Fcrlb (Fc receptor-like B) - Rat Genome Database

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Gene: Fcrlb (Fc receptor-like B) Rattus norvegicus
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Symbol: Fcrlb
Name: Fc receptor-like B
RGD ID: 1563018
Description: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immunoglobulin mediated immune response. Predicted to act upstream of or within negative regulation of immune response. Predicted to be located in cytoplasm. Predicted to be active in external side of plasma membrane. Orthologous to human FCRLB (Fc receptor like B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC498275; RGD1563018; similar to hypothetical protein FLJ31052 isoform a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,681,403 - 85,689,880 (-)NCBIGRCr8
mRatBN7.21383,148,685 - 83,157,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,149,751 - 83,155,957 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,769,635 - 85,775,146 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,063,103 - 87,068,617 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,300,968 - 84,306,440 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,284,801 - 89,293,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,285,998 - 89,291,371 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01393,897,175 - 93,904,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,764,537 - 86,770,041 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1382,802,640 - 82,808,144 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15815692   PMID:20869045  


Genomics

Comparative Map Data
Fcrlb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,681,403 - 85,689,880 (-)NCBIGRCr8
mRatBN7.21383,148,685 - 83,157,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,149,751 - 83,155,957 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,769,635 - 85,775,146 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,063,103 - 87,068,617 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,300,968 - 84,306,440 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,284,801 - 89,293,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,285,998 - 89,291,371 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01393,897,175 - 93,904,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,764,537 - 86,770,041 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1382,802,640 - 82,808,144 (-)NCBICelera
Cytogenetic Map13q24NCBI
FCRLB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,721,544 - 161,728,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,721,544 - 161,728,143 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,691,334 - 161,697,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,959,081 - 159,964,557 (+)NCBINCBI36Build 36hg18NCBI36
Celera1134,795,903 - 134,801,378 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,936,998 - 132,942,472 (+)NCBIHuRef
CHM1_11163,114,257 - 163,119,734 (+)NCBICHM1_1
T2T-CHM13v2.01161,065,867 - 161,072,464 (+)NCBIT2T-CHM13v2.0
Fcrlb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,734,284 - 170,741,396 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,734,842 - 170,740,510 (-)EnsemblGRCm39 Ensembl
GRCm381170,906,715 - 170,913,829 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,907,273 - 170,912,941 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,837,404 - 172,843,072 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,743,948 - 172,749,616 (-)NCBIMGSCv36mm8
Celera1173,355,542 - 173,361,196 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map177.56NCBI
Fcrlb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546214,591,877 - 14,596,418 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546214,591,367 - 14,597,183 (-)NCBIChiLan1.0ChiLan1.0
FCRLB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,058,650 - 88,064,537 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1187,726,984 - 87,732,036 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01137,134,362 - 137,140,232 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,933,226 - 140,939,805 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,934,358 - 140,939,324 (+)Ensemblpanpan1.1panPan2
FCRLB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13820,943,351 - 20,950,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3820,995,264 - 21,001,636 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,026,203 - 21,032,614 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,026,194 - 21,032,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13820,998,202 - 21,004,571 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,351,224 - 21,357,594 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,627,399 - 21,633,773 (-)NCBIUU_Cfam_GSD_1.0
Fcrlb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,608,819 - 7,613,625 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937131128,260 - 132,589 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937131128,256 - 132,577 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCRLB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl488,833,651 - 88,839,308 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1488,832,726 - 88,839,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,850,087 - 96,856,376 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FCRLB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,344,021 - 2,351,838 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,344,502 - 2,349,502 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,386,705 - 1,392,809 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcrlb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624826143,247 - 147,526 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624826141,409 - 147,668 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:33
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000004181
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134760142692601426Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 24 103 79 78 47 25 47 6 169 68 83 43 54 31

Sequence


Ensembl Acc Id: ENSRNOT00000004181   ⟹   ENSRNOP00000004181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,149,751 - 83,155,957 (-)Ensembl
Rnor_6.0 Ensembl1389,285,998 - 89,291,371 (-)Ensembl
RefSeq Acc Id: NM_001191931   ⟹   NP_001178860
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,682,472 - 85,687,978 (-)NCBI
mRatBN7.21383,149,751 - 83,155,254 (-)NCBI
Rnor_6.01389,285,867 - 89,291,371 (-)NCBI
Rnor_5.01393,897,175 - 93,904,551 (-)NCBI
Celera1382,802,640 - 82,808,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769747   ⟹   XP_008767969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,681,403 - 85,687,913 (-)NCBI
mRatBN7.21383,148,685 - 83,155,189 (-)NCBI
Rnor_6.01389,284,801 - 89,290,950 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598891   ⟹   XP_017454380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,681,403 - 85,689,880 (-)NCBI
mRatBN7.21383,148,685 - 83,157,157 (-)NCBI
Rnor_6.01389,284,801 - 89,292,074 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090975   ⟹   XP_038946903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,681,403 - 85,688,585 (-)NCBI
mRatBN7.21383,148,685 - 83,155,861 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178860 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767969 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454380 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946903 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09241 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004181.4
RefSeq Acc Id: NP_001178860   ⟸   NM_001191931
- Peptide Label: precursor
- UniProtKB: D4A8M3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767969   ⟸   XM_008769747
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454380   ⟸   XM_017598891
- Peptide Label: isoform X2
- UniProtKB: D4A8M3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004181   ⟸   ENSRNOT00000004181
RefSeq Acc Id: XP_038946903   ⟸   XM_039090975
- Peptide Label: isoform X1
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8M3-F1-model_v2 AlphaFold D4A8M3 1-426 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563018 AgrOrtholog
BioCyc Gene G2FUF-17462 BioCyc
Ensembl Genes ENSRNOG00000003135 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004181.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_Fc_receptor UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
KEGG Report rno:498275 UniProtKB/TrEMBL
NCBI Gene 498275 ENTREZGENE
PANTHER FC RECEPTOR-LIKE B UniProtKB/TrEMBL
  IMMUNOGLOBULIN FC RECEPTOR UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
PhenoGen Fcrlb PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003135 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt D4A8M3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Fcrlb  Fc receptor-like B  RGD1563018_predicted  similar to hypothetical protein FLJ31052 isoform a (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563018_predicted  similar to hypothetical protein FLJ31052 isoform a (predicted)  LOC498275  similar to hypothetical protein FLJ31052 isoform a  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498275  similar to hypothetical protein FLJ31052 isoform a      Symbol and Name status set to provisional 70820 PROVISIONAL