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Gene: Kdm5b (lysine demethylase 5B) Rattus norvegicus

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Symbol:

Kdm5b

Name:

lysine demethylase 5B

RGD ID:

1565602

Description:

Predicted to enable several functions, including histone H3K4me/H3K4me2/H3K4me3 demethylase activity; transcription corepressor activity; and zinc ion binding activity. Involved in cellular response to fibroblast growth factor stimulus; lens fiber cell differentiation; and response to fungicide. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 65; breast cancer; and high grade glioma. Orthologous to human KDM5B (lysine demethylase 5B); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Jarid1b; jumonji, AT rich interactive domain 1B; jumonji, AT rich interactive domain 1B (Rbp2 like); Jumonji, AT rich interactive domain 1B (RBP2-like); LOC304809; lysine (K)-specific demethylase 5B; lysine-specific demethylase 5B; RGD1565602; similar to PLU1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KDM5B (lysine demethylase 5B)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Kdm5b (lysine demethylase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kdm5b (lysine demethylase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KDM5B (lysine demethylase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KDM5B (lysine demethylase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kdm5b (lysine demethylase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KDM5B (lysine demethylase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KDM5B (lysine demethylase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kdm5b (lysine demethylase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KDM5B (lysine demethylase 5B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kdm5b (lysine demethylase 5B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kdm5bb (lysine (K)-specific demethylase 5Bb)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kdm5ba (lysine (K)-specific demethylase 5Ba)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	lid	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rbr-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	JHD2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	kdm5b	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	48,554,367 - 48,625,721 (+)	NCBI		GRCr8
mRatBN7.2	13	46,001,589 - 46,073,868 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	46,002,542 - 46,073,872 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	48,608,619 - 48,679,295 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	49,896,685 - 49,967,365 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	47,162,325 - 47,233,666 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	51,384,371 - 51,455,392 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	51,384,389 - 51,455,357 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	56,438,019 - 56,509,593 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	47,502,602 - 47,576,946 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	13	46,328,788 - 46,400,255 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kdm5b	Rat	breast cancer	treatment	ISO	RGD:1322449	9587774	human gene in a mouse model	RGD
Kdm5b	Rat	Breast Neoplasms	severity	ISO	RGD:1322449	9587743	mRNA:increased expression:breast (human)	RGD
Kdm5b	Rat	Colorectal Neoplasms	severity	ISO	RGD:1322449	9587777		RGD
Kdm5b	Rat	esophagus squamous cell carcinoma	severity	ISO	RGD:1322449	9587776	protein:increased expression:esophageal mucosa, cytoplasm (human)	RGD
Kdm5b	Rat	high grade glioma		ISO	RGD:1322449	13702126		RGD
Kdm5b	Rat	high grade glioma	disease_progression	ISO	RGD:1322449	13702126		RGD
Kdm5b	Rat	myocardial infarction	ameliorates	ISO	RGD:1557118	329901769		RGD
Kdm5b	Rat	prostate cancer	severity	ISO	RGD:1322449	9587744	mRNA:increased expression:prostate gland (human)	RGD
Kdm5b	Rat	pulmonary hypertension		ISO	RGD:1557118	329955443	associated with Hypoxia;protein:increased expression:pulmonary artery,smooth muscle tissue (mouse)	RGD
Kdm5b	Rat	urinary bladder cancer		ISO	RGD:1322449	9587778	mRNA:increased expression:urinary bladder (human)	RGD
Kdm5b	Rat	uveal melanoma	severity	ISO	RGD:1322449	9587775	protein:increased expression:uvea (human)	RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kdm5b	Rat	autism spectrum disorder		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: Autism spectrum disorder \| ClinVar Annotator: match by term: Autism more ...	ClinVar	PMID:25741868
Kdm5b	Rat	autosomal recessive intellectual developmental disorder 65		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 65 \| ClinVar Annotator: match more ...	ClinVar	PMID:25363768\|PMID:25741868\|PMID:28492532\|PMID:29276005\|PMID:30217758\|PMID:30409806\|PMID:32368696
Kdm5b	Rat	bladder exstrophy-epispadias-cloacal exstrophy complex		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: Bladder exstrophy-epispadias-cloacal exstrophy complex	ClinVar	PMID:25741868
Kdm5b	Rat	Developmental Disease		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: Developmental disorder	ClinVar	PMID:25741868
Kdm5b	Rat	diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype	ClinVar	PMID:25741868
Kdm5b	Rat	familial adult myoclonic epilepsy 5		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: Epilepsy, familial adult myoclonic, 5	ClinVar	PMID:28492532
Kdm5b	Rat	gastrointestinal stromal tumor		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: Gastrointestinal stromal tumor	ClinVar	PMID:28492532
Kdm5b	Rat	genetic disease		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868\|PMID:28492532\|PMID:32368696
Kdm5b	Rat	Hypokalemic Periodic Paralysis, Type 1		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: Hypokalemic periodic paralysis, type 1	ClinVar	PMID:28492532
Kdm5b	Rat	intellectual disability		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: intellectual disabilities	ClinVar
Kdm5b	Rat	Neurodevelopmental Disorders		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: Neurodevelopmental abnormality \| ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868\|PMID:29276005\|PMID:30217758\|PMID:30409806
Kdm5b	Rat	parathyroid carcinoma		ISO	RGD:1322449	8554872	ClinVar Annotator: match by term: Parathyroid carcinoma	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kdm5b	Rat	Colonic Neoplasms		ISO	RGD:1322449	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:25043185

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kdm5b	Rat	autosomal recessive intellectual developmental disorder 65		ISO	RGD:1322449	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kdm5b	Rat	1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene	multiple interactions	ISO	RGD:1557118	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Kdm5b	Rat	1,2-dichloroethane	increases expression	ISO	RGD:1557118	6480464	ethylene dichloride results in increased expression of KDM5B mRNA	CTD	PMID:28960355
Kdm5b	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1557118	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of KDM5B mRNA	CTD	PMID:22206623
Kdm5b	Rat	17alpha-ethynylestradiol	affects expression	ISO	RGD:1557118	6480464	Ethinyl Estradiol affects the expression of KDM5B mRNA	CTD	PMID:17555576
Kdm5b	Rat	2,2',4,4',5,5'-hexachlorobiphenyl	multiple interactions	ISO	RGD:1557118	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Kdm5b	Rat	2,2',5,5'-tetrachlorobiphenyl	multiple interactions	ISO	RGD:1557118	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Kdm5b	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of KDM5B mRNA	CTD	PMID:34747641
Kdm5b	Rat	2,4,4'-trichlorobiphenyl	multiple interactions	ISO	RGD:1557118	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Kdm5b	Rat	3,4-methylenedioxymethamphetamine	decreases expression	ISO	RGD:1557118	6480464	N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of KDM5B mRNA	CTD	PMID:20188158
Kdm5b	Rat	4,4'-diaminodiphenylmethane	increases expression	ISO	RGD:1557118	6480464	4,4'-diaminodiphenylmethane results in increased expression of KDM5B mRNA	CTD	PMID:18648102
Kdm5b	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of KDM5B mRNA	CTD	PMID:30047161
Kdm5b	Rat	acetylsalicylic acid	decreases expression	ISO	RGD:1322449	6480464	Aspirin results in decreased expression of KDM5B mRNA	CTD	PMID:15928584
Kdm5b	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1557118	6480464	Tretinoin results in decreased expression of KDM5B mRNA	CTD	PMID:16788091
Kdm5b	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:1322449	6480464	Tretinoin results in increased expression of KDM5B mRNA	CTD	PMID:22906706\|PMID:23724009
Kdm5b	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1322449	6480464	Tretinoin results in decreased expression of KDM5B mRNA	CTD	PMID:15498508
Kdm5b	Rat	amitrole	decreases expression	EXP		6480464	Amitrole results in decreased expression of KDM5B mRNA	CTD	PMID:30047161\|PMID:38685447
Kdm5b	Rat	antimycin A	decreases expression	ISO	RGD:1322449	6480464	Antimycin A results in decreased expression of KDM5B mRNA	CTD	PMID:33512557
Kdm5b	Rat	atrazine	increases expression	ISO	RGD:1557118	6480464	Atrazine results in increased expression of KDM5B mRNA	CTD	PMID:27655631
Kdm5b	Rat	benzene	increases expression	ISO	RGD:1322449	6480464	Benzene results in increased expression of KDM5B mRNA	CTD	PMID:19162166
Kdm5b	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1557118	6480464	Benzo(a)pyrene results in increased expression of KDM5B mRNA	CTD	PMID:20504355
Kdm5b	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1322449	6480464	Benzo(a)pyrene affects the methylation of KDM5B promoter	CTD	PMID:27901495
Kdm5b	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1322449	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KDM5B mRNA	CTD	PMID:19150397\|PMID:20018196
Kdm5b	Rat	benzo[b]fluoranthene	decreases expression	ISO	RGD:1557118	6480464	benzo(b)fluoranthene results in decreased expression of KDM5B mRNA	CTD	PMID:26377693
Kdm5b	Rat	berberine	increases expression	ISO	RGD:1322449	6480464	Berberine results in increased expression of KDM5B mRNA	CTD	PMID:27311644
Kdm5b	Rat	beta-lapachone	increases expression	ISO	RGD:1322449	6480464	beta-lapachone results in increased expression of KDM5B mRNA	CTD	PMID:38218311
Kdm5b	Rat	bis(2-chloroethyl) sulfide	decreases expression	ISO	RGD:1557118	6480464	Mustard Gas results in decreased expression of KDM5B mRNA	CTD	PMID:26392148
Kdm5b	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RGD:1557118	6480464	Diethylhexyl Phthalate results in decreased expression of KDM5B mRNA	CTD	PMID:33754040
Kdm5b	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of KDM5B mRNA	CTD	PMID:25181051\|PMID:30816183\|PMID:32528016\|PMID:34947998
Kdm5b	Rat	bisphenol A	decreases expression	ISO	RGD:1322449	6480464	bisphenol A results in decreased expression of KDM5B mRNA	CTD	PMID:31610501
Kdm5b	Rat	bisphenol A	multiple interactions	ISO	RGD:1322449	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of KDM5B gene	CTD	PMID:31601247
Kdm5b	Rat	bisphenol A	increases expression	ISO	RGD:1557118	6480464	bisphenol A results in increased expression of KDM5B mRNA	CTD	PMID:30303745
Kdm5b	Rat	bisphenol A	increases expression	ISO	RGD:1322449	6480464	bisphenol A results in increased expression of KDM5B mRNA	CTD	PMID:29275510
Kdm5b	Rat	bisphenol A	affects methylation	ISO	RGD:1557118	6480464	bisphenol A affects the methylation of KDM5B promoter	CTD	PMID:27334623
Kdm5b	Rat	cadmium atom	decreases expression	ISO	RGD:1322449	6480464	Cadmium results in decreased expression of KDM5B mRNA	CTD	PMID:23369406
Kdm5b	Rat	cadmium dichloride	decreases expression	ISO	RGD:1322449	6480464	Cadmium Chloride results in decreased expression of KDM5B mRNA	CTD	PMID:38568856
Kdm5b	Rat	carbamazepine	affects expression	ISO	RGD:1322449	6480464	Carbamazepine affects the expression of KDM5B mRNA	CTD	PMID:25979313
Kdm5b	Rat	carbon nanotube	decreases expression	ISO	RGD:1557118	6480464	Nanotubes, Carbon analog results in decreased expression of KDM5B mRNA; Nanotubes, Carbon results in decreased more ...	CTD	PMID:25554681
Kdm5b	Rat	CGP 52608	multiple interactions	ISO	RGD:1322449	6480464	CGP 52608 promotes the reaction [RORA protein binds to KDM5B gene]	CTD	PMID:28238834
Kdm5b	Rat	chlorpyrifos	decreases expression	EXP		6480464	Chlorpyrifos results in decreased expression of KDM5B mRNA	CTD	PMID:18668222
Kdm5b	Rat	cisplatin	decreases expression	ISO	RGD:1322449	6480464	Cisplatin results in decreased expression of KDM5B mRNA	CTD	PMID:27594783
Kdm5b	Rat	cobalt dichloride	increases expression	ISO	RGD:1322449	6480464	cobaltous chloride results in increased expression of KDM5B mRNA	CTD	PMID:19376846
Kdm5b	Rat	copper(II) sulfate	increases expression	ISO	RGD:1322449	6480464	Copper Sulfate results in increased expression of KDM5B mRNA	CTD	PMID:19549813
Kdm5b	Rat	coumestrol	multiple interactions	ISO	RGD:1322449	6480464	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KDM5B mRNA; [Coumestrol co-treated with resveratrol] more ...	CTD	PMID:19167446
Kdm5b	Rat	coumestrol	decreases expression	ISO	RGD:1322449	6480464	Coumestrol results in decreased expression of KDM5B mRNA	CTD	PMID:19167446
Kdm5b	Rat	crocidolite asbestos	increases expression	ISO	RGD:1322449	6480464	Asbestos, Crocidolite results in increased expression of KDM5B mRNA	CTD	PMID:18687144
Kdm5b	Rat	crocidolite asbestos	decreases expression	ISO	RGD:1557118	6480464	Asbestos, Crocidolite results in decreased expression of KDM5B mRNA	CTD	PMID:29279043
Kdm5b	Rat	cyclosporin A	decreases expression	ISO	RGD:1322449	6480464	Cyclosporine results in decreased expression of KDM5B mRNA	CTD	PMID:27989131
Kdm5b	Rat	deguelin	decreases expression	ISO	RGD:1322449	6480464	deguelin results in decreased expression of KDM5B mRNA	CTD	PMID:33512557
Kdm5b	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1322449	6480464	di-n-butylphosphoric acid affects the expression of KDM5B mRNA	CTD	PMID:37042841
Kdm5b	Rat	dioxygen	multiple interactions	ISO	RGD:1322449	6480464	KDM5B protein promotes the reaction [Oxygen deficiency results in decreased expression of MLH1 mRNA]	CTD	PMID:25043185
Kdm5b	Rat	dioxygen	decreases expression	ISO	RGD:1322449	6480464	Oxygen deficiency results in decreased expression of KDM5B protein	CTD	PMID:25043185
Kdm5b	Rat	diuron	decreases expression	EXP		6480464	Diuron results in decreased expression of KDM5B mRNA	CTD	PMID:25152437
Kdm5b	Rat	doxorubicin	increases expression	ISO	RGD:1322449	6480464	Doxorubicin results in increased expression of KDM5B mRNA	CTD	PMID:29803840
Kdm5b	Rat	Enterolactone	multiple interactions	ISO	RGD:1322449	6480464	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KDM5B mRNA	CTD	PMID:19167446
Kdm5b	Rat	ethanol	decreases expression	ISO	RGD:1322449	6480464	Ethanol results in decreased expression of KDM5B protein	CTD	PMID:35149083
Kdm5b	Rat	fenpyroximate	decreases expression	ISO	RGD:1322449	6480464	fenpyroximate results in decreased expression of KDM5B mRNA	CTD	PMID:33512557
Kdm5b	Rat	folic acid	multiple interactions	ISO	RGD:1557118	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of KDM5B mRNA	CTD	PMID:22206623
Kdm5b	Rat	FR900359	affects phosphorylation	ISO	RGD:1322449	6480464	FR900359 affects the phosphorylation of KDM5B protein	CTD	PMID:37730182
Kdm5b	Rat	fulvestrant	multiple interactions	ISO	RGD:1322449	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of KDM5B gene	CTD	PMID:31601247
Kdm5b	Rat	fumonisin B1	increases expression	ISO	RGD:1322449	6480464	fumonisin B1 results in increased expression of KDM5B mRNA	CTD	PMID:24280379
Kdm5b	Rat	hydrogen chloride	decreases expression	ISO	RGD:1322449	6480464	Hydrochloric Acid results in decreased expression of KDM5B mRNA	CTD	PMID:15046208
Kdm5b	Rat	methimazole	decreases expression	EXP		6480464	Methimazole results in decreased expression of KDM5B mRNA	CTD	PMID:30047161
Kdm5b	Rat	nefazodone	decreases expression	EXP		6480464	nefazodone results in decreased expression of KDM5B mRNA	CTD	PMID:24136188
Kdm5b	Rat	niclosamide	increases expression	ISO	RGD:1322449	6480464	Niclosamide results in increased expression of KDM5B mRNA	CTD	PMID:36318118
Kdm5b	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of KDM5B mRNA	CTD	PMID:25729387
Kdm5b	Rat	parathion	decreases expression	ISO	RGD:1557118	6480464	Parathion results in decreased expression of KDM5B mRNA	CTD	PMID:34813904
Kdm5b	Rat	PCB138	multiple interactions	ISO	RGD:1557118	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Kdm5b	Rat	phenobarbital	affects expression	ISO	RGD:1557118	6480464	Phenobarbital affects the expression of KDM5B mRNA	CTD	PMID:23091169
Kdm5b	Rat	picoxystrobin	decreases expression	ISO	RGD:1322449	6480464	picoxystrobin results in decreased expression of KDM5B mRNA	CTD	PMID:33512557
Kdm5b	Rat	pyrimidifen	decreases expression	ISO	RGD:1322449	6480464	pyrimidifen results in decreased expression of KDM5B mRNA	CTD	PMID:33512557
Kdm5b	Rat	resveratrol	multiple interactions	ISO	RGD:1322449	6480464	[Coumestrol co-treated with Resveratrol] results in decreased expression of KDM5B mRNA; [Plant Extracts co-treated with more ...	CTD	PMID:19167446\|PMID:23557933
Kdm5b	Rat	rotenone	increases expression	EXP		6480464	Rotenone results in increased expression of KDM5B mRNA	CTD	PMID:19013527
Kdm5b	Rat	rotenone	decreases expression	ISO	RGD:1322449	6480464	Rotenone results in decreased expression of KDM5B mRNA	CTD	PMID:33512557
Kdm5b	Rat	sodium arsenate	decreases expression	ISO	RGD:1557118	6480464	sodium arsenate results in decreased expression of KDM5B protein	CTD	PMID:26193056
Kdm5b	Rat	sodium arsenate	increases expression	ISO	RGD:1557118	6480464	sodium arsenate results in increased expression of KDM5B mRNA	CTD	PMID:21795629
Kdm5b	Rat	sodium arsenite	increases expression	ISO	RGD:1322449	6480464	sodium arsenite results in increased expression of KDM5B mRNA	CTD	PMID:38568856
Kdm5b	Rat	sulfadimethoxine	decreases expression	EXP		6480464	Sulfadimethoxine results in decreased expression of KDM5B mRNA	CTD	PMID:30047161
Kdm5b	Rat	tamibarotene	affects expression	ISO	RGD:1322449	6480464	tamibarotene affects the expression of KDM5B mRNA	CTD	PMID:15498508
Kdm5b	Rat	tamoxifen	affects expression	ISO	RGD:1557118	6480464	Tamoxifen affects the expression of KDM5B mRNA	CTD	PMID:17555576
Kdm5b	Rat	tebufenpyrad	decreases expression	ISO	RGD:1322449	6480464	4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of KDM5B mRNA	CTD	PMID:33512557
Kdm5b	Rat	titanium dioxide	decreases methylation	ISO	RGD:1557118	6480464	titanium dioxide results in decreased methylation of KDM5B promoter alternative form	CTD	PMID:35295148
Kdm5b	Rat	titanium dioxide	decreases expression	ISO	RGD:1557118	6480464	titanium dioxide results in decreased expression of KDM5B mRNA	CTD	PMID:35295148
Kdm5b	Rat	titanium dioxide	increases methylation	ISO	RGD:1557118	6480464	titanium dioxide results in increased methylation of KDM5B gene	CTD	PMID:35295148
Kdm5b	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of KDM5B mRNA	CTD	PMID:25729387
Kdm5b	Rat	triphenyl phosphate	affects expression	ISO	RGD:1322449	6480464	triphenyl phosphate affects the expression of KDM5B mRNA	CTD	PMID:37042841
Kdm5b	Rat	triptonide	increases expression	ISO	RGD:1557118	6480464	triptonide results in increased expression of KDM5B mRNA	CTD	PMID:33045310
Kdm5b	Rat	troglitazone	increases expression	ISO	RGD:1322449	6480464	troglitazone results in increased expression of KDM5B mRNA	CTD	PMID:19140230
Kdm5b	Rat	tungsten	decreases expression	ISO	RGD:1557118	6480464	Tungsten results in decreased expression of KDM5B mRNA	CTD	PMID:30912803
Kdm5b	Rat	uranium atom	affects expression	ISO	RGD:1322449	6480464	Uranium affects the expression of KDM5B mRNA	CTD	PMID:15672453
Kdm5b	Rat	urethane	increases expression	ISO	RGD:1322449	6480464	Urethane results in increased expression of KDM5B mRNA	CTD	PMID:28818685
Kdm5b	Rat	valproic acid	decreases expression	ISO	RGD:1322449	6480464	Valproic Acid results in decreased expression of KDM5B mRNA	CTD	PMID:23179753
Kdm5b	Rat	valproic acid	affects expression	ISO	RGD:1322449	6480464	Valproic Acid affects the expression of KDM5B mRNA	CTD	PMID:25979313
Kdm5b	Rat	vinclozolin	affects expression	EXP		6480464	vinclozolin affects the expression of KDM5B mRNA	CTD	PMID:19015723

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kdm5b	Rat	branching involved in mammary gland duct morphogenesis	acts_upstream_of_or_within	ISO	RGD:1557118	1624291	MGI:4329395 PMID:24802759	RGD	PMID:24802759
Kdm5b	Rat	branching involved in mammary gland duct morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	cellular response to fibroblast growth factor stimulus		IEP		9587771		RGD
Kdm5b	Rat	cellular response to leukemia inhibitory factor	acts_upstream_of_or_within	ISO	RGD:1557118	1624291	PMID:20439489	RGD	PMID:20439489
Kdm5b	Rat	cellular response to leukemia inhibitory factor	acts_upstream_of_or_within	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	chromatin organization	involved_in	IEA	UniProtKB-KW:KW-0156	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kdm5b	Rat	chromatin remodeling	involved_in	IBA	FB:FBgn0036004\|MGI:104813\|MGI:2136980\|PANTHER:PTN000075014\|PomBase:SPAC1002.05c\|PomBase:SPAC343.11c\|PomBase:SPBP19A11.06\|SGD:S000003880\|TAIR:locus:2025635\|TAIR:locus:2031290\|TAIR:locus:2044697\|TAIR:locus:2128659\|TAIR:locus:2146653\|TAIR:locus:2170982\|TAIR:locus:504955644\|UniProtKB:C8VTU6\|UniProtKB:Q10RP4\|UniProtKB:Q336N8\|UniProtKB:Q53WJ1\|UniProtKB:Q5N712	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kdm5b	Rat	lens fiber cell differentiation		IEP		9587771		RGD
Kdm5b	Rat	mammary duct terminal end bud growth	acts_upstream_of_or_within	ISO	RGD:1557118	1624291	MGI:4329395 PMID:24802759	RGD	PMID:24802759
Kdm5b	Rat	mammary duct terminal end bud growth	acts_upstream_of_or_within	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	negative regulation of DNA-templated transcription	involved_in	ISO	RGD:1557118	1624291	PMID:21960634	RGD	PMID:21960634
Kdm5b	Rat	negative regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	negative regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	negative regulation of DNA-templated transcription	involved_in	ISO	RGD:1322449	1624291	PMID:12657635	RGD	PMID:12657635
Kdm5b	Rat	positive regulation of gene expression	acts_upstream_of_or_within	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	positive regulation of gene expression	acts_upstream_of_or_within	ISO	RGD:1557118	1624291	MGI:95663 PMID:24802759	RGD	PMID:24802759
Kdm5b	Rat	positive regulation of mammary gland epithelial cell proliferation	acts_upstream_of_or_within	ISO	RGD:1557118	1624291	MGI:4329395 PMID:24802759	RGD	PMID:24802759
Kdm5b	Rat	positive regulation of mammary gland epithelial cell proliferation	acts_upstream_of_or_within	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	post-embryonic development	acts_upstream_of_or_within	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	post-embryonic development	acts_upstream_of_or_within	ISO	RGD:1557118	1624291	MGI:4329395 PMID:24802759	RGD	PMID:24802759
Kdm5b	Rat	regulation of DNA-templated transcription	involved_in	IBA	FB:FBgn0031759\|MGI:1922855\|MGI:2136980\|MGI:99781\|PANTHER:PTN000075016\|SGD:S000003880\|UniProtKB:P29375	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kdm5b	Rat	regulation of estradiol secretion	acts_upstream_of_or_within	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	regulation of estradiol secretion	acts_upstream_of_or_within	ISO	RGD:1557118	1624291	MGI:4329395 PMID:24802759	RGD	PMID:24802759
Kdm5b	Rat	response to fungicide		IEP		9588300	vinclozolin	RGD
Kdm5b	Rat	single fertilization	acts_upstream_of_or_within	ISO	RGD:1557118	1624291	MGI:4329395 PMID:24802759	RGD	PMID:24802759
Kdm5b	Rat	single fertilization	acts_upstream_of_or_within	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	uterus morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	uterus morphogenesis	acts_upstream_of_or_within	ISO	RGD:1557118	1624291	MGI:4329395 PMID:24802759	RGD	PMID:24802759

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kdm5b	Rat	chromatin	is_active_in	IBA	FB:FBgn0031759\|FB:FBgn0033233\|FB:FBgn0036004\|MGI:1924054\|MGI:2442355\|MGI:2446210\|MGI:3606484\|PANTHER:PTN000075014\|PomBase:SPAC343.11c\|PomBase:SPBP19A11.06\|RGD:1307528\|UniProtKB:Q336N8\|UniProtKB:Q9H3R0	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kdm5b	Rat	cytosol	located_in	ISO	RGD:1322449\|UniProtKB:Q9UGL1-1	1624291		RGD	GO_REF:0000052
Kdm5b	Rat	cytosol	located_in	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	nucleoplasm	located_in	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	nucleoplasm	located_in	ISO	RGD:1322449\|UniProtKB:Q9UGL1-1	1624291		RGD	GO_REF:0000052
Kdm5b	Rat	nucleus	located_in	ISO	RGD:1322449	1624291	PMID:20403335	RGD	PMID:20403335
Kdm5b	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kdm5b	Rat	nucleus	located_in	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Kdm5b	Rat	nucleus	is_active_in	IBA	FB:FBgn0031759\|FB:FBgn0033233\|FB:FBgn0036004\|FB:FBgn0053182\|MGI:104813\|MGI:2136980\|MGI:3606484\|MGI:99781\|PANTHER:PTN000075014\|PomBase:SPAC343.11c\|PomBase:SPBC83.07\|PomBase:SPBP19A11.06\|SGD:S000002503\|TAIR:locus:2025635\|TAIR:locus:2031290\|TAIR:locus:2128659\|TAIR:locus:2146653\|TAIR:locus:504955644\|UniProtKB:B2RXH2\|UniProtKB:O75164\|UniProtKB:P29375\|UniProtKB:P41229\|UniProtKB:Q53WJ1\|UniProtKB:Q5N712\|UniProtKB:Q92833\|UniProtKB:Q9BY66\|UniProtKB:Q9UGL1\|WB:WBGene00004319	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kdm5b	Rat	dioxygenase activity	enables	IEA	UniProtKB-KW:KW-0223	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kdm5b	Rat	DNA binding	enables	ISO	RGD:1322449	1624291	PMID:15640446	RGD	PMID:15640446
Kdm5b	Rat	DNA binding	enables	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	DNA binding	enables	IEA	InterPro:IPR001606\|InterPro:IPR036431	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kdm5b	Rat	histone binding	enables	ISO	RGD:1322449	1624291	PMID:24952722	RGD	PMID:24952722
Kdm5b	Rat	histone binding	enables	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	histone H3K4 demethylase activity	enables	ISO	RGD:1322449	1624291	PMID:18048344, PMID:24952722, PMID:27214403, PMID:28262558	RGD	PMID:18048344\|PMID:24952722\|PMID:27214403\|PMID:28262558
Kdm5b	Rat	histone H3K4 demethylase activity	enables	IEA	UniProtKB:Q80Y84\|ensembl:ENSMUSP00000038138	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	histone H3K4 demethylase activity	enables	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	histone H3K4 demethylase activity	enables	ISO	RGD:1557118	1624291	PMID:17320160	RGD	PMID:17320160
Kdm5b	Rat	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	enables	ISO	RGD:1322449	1624291	PMID:20228790, PMID:20403335	RGD	PMID:20228790\|PMID:20403335
Kdm5b	Rat	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	enables	IEA	EC:1.14.11.67	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Kdm5b	Rat	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	enables	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	enables	IBA	FB:FBgn0031759\|PANTHER:PTN000075016\|PomBase:SPAC1002.05c\|PomBase:SPBP19A11.06\|UniProtKB:P29375\|UniProtKB:Q9UGL1\|WB:WBGene00004319	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kdm5b	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kdm5b	Rat	nucleic acid binding	enables	ISO	RGD:1322449	1624291	PMID:20403335	RGD	PMID:20403335
Kdm5b	Rat	nucleic acid binding	enables	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	oxidoreductase activity	enables	IEA	UniProtKB-KW:KW-0560	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kdm5b	Rat	protein binding	enables	ISO	RGD:1322449	1624291	UniProtKB:P49711\|UniProtKB:P55316\|UniProtKB:P55771 PMID:12657635, PMID:24937458	RGD	PMID:12657635\|PMID:24937458
Kdm5b	Rat	protein binding	enables	ISO	RGD:1557118	1624291	UniProtKB:P60762 PMID:21448134	RGD	PMID:21448134
Kdm5b	Rat	sequence-specific double-stranded DNA binding	enables	ISO	RGD:1322449	1624291	PMID:20403335	RGD	PMID:20403335
Kdm5b	Rat	sequence-specific double-stranded DNA binding	enables	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	transcription corepressor activity	enables	ISO	RGD:1322449	1624291	PMID:12657635	RGD	PMID:12657635
Kdm5b	Rat	transcription corepressor activity	enables	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kdm5b	Rat	zinc ion binding	enables	ISO	RGD:1322449	1624291	PMID:24952722, PMID:27214403, PMID:28262558	RGD	PMID:24952722\|PMID:27214403\|PMID:28262558
Kdm5b	Rat	zinc ion binding	enables	IEA	UniProtKB-KW:KW-0863	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kdm5b	Rat	zinc ion binding	enables	IEA	UniProtKB:Q9UGL1\|ensembl:ENSP00000356234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kdm5b	Rat	histone modification pathway		ISO	RGD:1322449	7242632		RGD

#	Reference Title	Reference Citation
1.	Coexpression of nuclear receptors and histone methylation modifying genes in the testis: implications for endocrine disruptor modes of action.	Anderson AM, etal., PLoS One. 2012;7(4):e34158. doi: 10.1371/journal.pone.0034158. Epub 2012 Apr 4.
2.	Histone lysine methylation dynamics: establishment, regulation, and biological impact.	Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
3.	PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells.	Catchpole S, etal., Int J Oncol. 2011 May;38(5):1267-77. doi: 10.3892/ijo.2011.956. Epub 2011 Feb 28.
4.	Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21.	Dai B, etal., Biochem Biophys Res Commun. 2014 Nov 7;454(1):221-7. doi: 10.1016/j.bbrc.2014.10.078. Epub 2014 Oct 22.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.	Hayami S, etal., Mol Cancer. 2010 Mar 13;9:59. doi: 10.1186/1476-4598-9-59.
7.	Histone demethylase JARID1B regulates proliferation and migration of pulmonary arterial smooth muscle cells in mice with chronic hypoxia-induced pulmonary hypertension via nuclear factor-kappa B (NFkB).	Li Y, etal., Cardiovasc Pathol. 2018 Nov-Dec;37:8-14. doi: 10.1016/j.carpath.2018.07.004. Epub 2018 Aug 3.
8.	A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.	Lu PJ, etal., J Biol Chem. 1999 May 28;274(22):15633-45.
9.	Depletion of JARID1B induces cellular senescence in human colorectal cancer.	Ohta K, etal., Int J Oncol. 2013 Apr;42(4):1212-8. doi: 10.3892/ijo.2013.1799. Epub 2013 Jan 25.
10.	JARID1B protein expression and prognostic implications in uveal melanoma.	Radberger P, etal., Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4442-9. doi: 10.1167/iovs.11-9296.
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Comprehensive gene review and curation	RGD comprehensive gene curation
15.	Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma.	Sun LL, etal., Acta Histochem. 2013 Jan;115(1):56-62. doi: 10.1016/j.acthis.2012.04.001. Epub 2012 Apr 23.
16.	Loss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expression.	Wang B, etal., Exp Mol Med. 2022 Dec;54(12):2175-2187. doi: 10.1038/s12276-022-00904-y. Epub 2022 Dec 8.
17.	Identification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiation.	Wolf L, etal., G3 (Bethesda). 2013 Dec 9;3(12):2239-55. doi: 10.1534/g3.113.008698.
18.	JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer.	Xiang Y, etal., Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19226-31. Epub 2007 Nov 28.

PMID:12657635	PMID:15640446	PMID:17320160	PMID:20228790	PMID:20403335	PMID:20439489	PMID:21960634	PMID:22082260	PMID:24802759	PMID:24952722	PMID:27214403	PMID:28262558
PMID:34960080

Kdm5b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	48,554,367 - 48,625,721 (+)	NCBI		GRCr8
mRatBN7.2	13	46,001,589 - 46,073,868 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	46,002,542 - 46,073,872 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	48,608,619 - 48,679,295 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	49,896,685 - 49,967,365 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	47,162,325 - 47,233,666 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	51,384,371 - 51,455,392 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	51,384,389 - 51,455,357 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	56,438,019 - 56,509,593 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	47,502,602 - 47,576,946 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	13	46,328,788 - 46,400,255 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

KDM5B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	202,724,495 - 202,808,421 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	202,724,495 - 202,808,487 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	202,693,623 - 202,777,549 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	200,963,155 - 201,044,172 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	199,428,188 - 199,509,206	NCBI
Celera	1	175,824,418 - 175,906,769 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	173,862,355 - 173,943,136 (-)	NCBI		HuRef
CHM1_1	1	204,118,752 - 204,199,788 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	201,986,695 - 202,071,080 (-)	NCBI		T2T-CHM13v2.0

Kdm5b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	134,487,916 - 134,560,621 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	134,487,909 - 134,563,023 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	134,560,178 - 134,632,878 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	134,560,171 - 134,635,285 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	136,456,755 - 136,529,455 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	136,376,606 - 136,449,288 (+)	NCBI		MGSCv36	mm8
Celera	1	137,167,324 - 137,243,758 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	58.24	NCBI

Kdm5b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	38,755,220 - 38,823,088 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	38,755,220 - 38,823,094 (-)	NCBI	ChiLan1.0	ChiLan1.0

KDM5B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	46,574,059 - 46,654,480 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	46,540,718 - 46,623,372 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	178,323,073 - 178,406,608 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	182,620,358 - 182,702,994 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	182,622,425 - 182,702,994 (-)	Ensembl	panpan1.1		panPan2

KDM5B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	336,452 - 415,568 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	330,705 - 412,386 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	389,052 - 475,184 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	343,885 - 430,080 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	339,836 - 422,462 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	332,707 - 418,792 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	441,516 - 527,633 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	464,790 - 550,918 (+)	NCBI		UU_Cfam_GSD_1.0

Kdm5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	72,547,343 - 72,626,164 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936567	1,781,995 - 1,863,461 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936567	1,782,056 - 1,860,861 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KDM5B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	24,736,838 - 24,831,447 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	24,739,115 - 24,831,537 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	29,186,615 - 29,191,730 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KDM5B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	26,599,740 - 26,685,256 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	26,600,736 - 26,683,632 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	27,379,047 - 27,463,383 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kdm5b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	8,011,878 - 8,093,758 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	8,011,731 - 8,091,352 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Kdm5b
227 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	179
Count of miRNA genes:	125
Interacting mature miRNAs:	151
Transcripts:	ENSRNOT00000006290
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34663461	87525369	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
6893344	Cm79	Cardiac mass QTL 79	1.5	0.04	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	43720770	62022792	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
4145117	Mcs27	Mammary carcinoma susceptibility QTL 27		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	13	43437904	47841255	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	32284471	77284471	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
12879472	Bp399	Blood pressure QTL 399			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45228358	47841255	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat

D13Mco9

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	46,025,527 - 46,025,790 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	51,407,374 - 51,407,636	NCBI	Rnor6.0
Rnor_5.0	13	56,461,941 - 56,462,203	UniSTS	Rnor5.0
RGSC_v3.4	13	47,525,586 - 47,525,849	RGD	RGSC3.4
RGSC_v3.4	13	47,525,587 - 47,525,849	UniSTS	RGSC3.4
RGSC_v3.1	13	47,539,629 - 47,539,892	RGD
Celera	13	46,351,767 - 46,352,029	UniSTS
Cytogenetic Map	13	q13	UniSTS

RH132812

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	46,073,515 - 46,073,720 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	51,455,032 - 51,455,236	NCBI	Rnor6.0
Rnor_5.0	13	56,509,241 - 56,509,445	UniSTS	Rnor5.0
RGSC_v3.4	13	47,576,594 - 47,576,798	UniSTS	RGSC3.4
Celera	13	46,399,903 - 46,400,107	UniSTS
RH 3.4 Map	13	171.0	UniSTS
Cytogenetic Map	13	q13	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001107177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000077928 ⟹ ENSRNOP00000073808

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	46,002,542 - 46,073,872 (+)	Ensembl
Rnor_6.0 Ensembl	13	51,384,562 - 51,453,906 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087025 ⟹ ENSRNOP00000072712

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	46,002,542 - 46,073,868 (+)	Ensembl
Rnor_6.0 Ensembl	13	51,384,389 - 51,455,357 (+)	Ensembl

RefSeq Acc Id:

NM_001107177 ⟹ NP_001100647

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	48,554,397 - 48,625,713 (+)	NCBI
mRatBN7.2	13	46,002,542 - 46,073,868 (+)	NCBI
Rnor_6.0	13	51,384,396 - 51,455,384 (+)	NCBI
Rnor_5.0	13	56,438,019 - 56,509,593 (+)	NCBI
RGSC_v3.4	13	47,502,602 - 47,576,946 (+)	RGD
Celera	13	46,328,788 - 46,400,255 (+)	RGD

Sequence:

show sequence

CAAGACGTCGTCGGAGGAAGGCTGAAAAAGCCCTAGGTGTTGCCGTTGCTAGTAGAAGTCGGACTTGTCGCCCGAGCTGTGCGTGTGCACAGGTTTCGGACGGAGCGGAGCTCGCTGCCGCGGTTGCG
GAGCTTGCCCTGTGCTCGCCCCTGCCCACGTCGCGGTGATGGAGCCGGCCACCGCGCTGCCCCCAGGCCCGCGCCCGGCGCTGCCCCTTGGGGGCCCCGGCCCGCTGGGAGAGTTCCTGCCTCCCCCC
GAGTGTCCGGTCTTCGAGCCCAGCTGGGAAGAGTTCGCGGACCCCTTCGCTTTCATCCACAAGATCCGGCCCATAGCCGAGCAGACTGGGATCTGTAAGGTGCGGCCGCCGCCGGATTGGCAGCCACC
ATTCGCTTGTGATGTTGATAAACTTCATTTTACCCCGCGTATCCAGAGGCTTAATGAGCTGGAGGCCCAAACACGTGTAAAATTGAACTTCCTGGACCAGATTGCCAAGTATTGGGAGCTACAGGGAA
GTACTCTGAAGATTCCTCATGTGGAGAGAAAGATCTTAGACTTGTTCCAGCTAAATAAGTTAGTTGCAGAGGAAGGTGGGTTTGCAGTTGTTTGCAAGGACAGAAAATGGACCAAAATTGCCACCAAG
ATGGGTTTTGCTCCTGGTAAAGCAGTGGGCTCACATATCAGGGGACATTATGAGCGAATCCTCAATCCGTACAATTTGTTCCTATCTGGGGACAGCCTGAGGTGTCTTCAGAAGCCTAACCTGACCTC
GGACACAAAGGACAAGGAGTACAAACCCCATGATATTCCCCAGAGGCAGTCTGTGCAGCCCTCAGAAACCTGCCCTCCGGCCCGCCGAGCAAAGCGCATGAGAGCAGAGGCTATGAATATTAAAATTG
AGCCAGAAGAGGCAACAGAAGCCAGGACTCATAACCTGAGGCGCCGAATGGGCTGTGCCACTCCAAAACGGGAAAACGAGAAAGAAGTGAAAAGTACCATCAAGCAAGAACCCACCGAGAAGAAAGAC
TGTGTGTTAGAAAGTGAGAAGGACAAGCCCAAGAGCCGTGCCAAGAAAACCGCCACTGCTGTGGACCTGTATGTGTGCCTCTTATGTGGCAGCGGCAATGACGAGGACCGGCTGCTCCTGTGTGACGG
CTGTGACGACAGTTACCACACCTTCTGCCTGCTTCCCCCTCTCCATGATGTTCCCAAGGGAGACTGGAGGTGTCCTAAGTGTTTGGCTCAAGAGTGTAGTAAGCCACAAGAAGCTTTCGGCTTTGAAC
AGGCTGCAAGGGACTATACACTCCGTACGTTTGGGGAAATGGCAGATGCATTCAAATCTGATTACTTCAACATGCCGGTCCATATGGTTCCCACAGAGCTGGTGGAGAAGGAGTTTTGGCGGCTGGTA
AGCACTATTGAAGAAGACGTCACCGTGGAGTATGGAGCTGATATTGCTTCAAAAGAGTTTGGCAGTGGCTTTCCTGTTCGAGATGGCAAAATCAAGATTTCTCCTGAGGAAGAGGAGTATCTTGATAG
TGGCTGGAATTTGAATAACATGCCAGTGATGGAGCAGTCTGTCCTTGCTCACATTACTGCTGATATATGCGGCATGAAACTGCCTTGGTTGTATGTGGGCATGTGCTTTTCTTCCTTCTGTTGGCATA
TCGAAGACCACTGGAGCTATTCAATCAACTACCTGCACTGGGGTGAGCCGAAAACCTGGTATGGAGTTCCAGGATATGCTGCTGAGCAGCTTGAAAACGTAATGAAGAAGCTGGCTCCAGAGCTCTTT
GTGTCCCAGCCAGACCTCCTCCACCAGCTTGTGACGATCATGAACCCCAATACGCTGATGACTCACGAAGTGCCTGTGTATCGAACGAATCAGTGTGCTGGGGAGTTTGTCATTACGTTCCCGAGAGC
CTACCACAGTGGCTTCAATCAAGGCTTTAATTTTGCTGAGGCAGTTAACTTCTGCACTGTTGATTGGCTGCCGTTGGGCCGCCAGTGCGTGGAGCATTATCGCCTGCTGCACCGCTACTGCGTCTTTT
CCCATGATGAGATGATATGCAAGATGGCTTCCAAGGCTGATGTGTTAGACGTGGTAGTGGCATCCACTGTTCAGAAGGACATGGCCATCATGATTGAGGATGAAAAGGCTTTAAGGGAAACTGTCCGT
AAACTGGGAGTGATTGATTCTGAGAGAATGGACTTTGAGCTGTTGCCCGATGATGAGCGGCAGTGTATAAAGTGCAAAACTACGTGCTTCATGTCTGCCATCTCCTGCTCCTGTAAACCTGGCCTGCT
TGTTTGCCTGCATCATGTCAAAGAGCTGTGCTCCTGTCCCCCTTACAAGTATAACCTGCGGTATAGATACACTCTGGATGATCTCTATCCGATGATGAATGCGTTGAAGCTTCGAGCAGAGTCGTACA
ATGAATGGGCCTTAAATGTGAATGAAGCCTTGGAAGCAAAGATTAATAAGAAGAAAAGTCTCGTCAGCTTTAAAGCTTTGATTGAAGAATCAGAAATGAAGAAATTCCCAGACAATGATCTTTTGCGT
CACCTTCGCCTAGTTACGCAGGATGCAGAAAAGTGTGCCTCTGTTGCCCAGCAGTTGCTTAATGGCAAAAGGCAAACGAGGTATCGATCTGGTGGAGGGAAGTCTCAGAGTCAGCTGACAGTGAATGA
GCTTCGGCAGTTCGTGACTCAGCTGTGCGCTCTTCCCTGCGTCCTTAGTCAGACACCACTGCTAAAGGATCTCTTGAATCGTGTGGAAGATTTCCAGCAGCAAAGCCAGAGACTGCTGTCTGAGGAGA
GGCCCCGTGCTTCTGAGCTTCAGCAGTTGCTGGATGTCAGCTTCACTTTTGATGTTGAACTTCCACAGCTAGCTGAGATGCGTATCCGCTTAGAACAGGCCCGTTGGCTAGAAGAGGTTCAGCAGGCT
TGCCTGGACTCCAGCTCCCTTTCTTTGGATGATATGAGACGACTCATAGACTTAGGGGTGGGGCTAGCTCCATATTCTGCCGTGGAGAAAGCTATGGCCCGCCTGCAGGAACTGCTAACAGTGTCAGA
GCACTGGGACGACAAAGCCAAGAGTCTCCTCAGAGCAAGACCTCGGCATTCCTTGAGTAGCCTTGCTACAGCAGTAAAAGAGATGGAGGAGATCCCCGCCTATCTGCCCAATGGTACAGTCCTGAAGG
ATTCTGTGCAGAAAGCCAGAGACTGGGTTCAGGATGTAGATGCATTGCAGGCAGGAGGACGCGTGCCAGTGTTAGAAACACTCATTGAACTTGTCGCAAGAGGCCGATCCATCCCGGTACATCTGAAT
TCTTTACCCAGATTGGAAATGCTAGTATCCGAGGTTCATGCTTGGAAAGAAAGCGCTGCTAAAACATTCCTGCTTGAGAATTCGCCATACTCTCTGTTAGAGGTTCTTTGTCCTCGGTGTGACATTGG
CCTTTTGGGATTGAAAAGGAAGCAGAGAAAGTTGAAGGATCCCTTGCCAAGTGGGAAGAAGAGAAGCACCAAGTTAGAGAGTCTGAGTGATCTGGAAAGGGCTCTGACTGAGAGCAAAGAGACGGCGT
CAGCTATGGCAACTCTTGGGGAAGCTCGCCTACGAGAGATGGAAGCTTTGCAGTCTCTCAGATTTGCCAATGAAGAGAAATTGCTGTCACCTGCCCAAGATGTGGAGACGAAGGTTTGCTTGTGTCAG
AAGACTCCAGCCACTCCCATGATTCAGTGTGAACTCTGCAGGGATGCTTTCCATACTAGTTGTGTGGCGGTGTCCAGTATTTCACAAAGCTCCCGAATCTGGCTTTGTCCTCACTGTCGAAGGTCAGA
GAAGCCTCCATTAGAGAAAATTCTGCCTCTGCTGGCCTCCCTACAGCGTATAAGAGTTCGTCTTCCTGAAGGGGATGCACTCCGATACATGATTGAAAGAACCGTGAACTGGCAACATAGAGCCCAGC
AACTGCTTTCTTCAGGGAATCTAAAACTTGTGCAGGACCAAGCGGGTTCTGGACTGTTGTTTAGCAGATGGCCAGCCTCAGCAGGAACGGCGTCAGCAGCAGACAAGGTGTCTCAACCTCCTGGCACA
ACATCCTTTTCATTGCCGGAAGACTGGGACAACAGAACCTCATATTTACACTCTCCCTTCTCTACCGGTCAGAGTTGTATCCCCCTTCATGGTTTGAGTCCAGAGGTGAATGAATTGCTGATGGAAGC
CCAGTTGCTCCAGGTGTCCCTCCCTGAAGTCCAGGAGCTTTATCAGACTTTACTTACGAAGCCAAGCTCTGCTCAGCAAGCCGACCGAAGCTCACCAGTCAGACCCAGCAGTGAGAAGAACGATTGTC
TTCGAGGGAAACGAGATGCAATCAACAGTCTTGAGAGAAAACTGAAAAGACGCCCAGAAAGAGAAGGCCTTCCCAGTGAACGGTGGGATCGAGTTAAAAAAATGCGGACCCCTCAAAAGAAGAAAATC
AAACTGAGTCACCCCAAGGACATGAACAATTTCAAATTAGAAAGAGAGCGTAGCTATGACTTAGTCCGGAATGCTGAAACTCATTCCCTGCCCTCAGACACATCCTACTCCGAGCAGGAGGACTCTGA
GGATGAAGATGCCATCTGTCCAGCTGTGAGCTGCCTGCAGCCAGAAGGAGATGAGGTGGACTGGGTCCAGTGTGATGGCAGCTGCAATCAGTGGTTTCATCAGGTCTGTGTTGGTGTCTCTCCAGAGA
TGGCAGAGAAAGAAGACTACATCTGTGTGCGCTGTACTGGAAAGGACGCACCAAGCCGAAAGTAAAAACAAAACACACACTCACTTCATGTAATTCAGGACTCCAATAAAGAAGATTTCCTCAATCTC
AGCAAAGCTACAGGACTGGGATCGAGCCAGCCTGTACACGGTGCTATTTCTATTCCTTATGGGATCATTTTTCCAGAACTCTTTGAAAAAAAGAAAAAACAACTAAAAAATTTTTGACACTTTTTTGT
AATTTTTTCCTTAAAAGCTGTTTGTGGTTGTTGAAGTTTAAAATGCTGACTGTTTTTTGCAGGGGTCTCTACTGATTTCGAAGGTCTTGGAGTTTGCACCTTTTTGTGTACAGCATTAACATTGTACT
TGTGCCTGGGATACACCGGCCTAAGAGTCTAACTCAGTGTCAGGGCCCAGGACGGGCACCAGAATTCCAGTAGCCCTCGCTGAGCAGCCGCTCTCCTTTCTCTGTCACCACATTGGGGGACTTTTAAG
TTTTCACTTTGGGGTTTTTGTTCCTTTCTTTCTCTCCTTTTCCTTTCTGGTAGGCTAGGTTTATTTATCTGAGCAATAACTTCTATGTTGGTTTCAGTGGCTGGAATTAAAACAAAACAAACTTCTAA
ACAGTGTGTTGGTTTAGCATTTGGTTAATGTACAGAAAGCAAACGTCTAGTTTCTGGTGTCACTGAACTAGTGATGTAGGAAGAGACTTCGCTGTAAGTAATCGCCACGGCTGTATTTTGGCTTTCTC
CCTACTCAGTTCTTCCCCACCCCCATCTCACACCCCACCTTTTTTTTTTTTTTTGGTAGAATGTATCAAATGTTGCAGTTTTTATTGTGGAATAATAAATCCTTGGTCCTCTTATAACACTAGACTAC
AGAGCTTCTTCTGCCCTCCCCCCTGTGGGCCTGCACAACCAGAGGGGTTGTTTGCATTTGCTCCTTCCCAGGCAGCCTGCAGCAGGAGTGTGTGTGCTGGAGGAGTCTCTGTAGCCTGATTCTTTGTG
GGTCTGGGCCCTCTTGTCCCACTAATAGAGAGTCCCTGTCTTCAAAGACCACAGCCAGTTCTTCAAGCCGTGTTCTTTTTCCATAATCTCTCAGAATGTTGGAGCTGTCCCTCCATCACTCCAGACTG
TAAGACAGCACTCCCGTGGAATGCTTGACAGGGAAGTTTGGCCGAGAGTTAAGTTGCTGTGGCCCATCATCTTAGAGGGTTGGTTCTCTTGTATCATTTTTGGAGAACCTTGGGCCTGCCTGGGATTC
CTCTGCCTTCTATGTAATTCCATCAGTCTTTCTGGTTGTGGACGGCCCATACCTGTTTGCCCCTGTTCTGTAGAGAGGAGGACTTCCTGGTGAACAGAAGGACAAGCTCTCGCTCACTCGTCTTCCTC
ACTGTCTATAGCCATACGCCTGATGGTGGGCAGAGCTAGCAGACCTTTACTAAAACATCAAAAAGCGGTTTGTAAAGTAGCGAGAATTTAAATGTACTGTCCCCTATGCAATCCAGATAATTAAATCT
GTTT

hide sequence

RefSeq Acc Id:

XM_063272298 ⟹ XP_063128368

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	48,554,367 - 48,625,721 (+)	NCBI


Protein RefSeqs	NP_001100647	(Get FASTA)	NCBI Sequence Viewer
	XP_063128368	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM09721	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072712
	ENSRNOP00000072712.2
	ENSRNOP00000073808.2

RefSeq Acc Id:

NP_001100647 ⟸ NM_001107177

- UniProtKB:

A6ICC6 (UniProtKB/TrEMBL), A0A0G2K6G9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPATALPPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKIL
DLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTSDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMNIKIEPEEATEARTHNL
RRRMGCATPKRENEKEVKSTIKQEPTEKKDCVLESEKDKPKSRAKKTATAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLLPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGE
MADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKISPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLH
WGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKA
DVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCIKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYNLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEA
KINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQSQLTVNELRQFVTQLCALPCVLSQTPLLKDLLNRVEDFQQQSQRLLSEERPRASELQQLLDV
SFTFDVELPQLAEMRIRLEQARWLEEVQQACLDSSSLSLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSLLRARPRHSLSSLATAVKEMEEIPAYLPNGTVLKDSVQKARDWVQDV
DALQAGGRVPVLETLIELVARGRSIPVHLNSLPRLEMLVSEVHAWKESAAKTFLLENSPYSLLEVLCPRCDIGLLGLKRKQRKLKDPLPSGKKRSTKLESLSDLERALTESKETASAMATLGEARLRE
MEALQSLRFANEEKLLSPAQDVETKVCLCQKTPATPMIQCELCRDAFHTSCVAVSSISQSSRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKLVQD
QAGSGLLFSRWPASAGTASAADKVSQPPGTTSFSLPEDWDNRTSYLHSPFSTGQSCIPLHGLSPEVNELLMEAQLLQVSLPEVQELYQTLLTKPSSAQQADRSSPVRPSSEKNDCLRGKRDAINSLER
KLKRRPEREGLPSERWDRVKKMRTPQKKKIKLSHPKDMNNFKLERERSYDLVRNAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCT
GKDAPSRK

hide sequence

Ensembl Acc Id:

ENSRNOP00000072712 ⟸ ENSRNOT00000087025

Ensembl Acc Id:

ENSRNOP00000073808 ⟸ ENSRNOT00000077928

RefSeq Acc Id:	XP_063128368 ⟸ XM_063272298
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K6G9 (UniProtKB/TrEMBL), A0A0G2K3N6 (UniProtKB/TrEMBL)

Protein Domains

ARID JmjC JmjN PHD-type

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K6G9-F1-model_v2	AlphaFold	A0A0G2K6G9	1-1545	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13698847

Promoter ID:

EPDNEW_R9359

Type:

initiation region

Name:

Kdm5b_1

Description:

lysine demethylase 5B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	51,384,449 - 51,384,509	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-18225	BioCyc
Ensembl Genes	ENSRNOG00000060544	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000077928.2	UniProtKB/TrEMBL
	ENSRNOT00000087025	ENTREZGENE
	ENSRNOT00000087025.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.60	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	Cupin	UniProtKB/TrEMBL
InterPro	ARID/BRIGHT_DNA-bd	UniProtKB/TrEMBL
	ARID_dom_sf	UniProtKB/TrEMBL
	KDM5_C-hel	UniProtKB/TrEMBL
	KDM5B_ARID	UniProtKB/TrEMBL
	KDM5B_PHD1	UniProtKB/TrEMBL
	KDM5B_PHD3	UniProtKB/TrEMBL
	PLU-1	UniProtKB/TrEMBL
	TF_JmjC_AAH	UniProtKB/TrEMBL
	TF_JmjN	UniProtKB/TrEMBL
	Zinc_finger_PHD-type_CS	UniProtKB/TrEMBL
	Znf_C5HC2	UniProtKB/TrEMBL
	Znf_FYVE_PHD	UniProtKB/TrEMBL
	Znf_PHD	UniProtKB/TrEMBL
	Znf_PHD-finger	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:304809	UniProtKB/TrEMBL
NCBI Gene	304809	ENTREZGENE
PANTHER	LYSINE-SPECIFIC DEMETHYLASE	UniProtKB/TrEMBL
	LYSINE-SPECIFIC DEMETHYLASE 5B	UniProtKB/TrEMBL
Pfam	ARID	UniProtKB/TrEMBL
	JmjC	UniProtKB/TrEMBL
	JmjN	UniProtKB/TrEMBL
	KDM5_C-hel	UniProtKB/TrEMBL
	PHD	UniProtKB/TrEMBL
	PLU-1	UniProtKB/TrEMBL
	zf-C5HC2	UniProtKB/TrEMBL
PhenoGen	Kdm5b	PhenoGen
PROSITE	ARID	UniProtKB/TrEMBL
	JMJC	UniProtKB/TrEMBL
	JMJN	UniProtKB/TrEMBL
	ZF_PHD_1	UniProtKB/TrEMBL
	ZF_PHD_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000060544	RatGTEx
SMART	ARID	UniProtKB/TrEMBL
	BRIGHT	UniProtKB/TrEMBL
	JmjC	UniProtKB/TrEMBL
	JmjN	UniProtKB/TrEMBL
	PHD	UniProtKB/TrEMBL
Superfamily-SCOP	ARID	UniProtKB/TrEMBL
	Clavaminate synthase-like	UniProtKB/TrEMBL
	FYVE_PHD_ZnF	UniProtKB/TrEMBL
UniProt	A0A0G2K3N6	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2K6G9	ENTREZGENE, UniProtKB/TrEMBL
	A6ICC6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Kdm5b	lysine demethylase 5B	Kdm5b	lysine (K)-specific demethylase 5B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-05-06	Kdm5b	lysine (K)-specific demethylase 5B	Jarid1b	jumonji, AT rich interactive domain 1B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-06	Jarid1b	jumonji, AT rich interactive domain 1B	Jarid1b	jumonji, AT rich interactive domain 1B (Rbp2 like)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Jarid1b	jumonji, AT rich interactive domain 1B (Rbp2 like)	RGD1565602_predicted	similar to PLU1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565602_predicted	similar to PLU1 (predicted)	LOC304809	similar to PLU1	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC304809	similar to PLU1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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