Cfp (complement factor properdin) - Rat Genome Database

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Gene: Cfp (complement factor properdin) Rattus norvegicus
Analyze
Symbol: Cfp
Name: complement factor properdin
RGD ID: 1594557
Description: Predicted to be involved in complement activation, alternative pathway. Predicted to be located in cytoplasmic side of Golgi membrane; extracellular space; and secretory granule. Human ortholog(s) of this gene implicated in X-linked properdin deficiency. Orthologous to human CFP (complement factor properdin); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Pfc; Pfc_mapped; properdin; properdin factor, complement; properdin factor, complement (mapped); Properdin P factor, complement
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,715,551 - 3,721,113 (+)NCBIGRCr8
mRatBN7.2X1,162,014 - 1,167,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,161,979 - 1,167,573 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,190,089 - 1,195,651 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,665,782 - 4,671,345 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X987,013 - 992,576 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,311,121 - 1,316,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,311,121 - 1,316,682 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,126,142 - 2,131,704 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,584,709 - 12,590,271 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX1,730,903 - 1,736,462 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
D-glucose  (ISO)
endosulfan  (EXP)
flutamide  (EXP)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
glucose  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
silicon dioxide  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
versicolorin A  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs. Goundis D and Reid KB, Nature 1988 Sep 1;335(6185):82-5.
2. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Circulating immune complexes and complement levels in hemophilic children. Verroust F, etal., J Clin Lab Immunol. 1981 Sep;6(2):127-30.
Additional References at PubMed
PMID:12477932   PMID:18292556   PMID:20551380   PMID:21135110   PMID:22815489  


Genomics

Comparative Map Data
Cfp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,715,551 - 3,721,113 (+)NCBIGRCr8
mRatBN7.2X1,162,014 - 1,167,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,161,979 - 1,167,573 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,190,089 - 1,195,651 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,665,782 - 4,671,345 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X987,013 - 992,576 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,311,121 - 1,316,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,311,121 - 1,316,682 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,126,142 - 2,131,704 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,584,709 - 12,590,271 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX1,730,903 - 1,736,462 (+)NCBICelera
Cytogenetic MapXq11NCBI
CFP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,623,282 - 47,630,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,623,172 - 47,630,305 (-)EnsemblGRCh38hg38GRCh38
GRCh37X47,482,681 - 47,489,704 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,368,569 - 47,374,648 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X47,239,878 - 47,245,958NCBI
CeleraX51,678,874 - 51,684,967 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX45,196,561 - 45,202,654 (-)NCBIHuRef
CHM1_1X47,514,712 - 47,520,808 (-)NCBICHM1_1
T2T-CHM13v2.0X47,033,182 - 47,040,206 (-)NCBIT2T-CHM13v2.0
Cfp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,791,693 - 20,797,794 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,791,693 - 20,797,794 (-)EnsemblGRCm39 Ensembl
GRCm38X20,925,454 - 20,931,555 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,925,454 - 20,931,555 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X20,502,661 - 20,508,650 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,082,494 - 20,088,465 (-)NCBIMGSCv36mm8
CeleraX19,059,397 - 19,065,386 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.44NCBI
Cfp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516449,993 - 456,492 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955516449,993 - 455,897 (+)NCBIChiLan1.0ChiLan1.0
CFP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,250,665 - 49,259,498 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,254,037 - 49,265,230 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,060,106 - 40,066,720 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,956,191 - 47,961,965 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,956,191 - 47,961,965 (-)Ensemblpanpan1.1panPan2
CFP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,245,868 - 41,252,194 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,245,905 - 41,251,623 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,620,466 - 15,626,213 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,379,663 - 41,385,406 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,379,658 - 41,385,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,367,204 - 41,372,947 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,355,500 - 41,361,239 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,448,168 - 41,453,913 (-)NCBIUU_Cfam_GSD_1.0
Cfp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,550,861 - 33,558,058 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,391,535 - 13,397,440 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650213,391,613 - 13,398,723 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,143,697 - 42,152,868 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,145,754 - 42,152,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,326,173 - 47,335,086 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231897
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,801,388 - 44,807,177 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,801,354 - 44,807,402 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366686812,398 - 18,196 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978184,286 - 190,970 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624978180,352 - 194,467 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cfp
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:48
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000038909
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat

Markers in Region
DXWox21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,156,621 - 1,156,808 (+)MAPPERmRatBN7.2
Rnor_6.0X1,305,731 - 1,305,917NCBIRnor6.0
Rnor_5.0X2,120,752 - 2,120,938UniSTSRnor5.0
RGSC_v3.4X12,595,475 - 12,595,661UniSTSRGSC3.4
CeleraX1,725,513 - 1,725,699UniSTS
Cytogenetic MapXq12UniSTS
RH141135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,160,027 - 1,160,212 (+)MAPPERmRatBN7.2
Rnor_6.0X1,309,135 - 1,309,319NCBIRnor6.0
Rnor_5.0X2,124,156 - 2,124,340UniSTSRnor5.0
RGSC_v3.4X12,592,073 - 12,592,257UniSTSRGSC3.4
CeleraX1,728,917 - 1,729,101UniSTS
RH 3.4 Map6789.4UniSTS
Cytogenetic MapXq12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 20 56 41 19 41 70 25 34 11
Low 23 1 8 11 4 10 7 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000038909   ⟹   ENSRNOP00000031039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,161,979 - 1,167,573 (+)Ensembl
Rnor_6.0 EnsemblX1,311,121 - 1,316,682 (+)Ensembl
RefSeq Acc Id: NM_001106757   ⟹   NP_001100227
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,715,551 - 3,721,113 (+)NCBI
mRatBN7.2X1,162,014 - 1,167,576 (+)NCBI
Rnor_6.0X1,311,121 - 1,316,683 (+)NCBI
Rnor_5.0X2,126,142 - 2,131,704 (+)NCBI
RGSC_v3.4X12,584,709 - 12,590,271 (-)RGD
CeleraX1,730,903 - 1,736,462 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100227 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58890 (Get FASTA)   NCBI Sequence Viewer  
  EDL97727 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031039
  ENSRNOP00000031039.4
RefSeq Acc Id: NP_001100227   ⟸   NM_001106757
- Peptide Label: precursor
- UniProtKB: B0BNN4 (UniProtKB/TrEMBL),   A6JZQ8 (UniProtKB/TrEMBL),   F7EX91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031039   ⟸   ENSRNOT00000038909

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNN4-F1-model_v2 AlphaFold B0BNN4 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701690
Promoter ID:EPDNEW_R12212
Type:initiation region
Name:Cfp_1
Description:complement factor properdin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X1,311,120 - 1,311,180EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594557 AgrOrtholog
BioCyc Gene G2FUF-3202 BioCyc
Ensembl Genes ENSRNOG00000025811 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038909 ENTREZGENE
  ENSRNOT00000038909.7 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8375684 IMAGE-MGC_LOAD
InterPro CFP_TSR-0 UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report rno:299314 UniProtKB/TrEMBL
MGC_CLONE MGC:188620 IMAGE-MGC_LOAD
NCBI Gene 299314 ENTREZGENE
PANTHER PROPERDIN UniProtKB/TrEMBL
  PROPERDIN UniProtKB/TrEMBL
Pfam TSP_1 UniProtKB/TrEMBL
  TSR UniProtKB/TrEMBL
PhenoGen Cfp PhenoGen
PRINTS TSP1REPEAT UniProtKB/TrEMBL
PROSITE TSP1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025811 RatGTEx
SMART TSP1 UniProtKB/TrEMBL
Superfamily-SCOP TSP1 UniProtKB/TrEMBL
UniProt A6JZQ8 ENTREZGENE, UniProtKB/TrEMBL
  B0BNN4 ENTREZGENE
  F7EX91 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B0BNN4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Cfp  complement factor properdin  Pfc  properdin factor, complement  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   properdin factor, complement  Pfc  properdin factor, complement (mapped)  Name updated 737654 APPROVED
2007-04-11 Pfc  properdin factor, complement (mapped)  Pfc_mapped  properdin factor, complement (mapped)  Data merged from RGD:3306 737654 APPROVED
2006-11-20 Pfc  properdin factor, complement (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Pfc_mapped  properdin factor, complement (mapped)  Pfc  properdin factor, complement  Symbol and Name updated 1556543 APPROVED
2002-06-10 Pfc  Properdin P factor, complement      Symbol and Name status set to approved 70586 APPROVED