Dtl (denticleless E3 ubiquitin protein ligase homolog)

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Gene: Dtl (denticleless E3 ubiquitin protein ligase homolog) Rattus norvegicus

Analyze

Symbol:

Dtl

Name:

denticleless E3 ubiquitin protein ligase homolog

RGD ID:

1310439

Description:

Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Predicted to be located in centrosome; cytosol; and nuclear lumen. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

denticleless E3 ubiquitin protein ligase homolog (Drosophila); denticleless homolog; denticleless homolog (Drosophila); denticleless protein homolog; LOC100909566; LOC305073; RGD1310439; similar to retinoic acid-regulated nuclear matrix-associated protein

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	103,115,810 - 103,155,029 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	13	103,117,186 - 103,154,890 (-)	Ensembl
Rnor_6.0	13	110,219,276 - 110,257,345 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,220,283 - 110,257,367 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	114,783,177 - 114,821,239 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,603,353 - 107,640,812 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	13	107,792,703 - 107,830,078 (-)	NCBI
Celera	13	102,555,070 - 102,594,148 (-)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

COVID-19 (ISO)

gastrointestinal stromal tumor (ISO)

hepatocellular carcinoma (ISO)

parathyroid carcinoma (ISO)

Salivary Gland Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

atrazine (ISO)

azathioprine (ISO)

bazedoxifene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

beta-hexachlorocyclohexane (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chrysene (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

DDT (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dichloroacetic acid (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

folpet (ISO)

genistein (ISO)

hexadecanoic acid (ISO)

Lasiocarpine (ISO)

lead(0) (ISO)

lead(2+) (ISO)

lipopolysaccharide (ISO)

lucanthone (ISO)

methamphetamine (ISO)

methyl methanesulfonate (ISO)

nickel atom (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

pravastatin (EXP,ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

senecionine (EXP)

Senkirkine (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to DNA damage stimulus (ISO)

mitotic G2 DNA damage checkpoint signaling (IBA,ISO)

positive regulation of G2/M transition of mitotic cell cycle (ISO)

positive regulation of protein catabolic process (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA)

protein monoubiquitination (ISO)

protein polyubiquitination (ISO)

regulation of cell cycle (ISO)

response to UV (ISO)

translesion synthesis (ISO)

ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

centrosome (ISO)

Cul4-RING E3 ubiquitin ligase complex (ISO)

Cul4A-RING E3 ubiquitin ligase complex (ISO)

Cul4B-RING E3 ubiquitin ligase complex (ISO)

cytosol (IEA,ISO)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

Molecular Function

protein binding (ISO)

protein-macromolecule adaptor activity (IBA)

ubiquitin-protein transferase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16949367	PMID:17085480	PMID:17106265	PMID:18794347	PMID:20129063	PMID:21628527	PMID:26431207

Genomics

Comparative Map Data

Dtl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	103,115,810 - 103,155,029 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	13	103,117,186 - 103,154,890 (-)	Ensembl
Rnor_6.0	13	110,219,276 - 110,257,345 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,220,283 - 110,257,367 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	114,783,177 - 114,821,239 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,603,353 - 107,640,812 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	13	107,792,703 - 107,830,078 (-)	NCBI
Celera	13	102,555,070 - 102,594,148 (-)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

DTL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	212,035,748 - 212,105,013 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	212,035,553 - 212,107,400 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	212,209,090 - 212,278,355 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	210,275,754 - 210,344,809 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	1	185,435,998 - 185,505,287 (+)	NCBI
Cytogenetic Map	1	q32.3	NCBI
HuRef	1	182,885,955 - 182,955,234 (+)	NCBI		HuRef
CHM1_1	1	213,481,305 - 213,550,518 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	211,281,835 - 211,351,118 (+)	NCBI

Dtl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	191,269,468 - 191,307,656 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	1	191,269,468 - 191,307,656 (-)	Ensembl
GRCm38	1	191,537,356 - 191,575,544 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	191,537,356 - 191,575,544 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	193,361,244 - 193,399,413 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	1	193,237,980 - 193,276,149 (-)	NCBI			mm8
Celera	1	198,486,790 - 198,526,178 (-)	NCBI		Celera
Cytogenetic Map	1	H6	NCBI

Dtl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	5,254,558 - 5,299,573 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	5,256,057 - 5,299,573 (-)	NCBI	ChiLan1.0	ChiLan1.0

DTL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	192,466,408 - 192,535,071 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	192,466,408 - 192,535,071 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	187,603,600 - 187,672,006 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

DTL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	10,323,842 - 10,368,529 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	10,323,559 - 10,369,560 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	9,901,494 - 9,944,363 (+)	NCBI
ROS_Cfam_1.0	7	10,030,330 - 10,073,724 (+)	NCBI
ROS_Cfam_1.0 Ensembl	7	10,030,370 - 10,073,719 (+)	Ensembl
UMICH_Zoey_3.1	7	9,952,445 - 9,997,665 (+)	NCBI
UNSW_CanFamBas_1.0	7	10,055,386 - 10,098,331 (+)	NCBI
UU_Cfam_GSD_1.0	7	10,179,868 - 10,228,472 (+)	NCBI

Dtl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	64,087,630 - 64,149,419 (-)	NCBI
SpeTri2.0	NW_004936557	1,347,991 - 1,389,836 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DTL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	131,182,423 - 131,275,451 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	131,225,840 - 131,275,426 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	144,272,743 - 144,325,340 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DTL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	17,418,078 - 17,485,320 (-)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	25	17,418,090 - 17,485,164 (-)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666055	17,940,853 - 18,008,338 (-)	NCBI	Vero_WHO_p1.0

Dtl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	17,612,284 - 17,662,405 (+)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624771	17,612,264 - 17,660,772 (+)	NCBI	HetGla_female_1.0		hetGla2

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	179
Count of miRNA genes:	132
Interacting mature miRNAs:	138
Transcripts:	ENSRNOT00000005576, ENSRNOT00000005628
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	24	24	18	9	18			28	16	35
Low	2	9	16	9	10	9	4	4	40	12	6	11	4
Below cutoff		10	16	13		13	4	7	6	7			4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_001068900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006221606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_223074	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000005576 ⟹ ENSRNOP00000005576

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	103,117,186 - 103,154,890 (-)	Ensembl
Rnor_6.0 Ensembl	13	110,220,283 - 110,257,367 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095446 ⟹ ENSRNOP00000083831

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	103,117,186 - 103,154,890 (-)	Ensembl

RefSeq Acc Id:

XM_017599014 ⟹ XP_017454503

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	103,115,810 - 103,148,301 (-)	NCBI
Rnor_6.0	13	110,219,276 - 110,250,749 (-)	NCBI

Sequence:

show sequence

ATGCAAAGGCCACCAGTGCAGCCTCAAGTCTGTAGCTTTTTCCAAGTTTCAAAAAGCTCCTTTC
GTGTCAGTCCATATTCTCAAACATCTGTGTTCTGTACTGGTGGGAGAGACGGCAACATTATGAT
CTGGGACACCAGGTGCAACAAAAAAGATGGATTTTATAGACAAGTGAATCAAATCAGTGGCGCT
CACAATACTGCAGACAAGCAAACCCCTTCAAAACCCAAGAAGAAACAAAATTCAAAAGGACTTG
CTCCATCTGTGGATTCCCAGCAGAGTGTTACTGTGGTCCTCTTTCAGGATGAGAATACAGTAGT
CTCAGCAGGAGCCGTGGATGGAATAATCAAAGTATGGGATTTACGCAAGAATTACACTGCTTAT
CGACAAGAACCCATAGCATCCAAGTCTTTCCTGTACCCAGGTACCAGCACTAGAAAACTAGGAT
ACTCGAGTTTGGTTCTAGACTCTACTGGCTCTACTCTGTTTGCTAACTGCACAGATGACAACAT
CTATATGTTCAATATGACTGGCTTAAAGACTTCTCCACTGGCTGTCTTCAATGGACACCAGAAC
TCTACCTTTTATGTAAAATCAAGTCTTAGTCCAGATGACCAGTTTTTAATCAGTGGTTCAAGTG
ACGAAGCTGCCTACATTTGGAAGGTTTCTATGCCATGGCATCCTCCTACCGTACTCCTGGGTCA
TTCTCAAGAAGTCACGTCTGTGTGCTGGTGTCCATCAGACTTCACCAAGATTGCAACCTGCTCT
GATGATAATACACTAAAAATCTGGCGCTTGAACAGAGGCCTAGAGGAGAAACCAGAAGGTGATA
AACATTCCATAGTAGGTTGGACCTCTCAGAAGAAAAAGGAAGTGAAAGCCGGCCCAGTATCGGC
ACCAAATAGCCTGAGCACCCCTGCCAAAGCCCCCAGGTCCCAGTGCAGCCCATCTGCTTCCTCT
CCTTCATCAGCTCGTACTCCAAGCTGTGCGGGAGACCTCCCCCTTCCCTCAAATACCTCCACCT
TCTCAGTCAAAACCACTCCGGTCACGACCCGTTCTCCAGTCAGCAGAAGAGGTTCCAGCTCTTC
TGTGTCTCCCAAGCCACCCTCATCTTTCAAGATGTCACTTAGAAACTGGGTGACCCGAACACCT
TCCTCATCACCACCTGTCACTCCACCTGCTTCTGAGACAAAGATCTCATCTCCGAGAAAAGCCC
TTATTCCTGTGAGCCAGAAGTCATCACAAGCAGATGCTTGCTCTGAATCTAGAAATAGAGTGAA
GAGGCGTCTCGACTCGAGCTGTCTGGAGAGTGTGAAACAAAAGTGTGTGAAGAGTTGCAACTGT
GTCACTGAGCTTGACGGCCAAGTGGAGAGTCTTCATTTGGATCTGTGCTGCCTTTCCGGCACCC
AGGAAGTCCTTAGCCAAGATTCTGCGGGTCCTACCAAATCAAGCAAGACGGAAGGTACTGGCAC
GAGCATCTCAGAGCCCCCTTCTCCTGTCAGTCCTTTTGCTTCTGAAGGCTGTGGACCACTGCCT
CTTCCTTTGGGACCTTGTGGAGAAGGATCTGAAATGGTGGGCAAAGAGAATAGCTCCCCAGAGA
ATAAGAACTGGTTGTTGGCCATGGCAGCCAAACACAAGGCGGAGAATTCATCCCCAAGAAGTCC
ATCATCCCAGACACCCAGTTCCAGGAGACAGAGTAGAAAGACGTCACCAGGCCCGGTCACCATT
ACCCCCAACTCCATGAGGAAGATATGCACATATTTTCGCAGAAAGACTCAAGATGACTTCTGTA
GTCCTGAACATTCAACTGAGTTATAAATTCTAATCTCAAAGTTTGATGAACTTGGGTCTACAAA
GATTTTTTTAAAAACCTTTAAAATCTGGTCTTTAAGAAAATGGTCATGTTTTGATTTTGGAAAA
AAGTTCTAATACTCTTTGGCAGACCTAGTCAAACCCCACTGTGTATAGACACAGCAGCCTGGGT
GAGTGCTGTATCCAGTTCACGGGGCGGCTTGTCCTCTGCAGTCTGTGATAACCACATCCAGCTC
ATGGATGCAGAAAGCCAGGCATGCTTCTATGGCTATGGAGAGTGTCCACTAGCCCAGCATAGGG
CCCATCTGTGAGGCCAGTCTGAAGTCATCCTTTGCAGAAGGTAGATGCCTTAAGCAATCGTGAG
CTTATTTGAAATACATAATTTGTTCACTATACTTTTGTGTGTGTGTTTCTCAAACTGTATGAAG
ATGTGATATTCATGGAGTACATTCATACTGTTTTCATGGACCGTATTTTGAGTTGAGGTCGTGA
TTATTTTAAATGCGGTGATCAATGTCATGTCTTTGGAGAACATAGGAGAAAACAACAGAGAGCT
GGATTTGTTTCCATGAAAGCTGGGGAGGTCCCATATTTTTTTTACCAGATTTCTATTACAAACC
AGCATCACTCATGTGTGGGGGAGGCACTTTCTTGAGAGGGATCCTTTATAAAATCAGTATACAC
TAAAACCAGAGTCTACATTTAAGTGTAATTCTCAGTTTTCTAGGTCTGTGACTTTTTTAAAATG
CCATTAGATTTTTAAGATAAAGTAATTTCTTACTAGTGTTTTTTATAAAAGACGATACTACAAA
ACTGAAAATCTAGAACCTGGGTTTTTTTTTTTTTTTTTTTTTTCTTTTTTTCAAAAGGCACTGG
CCCTCTAGTATATTGGTAAGCAAAAAATAAACACAGCACTTTATCTAGACAGTGCACAGAGTGT
GACAGCTGACTCTAAATAGTATTTGAAATTCTGCAGCCTCTGCCTTAAATGCTACATGTGGGTC
CTCATGAAATGAGCATCATGCCTCCCTTTGCAGACTCCTGGAGAGGAAGAAACTATGTTTGAGA
AAGGCATTCATTCCCTTACAATTAGGACAGAGTTTGTTCCATTCAAATCTCTGGGGACTGGTTA
AACTTTATTTCTATTATGATTTTTAAATCTTTTATTAAAAACTTTAAGTCCTTTGAGATTGTAA
ATTAAGCTTATAAAACAAACCAAACTGAGATTAAGTAATAAGCATTGGTTTTCGGTAATTTTAT
TCAAAAAAAAATTAAAGGAAGTCAGATTAGTCAGACCACATACACACACACACACACACACACA
CACACACACACACACACACAGAGAGTGGCTTTCACTGAGTGCTGGATGTCTGCAGTAATGTTAG
CGTTTTGAGCAGTAGGCAGTGGGAAGAAATTTTTAATAACGCAGAACTGCCAATAATGTTGCAT
ATCTGTTGCTCTGAGAGCAGGTAGTGGTGGTCAGTAAAGCAGATGACTTGTGTCTGTGTCTGGA
GGCACTGCCAGGTGAAGCTGGGGTGAGCGGCTGTCAGGAACTCCAGGCTGTGCTTGAAAAGTAG
TCCACAGATGGGTGTCCAAGGTTATGTGTAACGAAGTAGTGATTATCCCTGCTGTGTGATTTTC
AGCTGACCCTGAATAATAAGCCTTTTACCTTGTCTGATAGTGTCCTTTCCTAAGCTTTTTACAG
TGACCTGAAAGCAATCCACACAAAAGGAAGTAATCATCTGAGTCCCTTCTGCTTGCTTGTAGAA
TAAAATGTGTTTGTTTCCAAAGGTATAATCTAAGAAAGAGGTTCTAATAAATGTTTTATTTCAT
CAAA

hide sequence

RefSeq Acc Id:

XM_039091504 ⟹ XP_038947432

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	103,115,810 - 103,154,811 (-)	NCBI

RefSeq Acc Id:

XM_039091505 ⟹ XP_038947433

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	103,115,810 - 103,154,812 (-)	NCBI

RefSeq Acc Id:

XM_039091506 ⟹ XP_038947434

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	103,115,810 - 103,154,843 (-)	NCBI

RefSeq Acc Id:

XM_223074 ⟹ XP_223074

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	103,115,810 - 103,155,029 (-)	NCBI
Rnor_6.0	13	110,219,276 - 110,257,345 (-)	NCBI
Rnor_5.0	13	114,783,177 - 114,821,239 (-)	NCBI
RGSC_v3.4	13	107,603,353 - 107,640,812 (-)	RGD

Sequence:

show sequence

AGAGAGCATGACGTCAGTTTGGCGCGGAGTTTGGCGGCCGGGGCTCGCAGTGGCGGGAGTTGGA
GGCAAAACCGTGTCGCGCTGTGGAGGGCGCAAGCGGAGGCTCCGGCGGAACTTGGGGGCGATCT
CCTCGGCGTTCTCCTCAGCTGAGTCTTCTCCTCAGGACGAAATGCTCTTCAACTCGGTGCTCCG
CCAGCCGCAGCTCGGCGTCCTGAGGAACGGGTGGTCTTCACATTATCCTCTGCAATCTCTCCTA
AGTGGTTATCGGTGCAGCTGTAACGATGAGCACACATCTTACGGAGAAACGGGAGTCCCAGTTC
CTCCTTTTGGATGCACCTTCTGTACTGCTCCCAGTATGGAGCATATATTAGCAGTTGCTAATGA
AGAAGGCTTTGTCAGATTATATAATACAGAATCACAAACTAGCAAAAAGACATGCTTCAAGGAG
TGGATGGCTCACTGGAATGCTGTCTTTGACCTGGCGTGGGTCCCTGGTGAACTTAAACTTGTTA
CAGCAGCCGGTGATCAGACAGCCAAATTTTGGGATGTAAAAGCTGGTGAGCTAATGGGAACATG
CAAAGGCCACCAGTGCAGCCTCAAGTCTGTAGCTTTTTCCAAGTTTCAAAAAGCTGTGTTCTGT
ACTGGTGGGAGAGACGGCAACATTATGATCTGGGACACCAGGTGCAACAAAAAAGATGGATTTT
ATAGACAAGTGAATCAAATCAGTGGCGCTCACAATACTGCAGACAAGCAAACCCCTTCAAAACC
CAAGAAGAAACAAAATTCAAAAGGACTTGCTCCATCTGTGGATTCCCAGCAGAGTGTTACTGTG
GTCCTCTTTCAGGATGAGAATACAGTAGTCTCAGCAGGAGCCGTGGATGGAATAATCAAAGTAT
GGGATTTACGCAAGAATTACACTGCTTATCGACAAGAACCCATAGCATCCAAGTCTTTCCTGTA
CCCAGGTACCAGCACTAGAAAACTAGGATACTCGAGTTTGGTTCTAGACTCTACTGGCTCTACT
CTGTTTGCTAACTGCACAGATGACAACATCTATATGTTCAATATGACTGGCTTAAAGACTTCTC
CACTGGCTGTCTTCAATGGACACCAGAACTCTACCTTTTATGTAAAATCAAGTCTTAGTCCAGA
TGACCAGTTTTTAATCAGTGGTTCAAGTGACGAAGCTGCCTACATTTGGAAGGTTTCTATGCCA
TGGCATCCTCCTACCGTACTCCTGGGTCATTCTCAAGAAGTCACGTCTGTGTGCTGGTGTCCAT
CAGACTTCACCAAGATTGCAACCTGCTCTGATGATAATACACTAAAAATCTGGCGCTTGAACAG
AGGCCTAGAGGAGAAACCAGAAGGTGATAAACATTCCATAGTAGGTTGGACCTCTCAGAAGAAA
AAGGAAGTGAAAGCCGGCCCAGTATCGGCACCAAATAGCCTGAGCACCCCTGCCAAAGCCCCCA
GGTCCCAGTGCAGCCCATCTGCTTCCTCTCCTTCATCAGCTCGTACTCCAAGCTGTGCGGGAGA
CCTCCCCCTTCCCTCAAATACCTCCACCTTCTCAGTCAAAACCACTCCGGTCACGACCCGTTCT
CCAGTCAGCAGAAGAGGTTCCAGCTCTTCTGTGTCTCCCAAGCCACCCTCATCTTTCAAGATGT
CACTTAGAAACTGGGTGACCCGAACACCTTCCTCATCACCACCTGTCACTCCACCTGCTTCTGA
GACAAAGATCTCATCTCCGAGAAAAGCCCTTATTCCTGTGAGCCAGAAGTCATCACAAGCAGAT
GCTTGCTCTGAATCTAGAAATAGAGTGAAGAGGCGTCTCGACTCGAGCTGTCTGGAGAGTGTGA
AACAAAAGTGTGTGAAGAGTTGCAACTGTGTCACTGAGCTTGACGGCCAAGTGGAGAGTCTTCA
TTTGGATCTGTGCTGCCTTTCCGGCACCCAGGAAGTCCTTAGCCAAGATTCTGCGGGTCCTACC
AAATCAAGCAAGACGGAAGGTACTGGCACGAGCATCTCAGAGCCCCCTTCTCCTGTCAGTCCTT
TTGCTTCTGAAGGCTGTGGACCACTGCCTCTTCCTTTGGGACCTTGTGGAGAAGGATCTGAAAT
GGTGGGCAAAGAGAATAGCTCCCCAGAGAATAAGAACTGGTTGTTGGCCATGGCAGCCAAACAC
AAGGCGGAGAATTCATCCCCAAGAAGTCCATCATCCCAGACACCCAGTTCCAGGAGACAGAGTA
GAAAGACGTCACCAGGCCCGGTCACCATTACCCCCAACTCCATGAGGAAGATATGCACATATTT
TCGCAGAAAGACTCAAGATGACTTCTGTAGTCCTGAACATTCAACTGAGTTATAAATTCTAATC
TCAAAGTTTGATGAACTTGGGTCTACAAAGATTTTTTTAAAAACCTTTAAAATCTGGTCTTTAA
GAAAATGGTCATGTTTTGATTTTGGAAAAAAGTTCTAATACTCTTTGGCAGACCTAGTCAAACC
CCACTGTGTATAGACACAGCAGCCTGGGTGAGTGCTGTATCCAGTTCACGGGGCGGCTTGTCCT
CTGCAGTCTGTGATAACCACATCCAGCTCATGGATGCAGAAAGCCAGGCATGCTTCTATGGCTA
TGGAGAGTGTCCACTAGCCCAGCATAGGGCCCATCTGTGAGGCCAGTCTGAAGTCATCCTTTGC
AGAAGGTAGATGCCTTAAGCAATCGTGAGCTTATTTGAAATACATAATTTGTTCACTATACTTT
TGTGTGTGTGTTTCTCAAACTGTATGAAGATGTGATATTCATGGAGTACATTCATACTGTTTTC
ATGGACCGTATTTTGAGTTGAGGTCGTGATTATTTTAAATGCGGTGATCAATGTCATGTCTTTG
GAGAACATAGGAGAAAACAACAGAGAGCTGGATTTGTTTCCATGAAAGCTGGGGAGGTCCCATA
TTTTTTTTACCAGATTTCTATTACAAACCAGCATCACTCATGTGTGGGGGAGGCACTTTCTTGA
GAGGGATCCTTTATAAAATCAGTATACACTAAAACCAGAGTCTACATTTAAGTGTAATTCTCAG
TTTTCTAGGTCTGTGACTTTTTTAAAATGCCATTAGATTTTTAAGATAAAGTAATTTCTTACTA
GTGTTTTTTATAAAAGACGATACTACAAAACTGAAAATCTAGAACCTGGGTTTTTTTTTTTTTT
TTTTTTTTCTTTTTTTCAAAAGGCACTGGCCCTCTAGTATATTGGTAAGCAAAAAATAAACACA
GCACTTTATCTAGACAGTGCACAGAGTGTGACAGCTGACTCTAAATAGTATTTGAAATTCTGCA
GCCTCTGCCTTAAATGCTACATGTGGGTCCTCATGAAATGAGCATCATGCCTCCCTTTGCAGAC
TCCTGGAGAGGAAGAAACTATGTTTGAGAAAGGCATTCATTCCCTTACAATTAGGACAGAGTTT
GTTCCATTCAAATCTCTGGGGACTGGTTAAACTTTATTTCTATTATGATTTTTAAATCTTTTAT
TAAAAACTTTAAGTCCTTTGAGATTGTAAATTAAGCTTATAAAACAAACCAAACTGAGATTAAG
TAATAAGCATTGGTTTTCGGTAATTTTATTCAAAAAAAAATTAAAGGAAGTCAGATTAGTCAGA
CCACATACACACACACACACACACACACACACACACACACACACACACAGAGAGTGGCTTTCAC
TGAGTGCTGGATGTCTGCAGTAATGTTAGCGTTTTGAGCAGTAGGCAGTGGGAAGAAATTTTTA
ATAACGCAGAACTGCCAATAATGTTGCATATCTGTTGCTCTGAGAGCAGGTAGTGGTGGTCAGT
AAAGCAGATGACTTGTGTCTGTGTCTGGAGGCACTGCCAGGTGAAGCTGGGGTGAGCGGCTGTC
AGGAACTCCAGGCTGTGCTTGAAAAGTAGTCCACAGATGGGTGTCCAAGGTTATGTGTAACGAA
GTAGTGATTATCCCTGCTGTGTGATTTTCAGCTGACCCTGAATAATAAGCCTTTTACCTTGTCT
GATAGTGTCCTTTCCTAAGCTTTTTACAGTGACCTGAAAGCAATCCACACAAAAGGAAGTAATC
ATCTGAGTCCCTTCTGCTTGCTTGTAGAATAAAATGTGTTTGTTTCCAAAGGTATAATCTAAGA
AAGAGGTTCTAATAAATGTTTTATTTCATCAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_017454503	(Get FASTA)	NCBI Sequence Viewer
	XP_038947432	(Get FASTA)	NCBI Sequence Viewer
	XP_038947433	(Get FASTA)	NCBI Sequence Viewer
	XP_038947434	(Get FASTA)	NCBI Sequence Viewer
	XP_223074	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95005	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_223074 ⟸ XM_223074
- Peptide Label:	isoform X1
- UniProtKB:	D3ZER4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTSVWRGVWRPGLAVAGVGGKTVSRCGGRKRRLRRNLGAISSAFSSAESSPQDEMLFNSVLRQP QLGVLRNGWSSHYPLQSLLSGYRCSCNDEHTSYGETGVPVPPFGCTFCTAPSMEHILAVANEEG FVRLYNTESQTSKKTCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELMGTCKG HQCSLKSVAFSKFQKAVFCTGGRDGNIMIWDTRCNKKDGFYRQVNQISGAHNTADKQTPSKPKK KQNSKGLAPSVDSQQSVTVVLFQDENTVVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPG TSTRKLGYSSLVLDSTGSTLFANCTDDNIYMFNMTGLKTSPLAVFNGHQNSTFYVKSSLSPDDQ FLISGSSDEAAYIWKVSMPWHPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGL EEKPEGDKHSIVGWTSQKKKEVKAGPVSAPNSLSTPAKAPRSQCSPSASSPSSARTPSCAGDLP LPSNTSTFSVKTTPVTTRSPVSRRGSSSSVSPKPPSSFKMSLRNWVTRTPSSSPPVTPPASETK ISSPRKALIPVSQKSSQADACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVESLHLD LCCLSGTQEVLSQDSAGPTKSSKTEGTGTSISEPPSPVSPFASEGCGPLPLPLGPCGEGSEMVG KENSSPENKNWLLAMAAKHKAENSSPRSPSSQTPSSRRQSRKTSPGPVTITPNSMRKICTYFRR KTQDDFCSPEHSTEL hide sequence

RefSeq Acc Id:

XP_017454503 ⟸ XM_017599014

- Peptide Label:

isoform X3

- Sequence:

show sequence

MQRPPVQPQVCSFFQVSKSSFRVSPYSQTSVFCTGGRDGNIMIWDTRCNKKDGFYRQVNQISGA
HNTADKQTPSKPKKKQNSKGLAPSVDSQQSVTVVLFQDENTVVSAGAVDGIIKVWDLRKNYTAY
RQEPIASKSFLYPGTSTRKLGYSSLVLDSTGSTLFANCTDDNIYMFNMTGLKTSPLAVFNGHQN
STFYVKSSLSPDDQFLISGSSDEAAYIWKVSMPWHPPTVLLGHSQEVTSVCWCPSDFTKIATCS
DDNTLKIWRLNRGLEEKPEGDKHSIVGWTSQKKKEVKAGPVSAPNSLSTPAKAPRSQCSPSASS
PSSARTPSCAGDLPLPSNTSTFSVKTTPVTTRSPVSRRGSSSSVSPKPPSSFKMSLRNWVTRTP
SSSPPVTPPASETKISSPRKALIPVSQKSSQADACSESRNRVKRRLDSSCLESVKQKCVKSCNC
VTELDGQVESLHLDLCCLSGTQEVLSQDSAGPTKSSKTEGTGTSISEPPSPVSPFASEGCGPLP
LPLGPCGEGSEMVGKENSSPENKNWLLAMAAKHKAENSSPRSPSSQTPSSRRQSRKTSPGPVTI
TPNSMRKICTYFRRKTQDDFCSPEHSTEL

hide sequence

RefSeq Acc Id:

ENSRNOP00000005576 ⟸ ENSRNOT00000005576

RefSeq Acc Id:	XP_038947434 ⟸ XM_039091506
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038947433 ⟸ XM_039091505
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038947432 ⟸ XM_039091504
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000083831 ⟸ ENSRNOT00000095446

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZER4-F1-model_v2	AlphaFold	D3ZER4	1-783	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699133

Promoter ID:

EPDNEW_R9642

Type:

initiation region

Name:

Dtl_1

Description:

denticleless E3 ubiquitin protein ligase homolog

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	110,257,288 - 110,257,348	EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)

ACI/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Damaging Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
13	110257212	110257213	C	G	snv	WN/N (2020), WN/N (MCW)

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
13	114821113	114821114	C	G	snv	WN/N (KNAW)

Assembly: mRatBN7.2

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
13	103154764	103154765	C	G	snv	WN/N (2020)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310439	AgrOrtholog
BioCyc Gene	G2FUF-16841	BioCyc
Ensembl Genes	ENSRNOG00000004195	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000005576	ENTREZGENE
	ENSRNOP00000005576.6	UniProtKB/TrEMBL
	ENSRNOP00000083831.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005576	ENTREZGENE
	ENSRNOT00000005576.8	UniProtKB/TrEMBL
	ENSRNOT00000095446.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	305073	ENTREZGENE
Pfam	WD40	UniProtKB/TrEMBL
PhenoGen	Dtl	PhenoGen
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	WD40_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZW16_RAT	UniProtKB/TrEMBL
	D3ZER4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Dtl	denticleless E3 ubiquitin protein ligase homolog	LOC100909566	denticleless protein homolog	Data Merged	737654	PROVISIONAL
2016-01-27	Dtl	denticleless E3 ubiquitin protein ligase homolog	Dtl	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-16	Dtl	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	Dtl	denticleless homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-05	LOC100909566	denticleless protein homolog			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-02-27	Dtl	denticleless homolog (Drosophila)	RGD1310439_predicted	similar to retinoic acid-regulated nuclear matrix-associated protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1310439_predicted	similar to retinoic acid-regulated nuclear matrix-associated protein (predicted)	LOC305073_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC305073_predicted	similar to retinoic acid-regulated nuclear matrix-associated protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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