Lingo1 (leucine rich repeat and Ig domain containing 1) - Rat Genome Database

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Gene: Lingo1 (leucine rich repeat and Ig domain containing 1) Rattus norvegicus
Analyze
Symbol: Lingo1
Name: leucine rich repeat and Ig domain containing 1
RGD ID: 1308668
Description: Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within negative regulation of oligodendrocyte differentiation; neuron development; and protein kinase B signaling. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leucine rich repeat neuronal 6A; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; LOC315691; Lrrn6a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2857,011,272 - 57,193,496 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,010,007 - 57,196,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx862,541,946 - 62,558,082 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0860,820,958 - 60,837,094 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0858,685,217 - 58,701,353 (-)NCBIRnor_WKY
Rnor_6.0861,272,125 - 61,455,480 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl861,274,017 - 61,290,240 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0859,842,273 - 60,025,178 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4860,335,369 - 60,351,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1860,353,788 - 60,376,585 (-)NCBI
Celera856,482,212 - 56,498,460 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma. Fu QL, etal., Neuroscience. 2009 Aug 18;162(2):375-82. doi: 10.1016/j.neuroscience.2009.04.075. Epub 2009 May 5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15895088   PMID:17202489   PMID:17726113   PMID:18183482   PMID:20659559   PMID:22871113   PMID:23482566   PMID:26491860   PMID:26546150   PMID:28193690  
PMID:29383653   PMID:30759305   PMID:32462552  


Genomics

Comparative Map Data
Lingo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2857,011,272 - 57,193,496 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,010,007 - 57,196,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx862,541,946 - 62,558,082 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0860,820,958 - 60,837,094 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0858,685,217 - 58,701,353 (-)NCBIRnor_WKY
Rnor_6.0861,272,125 - 61,455,480 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl861,274,017 - 61,290,240 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0859,842,273 - 60,025,178 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4860,335,369 - 60,351,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1860,353,788 - 60,376,585 (-)NCBI
Celera856,482,212 - 56,498,460 (-)NCBICelera
Cytogenetic Map8q24NCBI
LINGO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381577,613,027 - 77,820,900 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1577,613,027 - 77,820,900 (-)EnsemblGRCh38hg38GRCh38
GRCh371577,905,369 - 78,113,242 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361575,692,424 - 75,711,764 (-)NCBINCBI36Build 36hg18NCBI36
Build 341575,692,423 - 75,711,764NCBI
Celera1554,843,608 - 54,862,572 (-)NCBICelera
Cytogenetic Map15q24.3NCBI
HuRef1554,660,535 - 54,680,264 (-)NCBIHuRef
CHM1_11578,023,300 - 78,042,675 (-)NCBICHM1_1
T2T-CHM13v2.01575,473,724 - 75,683,106 (-)NCBIT2T-CHM13v2.0
Lingo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39956,525,743 - 56,704,355 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl956,525,759 - 56,703,752 (-)EnsemblGRCm39 Ensembl
GRCm38956,618,460 - 56,796,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl956,618,475 - 56,796,468 (-)EnsemblGRCm38mm10GRCm38
MGSCv37956,466,282 - 56,533,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36956,416,612 - 56,483,390 (-)NCBIMGSCv36mm8
Celera953,844,163 - 53,910,841 (-)NCBICelera
Cytogenetic Map9BNCBI
Lingo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554502,435,662 - 2,452,213 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554502,435,768 - 2,493,387 (-)NCBIChiLan1.0ChiLan1.0
LINGO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11572,328,076 - 72,534,429 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1572,328,079 - 72,347,016 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01556,424,422 - 56,747,075 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LINGO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13038,668,199 - 38,738,178 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3038,721,394 - 38,737,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3038,590,466 - 38,611,287 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03038,873,710 - 38,942,658 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,866,779 - 38,942,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13038,718,990 - 38,892,481 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,870,129 - 38,939,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03039,107,012 - 39,176,028 (+)NCBIUU_Cfam_GSD_1.0
Lingo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640116,690,565 - 116,881,599 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647134,706,198 - 34,731,037 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647134,657,073 - 34,729,662 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LINGO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl757,684,589 - 57,890,126 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1757,684,591 - 57,890,121 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2762,376,757 - 62,583,077 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LINGO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,485,059 - 5,690,531 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl265,688,293 - 5,690,155 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048136,058,467 - 136,267,092 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lingo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624894648,785 - 791,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624894648,357 - 791,168 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lingo1
963 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:113
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000023084
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat

Markers in Region
WI-21778  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2857,011,960 - 57,012,141 (+)MAPPERmRatBN7.2
Rnor_6.0861,274,029 - 61,274,209NCBIRnor6.0
Rnor_5.0859,844,177 - 59,844,357UniSTSRnor5.0
RGSC_v3.4860,209,634 - 60,209,814UniSTSRGSC3.4
RGSC_v3.4860,335,406 - 60,335,586UniSTSRGSC3.4
Celera856,482,249 - 56,482,429UniSTS
Cytogenetic Map8q24UniSTS
RH133868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2857,011,336 - 57,011,532 (+)MAPPERmRatBN7.2
Rnor_6.0861,273,405 - 61,273,600NCBIRnor6.0
Rnor_5.0859,843,553 - 59,843,748UniSTSRnor5.0
RGSC_v3.4860,334,782 - 60,334,977UniSTSRGSC3.4
RGSC_v3.4860,209,010 - 60,209,205UniSTSRGSC3.4
Celera856,481,625 - 56,481,820UniSTS
RH 3.4 Map8636.19UniSTS
Cytogenetic Map8q24UniSTS
Lingo1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2857,012,450 - 57,013,686 (+)MAPPERmRatBN7.2
Rnor_6.0861,274,519 - 61,275,754NCBIRnor6.0
Rnor_5.0859,844,667 - 59,845,902UniSTSRnor5.0
RGSC_v3.4860,335,896 - 60,337,131UniSTSRGSC3.4
Celera856,482,739 - 56,483,974UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 66 6 22
Low 1 28 10 10 2 10 1 8 15 16 2
Below cutoff 2 12 40 24 17 24 8 10 14 3 9 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005487818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC092632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE108045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF547075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000023084   ⟹   ENSRNOP00000023084
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,011,949 - 57,028,173 (-)Ensembl
Rnor_6.0 Ensembl861,274,017 - 61,290,240 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094295   ⟹   ENSRNOP00000080188
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,011,166 - 57,114,544 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096263   ⟹   ENSRNOP00000084606
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,010,052 - 57,196,544 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103010   ⟹   ENSRNOP00000096831
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,010,186 - 57,193,155 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105281   ⟹   ENSRNOP00000094597
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,010,186 - 57,193,155 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105816   ⟹   ENSRNOP00000078102
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,010,007 - 57,192,216 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111614   ⟹   ENSRNOP00000097278
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,010,057 - 57,028,839 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113428   ⟹   ENSRNOP00000086992
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,010,841 - 57,071,323 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114132   ⟹   ENSRNOP00000087521
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,010,186 - 57,193,155 (-)Ensembl
RefSeq Acc Id: NM_001100722   ⟹   NP_001094192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2857,011,924 - 57,028,173 (-)NCBI
Rnor_6.0861,273,992 - 61,290,240 (-)NCBI
Rnor_5.0859,842,273 - 60,025,178 (-)NCBI
RGSC_v3.4860,335,369 - 60,351,617 (-)RGD
Celera856,482,212 - 56,498,460 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243120   ⟹   XP_006243182
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2857,011,272 - 57,028,849 (-)NCBI
Rnor_6.0861,272,125 - 61,290,557 (-)NCBI
Rnor_5.0859,842,273 - 60,025,178 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008766270   ⟹   XP_008764492
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2857,011,272 - 57,193,022 (-)NCBI
Rnor_6.0861,272,125 - 61,455,480 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595646   ⟹   XP_017451135
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2857,011,272 - 57,193,022 (-)NCBI
Rnor_6.0861,272,125 - 61,455,480 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595647   ⟹   XP_017451136
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2857,011,272 - 57,193,022 (-)NCBI
Rnor_6.0861,272,125 - 61,455,480 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081468   ⟹   XP_038937396
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2857,011,272 - 57,173,090 (-)NCBI
RefSeq Acc Id: XM_039081469   ⟹   XP_038937397
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2857,011,272 - 57,030,202 (-)NCBI
RefSeq Acc Id: XR_005487818
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2857,146,153 - 57,193,496 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001094192   ⟸   NM_001100722
- Peptide Label: precursor
- UniProtKB: G3V881 (UniProtKB/TrEMBL),   Q562A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243182   ⟸   XM_006243120
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764492   ⟸   XM_008766270
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451135   ⟸   XM_017595646
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451136   ⟸   XM_017595647
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023084   ⟸   ENSRNOT00000023084
RefSeq Acc Id: XP_038937396   ⟸   XM_039081468
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937397   ⟸   XM_039081469
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086992   ⟸   ENSRNOT00000113428
RefSeq Acc Id: ENSRNOP00000087521   ⟸   ENSRNOT00000114132
RefSeq Acc Id: ENSRNOP00000078102   ⟸   ENSRNOT00000105816
RefSeq Acc Id: ENSRNOP00000096831   ⟸   ENSRNOT00000103010
RefSeq Acc Id: ENSRNOP00000084606   ⟸   ENSRNOT00000096263
RefSeq Acc Id: ENSRNOP00000080188   ⟸   ENSRNOT00000094295
RefSeq Acc Id: ENSRNOP00000094597   ⟸   ENSRNOT00000105281
RefSeq Acc Id: ENSRNOP00000097278   ⟸   ENSRNOT00000111614
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V881-F1-model_v2 AlphaFold G3V881 1-620 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308668 AgrOrtholog
BioCyc Gene G2FUF-30351 BioCyc
Ensembl Genes ENSRNOG00000017193 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023084 ENTREZGENE
  ENSRNOP00000023084.4 UniProtKB/TrEMBL
  ENSRNOP00000078102 ENTREZGENE
  ENSRNOP00000078102.1 UniProtKB/TrEMBL
  ENSRNOP00000080188 ENTREZGENE
  ENSRNOP00000080188.1 UniProtKB/TrEMBL
  ENSRNOP00000084606.1 UniProtKB/TrEMBL
  ENSRNOP00000086992.1 UniProtKB/TrEMBL
  ENSRNOP00000087521.1 UniProtKB/TrEMBL
  ENSRNOP00000094597 ENTREZGENE
  ENSRNOP00000094597.1 UniProtKB/TrEMBL
  ENSRNOP00000096831 ENTREZGENE
  ENSRNOP00000096831.1 UniProtKB/TrEMBL
  ENSRNOP00000097278 ENTREZGENE
  ENSRNOP00000097278.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023084 ENTREZGENE
  ENSRNOT00000023084.6 UniProtKB/TrEMBL
  ENSRNOT00000094295 ENTREZGENE
  ENSRNOT00000094295.1 UniProtKB/TrEMBL
  ENSRNOT00000096263.1 UniProtKB/TrEMBL
  ENSRNOT00000103010 ENTREZGENE
  ENSRNOT00000103010.1 UniProtKB/TrEMBL
  ENSRNOT00000105281 ENTREZGENE
  ENSRNOT00000105281.1 UniProtKB/TrEMBL
  ENSRNOT00000105816 ENTREZGENE
  ENSRNOT00000105816.1 UniProtKB/TrEMBL
  ENSRNOT00000111614 ENTREZGENE
  ENSRNOT00000111614.1 UniProtKB/TrEMBL
  ENSRNOT00000113428.1 UniProtKB/TrEMBL
  ENSRNOT00000114132.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7314870 IMAGE-MGC_LOAD
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR-contain_N UniProtKB/TrEMBL
  LRR_5 UniProtKB/TrEMBL
KEGG Report rno:315691 UniProtKB/TrEMBL
MGC_CLONE MGC:109332 IMAGE-MGC_LOAD
NCBI Gene 315691 ENTREZGENE
Pfam I-set UniProtKB/TrEMBL
  LRR_5 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
PhenoGen Lingo1 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8I5ZPI2 ENTREZGENE, UniProtKB/TrEMBL
  G3V881 ENTREZGENE, UniProtKB/TrEMBL
  Q562A6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Lingo1  leucine rich repeat and Ig domain containing 1  Lrrn6a  leucine rich repeat neuronal 6A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Lrrn6a  leucine rich repeat neuronal 6A  Lrrn6a_predicted  leucine rich repeat neuronal 6A (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lrrn6a_predicted  leucine rich repeat neuronal 6A (predicted)      Symbol and Name status set to approved 70820 APPROVED