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Gene: Cdh12 (cadherin 12) Rattus norvegicus

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Symbol:

Cdh12

Name:

cadherin 12

RGD ID:

1566350

Description:

Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Orthologous to human CDH12 (cadherin 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cadherin-12; LOC301887; RGD1566350; similar to cadherin 12, type 2 preproprotein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CDH12 (cadherin 12)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Cdh12 (cadherin 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cdh12 (cadherin 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CDH12 (cadherin 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CDH12 (cadherin 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cdh12 (cadherin 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CDH12 (cadherin 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CDH12 (cadherin 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CDH12 (cadherin 12)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cdh12 (cadherin 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cdh12a (cadherin 12, type 2a (N-cadherin 2))	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cdh12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	72,201,859 - 73,436,039 (+)	NCBI		GRCr8
mRatBN7.2	2	70,474,679 - 71,705,369 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	70,475,043 - 71,700,572 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	71,310,228 - 72,540,063 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	72,006,099 - 72,540,263 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	91,039,561 - 92,271,682 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	72,175,690 - 72,598,944 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	66,295,278 - 67,494,155 (+)	NCBI		Celera
Cytogenetic Map	2	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neurodevelopmental Disorders (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

copper atom (ISO)

copper(0) (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

cypermethrin (EXP)

endosulfan (EXP)

Enterolactone (ISO)

entinostat (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

niclosamide (ISO)

O-methyleugenol (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

triclosan (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adherens junction organization (IBA)

biological_process (ND)

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (IBA)

cell migration (IBA)

cell morphogenesis (IBA)

cell-cell adhesion mediated by cadherin (IBA)

cell-cell junction assembly (IBA)

homophilic cell adhesion via plasma membrane adhesion molecules (IEA)

Cellular Component

adherens junction (IBA)

catenin complex (IBA)

Molecular Function

beta-catenin binding (IBA)

cadherin binding (IBA)

calcium ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:15485826

Genomics

Comparative Map Data

Cdh12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	72,201,859 - 73,436,039 (+)	NCBI		GRCr8
mRatBN7.2	2	70,474,679 - 71,705,369 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	70,475,043 - 71,700,572 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	71,310,228 - 72,540,063 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	72,006,099 - 72,540,263 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	91,039,561 - 92,271,682 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	72,175,690 - 72,598,944 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	66,295,278 - 67,494,155 (+)	NCBI		Celera
Cytogenetic Map	2	q22	NCBI

CDH12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	21,750,673 - 22,853,344 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	21,750,673 - 22,853,344 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	21,750,782 - 22,853,453 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	21,786,911 - 22,889,488 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	21,786,910 - 22,889,488	NCBI
Celera	5	21,615,397 - 22,740,089 (-)	NCBI		Celera
Cytogenetic Map	5	p14.3	NCBI
HuRef	5	21,604,798 - 22,819,780 (-)	NCBI		HuRef
CHM1_1	5	21,750,833 - 22,853,585 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	21,857,991 - 22,961,025 (-)	NCBI		T2T-CHM13v2.0

Cdh12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	20,448,967 - 21,598,668 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	20,449,351 - 21,589,619 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	20,448,878 - 21,598,421 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	20,449,265 - 21,589,533 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	21,041,207 - 21,519,288 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	21,056,177 - 21,534,258 (+)	NCBI		MGSCv36	mm8
Celera	15	22,028,455 - 22,369,031 (+)	NCBI		Celera
Cytogenetic Map	15	A2	NCBI
cM Map	15	8.25	NCBI

Cdh12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	9,651,959 - 10,059,415 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955426	9,652,418 - 10,610,762 (-)	NCBI	ChiLan1.0	ChiLan1.0

CDH12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	87,502,309 - 88,605,663 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	85,655,954 - 86,759,309 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	88,532,493 - 88,636,522 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	94,143,751 - 94,269,418 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	94,160,742 - 94,268,811 (+)	Ensembl	panpan1.1		panPan2

CDH12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	82,501,335 - 83,124,378 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	82,875,494 - 83,123,473 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	81,810,642 - 82,766,572 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	82,774,803 - 83,742,031 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	83,327,616 - 83,741,351 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	82,308,589 - 83,268,674 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	82,561,447 - 83,521,372 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	83,263,631 - 84,299,820 (+)	NCBI		UU_Cfam_GSD_1.0

Cdh12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	214,331,894 - 215,268,682 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936775	516,237 - 789,589 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936775	515,504 - 789,575 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDH12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	9,985,126 - 10,384,663 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	9,985,759 - 10,975,489 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	10,811,499 - 11,212,363 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDH12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	21,183,585 - 22,272,005 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666064	6,125,823 - 7,234,642 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	19
Count of miRNA genes:	17
Interacting mature miRNAs:	17
Transcripts:	ENSRNOT00000034044
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	61556902	106556902	Rat
6480225	Gdil1	Gastrointestinal dilation QTL 1			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	58388201	77302351	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	61051883	104684275	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	36750344	81750344	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	61051541	105724065	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	28889991	73889991	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	41801363	104744824	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	44904355	85286097	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	44537979	112567334	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	61051541	105724065	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	51266859	96266859	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	60861391	105861391	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	38426449	111295694	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	36868643	81868643	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	44904355	89904355	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	33269996	78269996	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	61051541	143746880	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	73652666	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	4	21	106	49	47	20	24	20	2	120	60	91	27	47	27

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591414	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591415	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000034044 ⟹ ENSRNOP00000032511

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	70,475,043 - 71,700,572 (+)	Ensembl
Rnor_6.0 Ensembl	2	72,006,099 - 72,540,263 (+)	Ensembl

RefSeq Acc Id:

NM_001427475 ⟹ NP_001414404

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	72,886,532 - 73,436,039 (+)	NCBI

RefSeq Acc Id:

XM_017591412 ⟹ XP_017446901

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	72,201,859 - 73,436,039 (+)	NCBI
mRatBN7.2	2	70,474,679 - 71,705,369 (+)	NCBI
Rnor_6.0	2	71,310,228 - 72,540,063 (+)	NCBI

Sequence:

show sequence

GCCTCCCCAACACCCCCACCCCCTCCGCCCTGAGAGCATTATTGATCTGAAGGGTAAATGTGGA
GGGAGCCACAGAGAGGGTCCAGGCGTTTCTGAGAAGAGAGGCTGACTCTTCCAGGAACAAAGTG
GTGTCTGCTGGCTGCCTGGCCTGGGAATCTTCTGTGAATTAAAGGGGACAAAATGCGCGGTCGT
GGTTCGCTACAGTGATTGAGAAGAGGGAAGAGACAGAGAGGCAGAGGGAGAAGTCGCACCTTGG
AGCGAGGCTGTGTTGTTTCATCCCGCTGCTGCCCTTTCTCCGTTGCTGTTCCTGTGCTGCGTCT
GCTCTCAGCCATCAGCACAATTACCTGACTGGTCCTTTGTACGGAGGATTGTAATGACGTTGGA
AAACAAGCGAAGTCTGGGGTATTGAGAGAATGGTAGCCTTTTTAAAGACAGCGAGGAGCTTGGC
ATAAACAGAGGCAAAGGAGAAGAGCACGCTGCCACTCTGTGGGTGTTGATTGAAAACTTCGATC
TCCTCACCCATTTATGGTTGATCTAAAGGATTTCTCACTTGATCACCGAGAGTATTTCAATTAA
GGTCTCCTTAGATGGAATGTCATAAACCAGAAACTTCCAAAGCATCAATGTGTGAATTACTGTC
ACTGCACTAAAACAGAAAGCTCAGTGGTCACAGACACTTCAACCCTGGATCCCACCATTCTACA
TTAAGTACTGGAGTATTTATTACTCTTCTGTAGAAGAAAGACTTTGCCAATGCTTACAAGGAAC
TCTTTATACCTGCTTCTCTGGATCCTGTTTGATGGAGGTCTCCTAACACCACTGCAGCCACAGC
CACAACAAACTTTAGCCACAGAACCAAAAGACAATGTTATCCACCTTCTGGGGAGACGGTCCCA
TTTCCAACGAGTTAAACGTGGCTGGGTATGGAATCAGTTTTTTGTGCTGGAAGAGTACATGGGA
TCCGAACCTCAATATGTGGGAAAGTTACACTCTGACCTGGACAAGGGAGAAGGCACTGTTAAAT
ACACGCTCTCTGGAGATGGTGCTGGCACTGTTTTCACGATTGATGAAACTACAGGAGACATTCA
TGCAATAAGAAGCCTGGATAGAGAAGAAAAACCTTTCTACACTCTTCGTGCTCAGGCAGTGGAC
ATAGAAACCAGGAAGCCACTGGAGCCCGAATCAGAGTTCATCATTAAAGTGCAGGATATTAACG
ATAATGAGCCAAAGTTTTTGGATGGACCATATGTTGCTAGTGTTCCAGAAATGTCTCCTGTGGG
TGCATATGTGCTACAGGTCAAGGCCACAGATGCAGATGACCCCACCTATGGAAACAGTGCCAGA
GTTGTTTACAGCATCCTTCAGGGGCAGCCTTATTTCTCCATTGATCCCAAAACAGGTGTCATTA
GAACAGCATTGCCAAACATGGACAGAGAAGTCAAGGAGCAGTACCAGGTCCTCATTCAAGCGAA
GGACATGGGAGGACAGCTCGGAGGACTCGCTGGAACTACCATTGTCAACATCACCCTTACTGAT
GTCAATGACAACCCACCTCGATTCCCAAAAAGCATCTTCCATCTAAAAGTTCCCGAGTCCTCCC
CTGTTGGCTCAGCTATTGGAAGAATAAGAGCAGTAGATCCTGATTTTGGAAAAAATGCAGAAAT
TGAATACAACATTGTCCCAGGAGATGGGGGAAATTTGTTTGACATTGTCACAGATGAGGATACA
CAAGAAGGAATCATCAAATTGAAAAAGCCATTAGATTTTGAAACAAAGAAGGCATATACTTTTA
AAGTAGAGGCCTCCAACCTTCACCTTGACCACCGCTTTCACTCAGCTGGGCCATTTAAAGATAC
TGCTACGGTAAAAATAAGCGTGCTGGATGTGGACGAGCCGCCAGTGTTCAGCAAGCCACTTTAC
ACCATGGAGGTTTATGAAGACACTCCTGTGGGGACCATCATCGGAGCTGTCACAGCACAAGACC
TTGATGTGGGCAGTAGTGCTGTTAGGTACTTCATAGATTGGAAGAGTGATGGGGACAGCTACTT
CACAATAGATGGAACGGAAGGAACCATCGCCACTAATGAATTACTAGACAGAGAGAACACAGCA
CAGTATAATTTCTCAATAATTGCAAGTAAAGTTAGTAACCCATCATTAACTAGCAAAGTTAATA
TATTAATTAATGTCCTAGATGTCAATGAATTTCCGCCAGAAATATCTGTGCCATATGAGACAGC
TGTGTGTGAAAATGCCAAACCAGGACAGATCATTCAGATAGTCGGTGCTGTAGATCGAGATCTC
TCACCTGCTGGGCAGCAATTCTCCTTTAGATTAGCACCAGAAGCTGTCATCAAACCAAATTTTA
CAGTTCATGACTTCAGAAACAACACAGCTGGAATCGAAACCCGGAGAAATGGCTACAGCCGCAG
GCAACAAGAATTGTATTTCCTTCCTATTGTTATAGAAGACAGCAGTTACCCTGTCCAAAGCAGC
ACGAATACAATGACAATTCGTGTTTGTAGATGTGACTCTGATGGAACCATCCTGTCTTGCAACG
TGGAAGCAATTTTTCTACCTGTAGGACTTAGCACCGGAGCTTTGATTGCAATCCTACTATGCAT
TGTTATACTCTTAGCTATTGTTGTGCTGTATGTAGCACTGAGGAGGCAGAAGAAGAAAGACACC
CTTATGACCTCCAAAGAAGACATCAGAGACAATGTTATCCATTATGATGATGAAGGAGGTGGGG
AGGAGGACACCCAAGCCTTTGACATTGGGGCTCTGAGAAATCCGAAGGTGATCGAAGAGAACAA
AATTCGCAGAGATATAAAACCAGACTCCTTCTGTTTACCTCGTCAGAGACCACAAGTGGAAGAC
AACACAGACATAAGGGATTTTATTCACCAAAGGCTACAGGAAAATGATGCAGATCCAGCTGCAC
CCCCATATGATTCCTTGGCCACTTATGCTTATGAGGGGAATGGGTCAGTGGCTGAGTCACTCAG
CTCCATAGACTCTCTCACCTCAGAGGCTGACCAGGACTATGATTATCTATCAGACTGGGGACCC
CGCTTTAAGGTCTTGGCAGACATGTTTGGAGAAGAAGAGAGTTACAACCCTGACAATGTTACCT
AGGGGAGAAGGAAAGGCTGATACATATCTAAAGGAGAAAGTTTTGAGAAAAATAACACAAATTA
CACACACACACACACACACACACACAAACACACACACACACAGATTTTGCAGGACAAGACTTTT
TTGATTATCCAGTTTCTAACAAGTTGCTCTATTTATCATATTGTCATTTTGGTTTACTCTGTAG
ACAAAAGATAAATCTTATAATATGTACTTGCTTTGTTCTGTTTTGTTATTTGGGAAACCCATCG
AGATGAGCTCAGGCCTATTAAATGCAATTCACTGACATGACAACCTAGAATGAAGATAGCTATG
TGGCGTCACAGTGGAAGAGTGTGCGATTTTTCTTAATTCCACTAAAGTGCCTATTGAAACTCTT
ATCATTATAGTGGTGTTCATAACACTCTGCTGTGATGGCTTTGCAGGAGTCAGAAATAAGAAGG
AACAAAGCAGACAGTGTCTCTATGTCAAGGAGCAATAGTGACAAGCTGATTCTCATTTCTTTCA
AGAACAGAGAAGAATAATTCCCAAGCTCCATCTTCTTATACGGCAATGCTTTTCCTTTTGTAAA
CTGTAAACTAAAAACAATGCTTTTACTATTCTTTCAGAAACTGGAATAAAAGAGACATTATTAA
ATTCAATATGTAAGTTATGAATTCTGAGAGAAATGCTTGAGTCATAGCATTAGTTCATGTAAAC
AATGTTAATTAAGCTGTTAGTTTTTCCAAAATAACTAAATAAACTTATACAGAAGGAAATAAAA
AGAATCCCTCTTTATAAAGAGAGGCCTCAGGGCTCAAATTCCAACATCAAGTCAATATCGGTTT
GTTTAATTCTATACTGGCGTATAGACATTGTTTTTTAACAAATCATTGAGTCATTTAAGCTTTC
AGTCATAGACAAAATTTCAGCTTGTGTTTCTGCTGAATTTTGGGACAGGAAATATGCTATTAAT
TTAACCATGAGAAAAATTTAACATTGTGATTCTCAGAGTTTCTCTCTGAGAATCTCTAGTGGTA
ATTTGATGAATGATTCAAACAAAATACATATCAAATATTGCAATTTATAATGAGCATATATGTT
TATTCTATACTACTGAACAAATAAGTCAGGGAACCTCAAAAATAAAACCAATGACTAAATCCCA
AAGGGAGCAAAACTTCAATGCCAGGCAGCTGATTCACTTTCTCTCATGATGTGAATTTTAACTT
TGTGAAGTCAGTTATTATATCAGCCCAGCGTCACCTCTTTATTATCTCATTTACACAAACCCTC
ATGGAAATTACTCCTCATAACTCTTTAAATAAAACTTCTCCAGTTCATGGAAATGCCTAAGAAA
TGATGGAATTTGTGACTATATTAGTAATATACATAGTTCAAATCAATTCCATTTGGATTAAAAA
TCATTTAGAGATTCACAGGATACAACACTTACAAATCAACCATAAAGTAACGATGTAGTTAAAA
CAATTAACAACTTTTACCTATAGGTTGGAAAAATTAAAGTGAAAGAGTTGTTTATCACATATGG
ATAGTATCTGGTTTTATGATAAATTTCTGTGAATATCATTATTATTTGTGAGGCTATGAAGATA
AAAACTCACACTATAAAATCTAAGAAATTTACAAAATTAAACAACTTAATTTTAGGCATATTCT
AAAATGCATATTTTAAATTACTTATTGTGTGGAAATATGCGCCCTGTTTCTTTGTCCACCATTT
TGTAGACTGTTTTCTCCCTTTTGGAATGGGAGATTTAACCTTCGTTTTTCAGTCAGTCCTCCAT
AATTCTCGTTTCAATTTTCATGTAAAAAACAATTATATTCAGTATTTTACATTTGAGAAAAATA
ACTGTTTTATAAATCTTAGAATTGCCATGCTAGAGAAGAAAAATTTGATAAGACTTGTTTTTTA
ATCTCACTATGTATGGAGAATGTCTTCTTGAAGAAGGTTAATATTCAAGACCACACCCTATTAC
AATCTGACTCTTGTCAAAGACTATTACACCTGATATGTTGACAGGAAAGAAAATGGCCTTTTCG
AGAAGTTGCTAAGCAGAAGCCATGATGACCTGAAGATTTGAGAGGCAGATGGCTTCAATCACAC
GCCTAAGAAGATAGAAAAATATGCAATGTGTGGCTCTTAGGTCTCACCACACTCATATCTTCGT
AATTTCCTACATTACTTCATTAGCTCAAAAGAAATGATCATAGAAAAAGTGGTTTTAAACAGTA
GCAGTTTATATCCACAGCTCTGGTGGCAGGTTTCCTCTGACCATCTTCCCCTCTTCATGGAGAA
GACCACATTTTTTCACCACTGGGTCTCATTTTGTGCTTGTTTCTGTTTCTCTTCTCACAAGGGC
ACTCTTTGTATGAGAGCAGTATCTTCCCAGAGGACCTCTATTTACCTTGTTTAATAATAATGGC
CTTACCACCAAATCCTATTTGAACTGGGACTACAGCATGTGGATTCATGCAATCCCAATCTGAA
GATACTATCAATGTTTATTTTCTAAATAGCATCTCACTTACAAGAACCAATAAAGGAAACAAAC
ATAAACAAGCAGAATGTTAAAAAATAATATATGATGTGGAAAGGAGATCCTTTGGTGCTTATAA
TTAGAGGAACTATGATAGCTTTAGGCTACTGAAAGGACTAAGCCCAGTATTTCAATACCTGTAA
TACCTTGGGATGTTTTTCATTCATAAGACAGGTGTTGACCGTCATTCAAGCATTAAGCAATATA
AAAATGTTTAAAATTTGTATGAATGATTTAGCTATAAACAAACAGCAATTTTGTTATTGGCTTG
CATGTCTATCTTTATAGAGCTACATACATATGTACATATATATAACTTATATGTTGCCTTCAAT
GCTACTCAAAGAAATGTATAGTCAGCATCCAAAAAGTGAAGCAGTGTTCATTGACGTACTAGAA
ATGATCTGTGTATGTTGAACTTTAACCCGTTTTGACTCAAAATGTCCTATGGATCAAATTCCTT
GCCTTTCTTTTATTTTCTTTAGTAAAACCAGTTTCATATATTCAGTGTTGTGGACAATTAATCT
GAAATTTTCTTGTCATTAAATTACAGCAATGGTTGAAATATATCAAATAGCTTACCTACAGGCT
ATGCTAATTTAAACATGCATAGTACATCATTATAAGTCGTAGTACATAAATTTTTGAATCATGT
AGGGATTTGACTGATCTTTTATCAAAATCACTAGTTCTACTTAGAAAACCCCACGACTACTTTT
CATCAATATACCTGAATATTCTTCTGTGAAATCAAGAGAAAAAGAAGTGTACAGGATGAGAGAA
AAATGATCCTAAATTAGATATAGTGTGAGGATGTTCTCTTCCCTTAAATATTATGCTAAAATTT
CAATACCTGTAGAGAATATGGGATCGGTATGCAACACCATGATGCAGTAATTAATGTGCACAAG
CTCTGGGTTCCCTCCCAGGGCCACAAATATAGAAAAATAATAGTAATGATGATGTGATAATGAT
AAACAATGTAATGCAGATGTAAATAAGAAAACAAGGTATTTAAGTGGATCCCTGATTAAACCTA
TACCTAAAAACAGAGGTGTTTTATATTAGTAGCCTCACTATGTTACCAGCAAACAGACTGATTG
TATGAAAGAGAGGATTATTTACATAAGAACTTCTGCTGAACCGTTTTTCTCCTTAACCTCTTAA
ACCTGCTAGCTAGGCTAGCCCTCCAAAATGTATTCAGAACCATTGTTTCCTCAGTACCTTAAAA
GCATTTTGAGAGGAAGGGAAATTGCTTAGCCTTAAAACTAACCTGCTGCTCTTCAAGATGATCT
GTGTTCATTTCCAGAACTTACATGAAAATGTCTCACAGCTGTCATTAAGTCCCACACCAGGGGA
TCTGATATCCACTTCTGAGATTATTTTACATATGCAGATATCAACATGTGGATAAACACATATG
CACACGACTAAAATTAAAAAAAACAATCTTGGAAAAGTTATTTTCTCTCATGTCCTATCATAAA
TTCACTGGTGAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001414404	(Get FASTA)	NCBI Sequence Viewer
	XP_017446901	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL82601	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000032511.4

RefSeq Acc Id:	XP_017446901 ⟸ XM_017591412
- Peptide Label:	isoform X1
- UniProtKB:	F1M1A2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLTRNSLYLLLWILFDGGLLTPLQPQPQQTLATEPKDNVIHLLGRRSHFQRVKRGWVWNQFFVL EEYMGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLR AQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVASVPEMSPVGAYVLQVKATDADDPTY GNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVN ITLTDVNDNPPRFPKSIFHLKVPESSPVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDIV TDEDTQEGIIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVF SKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGTEGTIATNELLD RENTAQYNFSIIASKVSNPSLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVGA VDRDLSPAGQQFSFRLAPEAVIKPNFTVHDFRNNTAGIETRRNGYSRRQQELYFLPIVIEDSSY PVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQ KKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSFCLPRQR PQVEDNTDIRDFIHQRLQENDADPAAPPYDSLATYAYEGNGSVAESLSSIDSLTSEADQDYDYL SDWGPRFKVLADMFGEEESYNPDNVT hide sequence

Ensembl Acc Id:

ENSRNOP00000032511 ⟸ ENSRNOT00000034044

RefSeq Acc Id:	NP_001414404 ⟸ NM_001427475
- Peptide Label:	precursor
- UniProtKB:	F1M1A2 (UniProtKB/TrEMBL)

Protein Domains

Cadherin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M1A2-F1-model_v2	AlphaFold	F1M1A2	1-794	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566350	AgrOrtholog
BioCyc Gene	G2FUF-53990	BioCyc
Ensembl Genes	ENSRNOG00000026392	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000034044.6	UniProtKB/TrEMBL
Gene3D-CATH	4.10.900.10	UniProtKB/TrEMBL
	Cadherins	UniProtKB/TrEMBL
InterPro	Cadherin	UniProtKB/TrEMBL
	Cadherin	UniProtKB/TrEMBL
	Cadherin-like	UniProtKB/TrEMBL
	Cadherin_CS	UniProtKB/TrEMBL
	Cadherin_cytoplasmic-dom	UniProtKB/TrEMBL
	Catenin_binding_dom	UniProtKB/TrEMBL
KEGG Report	rno:301887	UniProtKB/TrEMBL
NCBI Gene	301887	ENTREZGENE
PANTHER	CADHERIN-12	UniProtKB/TrEMBL
	PTHR24027	UniProtKB/TrEMBL
Pfam	Cadherin	UniProtKB/TrEMBL
	Cadherin_C	UniProtKB/TrEMBL
PhenoGen	Cdh12	PhenoGen
PRINTS	CADHERIN	UniProtKB/TrEMBL
PROSITE	CADHERIN_1	UniProtKB/TrEMBL
	CADHERIN_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000026392	RatGTEx
SMART	SM00112	UniProtKB/TrEMBL
Superfamily-SCOP	Cadherin	UniProtKB/TrEMBL
UniProt	F1M1A2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Cdh12	cadherin 12	RGD1566350_predicted	similar to cadherin 12, type 2 preproprotein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1566350_predicted	similar to cadherin 12, type 2 preproprotein (predicted)	LOC301887	similar to cadherin 12, type 2 preproprotein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC301887	similar to cadherin 12, type 2 preproprotein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD