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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3722
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snai2
Name: snail family transcriptional repressor 2
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Snai2decreases expressionISOSNAI2 (Homo sapiens)6480464CTDNiclosamide results in decreased expression of SNAI2 proteinPMID:25174399
Snai2multiple interactionsISOSNAI2 (Homo sapiens)6480464CTDNiclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SNAI2 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]PMID:25174399 PMID:36870549
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