnsemblGRCh38hg38GRCh38
GRCh371493,813,528 - 93,814,702 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361492,883,290 - 92,884,453 (+)NCBINCBI36Build 36hg18NCBI36
Build 341492,883,289 - 92,884,453NCBI
Celera1473,867,551 - 73,868,714 (+)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1473,993,564 - 73,994,727 (+)NCBIHuRef
CHM1_11493,751,557 - 93,752,720 (+)NCBICHM1_1
T2T-CHM13v2.01487,579,055 - 87,580,228 (+)NCBIT2T-CHM13v2.0
Cox8c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,865,565 - 102,866,793 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,865,575 - 102,866,785 (+)EnsemblGRCm39 Ensembl
GRCm3812102,899,306 - 102,900,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,899,316 - 102,900,526 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712104,137,516 - 104,138,744 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612103,300,356 - 103,301,584 (+)NCBIMGSCv36mm8
Celera12104,116,515 - 104,117,743 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.55NCBI
LOC102005637
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543815,480,509 - 15,481,812 (+)NCBIChiLan1.0ChiLan1.0
LOC100984553
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21594,493,815 - 94,571,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11493,707,703 - 93,772,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01473,979,629 - 73,984,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11493,316,013 - 93,317,217 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1493,316,013 - 93,317,217 (+)Ensemblpanpan1.1panPan2
LOC100856429
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,401,351 - 25,402,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,051,304 - 25,052,818 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01825,928,113 - 25,929,627 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11825,496,165 - 25,497,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,140,874 - 25,142,388 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,753,536 - 25,755,050 (-)NCBIUU_Cfam_GSD_1.0
LOC100157935
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.17114,727,841 - 114,729,102 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27121,313,089 - 121,314,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COX8C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12471,098,014 - 71,099,417 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2471,098,346 - 71,099,180 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605358,339,240 - 58,350,907 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cox8c
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:86
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000052296
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6
Medium 2
Low 1 2 2 1 2 2 2 1 10 2 2
Below cutoff 4 12 7 6 7 2 4 12 4 13 4 2

Sequence


RefSeq Acc Id: ENSRNOT00000052296   ⟹   ENSRNOP00000047295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6122,028,566 - 122,029,889 (+)Ensembl
Rnor_6.0 Ensembl6126,766,967 - 126,768,290 (+)Ensembl
RefSeq Acc Id: NM_183055   ⟹   NP_898878
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86127,793,379 - 127,794,702 (+)NCBI
mRatBN7.26122,028,566 - 122,029,889 (+)NCBI
Rnor_6.06126,766,967 - 126,768,290 (+)NCBI
Rnor_5.06135,972,917 - 135,974,240 (+)NCBI
RGSC_v3.46127,161,354 - 127,162,677 (+)RGD
Celera6119,515,028 - 119,516,351 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_898878 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO26194 (Get FASTA)   NCBI Sequence Viewer  
  EDL81762 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047295
  ENSRNOP00000047295.1
  ENSRNOP00055022205
  ENSRNOP00060006221
  ENSRNOP00065018325
GenBank Protein Q7TNN2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_898878   ⟸   NM_183055
- UniProtKB: Q7TNN2 (UniProtKB/Swiss-Prot),   A6JEL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047295   ⟸   ENSRNOT00000052296

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TNN2-F1-model_v2 AlphaFold Q7TNN2 1-72 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694789
Promoter ID:EPDNEW_R5313
Type:initiation region
Name:Cox8c_1
Description:cytochrome c oxidase subunit 8C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06126,766,994 - 126,767,054EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727840 AgrOrtholog
BioCyc Gene G2FUF-36430 BioCyc
Ensembl Genes ENSRNOG00000031106 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055016323 UniProtKB/Swiss-Prot
  ENSRNOG00060004960 UniProtKB/Swiss-Prot
  ENSRNOG00065014287 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000052296 ENTREZGENE
  ENSRNOT00000052296.2 UniProtKB/Swiss-Prot
  ENSRNOT00055027670 UniProtKB/Swiss-Prot
  ENSRNOT00060008275 UniProtKB/Swiss-Prot
  ENSRNOT00065023559 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.81.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_c_oxidase_su8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxidase_su8_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 360229 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE POLYPEPTIDE VIII UniProtKB/TrEMBL
  CYTOCHROME C OXIDASE SUBUNIT 8C, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16717 UniProtKB/Swiss-Prot
Pfam COX8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cox8c PhenoGen
RatGTEx ENSRNOG00000031106 RatGTEx
  ENSRNOG00055016323 RatGTEx
  ENSRNOG00060004960 RatGTEx
  ENSRNOG00065014287 RatGTEx
Superfamily-SCOP Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX) UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JEL8 ENTREZGENE, UniProtKB/TrEMBL
  COX8C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Cox8c  cytochrome c oxidase subunit 8C  Cox8c  cytochrome c oxidase, subunit VIIIc  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-18 Cox8c  cytochrome c oxidase, subunit VIIIc  Cox8c  cytochrome c oxidase, subunit 8C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Cox8c  cytochrome c oxidase, subunit 8C  Cox8c  cytochrome c oxidase, subunit 8c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Cox8c  cytochrome c oxidase, subunit 8c  LOC360229  cytochrome c oxidase subunit VIII isoform 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-28 LOC360229        Symbol and Name status set to provisional 70820 PROVISIONAL