FCRLB (Fc receptor like B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: FCRLB (Fc receptor like B) Homo sapiens
Analyze
Symbol: FCRLB
Name: Fc receptor like B
RGD ID: 1605583
HGNC Page HGNC:26431
Description: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immunoglobulin mediated immune response. Predicted to act upstream of or within negative regulation of immune response. Located in cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fc receptor homolog expressed in B cells protein 2; Fc receptor homolog expressed in B-cells protein 2; Fc receptor like 2; Fc receptor-like and mucin-like 2; fc receptor-like and mucin-like protein 2; Fc receptor-like B; fc receptor-like protein 2; fc receptor-related protein Y; FCRL2; FCRLM2; FCRLY; FcRY; FLJ31052; FREB-2; FREB2; RP11-474I16.6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,721,544 - 161,728,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,721,544 - 161,728,143 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,691,334 - 161,697,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,959,081 - 159,964,557 (+)NCBINCBI36Build 36hg18NCBI36
Celera1134,795,903 - 134,801,378 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,936,998 - 132,942,472 (+)NCBIHuRef
CHM1_11163,114,257 - 163,119,734 (+)NCBICHM1_1
T2T-CHM13v2.01161,065,867 - 161,072,464 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15676285   PMID:15815692   PMID:16263223   PMID:17273841   PMID:17975119   PMID:19023099   PMID:21873635   PMID:23593433   PMID:36724073   PMID:39358380  


Genomics

Comparative Map Data
FCRLB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,721,544 - 161,728,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,721,544 - 161,728,143 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,691,334 - 161,697,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,959,081 - 159,964,557 (+)NCBINCBI36Build 36hg18NCBI36
Celera1134,795,903 - 134,801,378 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,936,998 - 132,942,472 (+)NCBIHuRef
CHM1_11163,114,257 - 163,119,734 (+)NCBICHM1_1
T2T-CHM13v2.01161,065,867 - 161,072,464 (+)NCBIT2T-CHM13v2.0
Fcrlb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,734,284 - 170,741,396 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,734,842 - 170,740,510 (-)EnsemblGRCm39 Ensembl
GRCm381170,906,715 - 170,913,829 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,907,273 - 170,912,941 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,837,404 - 172,843,072 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,743,948 - 172,749,616 (-)NCBIMGSCv36mm8
Celera1173,355,542 - 173,361,196 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map177.56NCBI
Fcrlb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,681,403 - 85,689,880 (-)NCBIGRCr8
mRatBN7.21383,148,685 - 83,157,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,149,751 - 83,155,957 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,769,635 - 85,775,146 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,063,103 - 87,068,617 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,300,968 - 84,306,440 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,284,801 - 89,293,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,285,998 - 89,291,371 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01393,897,175 - 93,904,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,764,537 - 86,770,041 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1382,802,640 - 82,808,144 (-)NCBICelera
Cytogenetic Map13q24NCBI
Fcrlb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546214,591,877 - 14,596,418 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546214,591,367 - 14,597,183 (-)NCBIChiLan1.0ChiLan1.0
FCRLB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,058,650 - 88,064,537 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1187,726,984 - 87,732,036 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01137,134,362 - 137,140,232 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,933,226 - 140,939,805 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,934,358 - 140,939,324 (+)Ensemblpanpan1.1panPan2
FCRLB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13820,943,351 - 20,950,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3820,995,264 - 21,001,636 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,026,203 - 21,032,614 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,026,194 - 21,032,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13820,998,202 - 21,004,571 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,351,224 - 21,357,594 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,627,399 - 21,633,773 (-)NCBIUU_Cfam_GSD_1.0
Fcrlb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,608,819 - 7,613,625 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937131128,260 - 132,589 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937131128,256 - 132,577 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCRLB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl488,833,651 - 88,839,308 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1488,832,726 - 88,839,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,850,087 - 96,856,376 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FCRLB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,344,021 - 2,351,838 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,344,502 - 2,349,502 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,386,705 - 1,392,809 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcrlb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624826143,247 - 147,526 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624826141,409 - 147,668 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FCRLB
35 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.2-24.1(chr1:159479887-166895086)x1 copy number loss See cases [RCV000051172] Chr1:159479887..166895086 [GRCh38]
Chr1:159449677..166864323 [GRCh37]
Chr1:157716301..165130947 [NCBI36]
Chr1:1q23.2-24.1		 pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1		 pathogenic
GRCh38/hg38 1q23.3-24.2(chr1:160789732-168617494)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|See cases [RCV000053913] Chr1:160789732..168617494 [GRCh38]
Chr1:160759522..168586732 [GRCh37]
Chr1:159026146..166853356 [NCBI36]
Chr1:1q23.3-24.2		 pathogenic
NM_001002901.3(FCRLB):c.86C>T (p.Pro29Leu) single nucleotide variant Malignant melanoma [RCV000064278] Chr1:161723400 [GRCh38]
Chr1:161693190 [GRCh37]
Chr1:159959814 [NCBI36]
Chr1:1q23.3		 not provided
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
GRCh37/hg19 1q23.2-25.1(chr1:160369890-175796325) copy number loss not provided [RCV000767779] Chr1:160369890..175796325 [GRCh37]
Chr1:1q23.2-25.1		 pathogenic
GRCh37/hg19 1q23.3-25.3(chr1:161676893-184071723)x1 copy number loss See cases [RCV000447098] Chr1:161676893..184071723 [GRCh37]
Chr1:1q23.3-25.3		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_001002901.4(FCRLB):c.923C>T (p.Ala308Val) single nucleotide variant not specified [RCV004302526] Chr1:161727304 [GRCh38]
Chr1:161697094 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.3(chr1:161469309-162517412)x3 copy number gain not provided [RCV000684667] Chr1:161469309..162517412 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q23.2-25.2(chr1:159815642-177026983)x1 copy number loss not provided [RCV000736717] Chr1:159815642..177026983 [GRCh37]
Chr1:1q23.2-25.2		 pathogenic
GRCh37/hg19 1q23.3(chr1:160744174-162583871)x3 copy number gain not provided [RCV000849025] Chr1:160744174..162583871 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.1-24.2(chr1:157321299-167391423)x1 copy number loss not provided [RCV000848773] Chr1:157321299..167391423 [GRCh37]
Chr1:1q23.1-24.2		 pathogenic
NM_001002901.4(FCRLB):c.91T>G (p.Trp31Gly) single nucleotide variant not specified [RCV004326489] Chr1:161723405 [GRCh38]
Chr1:161693195 [GRCh37]
Chr1:1q23.3		 uncertain significance
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
GRCh37/hg19 1q23.2-24.1(chr1:160417296-166197042) copy number loss not specified [RCV002053658] Chr1:160417296..166197042 [GRCh37]
Chr1:1q23.2-24.1		 pathogenic
NC_000001.10:g.(?_158581054)_(162750036_?)dup duplication Autoimmune interstitial lung disease-arthritis syndrome [RCV001918952]|not provided [RCV001918953] Chr1:158581054..162750036 [GRCh37]
Chr1:1q23.1-23.3		 uncertain significance|no classifications from unflagged records
NC_000001.10:g.(?_161645027)_(161772082_?)dup duplication not provided [RCV001883368] Chr1:161645027..161772082 [GRCh37]
Chr1:1q23.3		 uncertain significance
NC_000001.10:g.(?_161279609)_(161751809_?)dup duplication Charcot-Marie-Tooth disease, type I [RCV003111375] Chr1:161279609..161751809 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.646G>A (p.Val216Met) single nucleotide variant not specified [RCV004165548] Chr1:161726774 [GRCh38]
Chr1:161696564 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.944C>T (p.Ser315Phe) single nucleotide variant not specified [RCV004230163] Chr1:161727325 [GRCh38]
Chr1:161697115 [GRCh37]
Chr1:1q23.3		 likely benign
NM_001002901.4(FCRLB):c.752A>G (p.Glu251Gly) single nucleotide variant not specified [RCV004175283] Chr1:161726880 [GRCh38]
Chr1:161696670 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.673C>T (p.Pro225Ser) single nucleotide variant not specified [RCV004195551] Chr1:161726801 [GRCh38]
Chr1:161696591 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.863C>A (p.Pro288Gln) single nucleotide variant not specified [RCV004143679] Chr1:161726991 [GRCh38]
Chr1:161696781 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.1225A>G (p.Thr409Ala) single nucleotide variant not specified [RCV004213327] Chr1:161727606 [GRCh38]
Chr1:161697396 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.679A>G (p.Lys227Glu) single nucleotide variant not specified [RCV004121539] Chr1:161726807 [GRCh38]
Chr1:161696597 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.700T>A (p.Phe234Ile) single nucleotide variant not specified [RCV004110267] Chr1:161726828 [GRCh38]
Chr1:161696618 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.1247C>G (p.Pro416Arg) single nucleotide variant not specified [RCV004191045] Chr1:161727628 [GRCh38]
Chr1:161697418 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.703G>T (p.Ala235Ser) single nucleotide variant not specified [RCV004134814] Chr1:161726831 [GRCh38]
Chr1:161696621 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.1211C>T (p.Thr404Met) single nucleotide variant not specified [RCV004083611] Chr1:161727592 [GRCh38]
Chr1:161697382 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.1210A>C (p.Thr404Pro) single nucleotide variant not specified [RCV004268082] Chr1:161727591 [GRCh38]
Chr1:161697381 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.1001C>G (p.Thr334Ser) single nucleotide variant not specified [RCV004268698] Chr1:161727382 [GRCh38]
Chr1:161697172 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.404T>C (p.Leu135Pro) single nucleotide variant not specified [RCV004328633] Chr1:161725917 [GRCh38]
Chr1:161695707 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.222C>A (p.Ser74Arg) single nucleotide variant not specified [RCV004342675] Chr1:161723536 [GRCh38]
Chr1:161693326 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.1-23.3(chr1:158001058-162858285)x1 copy number loss not provided [RCV003483944] Chr1:158001058..162858285 [GRCh37]
Chr1:1q23.1-23.3		 likely pathogenic
NM_001002901.4(FCRLB):c.211C>A (p.His71Asn) single nucleotide variant not specified [RCV004391607] Chr1:161723525 [GRCh38]
Chr1:161693315 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.374G>A (p.Arg125His) single nucleotide variant not specified [RCV004391608] Chr1:161725887 [GRCh38]
Chr1:161695677 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.670C>T (p.His224Tyr) single nucleotide variant not specified [RCV004391609] Chr1:161726798 [GRCh38]
Chr1:161696588 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.1064C>A (p.Ala355Asp) single nucleotide variant not specified [RCV004391606] Chr1:161727445 [GRCh38]
Chr1:161697235 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.715T>C (p.Tyr239His) single nucleotide variant not specified [RCV004391611] Chr1:161726843 [GRCh38]
Chr1:161696633 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.875T>C (p.Leu292Pro) single nucleotide variant not specified [RCV004391612] Chr1:161727256 [GRCh38]
Chr1:161697046 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.1024C>G (p.Pro342Ala) single nucleotide variant not specified [RCV004391605] Chr1:161727405 [GRCh38]
Chr1:161697195 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.433C>A (p.Arg145Ser) single nucleotide variant not specified [RCV004618558] Chr1:161725946 [GRCh38]
Chr1:161695736 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.224T>C (p.Ile75Thr) single nucleotide variant not specified [RCV004618561] Chr1:161723538 [GRCh38]
Chr1:161693328 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.266G>A (p.Gly89Glu) single nucleotide variant not specified [RCV004618557] Chr1:161723580 [GRCh38]
Chr1:161693370 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.1118T>C (p.Leu373Pro) single nucleotide variant not specified [RCV004618559] Chr1:161727499 [GRCh38]
Chr1:161697289 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.1201C>T (p.Leu401Phe) single nucleotide variant not specified [RCV004921441] Chr1:161727582 [GRCh38]
Chr1:161697372 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.725C>T (p.Ala242Val) single nucleotide variant not specified [RCV004921442] Chr1:161726853 [GRCh38]
Chr1:161696643 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.808G>C (p.Ala270Pro) single nucleotide variant not specified [RCV004921443] Chr1:161726936 [GRCh38]
Chr1:161696726 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_001002901.4(FCRLB):c.584G>T (p.Arg195Leu) single nucleotide variant not specified [RCV004921444] Chr1:161726712 [GRCh38]
Chr1:161696502 [GRCh37]
Chr1:1q23.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1935
Count of miRNA genes:651
Interacting mature miRNAs:744
Transcripts:ENST00000336830, ENST00000367944, ENST00000367945, ENST00000367946, ENST00000367948, ENST00000392158, ENST00000495397
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597271529GWAS1367603_Hlow affinity immunoglobulin gamma Fc region receptor II-b measurement QTL GWAS1367603 (human)2e-26low affinity immunoglobulin gamma Fc region receptor II-b measurement1161722364161722365Human
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human
597406986GWAS1503060_Hlow affinity immunoglobulin gamma Fc region receptor II-a measurement QTL GWAS1503060 (human)5e-12low affinity immunoglobulin gamma Fc region receptor II-a measurement1161726591161726592Human
597067719GWAS1163793_Hleukocyte count QTL GWAS1163793 (human)2e-08leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)1161727208161727209Human
597244060GWAS1340134_Hblood protein measurement QTL GWAS1340134 (human)1e-19blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)1161727359161727360Human
597071357GWAS1167431_Hserum non-albumin protein measurement QTL GWAS1167431 (human)3e-09serum non-albumin protein measurementserum globulin level (CMO:0002399)1161727208161727209Human
597245525GWAS1341599_Hserum non-albumin protein measurement QTL GWAS1341599 (human)5e-20serum non-albumin protein measurementserum globulin level (CMO:0002399)1161727529161727530Human
597177557GWAS1273631_Hprotein measurement QTL GWAS1273631 (human)8e-45protein measurement1161722246161722247Human
597271975GWAS1368049_Hlow affinity immunoglobulin gamma Fc region receptor II-a measurement QTL GWAS1368049 (human)1e-15low affinity immunoglobulin gamma Fc region receptor II-a measurement1161723409161723410Human
597177558GWAS1273632_Hprotein measurement QTL GWAS1273632 (human)2e-21protein measurement1161723409161723410Human
597243655GWAS1339729_Hblood protein measurement QTL GWAS1339729 (human)6e-14blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)1161727529161727530Human
597246070GWAS1342144_Hserum non-albumin protein measurement QTL GWAS1342144 (human)3e-39serum non-albumin protein measurementserum globulin level (CMO:0002399)1161727359161727360Human

Markers in Region
D6S419  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376157,779,037 - 157,779,173UniSTSGRCh37
Build 366157,699,025 - 157,699,161RGDNCBI36
Celera6158,418,180 - 158,418,311RGD
Cytogenetic Map1q23.3UniSTS
HuRef1132,938,870 - 132,939,579UniSTS
HuRef6155,242,756 - 155,242,884UniSTS
Marshfield Genetic Map6159.98UniSTS
Marshfield Genetic Map6159.98RGD
Genethon Genetic Map6162.3UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2412 2713 2237 4958 1715 2324 5 617 1933 458 2263 7176 6425 49 3724 1 849 1737 1596 173 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001002901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC243424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY670683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY670684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY670685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY670686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY670687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY786314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ014014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX364259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ021957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000336830   ⟹   ENSP00000338598
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,722,659 - 161,727,664 (+)Ensembl
Ensembl Acc Id: ENST00000367944   ⟹   ENSP00000356921
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,722,659 - 161,727,664 (+)Ensembl
Ensembl Acc Id: ENST00000367945   ⟹   ENSP00000356922
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,722,659 - 161,727,664 (+)Ensembl
Ensembl Acc Id: ENST00000367946   ⟹   ENSP00000356923
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,722,659 - 161,727,664 (+)Ensembl
Ensembl Acc Id: ENST00000367948   ⟹   ENSP00000356925
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,721,544 - 161,728,143 (+)Ensembl
Ensembl Acc Id: ENST00000495397
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,725,901 - 161,728,142 (+)Ensembl
RefSeq Acc Id: NM_001002901   ⟹   NP_001002901
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,721,544 - 161,728,143 (+)NCBI
GRCh371161,691,598 - 161,697,933 (+)NCBI
Build 361159,959,081 - 159,964,557 (+)NCBI Archive
Celera1134,795,903 - 134,801,378 (+)RGD
HuRef1132,935,875 - 132,942,472 (+)NCBI
CHM1_11163,113,134 - 163,119,734 (+)NCBI
T2T-CHM13v2.01161,065,867 - 161,072,464 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001288829   ⟹   NP_001275758
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,722,653 - 161,728,143 (+)NCBI
HuRef1132,935,875 - 132,942,472 (+)NCBI
CHM1_11163,114,243 - 163,119,734 (+)NCBI
T2T-CHM13v2.01161,066,976 - 161,072,464 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001288830   ⟹   NP_001275759
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,722,653 - 161,728,143 (+)NCBI
HuRef1132,935,875 - 132,942,472 (+)NCBI
CHM1_11163,114,243 - 163,119,734 (+)NCBI
T2T-CHM13v2.01161,066,976 - 161,072,464 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001288831   ⟹   NP_001275760
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,722,653 - 161,728,143 (+)NCBI
HuRef1132,935,875 - 132,942,472 (+)NCBI
CHM1_11163,114,243 - 163,119,734 (+)NCBI
T2T-CHM13v2.01161,066,976 - 161,072,464 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001288832   ⟹   NP_001275761
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,722,653 - 161,728,143 (+)NCBI
HuRef1132,935,875 - 132,942,472 (+)NCBI
CHM1_11163,114,243 - 163,119,734 (+)NCBI
T2T-CHM13v2.01161,066,976 - 161,072,464 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001320241   ⟹   NP_001307170
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,722,257 - 161,728,143 (+)NCBI
CHM1_11163,113,847 - 163,119,734 (+)NCBI
T2T-CHM13v2.01161,066,580 - 161,072,464 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001002901   ⟸   NM_001002901
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6BAA3 (UniProtKB/Swiss-Prot),   Q6BAA2 (UniProtKB/Swiss-Prot),   Q6BAA1 (UniProtKB/Swiss-Prot),   Q6BAA0 (UniProtKB/Swiss-Prot),   Q5VXA6 (UniProtKB/Swiss-Prot),   A2A3J7 (UniProtKB/Swiss-Prot),   A2A3J5 (UniProtKB/Swiss-Prot),   Q8IXZ7 (UniProtKB/Swiss-Prot),   Q6BAA4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001275760   ⟸   NM_001288831
- Peptide Label: isoform 4 precursor
- UniProtKB: Q6BAA4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001275758   ⟸   NM_001288829
- Peptide Label: isoform 2 precursor
- UniProtKB: Q6BAA4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001275761   ⟸   NM_001288832
- Peptide Label: isoform 5 precursor
- UniProtKB: Q6BAA4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001275759   ⟸   NM_001288830
- Peptide Label: isoform 3 precursor
- UniProtKB: Q6BAA4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001307170   ⟸   NM_001320241
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6BAA3 (UniProtKB/Swiss-Prot),   Q6BAA2 (UniProtKB/Swiss-Prot),   Q6BAA1 (UniProtKB/Swiss-Prot),   Q6BAA0 (UniProtKB/Swiss-Prot),   Q5VXA6 (UniProtKB/Swiss-Prot),   A2A3J7 (UniProtKB/Swiss-Prot),   A2A3J5 (UniProtKB/Swiss-Prot),   Q8IXZ7 (UniProtKB/Swiss-Prot),   Q6BAA4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000338598   ⟸   ENST00000336830
Ensembl Acc Id: ENSP00000356923   ⟸   ENST00000367946
Ensembl Acc Id: ENSP00000356922   ⟸   ENST00000367945
Ensembl Acc Id: ENSP00000356925   ⟸   ENST00000367948
Ensembl Acc Id: ENSP00000356921   ⟸   ENST00000367944
Protein Domains
Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6BAA4-F1-model_v2 AlphaFold Q6BAA4 1-426 view protein structure

Promoters
RGD ID:6785580
Promoter ID:HG_KWN:5883
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:UC001GBI.1,   UC001GBJ.1,   UC001GBK.1,   UC001GBL.1,   UC001GBM.1,   UC009WUS.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361159,958,294 - 159,958,794 (+)MPROMDB
RGD ID:6785575
Promoter ID:HG_KWN:5884
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:UC001GBN.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361159,961,436 - 159,963,397 (+)MPROMDB
RGD ID:6809545
Promoter ID:HG_ACW:4494
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   Lymphoblastoid
Transcripts:FCRLB.EAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 361159,963,341 - 159,963,841 (+)MPROMDB
RGD ID:6857904
Promoter ID:EPDNEW_H2117
Type:initiation region
Name:FCRLB_2
Description:Fc receptor like B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2118  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,722,018 - 161,722,078EPDNEW
RGD ID:6857906
Promoter ID:EPDNEW_H2118
Type:initiation region
Name:FCRLB_1
Description:Fc receptor like B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2117  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,725,873 - 161,725,933EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:26431 AgrOrtholog
COSMIC FCRLB COSMIC
Ensembl Genes ENSG00000162746 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000336830 ENTREZGENE
  ENST00000336830.9 UniProtKB/Swiss-Prot
  ENST00000367944 ENTREZGENE
  ENST00000367944.3 UniProtKB/Swiss-Prot
  ENST00000367945 ENTREZGENE
  ENST00000367945.5 UniProtKB/Swiss-Prot
  ENST00000367946 ENTREZGENE
  ENST00000367946.7 UniProtKB/Swiss-Prot
  ENST00000367948 ENTREZGENE
  ENST00000367948.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000162746 GTEx
HGNC ID HGNC:26431 ENTREZGENE
Human Proteome Map FCRLB Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_Fc_receptor UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
KEGG Report hsa:127943 UniProtKB/Swiss-Prot
NCBI Gene 127943 ENTREZGENE
OMIM 609251 OMIM
PANTHER FC RECEPTOR-LIKE B UniProtKB/Swiss-Prot
  IMMUNOGLOBULIN FC RECEPTOR UniProtKB/Swiss-Prot
Pfam Ig_2 UniProtKB/Swiss-Prot
PharmGKB PA162388195 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot
SMART SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A2A3J5 ENTREZGENE
  A2A3J7 ENTREZGENE
  FCRLB_HUMAN UniProtKB/Swiss-Prot
  Q5VXA6 ENTREZGENE
  Q6BAA0 ENTREZGENE
  Q6BAA1 ENTREZGENE
  Q6BAA2 ENTREZGENE
  Q6BAA3 ENTREZGENE
  Q6BAA4 ENTREZGENE
  Q8IXZ7 ENTREZGENE
UniProt Secondary A2A3J5 UniProtKB/Swiss-Prot
  A2A3J7 UniProtKB/Swiss-Prot
  Q5VXA6 UniProtKB/Swiss-Prot
  Q6BAA0 UniProtKB/Swiss-Prot
  Q6BAA1 UniProtKB/Swiss-Prot
  Q6BAA2 UniProtKB/Swiss-Prot
  Q6BAA3 UniProtKB/Swiss-Prot
  Q8IXZ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 FCRLB  Fc receptor like B  FCRLB  Fc receptor-like B  Symbol and/or name change 5135510 APPROVED