Cacna1e (calcium voltage-gated channel subunit alpha1 E) - Rat Genome Database

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Gene: Cacna1e (calcium voltage-gated channel subunit alpha1 E) Rattus norvegicus
Analyze
Symbol: Cacna1e
Name: calcium voltage-gated channel subunit alpha1 E
RGD ID: 2246
Description: Enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in calcium ion import and regulation of synaptic vesicle exocytosis. Located in perikaryon. Part of voltage-gated calcium channel complex. Is active in GABA-ergic synapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 69. Orthologous to human CACNA1E (calcium voltage-gated channel subunit alpha1 E); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BII; brain calcium channel II; CACHA1E; calcium channel, L type, alpha-1 polypeptide; calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, voltage-dependent, L type, alpha 1E subunit; calcium channel, voltage-dependent, R type, alpha 1E subunit; Cav2.3; RBE-II; RBE2; voltage gated calcium channel alpha1E subunit; voltage-dependent calcium channel alpha1-E subunit; voltage-dependent R-type calcium channel subunit alpha-1E; voltage-gated calcium channel subunit alpha Cav2.3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21366,574,659 - 67,063,443 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1366,581,920 - 66,894,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1369,159,829 - 69,478,689 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01370,484,751 - 70,793,099 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01367,745,152 - 68,054,007 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01371,899,445 - 72,534,992 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1371,906,702 - 72,367,980 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01376,843,146 - 77,473,206 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41369,367,254 - 69,683,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11369,380,942 - 69,697,975 (-)NCBI
Celera1366,463,930 - 66,771,500 (-)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Voltage-gated calcium channels. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
2. Two sets of amino acids of the domain I of Cav2.3 Ca(2+) channels contribute to their high sensitivity to extracellular protons. Cens T, etal., Pflugers Arch. 2011 Aug;462(2):303-14. doi: 10.1007/s00424-011-0974-x. Epub 2011 May 25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Isoflurane-sensitive presynaptic R-type calcium channels contribute to inhibitory synaptic transmission in the rat thalamus. Joksovic PM, etal., J Neurosci. 2009 Feb 4;29(5):1434-45. doi: 10.1523/JNEUROSCI.5574-08.2009.
6. Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation. Kim EY, etal., Structure. 2008 Oct 8;16(10):1455-67. doi: 10.1016/j.str.2008.07.010.
7. Expression of voltage-gated Ca2+ channel subtypes in cultured astrocytes. Latour I, etal., Glia 2003 Mar;41(4):347-53.
8. Mice lacking Ca(v)2.3 (alpha1E) calcium channel exhibit hyperglycemia. Matsuda Y, etal., Biochem Biophys Res Commun 2001 Dec 14;289(4):791-5.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Voltage-gated calcium channels in adult rat inferior colliculus neurons. N'Gouemo P and Morad M, Neuroscience 2003;120(3):815-26.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Antisense oligonucleotides against rat brain alpha1E DNA and its atrial homologue decrease T-type calcium current in atrial myocytes. Piedras-Renteria ES, etal., Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14936-41.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague-Dawley rats. Rijkers K, etal., Epilepsy Res. 2010 Sep;91(1):28-34. Epub 2010 Jul 16.
18. Structure and functional expression of a member of the low voltage-activated calcium channel family. Soong TW, etal., Science 1993 May 21;260(5111):1133-6.
19. Differential distribution of voltage-gated calcium channels in dopaminergic neurons of the rat retina. Witkovsky P, etal., J Comp Neurol. 2006 Jul 20;497(3):384-96.
Additional References at PubMed
PMID:8071363   PMID:9582423   PMID:10377343   PMID:10801976   PMID:11102459   PMID:11263998   PMID:11854466   PMID:11923483   PMID:11959138   PMID:12074836   PMID:12151091   PMID:12827191  
PMID:14519849   PMID:14976402   PMID:15258581   PMID:15630454   PMID:17369816   PMID:17376845   PMID:17893194   PMID:19726083   PMID:20568961   PMID:22846999   PMID:23015445   PMID:23537331  
PMID:30343943  


Genomics

Comparative Map Data
Cacna1e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21366,574,659 - 67,063,443 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1366,581,920 - 66,894,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1369,159,829 - 69,478,689 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01370,484,751 - 70,793,099 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01367,745,152 - 68,054,007 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01371,899,445 - 72,534,992 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1371,906,702 - 72,367,980 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01376,843,146 - 77,473,206 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41369,367,254 - 69,683,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11369,380,942 - 69,697,975 (-)NCBI
Celera1366,463,930 - 66,771,500 (-)NCBICelera
Cytogenetic Map13q21NCBI
CACNA1E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381181,317,699 - 181,808,084 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1181,317,690 - 181,813,262 (+)EnsemblGRCh38hg38GRCh38
GRCh371181,452,653 - 181,777,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361179,719,339 - 180,037,339 (+)NCBINCBI36Build 36hg18NCBI36
Build 341178,184,372 - 178,502,370NCBI
Celera1154,559,815 - 154,877,831 (+)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1152,684,592 - 153,007,527 (+)NCBIHuRef
CHM1_11182,875,471 - 183,198,679 (+)NCBICHM1_1
T2T-CHM13v2.01180,673,125 - 181,163,498 (+)NCBIT2T-CHM13v2.0
Cacna1e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,266,552 - 154,760,374 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,266,477 - 154,760,247 (-)EnsemblGRCm39 Ensembl
GRCm381154,390,806 - 154,884,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,390,731 - 154,884,501 (-)EnsemblGRCm38mm10GRCm38
MGSCv371156,239,649 - 156,573,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361156,158,170 - 156,488,574 (-)NCBIMGSCv36mm8
Celera1156,824,777 - 157,160,713 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map166.14NCBI
Cacna1e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540620,510,954 - 20,816,678 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540620,356,564 - 20,824,679 (+)NCBIChiLan1.0ChiLan1.0
CACNA1E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1167,630,599 - 68,013,823 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,796,855 - 157,296,987 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11160,627,210 - 160,957,228 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1160,628,089 - 160,949,270 (+)Ensemblpanpan1.1panPan2
CACNA1E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1714,892,165 - 15,267,418 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl714,707,801 - 15,267,422 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha714,468,762 - 14,855,678 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0714,765,860 - 15,001,883 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl714,504,232 - 15,000,034 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1714,528,588 - 14,909,826 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0714,637,758 - 15,018,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0714,762,516 - 15,144,544 (+)NCBIUU_Cfam_GSD_1.0
Cacna1e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934489,848,150 - 90,292,121 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364817,702,152 - 7,993,263 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364817,694,960 - 7,908,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9123,006,195 - 123,315,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19122,827,386 - 123,318,372 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29135,315,145 - 135,473,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNA1E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12547,589,859 - 47,924,081 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2547,597,808 - 47,922,969 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605548,962,031 - 49,465,823 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna1e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247711,733,215 - 2,039,784 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247711,554,875 - 2,047,597 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cacna1e
3084 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:64
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000003869, ENSRNOT00000003928
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat

Markers in Region
D13Got45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21366,706,825 - 66,707,096 (+)MAPPERmRatBN7.2
Rnor_6.01372,031,440 - 72,031,708NCBIRnor6.0
Rnor_5.01376,974,692 - 76,974,960UniSTSRnor5.0
RGSC_v3.41369,494,047 - 69,494,326RGDRGSC3.4
RGSC_v3.41369,494,047 - 69,494,315UniSTSRGSC3.4
RGSC_v3.11369,508,127 - 69,508,395RGD
Celera1366,584,506 - 66,584,761UniSTS
RH 3.4 Map13341.9RGD
RH 3.4 Map13341.9UniSTS
Cytogenetic Map13q21UniSTS
RH71332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21366,606,809 - 66,606,999 (+)MAPPERmRatBN7.2
Rnor_6.01371,931,591 - 71,931,780NCBIRnor6.0
Rnor_5.01376,875,016 - 76,875,205UniSTSRnor5.0
RGSC_v3.41369,391,752 - 69,391,941UniSTSRGSC3.4
RGSC_v3.475,332,129 - 5,332,317UniSTSRGSC3.4
Celera1366,488,428 - 66,488,617UniSTS
Celera73,069,950 - 3,070,138UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map13q21UniSTS
RH142860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21366,602,027 - 66,602,131 (+)MAPPERmRatBN7.2
Rnor_6.01371,926,810 - 71,926,913NCBIRnor6.0
Rnor_5.01376,870,235 - 76,870,338UniSTSRnor5.0
RGSC_v3.41369,386,971 - 69,387,074UniSTSRGSC3.4
Celera1366,483,647 - 66,483,750UniSTS
RH 3.4 Map13359.8UniSTS
Cytogenetic Map13q21UniSTS
AW530514  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21366,835,495 - 66,835,689 (+)MAPPERmRatBN7.2
Rnor_6.01372,309,010 - 72,309,203NCBIRnor6.0
Rnor_5.01377,247,959 - 77,248,152UniSTSRnor5.0
RGSC_v3.41369,623,579 - 69,623,772UniSTSRGSC3.4
Celera1366,712,994 - 66,713,187UniSTS
RH 3.4 Map13372.5UniSTS
Cytogenetic Map13q21UniSTS
BF409484  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21366,888,334 - 66,888,550 (+)MAPPERmRatBN7.2
Rnor_6.01372,361,872 - 72,362,087NCBIRnor6.0
Rnor_5.01377,300,394 - 77,300,609UniSTSRnor5.0
RGSC_v3.41369,677,828 - 69,678,043UniSTSRGSC3.4
Celera1366,765,385 - 66,765,600UniSTS
RH 3.4 Map13342.0UniSTS
Cytogenetic Map13q21UniSTS
BE119343  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21366,708,700 - 66,708,873 (+)MAPPERmRatBN7.2
Rnor_6.01372,033,312 - 72,033,484NCBIRnor6.0
Rnor_5.01376,976,564 - 76,976,736UniSTSRnor5.0
RGSC_v3.41369,495,919 - 69,496,091UniSTSRGSC3.4
Celera1366,586,363 - 66,586,535UniSTS
RH 3.4 Map13343.4UniSTS
Cytogenetic Map13q21UniSTS
Cacna1e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21366,894,614 - 66,894,738 (+)MAPPERmRatBN7.2
Rnor_6.01372,368,152 - 72,368,275NCBIRnor6.0
Rnor_5.01377,306,674 - 77,306,797UniSTSRnor5.0
RGSC_v3.41369,684,108 - 69,684,231UniSTSRGSC3.4
Celera1366,771,665 - 66,771,788UniSTS
Cytogenetic Map13q21UniSTS
Ptp4a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X137,875,660 - 137,876,614 (-)MAPPERmRatBN7.2
Rnor_6.0965,085,524 - 65,086,268NCBIRnor6.0
Rnor_6.01372,154,591 - 72,155,544NCBIRnor6.0
Rnor_5.01377,096,527 - 77,097,480UniSTSRnor5.0
Rnor_5.0964,882,122 - 64,882,866UniSTSRnor5.0
RGSC_v3.4X145,027,098 - 145,028,051UniSTSRGSC3.4
RGSC_v3.4956,853,881 - 56,854,858UniSTSRGSC3.4
Celera957,179,170 - 57,180,147UniSTS
CeleraX133,964,534 - 133,965,487UniSTS
Cytogenetic Map9q21UniSTS
Cytogenetic Map13q21UniSTS
Cytogenetic Map9q31UniSTS
Cytogenetic MapXq36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 58 1
Low 3 2 3 2 16 27 2
Below cutoff 3 38 26 11 15 11 8 8 29 13 9 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF009419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF057029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF146634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY029412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L15453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000003869   ⟹   ENSRNOP00000003869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1366,581,920 - 66,894,450 (-)Ensembl
Rnor_6.0 Ensembl1371,906,972 - 72,063,488 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000003928   ⟹   ENSRNOP00000003928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1366,581,920 - 66,894,443 (-)Ensembl
Rnor_6.0 Ensembl1371,907,171 - 72,367,980 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090544   ⟹   ENSRNOP00000069641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1366,581,920 - 66,894,450 (-)Ensembl
Rnor_6.0 Ensembl1371,906,702 - 72,063,347 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108662   ⟹   ENSRNOP00000077051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1366,582,062 - 66,894,414 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114343   ⟹   ENSRNOP00000079184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1366,581,920 - 66,894,450 (-)Ensembl
RefSeq Acc Id: NM_019294   ⟹   NP_062167
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,581,920 - 66,894,450 (-)NCBI
Rnor_6.01371,907,093 - 72,367,987 (-)NCBI
Rnor_5.01376,843,146 - 77,473,206 (-)NCBI
RGSC_v3.41369,367,254 - 69,683,943 (-)RGD
Celera1366,463,930 - 66,771,500 (-)RGD
Sequence:
RefSeq Acc Id: XM_017598908   ⟹   XP_017454397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,582,389 - 67,062,927 (-)NCBI
Rnor_6.01371,899,445 - 72,534,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598911   ⟹   XP_017454400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,581,920 - 67,062,927 (-)NCBI
Rnor_6.01371,907,093 - 72,534,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598913   ⟹   XP_017454402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,582,073 - 67,062,925 (-)NCBI
Rnor_6.01371,906,855 - 72,534,912 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598914   ⟹   XP_017454403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,582,389 - 67,062,926 (-)NCBI
Rnor_6.01371,907,171 - 72,534,912 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598915   ⟹   XP_017454404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,582,389 - 67,062,927 (-)NCBI
Rnor_6.01371,907,171 - 72,534,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091007   ⟹   XP_038946935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,574,659 - 67,062,927 (-)NCBI
RefSeq Acc Id: XM_039091008   ⟹   XP_038946936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,574,659 - 67,063,443 (-)NCBI
RefSeq Acc Id: XM_039091009   ⟹   XP_038946937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,574,659 - 67,012,195 (-)NCBI
RefSeq Acc Id: XM_039091010   ⟹   XP_038946938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,574,659 - 67,062,928 (-)NCBI
RefSeq Acc Id: XM_039091011   ⟹   XP_038946939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,574,659 - 67,062,928 (-)NCBI
RefSeq Acc Id: XM_039091012   ⟹   XP_038946940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,574,659 - 67,062,929 (-)NCBI
RefSeq Acc Id: XM_039091013   ⟹   XP_038946941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,574,659 - 67,062,927 (-)NCBI
RefSeq Acc Id: XM_039091015   ⟹   XP_038946943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,574,659 - 67,062,926 (-)NCBI
RefSeq Acc Id: XM_039091016   ⟹   XP_038946944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,574,659 - 67,062,926 (-)NCBI
RefSeq Acc Id: XM_039091017   ⟹   XP_038946945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,574,659 - 66,895,611 (-)NCBI
RefSeq Acc Id: XM_039091018   ⟹   XP_038946946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21366,598,736 - 67,062,929 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062167 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454397 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454400 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454402 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454403 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454404 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946935 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946936 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946937 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946938 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946939 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946940 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946941 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946943 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946944 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946945 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946946 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40855 (Get FASTA)   NCBI Sequence Viewer  
  AAB96650 (Get FASTA)   NCBI Sequence Viewer  
  AAC53581 (Get FASTA)   NCBI Sequence Viewer  
  AAD23737 (Get FASTA)   NCBI Sequence Viewer  
  AAD31924 (Get FASTA)   NCBI Sequence Viewer  
  AAK33009 (Get FASTA)   NCBI Sequence Viewer  
  EDM09520 (Get FASTA)   NCBI Sequence Viewer  
  EDM09521 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003869.7
  ENSRNOP00000003928
  ENSRNOP00000003928.7
  ENSRNOP00000069641.2
  ENSRNOP00000077051.1
  ENSRNOP00000079184.1
GenBank Protein Q07652 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062167   ⟸   NM_019294
- UniProtKB: Q923K6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454397   ⟸   XM_017598908
- Peptide Label: isoform X3
- UniProtKB: Q923K6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454402   ⟸   XM_017598913
- Peptide Label: isoform X10
- UniProtKB: A0A0G2JVW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454400   ⟸   XM_017598911
- Peptide Label: isoform X7
- UniProtKB: Q923K6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454404   ⟸   XM_017598915
- Peptide Label: isoform X12
- UniProtKB: A0A0G2JVW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454403   ⟸   XM_017598914
- Peptide Label: isoform X11
- UniProtKB: A0A0G2JVW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069641   ⟸   ENSRNOT00000090544
RefSeq Acc Id: ENSRNOP00000003928   ⟸   ENSRNOT00000003928
RefSeq Acc Id: ENSRNOP00000003869   ⟸   ENSRNOT00000003869
RefSeq Acc Id: XP_038946936   ⟸   XM_039091008
- Peptide Label: isoform X1
- UniProtKB: Q923K6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946940   ⟸   XM_039091012
- Peptide Label: isoform X5
- UniProtKB: F1LMS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946939   ⟸   XM_039091011
- Peptide Label: isoform X4
- UniProtKB: F1LMS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946938   ⟸   XM_039091010
- Peptide Label: isoform X2
- UniProtKB: Q923K6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946941   ⟸   XM_039091013
- Peptide Label: isoform X6
- UniProtKB: Q923K6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946935   ⟸   XM_039091007
- Peptide Label: isoform X1
- UniProtKB: Q923K6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946943   ⟸   XM_039091015
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZMA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946944   ⟸   XM_039091016
- Peptide Label: isoform X9
- UniProtKB: A0A0G2JVW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946937   ⟸   XM_039091009
- Peptide Label: isoform X1
- UniProtKB: Q923K6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946945   ⟸   XM_039091017
- Peptide Label: isoform X13
- UniProtKB: Q923K6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946946   ⟸   XM_039091018
- Peptide Label: isoform X14
RefSeq Acc Id: ENSRNOP00000079184   ⟸   ENSRNOT00000114343
RefSeq Acc Id: ENSRNOP00000077051   ⟸   ENSRNOT00000108662
Protein Domains
EF-hand   Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07652-F1-model_v2 AlphaFold Q07652 1-2222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2246 AgrOrtholog
BioCyc Gene G2FUF-17859 BioCyc
Ensembl Genes ENSRNOG00000002863 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003869.8 UniProtKB/TrEMBL
  ENSRNOT00000003928 ENTREZGENE
  ENSRNOT00000003928.8 UniProtKB/TrEMBL
  ENSRNOT00000090544.2 UniProtKB/TrEMBL
  ENSRNOT00000108662.1 UniProtKB/TrEMBL
  ENSRNOT00000114343.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2500 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPHH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_a1su_IQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_R_a1su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCCAlpha1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54234 UniProtKB/TrEMBL
NCBI Gene 54234 ENTREZGENE
PANTHER PTHR45628:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ca_chan_IQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPHH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacna1e PhenoGen
PRINTS CACHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RVDCCALPHA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002863 RatGTEx
SMART Ca_chan_IQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVW2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y5A8_RAT UniProtKB/TrEMBL
  A0A8I5ZMA4 ENTREZGENE, UniProtKB/TrEMBL
  A6ICX6_RAT UniProtKB/TrEMBL
  A6ICX7_RAT UniProtKB/TrEMBL
  CAC1E_RAT UniProtKB/Swiss-Prot
  F1LMS1 ENTREZGENE, UniProtKB/TrEMBL
  F1LNB9_RAT UniProtKB/TrEMBL
  Q07652 ENTREZGENE
  Q923K6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacna1e  calcium voltage-gated channel subunit alpha1 E  Cacna1e  calcium channel, voltage-dependent, R type, alpha 1E subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Cacna1e  calcium channel, voltage-dependent, R type, alpha 1E subunit  Cacna1e  calcium channel, voltage-dependent, L type, alpha 1E subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cacna1e  calcium channel, voltage-dependent, L type, alpha 1E subunit      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Cacna1e  calcium channel, voltage-dependent, L type, alpha 1E subunit      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain and atrial myocytes 69790
gene_function low voltage-activated calcium channel, T-type 69790
gene_process may be an important regulator of neuronal and muscle excitability, secretion, and possibly cell growth and differentiation 69790