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Gene: Dtl (denticleless E3 ubiquitin protein ligase homolog) Rattus norvegicus

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Symbol:

Dtl

Name:

denticleless E3 ubiquitin protein ligase homolog

RGD ID:

1310439

Description:

Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Predicted to be located in centrosome; cytosol; and nuclear lumen. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

denticleless E3 ubiquitin protein ligase homolog (Drosophila); denticleless homolog; denticleless homolog (Drosophila); denticleless protein homolog; LOC100909566; LOC305073; RGD1310439; similar to retinoic acid-regulated nuclear matrix-associated protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	105,646,908 - 105,685,921 (-)	NCBI		GRCr8
mRatBN7.2	13	103,115,810 - 103,155,029 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	103,117,186 - 103,154,890 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	13	110,219,276 - 110,257,345 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,220,283 - 110,257,367 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	114,783,177 - 114,821,239 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,603,353 - 107,640,812 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	107,792,703 - 107,830,078 (-)	NCBI
Celera	13	102,555,070 - 102,594,148 (-)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dtl	Rat	COVID-19		ISO	RGD:1604818	9068941	mRNA:increased expression:peripheral blood mononuclear cell (human)	RGD	PMID:32228226\|REF_RGD_ID:28912744

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dtl	Rat	gastrointestinal stromal tumor		ISO	RGD:1604818	8554872	ClinVar Annotator: match by term: Gastrointestinal stromal tumor	ClinVar	PMID:28492532
Dtl	Rat	parathyroid carcinoma		ISO	RGD:1604818	8554872	ClinVar Annotator: match by term: Parathyroid carcinoma	ClinVar	PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dtl	Rat	adenoid cystic carcinoma		ISO	RGD:1604818	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:16762588
Dtl	Rat	hepatocellular carcinoma		ISO	RGD:1604818	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:28284560
Dtl	Rat	Salivary Gland Neoplasms		ISO	RGD:1604818	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:16762588

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dtl	Rat	(-)-demecolcine	decreases expression	ISO	RGD:1604818	6480464	Demecolcine results in decreased expression of DTL mRNA	CTD	PMID:23649840
Dtl	Rat	1,1-dichloroethene	increases expression	ISO	RGD:1551993	6480464	vinylidene chloride results in increased expression of DTL mRNA	CTD	PMID:26682919
Dtl	Rat	1-naphthyl isothiocyanate	increases expression	EXP		6480464	1-Naphthylisothiocyanate results in increased expression of DTL mRNA	CTD	PMID:30723492
Dtl	Rat	17alpha-ethynylestradiol	increases expression	ISO	RGD:1604818	6480464	Ethinyl Estradiol results in increased expression of DTL mRNA	CTD	PMID:18936297
Dtl	Rat	17beta-estradiol	increases expression	ISO	RGD:1604818	6480464	Estradiol results in increased expression of DTL mRNA	CTD	PMID:16474171\|PMID:20106945
Dtl	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1604818	6480464	Tetrachlorodibenzodioxin results in decreased expression of DTL mRNA	CTD	PMID:21632981\|PMID:21802500
Dtl	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of DTL mRNA	CTD	PMID:33387578
Dtl	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of DTL mRNA	CTD	PMID:32109520
Dtl	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1551993	6480464	Tetrachlorodibenzodioxin affects the expression of DTL mRNA	CTD	PMID:26377647
Dtl	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1604818	6480464	Tetrachlorodibenzodioxin results in increased expression of DTL mRNA	CTD	PMID:26159488
Dtl	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1604818	6480464	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of DTL mRNA	CTD	PMID:26159488
Dtl	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1604818	6480464	Tetrachlorodibenzodioxin affects the expression of DTL mRNA	CTD	PMID:22574217
Dtl	Rat	2,4-dibromophenyl 2,4,5-tribromophenyl ether	affects expression	ISO	RGD:1551993	6480464	2,2',4,4',5-brominated diphenyl ether affects the expression of DTL mRNA	CTD	PMID:38648751
Dtl	Rat	2-hydroxypropanoic acid	increases expression	ISO	RGD:1604818	6480464	Lactic Acid results in increased expression of DTL mRNA	CTD	PMID:30851411
Dtl	Rat	2-methylcholine	affects expression	ISO	RGD:1604818	6480464	beta-methylcholine affects the expression of DTL mRNA	CTD	PMID:21179406
Dtl	Rat	2-palmitoylglycerol	increases expression	ISO	RGD:1604818	6480464	2-palmitoylglycerol results in increased expression of DTL mRNA	CTD	PMID:37199045
Dtl	Rat	3-methylcholanthrene	increases expression	ISO	RGD:1551993	6480464	Methylcholanthrene results in increased expression of DTL mRNA	CTD	PMID:20713471
Dtl	Rat	4,4'-sulfonyldiphenol	decreases expression	ISO	RGD:1604818	6480464	bisphenol S results in decreased expression of DTL mRNA	CTD	PMID:30616060
Dtl	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of DTL mRNA	CTD	PMID:25825206
Dtl	Rat	acrylamide	increases expression	EXP		6480464	Acrylamide results in increased expression of DTL mRNA	CTD	PMID:28959563
Dtl	Rat	acrylamide	decreases expression	ISO	RGD:1604818	6480464	Acrylamide results in decreased expression of DTL mRNA	CTD	PMID:32763439
Dtl	Rat	aflatoxin B1	affects expression	ISO	RGD:1604818	6480464	Aflatoxin B1 affects the expression of DTL protein	CTD	PMID:20106945
Dtl	Rat	aflatoxin B1	increases expression	ISO	RGD:1604818	6480464	Aflatoxin B1 results in increased expression of DTL mRNA	CTD	PMID:22100608
Dtl	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1604818	6480464	Tretinoin results in decreased expression of DTL mRNA	CTD	PMID:33167477
Dtl	Rat	arsenous acid	increases sumoylation	ISO	RGD:1604818	6480464	Arsenic Trioxide results in increased sumoylation of DTL protein	CTD	PMID:28318385
Dtl	Rat	atrazine	decreases expression	ISO	RGD:1604818	6480464	Atrazine results in decreased expression of DTL mRNA	CTD	PMID:22378314
Dtl	Rat	azathioprine	decreases expression	ISO	RGD:1604818	6480464	Azathioprine results in decreased expression of DTL mRNA	CTD	PMID:22623647
Dtl	Rat	bazedoxifene	decreases expression	ISO	RGD:1604818	6480464	bazedoxifene results in decreased expression of DTL mRNA	CTD	PMID:19914376
Dtl	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1551993	6480464	Benzo(a)pyrene results in increased expression of DTL mRNA	CTD	PMID:20713471
Dtl	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1604818	6480464	Benzo(a)pyrene results in increased expression of DTL mRNA	CTD	PMID:32234424
Dtl	Rat	benzo[a]pyrene	multiple interactions	ISO	RGD:1551993	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ...	CTD	PMID:27858113
Dtl	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1604818	6480464	Benzo(a)pyrene results in decreased expression of DTL mRNA	CTD	PMID:20064835\|PMID:21802500
Dtl	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1604818	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DTL mRNA	CTD	PMID:20382639
Dtl	Rat	benzo[a]pyrene diol epoxide I	increases expression	ISO	RGD:1604818	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DTL mRNA	CTD	PMID:26238291
Dtl	Rat	benzo[b]fluoranthene	increases expression	ISO	RGD:1551993	6480464	benzo(b)fluoranthene results in increased expression of DTL mRNA	CTD	PMID:26377693
Dtl	Rat	benzo[b]fluoranthene	multiple interactions	ISO	RGD:1551993	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ...	CTD	PMID:27858113
Dtl	Rat	beta-hexachlorocyclohexane	decreases expression	ISO	RGD:1551993	6480464	beta-hexachlorocyclohexane results in decreased expression of DTL mRNA	CTD	PMID:25270620
Dtl	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1551993	6480464	Diethylhexyl Phthalate results in increased expression of DTL mRNA	CTD	PMID:21318169
Dtl	Rat	bisphenol A	increases expression	ISO	RGD:1604818	6480464	bisphenol A results in increased expression of DTL mRNA	CTD	PMID:16474171
Dtl	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of DTL mRNA	CTD	PMID:32145629
Dtl	Rat	bisphenol A	affects expression	ISO	RGD:1604818	6480464	bisphenol A affects the expression of DTL mRNA	CTD	PMID:30903817
Dtl	Rat	bisphenol A	decreases expression	ISO	RGD:1604818	6480464	bisphenol A results in decreased expression of DTL mRNA	CTD	PMID:29275510
Dtl	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of DTL mRNA	CTD	PMID:25181051
Dtl	Rat	cadmium atom	increases expression	ISO	RGD:1604818	6480464	Cadmium results in increased expression of DTL mRNA	CTD	PMID:24376830
Dtl	Rat	cadmium dichloride	increases expression	ISO	RGD:1604818	6480464	Cadmium Chloride results in increased expression of DTL mRNA	CTD	PMID:26472689
Dtl	Rat	caffeine	affects phosphorylation	ISO	RGD:1604818	6480464	Caffeine affects the phosphorylation of DTL protein	CTD	PMID:35688186
Dtl	Rat	calcitriol	decreases expression	ISO	RGD:1604818	6480464	Calcitriol results in decreased expression of DTL mRNA	CTD	PMID:21592394
Dtl	Rat	calcitriol	multiple interactions	ISO	RGD:1604818	6480464	[Testosterone co-treated with Calcitriol] results in decreased expression of DTL mRNA	CTD	PMID:21592394
Dtl	Rat	carbamazepine	affects expression	ISO	RGD:1604818	6480464	Carbamazepine affects the expression of DTL mRNA	CTD	PMID:25979313
Dtl	Rat	carbon nanotube	affects expression	ISO	RGD:1551993	6480464	Nanotubes, Carbon affects the expression of DTL mRNA	CTD	PMID:25554681
Dtl	Rat	carbon nanotube	increases expression	ISO	RGD:1551993	6480464	Nanotubes, Carbon analog results in increased expression of DTL mRNA	CTD	PMID:25554681
Dtl	Rat	chlorpyrifos	decreases expression	ISO	RGD:1551993	6480464	Chlorpyrifos results in decreased expression of DTL mRNA	CTD	PMID:37019170
Dtl	Rat	chromium(6+)	multiple interactions	ISO	RGD:1604818	6480464	[zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression more ...	CTD	PMID:38479592
Dtl	Rat	chrysene	multiple interactions	ISO	RGD:1551993	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ...	CTD	PMID:27858113
Dtl	Rat	cisplatin	increases expression	ISO	RGD:1604818	6480464	Cisplatin results in increased expression of DTL mRNA	CTD	PMID:27594783
Dtl	Rat	copper atom	multiple interactions	ISO	RGD:1604818	6480464	[NSC 689534 binds to Copper] which results in decreased expression of DTL mRNA	CTD	PMID:20971185
Dtl	Rat	copper(0)	multiple interactions	ISO	RGD:1604818	6480464	[NSC 689534 binds to Copper] which results in decreased expression of DTL mRNA	CTD	PMID:20971185
Dtl	Rat	copper(II) chloride	increases expression	ISO	RGD:1604818	6480464	cupric chloride results in increased expression of DTL mRNA	CTD	PMID:38568856
Dtl	Rat	coumarin	affects phosphorylation	ISO	RGD:1604818	6480464	coumarin affects the phosphorylation of DTL protein	CTD	PMID:35688186
Dtl	Rat	cyclosporin A	decreases expression	ISO	RGD:1604818	6480464	Cyclosporine results in decreased expression of DTL mRNA	CTD	PMID:20106945\|PMID:21632981
Dtl	Rat	cyclosporin A	affects expression	ISO	RGD:1604818	6480464	Cyclosporine affects the expression of DTL mRNA	CTD	PMID:25562108
Dtl	Rat	DDT	decreases methylation	EXP		6480464	DDT results in decreased methylation of DTL gene	CTD	PMID:31682807
Dtl	Rat	diarsenic trioxide	increases sumoylation	ISO	RGD:1604818	6480464	Arsenic Trioxide results in increased sumoylation of DTL protein	CTD	PMID:28318385
Dtl	Rat	dibutyl phthalate	decreases expression	ISO	RGD:1551993	6480464	Dibutyl Phthalate results in decreased expression of DTL mRNA	CTD	PMID:17361019\|PMID:21266533
Dtl	Rat	dichloroacetic acid	increases expression	ISO	RGD:1551993	6480464	Dichloroacetic Acid results in increased expression of DTL mRNA	CTD	PMID:28962523
Dtl	Rat	dioxygen	decreases expression	ISO	RGD:1604818	6480464	Oxygen deficiency results in decreased expression of DTL mRNA	CTD	PMID:26516004
Dtl	Rat	dorsomorphin	multiple interactions	ISO	RGD:1604818	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Dtl	Rat	doxorubicin	decreases expression	ISO	RGD:1604818	6480464	Doxorubicin results in decreased expression of DTL mRNA	CTD	PMID:29803840\|PMID:30031762
Dtl	Rat	endosulfan	multiple interactions	ISO	RGD:1604818	6480464	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of DTL mRNA	CTD	PMID:26159488
Dtl	Rat	epoxiconazole	increases expression	ISO	RGD:1551993	6480464	epoxiconazole results in increased expression of DTL mRNA	CTD	PMID:35436446
Dtl	Rat	erastin	increases expression	ISO	RGD:1604818	6480464	erastin results in increased expression of DTL mRNA alternative form	CTD	PMID:35234341
Dtl	Rat	ethanol	increases expression	ISO	RGD:1551993	6480464	Ethanol results in increased expression of DTL mRNA	CTD	PMID:30319688
Dtl	Rat	ethyl methanesulfonate	increases expression	ISO	RGD:1604818	6480464	Ethyl Methanesulfonate results in increased expression of DTL mRNA	CTD	PMID:23649840
Dtl	Rat	folic acid	decreases expression	ISO	RGD:1551993	6480464	Folic Acid results in decreased expression of DTL mRNA	CTD	PMID:25629700
Dtl	Rat	folpet	decreases expression	ISO	RGD:1551993	6480464	folpet results in decreased expression of DTL mRNA	CTD	PMID:31558096
Dtl	Rat	FR900359	affects phosphorylation	ISO	RGD:1604818	6480464	FR900359 affects the phosphorylation of DTL protein	CTD	PMID:37730182
Dtl	Rat	genistein	increases expression	ISO	RGD:1604818	6480464	Genistein results in increased expression of DTL mRNA	CTD	PMID:16474171
Dtl	Rat	GSK-J4	decreases expression	ISO	RGD:1604818	6480464	GSK-J4 results in decreased expression of DTL mRNA	CTD	PMID:29301935
Dtl	Rat	hexadecanoic acid	increases phosphorylation	ISO	RGD:1604818	6480464	Palmitic Acid results in increased phosphorylation of DTL protein	CTD	PMID:28073184
Dtl	Rat	Lasiocarpine	increases expression	ISO	RGD:1604818	6480464	lasiocarpine results in increased expression of DTL mRNA	CTD	PMID:32234424
Dtl	Rat	lead(0)	affects expression	ISO	RGD:1604818	6480464	Lead affects the expression of DTL mRNA	CTD	PMID:28903495
Dtl	Rat	lidocaine	decreases expression	EXP		6480464	Lidocaine results in decreased expression of DTL mRNA	CTD	PMID:35283115
Dtl	Rat	lipopolysaccharide	affects expression	ISO	RGD:1604818	6480464	Lipopolysaccharides affects the expression of DTL mRNA	CTD	PMID:28070326
Dtl	Rat	lipopolysaccharide	multiple interactions	ISO	RGD:1604818	6480464	Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of DTL mRNA]	CTD	PMID:28070326
Dtl	Rat	lucanthone	decreases expression	ISO	RGD:1604818	6480464	Lucanthone results in decreased expression of DTL mRNA	CTD	PMID:21148553
Dtl	Rat	methamphetamine	decreases expression	ISO	RGD:1604818	6480464	Methamphetamine results in decreased expression of DTL mRNA	CTD	PMID:25290377
Dtl	Rat	methyl methanesulfonate	increases expression	ISO	RGD:1604818	6480464	Methyl Methanesulfonate results in increased expression of DTL mRNA	CTD	PMID:23649840
Dtl	Rat	methylparaben	increases expression	ISO	RGD:1604818	6480464	methylparaben results in increased expression of DTL mRNA	CTD	PMID:38568856
Dtl	Rat	nickel atom	increases expression	ISO	RGD:1604818	6480464	Nickel results in increased expression of DTL mRNA	CTD	PMID:25583101
Dtl	Rat	niclosamide	decreases expression	ISO	RGD:1604818	6480464	Niclosamide results in decreased expression of DTL mRNA	CTD	PMID:36318118
Dtl	Rat	okadaic acid	increases expression	ISO	RGD:1604818	6480464	Okadaic Acid results in increased expression of DTL mRNA	CTD	PMID:38832940
Dtl	Rat	ozone	multiple interactions	ISO	RGD:1551993	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ...	CTD	PMID:25658374\|PMID:27106289\|PMID:34911549
Dtl	Rat	ozone	increases expression	ISO	RGD:1551993	6480464	Ozone results in increased expression of DTL mRNA	CTD	PMID:33026818
Dtl	Rat	paracetamol	increases expression	ISO	RGD:1604818	6480464	Acetaminophen results in increased expression of DTL mRNA	CTD	PMID:22230336
Dtl	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of DTL mRNA	CTD	PMID:33387578
Dtl	Rat	paracetamol	decreases expression	ISO	RGD:1604818	6480464	Acetaminophen results in decreased expression of DTL mRNA	CTD	PMID:26690555
Dtl	Rat	phenobarbital	increases expression	ISO	RGD:1551993	6480464	Phenobarbital results in increased expression of DTL mRNA	CTD	PMID:23091169
Dtl	Rat	phenylmercury acetate	decreases expression	ISO	RGD:1604818	6480464	Phenylmercuric Acetate results in decreased expression of DTL mRNA	CTD	PMID:26272509
Dtl	Rat	phenylmercury acetate	multiple interactions	ISO	RGD:1604818	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Dtl	Rat	pirinixic acid	multiple interactions	ISO	RGD:1551993	6480464	[pirinixic acid co-treated with PPARA] results in increased expression of DTL mRNA; PPARA protein affects more ...	CTD	PMID:20813756\|PMID:21318169
Dtl	Rat	pirinixic acid	increases expression	ISO	RGD:1551993	6480464	pirinixic acid results in increased expression of DTL mRNA	CTD	PMID:20813756\|PMID:21318169
Dtl	Rat	piroxicam	decreases expression	ISO	RGD:1604818	6480464	Piroxicam results in decreased expression of DTL mRNA	CTD	PMID:21858171
Dtl	Rat	pravastatin	decreases expression	EXP		6480464	Pravastatin results in decreased expression of DTL mRNA	CTD	PMID:27225895
Dtl	Rat	pravastatin	affects expression	ISO	RGD:1551993	6480464	Pravastatin affects the expression of DTL mRNA	CTD	PMID:27225895
Dtl	Rat	progesterone	decreases expression	ISO	RGD:1604818	6480464	Progesterone results in decreased expression of DTL mRNA	CTD	PMID:21795739
Dtl	Rat	quercetin	increases expression	ISO	RGD:1604818	6480464	Quercetin results in increased expression of DTL mRNA	CTD	PMID:21632981
Dtl	Rat	rac-lactic acid	increases expression	ISO	RGD:1604818	6480464	Lactic Acid results in increased expression of DTL mRNA	CTD	PMID:30851411
Dtl	Rat	SB 431542	multiple interactions	ISO	RGD:1604818	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Dtl	Rat	senecionine	increases expression	EXP		6480464	senecionine results in increased expression of DTL mRNA	CTD	PMID:32419051
Dtl	Rat	Senkirkine	increases expression	EXP		6480464	senkirkine results in increased expression of DTL mRNA	CTD	PMID:32419051
Dtl	Rat	silicon dioxide	decreases expression	ISO	RGD:1551993	6480464	Silicon Dioxide results in decreased expression of DTL mRNA	CTD	PMID:19073995
Dtl	Rat	silicon dioxide	increases expression	ISO	RGD:1551993	6480464	Silicon Dioxide results in increased expression of DTL mRNA	CTD	PMID:29341224
Dtl	Rat	sodium arsenite	increases expression	ISO	RGD:1604818	6480464	sodium arsenite results in increased expression of DTL mRNA	CTD	PMID:29301061\|PMID:34032870
Dtl	Rat	sodium arsenite	decreases expression	ISO	RGD:1551993	6480464	sodium arsenite results in decreased expression of DTL mRNA	CTD	PMID:37682722
Dtl	Rat	sodium arsenite	decreases expression	ISO	RGD:1604818	6480464	sodium arsenite results in decreased expression of DTL mRNA	CTD	PMID:38568856
Dtl	Rat	succimer	multiple interactions	ISO	RGD:1551993	6480464	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of DTL mRNA	CTD	PMID:21641980
Dtl	Rat	sunitinib	decreases expression	ISO	RGD:1604818	6480464	Sunitinib results in decreased expression of DTL mRNA	CTD	PMID:31533062
Dtl	Rat	testosterone	multiple interactions	ISO	RGD:1604818	6480464	[Testosterone co-treated with Calcitriol] results in decreased expression of DTL mRNA	CTD	PMID:21592394
Dtl	Rat	testosterone	decreases expression	ISO	RGD:1604818	6480464	Testosterone results in decreased expression of DTL mRNA	CTD	PMID:21592394
Dtl	Rat	tetrachloromethane	increases expression	ISO	RGD:1551993	6480464	Carbon Tetrachloride results in increased expression of DTL mRNA	CTD	PMID:17484886
Dtl	Rat	tetraphene	multiple interactions	ISO	RGD:1551993	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ...	CTD	PMID:27858113
Dtl	Rat	thapsigargin	decreases expression	ISO	RGD:1604818	6480464	Thapsigargin results in decreased expression of DTL mRNA	CTD	PMID:22378314
Dtl	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of DTL mRNA	CTD	PMID:34492290
Dtl	Rat	titanium dioxide	increases expression	ISO	RGD:1551993	6480464	titanium dioxide results in increased expression of DTL mRNA	CTD	PMID:23557971
Dtl	Rat	titanium dioxide	decreases methylation	ISO	RGD:1551993	6480464	titanium dioxide results in decreased methylation of DTL gene	CTD	PMID:35295148
Dtl	Rat	triclosan	decreases expression	ISO	RGD:1604818	6480464	Triclosan results in decreased expression of DTL mRNA	CTD	PMID:30510588
Dtl	Rat	trimellitic anhydride	increases expression	ISO	RGD:1551993	6480464	trimellitic anhydride results in increased expression of DTL mRNA	CTD	PMID:19042947
Dtl	Rat	triphenyl phosphate	affects expression	ISO	RGD:1604818	6480464	triphenyl phosphate affects the expression of DTL mRNA	CTD	PMID:37042841
Dtl	Rat	triptonide	decreases expression	ISO	RGD:1551993	6480464	triptonide results in decreased expression of DTL mRNA	CTD	PMID:33045310
Dtl	Rat	tunicamycin	decreases expression	ISO	RGD:1604818	6480464	Tunicamycin results in decreased expression of DTL mRNA	CTD	PMID:22378314
Dtl	Rat	tunicamycin	increases expression	ISO	RGD:1604818	6480464	Tunicamycin results in increased expression of DTL mRNA	CTD	PMID:29453283
Dtl	Rat	urethane	decreases expression	ISO	RGD:1604818	6480464	Urethane results in decreased expression of DTL mRNA	CTD	PMID:28818685
Dtl	Rat	valproic acid	decreases methylation	ISO	RGD:1604818	6480464	Valproic Acid results in decreased methylation of DTL gene	CTD	PMID:29154799
Dtl	Rat	valproic acid	decreases expression	ISO	RGD:1604818	6480464	Valproic Acid results in decreased expression of DTL mRNA	CTD	PMID:23179753\|PMID:27188386
Dtl	Rat	vincristine	decreases expression	ISO	RGD:1604818	6480464	Vincristine results in decreased expression of DTL mRNA	CTD	PMID:23649840
Dtl	Rat	zaragozic acid A	decreases expression	ISO	RGD:1551993	6480464	squalestatin 1 results in decreased expression of DTL mRNA	CTD	PMID:27225895
Dtl	Rat	zaragozic acid A	decreases expression	EXP		6480464	squalestatin 1 results in decreased expression of DTL mRNA	CTD	PMID:27225895

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dtl	Rat	DNA damage response	involved_in	ISO	RGD:1604818	1624291	PMID:16949367, PMID:20129063	RGD	PMID:16949367\|PMID:20129063
Dtl	Rat	DNA damage response	involved_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	mitotic G2 DNA damage checkpoint signaling	involved_in	ISO	RGD:1604818	1624291	PMID:17085480	RGD	PMID:17085480
Dtl	Rat	mitotic G2 DNA damage checkpoint signaling	involved_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	mitotic G2 DNA damage checkpoint signaling	involved_in	IBA	PANTHER:PTN000523288\|UniProtKB:Q9NZJ0\|ZFIN:ZDB-GENE-020419-34	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Dtl	Rat	positive regulation of G2/M transition of mitotic cell cycle	involved_in	ISO	RGD:1604818	1624291	PMID:16949367	RGD	PMID:16949367
Dtl	Rat	positive regulation of G2/M transition of mitotic cell cycle	involved_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	positive regulation of protein catabolic process	involved_in	ISO	RGD:1604818	1624291	PMID:16949367	RGD	PMID:16949367
Dtl	Rat	positive regulation of protein catabolic process	involved_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	proteasome-mediated ubiquitin-dependent protein catabolic process	involved_in	IBA	PANTHER:PTN000523286\|WB:WBGene00011318	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Dtl	Rat	protein monoubiquitination	involved_in	ISO	RGD:1604818	1624291	PMID:20129063	RGD	PMID:20129063
Dtl	Rat	protein monoubiquitination	involved_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	protein polyubiquitination	involved_in	ISO	RGD:1604818	1624291	PMID:18794347	RGD	PMID:18794347
Dtl	Rat	protein polyubiquitination	involved_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	regulation of cell cycle	involved_in	ISO	RGD:1604818	1624291	PMID:17085480	RGD	PMID:17085480
Dtl	Rat	regulation of cell cycle	involved_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	response to UV	involved_in	ISO	RGD:1604818	1624291	PMID:18794347	RGD	PMID:18794347
Dtl	Rat	response to UV	involved_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	translesion synthesis	involved_in	ISO	RGD:1604818	1624291	PMID:20129063	RGD	PMID:20129063
Dtl	Rat	translesion synthesis	involved_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	ubiquitin-dependent protein catabolic process	involved_in	ISO	RGD:1604818	1624291	PMID:18794347, PMID:26431207	RGD	PMID:18794347\|PMID:26431207
Dtl	Rat	ubiquitin-dependent protein catabolic process	involved_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dtl	Rat	centrosome	located_in	ISO	RGD:1604818	1624291	PMID:17106265	RGD	PMID:17106265
Dtl	Rat	centrosome	located_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	Cul4-RING E3 ubiquitin ligase complex	part_of	ISO	RGD:1604818	1624291	PMID:16949367	RGD	PMID:16949367
Dtl	Rat	Cul4-RING E3 ubiquitin ligase complex	part_of	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	Cul4A-RING E3 ubiquitin ligase complex	part_of	ISO	RGD:1604818	1624291	PMID:17085480, PMID:18794347, PMID:20129063, PMID:21628527	RGD	PMID:17085480\|PMID:18794347\|PMID:20129063\|PMID:21628527
Dtl	Rat	Cul4A-RING E3 ubiquitin ligase complex	part_of	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	Cul4B-RING E3 ubiquitin ligase complex	part_of	ISO	RGD:1604818	1624291	PMID:18794347	RGD	PMID:18794347
Dtl	Rat	Cul4B-RING E3 ubiquitin ligase complex	part_of	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	cytosol	located_in	ISO	RGD:1604818\|UniProtKB:Q9NZJ0-1	1624291		RGD	GO_REF:0000052
Dtl	Rat	cytosol	located_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	nucleolus	located_in	ISO	RGD:1604818\|UniProtKB:Q9NZJ0-1	1624291		RGD	GO_REF:0000052
Dtl	Rat	nucleolus	located_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	nucleoplasm	located_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	nucleoplasm	located_in	ISO	RGD:1604818\|UniProtKB:Q9NZJ0-1	1624291		RGD	GO_REF:0000052
Dtl	Rat	nucleus	located_in	ISO	RGD:1604818	1624291	PMID:17106265, PMID:26431207	RGD	PMID:17106265\|PMID:26431207
Dtl	Rat	nucleus	located_in	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dtl	Rat	nucleus	is_active_in	IBA	FB:FBgn0013548\|PANTHER:PTN000523286\|PomBase:SPAC17H9.19c\|UniProtKB:Q9NZJ0\|WB:WBGene00011318\|Xenbase:XB-GENE-985623	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dtl	Rat	protein binding	enables	ISO	RGD:1604818	1624291	UniProtKB:P38936\|UniProtKB:P40337-2\|UniProtKB:P62258\|UniProtKB:Q13619\|UniProtKB:Q16526\|UniProtKB:Q16531\|UniProtKB:Q6IQ49 PMID:16949367, PMID:17041588, PMID:18794347, PMID:23213251, PMID:26431207, PMID:27906959, PMID:32814053, PMID:33961781, PMID:35271311, PMID:36931259	RGD	PMID:16949367\|PMID:17041588\|PMID:18794347\|PMID:23213251\|PMID:26431207\|PMID:27906959\|PMID:32814053\|PMID:33961781\|PMID:35271311\|PMID:36931259
Dtl	Rat	protein-macromolecule adaptor activity	enables	IBA	PANTHER:PTN000523286\|PomBase:SPAC17H9.19c	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Dtl	Rat	ubiquitin-protein transferase activity	contributes_to	ISO	RGD:1604818	1624291	PMID:18794347, PMID:20129063	RGD	PMID:18794347\|PMID:20129063
Dtl	Rat	ubiquitin-protein transferase activity	contributes_to	IEA	UniProtKB:Q9NZJ0\|ensembl:ENSP00000355958	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

COVID-19 (ISO)

gastrointestinal stromal tumor (ISO)

hepatocellular carcinoma (ISO)

parathyroid carcinoma (ISO)

Salivary Gland Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

2-palmitoylglycerol (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

atrazine (ISO)

azathioprine (ISO)

bazedoxifene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

beta-hexachlorocyclohexane (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

chrysene (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

coumarin (ISO)

cyclosporin A (ISO)

DDT (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dichloroacetic acid (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (ISO)

epoxiconazole (ISO)

erastin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

folpet (ISO)

FR900359 (ISO)

genistein (ISO)

GSK-J4 (ISO)

hexadecanoic acid (ISO)

Lasiocarpine (ISO)

lead(0) (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

lucanthone (ISO)

methamphetamine (ISO)

methyl methanesulfonate (ISO)

methylparaben (ISO)

nickel atom (ISO)

niclosamide (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

pravastatin (EXP,ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

senecionine (EXP)

Senkirkine (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage response (IEA,ISO)

mitotic G2 DNA damage checkpoint signaling (IBA,IEA,ISO)

positive regulation of G2/M transition of mitotic cell cycle (IEA,ISO)

positive regulation of protein catabolic process (IEA,ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA)

protein monoubiquitination (IEA,ISO)

protein polyubiquitination (IEA,ISO)

regulation of cell cycle (IEA,ISO)

response to UV (IEA,ISO)

translesion synthesis (IEA,ISO)

ubiquitin-dependent protein catabolic process (IEA,ISO)

Cellular Component

centrosome (IEA,ISO)

Cul4-RING E3 ubiquitin ligase complex (IEA,ISO)

Cul4A-RING E3 ubiquitin ligase complex (IEA,ISO)

Cul4B-RING E3 ubiquitin ligase complex (IEA,ISO)

cytosol (IEA,ISO)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

protein binding (ISO)

protein-macromolecule adaptor activity (IBA)

ubiquitin-protein transferase activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16949367	PMID:17085480	PMID:17106265	PMID:18794347	PMID:20129063	PMID:21628527	PMID:26431207

Genomics

Comparative Map Data

Dtl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	105,646,908 - 105,685,921 (-)	NCBI		GRCr8
mRatBN7.2	13	103,115,810 - 103,155,029 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	103,117,186 - 103,154,890 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	13	110,219,276 - 110,257,345 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,220,283 - 110,257,367 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	114,783,177 - 114,821,239 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,603,353 - 107,640,812 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	107,792,703 - 107,830,078 (-)	NCBI
Celera	13	102,555,070 - 102,594,148 (-)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

DTL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	212,035,748 - 212,105,013 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	212,035,553 - 212,107,400 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	212,209,090 - 212,278,355 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	210,275,754 - 210,344,809 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	185,435,998 - 185,505,287 (+)	NCBI		Celera
Cytogenetic Map	1	q32.3	NCBI
HuRef	1	182,885,955 - 182,955,234 (+)	NCBI		HuRef
CHM1_1	1	213,481,305 - 213,550,518 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	211,281,835 - 211,351,118 (+)	NCBI		T2T-CHM13v2.0

Dtl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	191,269,468 - 191,307,656 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	191,269,468 - 191,307,656 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	191,537,356 - 191,575,544 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	191,537,356 - 191,575,544 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	193,361,244 - 193,399,413 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	193,237,980 - 193,276,149 (-)	NCBI		MGSCv36	mm8
Celera	1	198,486,790 - 198,526,178 (-)	NCBI		Celera
Cytogenetic Map	1	H6	NCBI
cM Map	1	96.44	NCBI

Dtl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	5,254,558 - 5,299,573 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	5,256,057 - 5,299,573 (-)	NCBI	ChiLan1.0	ChiLan1.0

DTL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	37,300,460 - 37,367,503 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	37,264,941 - 37,331,990 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	187,603,600 - 187,672,006 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	192,466,408 - 192,535,071 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	192,466,408 - 192,535,071 (+)	Ensembl	panpan1.1		panPan2

DTL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	10,323,842 - 10,368,529 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	10,323,559 - 10,369,560 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	9,901,494 - 9,944,363 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	10,030,330 - 10,073,724 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	10,030,370 - 10,073,719 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	9,952,445 - 9,997,665 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	10,055,386 - 10,098,331 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	10,179,868 - 10,228,472 (+)	NCBI		UU_Cfam_GSD_1.0

Dtl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	64,087,630 - 64,149,419 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	1,347,991 - 1,389,836 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	1,347,991 - 1,389,836 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DTL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	131,227,705 - 131,275,451 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	131,225,840 - 131,275,426 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	144,272,743 - 144,325,340 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DTL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	17,418,078 - 17,485,320 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	17,418,090 - 17,485,164 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	17,940,853 - 18,008,338 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dtl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	17,612,284 - 17,662,405 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624771	17,612,264 - 17,660,772 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dtl
122 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	179
Count of miRNA genes:	132
Interacting mature miRNAs:	138
Transcripts:	ENSRNOT00000005576, ENSRNOT00000005628
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	66451204	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	90	89	58	25	58	6	217	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001068900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006221606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272399	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005576 ⟹ ENSRNOP00000005576

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	103,117,186 - 103,154,890 (-)	Ensembl
Rnor_6.0 Ensembl	13	110,220,283 - 110,257,367 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095446 ⟹ ENSRNOP00000083831

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	103,117,186 - 103,154,890 (-)	Ensembl

RefSeq Acc Id:

NM_001427431 ⟹ NP_001414360

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,646,908 - 105,685,921 (-)	NCBI

RefSeq Acc Id:

XM_017599014 ⟹ XP_017454503

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,646,908 - 105,679,386 (-)	NCBI
mRatBN7.2	13	103,115,810 - 103,148,301 (-)	NCBI
Rnor_6.0	13	110,219,276 - 110,250,749 (-)	NCBI

Sequence:

show sequence

ATGCAAAGGCCACCAGTGCAGCCTCAAGTCTGTAGCTTTTTCCAAGTTTCAAAAAGCTCCTTTC
GTGTCAGTCCATATTCTCAAACATCTGTGTTCTGTACTGGTGGGAGAGACGGCAACATTATGAT
CTGGGACACCAGGTGCAACAAAAAAGATGGATTTTATAGACAAGTGAATCAAATCAGTGGCGCT
CACAATACTGCAGACAAGCAAACCCCTTCAAAACCCAAGAAGAAACAAAATTCAAAAGGACTTG
CTCCATCTGTGGATTCCCAGCAGAGTGTTACTGTGGTCCTCTTTCAGGATGAGAATACAGTAGT
CTCAGCAGGAGCCGTGGATGGAATAATCAAAGTATGGGATTTACGCAAGAATTACACTGCTTAT
CGACAAGAACCCATAGCATCCAAGTCTTTCCTGTACCCAGGTACCAGCACTAGAAAACTAGGAT
ACTCGAGTTTGGTTCTAGACTCTACTGGCTCTACTCTGTTTGCTAACTGCACAGATGACAACAT
CTATATGTTCAATATGACTGGCTTAAAGACTTCTCCACTGGCTGTCTTCAATGGACACCAGAAC
TCTACCTTTTATGTAAAATCAAGTCTTAGTCCAGATGACCAGTTTTTAATCAGTGGTTCAAGTG
ACGAAGCTGCCTACATTTGGAAGGTTTCTATGCCATGGCATCCTCCTACCGTACTCCTGGGTCA
TTCTCAAGAAGTCACGTCTGTGTGCTGGTGTCCATCAGACTTCACCAAGATTGCAACCTGCTCT
GATGATAATACACTAAAAATCTGGCGCTTGAACAGAGGCCTAGAGGAGAAACCAGAAGGTGATA
AACATTCCATAGTAGGTTGGACCTCTCAGAAGAAAAAGGAAGTGAAAGCCGGCCCAGTATCGGC
ACCAAATAGCCTGAGCACCCCTGCCAAAGCCCCCAGGTCCCAGTGCAGCCCATCTGCTTCCTCT
CCTTCATCAGCTCGTACTCCAAGCTGTGCGGGAGACCTCCCCCTTCCCTCAAATACCTCCACCT
TCTCAGTCAAAACCACTCCGGTCACGACCCGTTCTCCAGTCAGCAGAAGAGGTTCCAGCTCTTC
TGTGTCTCCCAAGCCACCCTCATCTTTCAAGATGTCACTTAGAAACTGGGTGACCCGAACACCT
TCCTCATCACCACCTGTCACTCCACCTGCTTCTGAGACAAAGATCTCATCTCCGAGAAAAGCCC
TTATTCCTGTGAGCCAGAAGTCATCACAAGCAGATGCTTGCTCTGAATCTAGAAATAGAGTGAA
GAGGCGTCTCGACTCGAGCTGTCTGGAGAGTGTGAAACAAAAGTGTGTGAAGAGTTGCAACTGT
GTCACTGAGCTTGACGGCCAAGTGGAGAGTCTTCATTTGGATCTGTGCTGCCTTTCCGGCACCC
AGGAAGTCCTTAGCCAAGATTCTGCGGGTCCTACCAAATCAAGCAAGACGGAAGGTACTGGCAC
GAGCATCTCAGAGCCCCCTTCTCCTGTCAGTCCTTTTGCTTCTGAAGGCTGTGGACCACTGCCT
CTTCCTTTGGGACCTTGTGGAGAAGGATCTGAAATGGTGGGCAAAGAGAATAGCTCCCCAGAGA
ATAAGAACTGGTTGTTGGCCATGGCAGCCAAACACAAGGCGGAGAATTCATCCCCAAGAAGTCC
ATCATCCCAGACACCCAGTTCCAGGAGACAGAGTAGAAAGACGTCACCAGGCCCGGTCACCATT
ACCCCCAACTCCATGAGGAAGATATGCACATATTTTCGCAGAAAGACTCAAGATGACTTCTGTA
GTCCTGAACATTCAACTGAGTTATAAATTCTAATCTCAAAGTTTGATGAACTTGGGTCTACAAA
GATTTTTTTAAAAACCTTTAAAATCTGGTCTTTAAGAAAATGGTCATGTTTTGATTTTGGAAAA
AAGTTCTAATACTCTTTGGCAGACCTAGTCAAACCCCACTGTGTATAGACACAGCAGCCTGGGT
GAGTGCTGTATCCAGTTCACGGGGCGGCTTGTCCTCTGCAGTCTGTGATAACCACATCCAGCTC
ATGGATGCAGAAAGCCAGGCATGCTTCTATGGCTATGGAGAGTGTCCACTAGCCCAGCATAGGG
CCCATCTGTGAGGCCAGTCTGAAGTCATCCTTTGCAGAAGGTAGATGCCTTAAGCAATCGTGAG
CTTATTTGAAATACATAATTTGTTCACTATACTTTTGTGTGTGTGTTTCTCAAACTGTATGAAG
ATGTGATATTCATGGAGTACATTCATACTGTTTTCATGGACCGTATTTTGAGTTGAGGTCGTGA
TTATTTTAAATGCGGTGATCAATGTCATGTCTTTGGAGAACATAGGAGAAAACAACAGAGAGCT
GGATTTGTTTCCATGAAAGCTGGGGAGGTCCCATATTTTTTTTACCAGATTTCTATTACAAACC
AGCATCACTCATGTGTGGGGGAGGCACTTTCTTGAGAGGGATCCTTTATAAAATCAGTATACAC
TAAAACCAGAGTCTACATTTAAGTGTAATTCTCAGTTTTCTAGGTCTGTGACTTTTTTAAAATG
CCATTAGATTTTTAAGATAAAGTAATTTCTTACTAGTGTTTTTTATAAAAGACGATACTACAAA
ACTGAAAATCTAGAACCTGGGTTTTTTTTTTTTTTTTTTTTTTCTTTTTTTCAAAAGGCACTGG
CCCTCTAGTATATTGGTAAGCAAAAAATAAACACAGCACTTTATCTAGACAGTGCACAGAGTGT
GACAGCTGACTCTAAATAGTATTTGAAATTCTGCAGCCTCTGCCTTAAATGCTACATGTGGGTC
CTCATGAAATGAGCATCATGCCTCCCTTTGCAGACTCCTGGAGAGGAAGAAACTATGTTTGAGA
AAGGCATTCATTCCCTTACAATTAGGACAGAGTTTGTTCCATTCAAATCTCTGGGGACTGGTTA
AACTTTATTTCTATTATGATTTTTAAATCTTTTATTAAAAACTTTAAGTCCTTTGAGATTGTAA
ATTAAGCTTATAAAACAAACCAAACTGAGATTAAGTAATAAGCATTGGTTTTCGGTAATTTTAT
TCAAAAAAAAATTAAAGGAAGTCAGATTAGTCAGACCACATACACACACACACACACACACACA
CACACACACACACACACACAGAGAGTGGCTTTCACTGAGTGCTGGATGTCTGCAGTAATGTTAG
CGTTTTGAGCAGTAGGCAGTGGGAAGAAATTTTTAATAACGCAGAACTGCCAATAATGTTGCAT
ATCTGTTGCTCTGAGAGCAGGTAGTGGTGGTCAGTAAAGCAGATGACTTGTGTCTGTGTCTGGA
GGCACTGCCAGGTGAAGCTGGGGTGAGCGGCTGTCAGGAACTCCAGGCTGTGCTTGAAAAGTAG
TCCACAGATGGGTGTCCAAGGTTATGTGTAACGAAGTAGTGATTATCCCTGCTGTGTGATTTTC
AGCTGACCCTGAATAATAAGCCTTTTACCTTGTCTGATAGTGTCCTTTCCTAAGCTTTTTACAG
TGACCTGAAAGCAATCCACACAAAAGGAAGTAATCATCTGAGTCCCTTCTGCTTGCTTGTAGAA
TAAAATGTGTTTGTTTCCAAAGGTATAATCTAAGAAAGAGGTTCTAATAAATGTTTTATTTCAT
CAAA

hide sequence

RefSeq Acc Id:

XM_039091504 ⟹ XP_038947432

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,646,908 - 105,685,873 (-)	NCBI
mRatBN7.2	13	103,115,810 - 103,154,811 (-)	NCBI

RefSeq Acc Id:

XM_039091506 ⟹ XP_038947434

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,646,908 - 105,685,902 (-)	NCBI
mRatBN7.2	13	103,115,810 - 103,154,843 (-)	NCBI

RefSeq Acc Id:

XM_063272398 ⟹ XP_063128468

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,646,908 - 105,685,198 (-)	NCBI

RefSeq Acc Id:

XM_063272399 ⟹ XP_063128469

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,646,908 - 105,685,466 (-)	NCBI

RefSeq Acc Id:

XM_063272400 ⟹ XP_063128470

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,646,908 - 105,685,739 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414360	(Get FASTA)	NCBI Sequence Viewer
	XP_017454503	(Get FASTA)	NCBI Sequence Viewer
	XP_038947432	(Get FASTA)	NCBI Sequence Viewer
	XP_038947434	(Get FASTA)	NCBI Sequence Viewer
	XP_063128468	(Get FASTA)	NCBI Sequence Viewer
	XP_063128469	(Get FASTA)	NCBI Sequence Viewer
	XP_063128470	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95005	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005576
	ENSRNOP00000005576.6
	ENSRNOP00000083831
	ENSRNOP00000083831.1

RefSeq Acc Id:

XP_017454503 ⟸ XM_017599014

- Peptide Label:

isoform X2

- Sequence:

show sequence

MQRPPVQPQVCSFFQVSKSSFRVSPYSQTSVFCTGGRDGNIMIWDTRCNKKDGFYRQVNQISGA
HNTADKQTPSKPKKKQNSKGLAPSVDSQQSVTVVLFQDENTVVSAGAVDGIIKVWDLRKNYTAY
RQEPIASKSFLYPGTSTRKLGYSSLVLDSTGSTLFANCTDDNIYMFNMTGLKTSPLAVFNGHQN
STFYVKSSLSPDDQFLISGSSDEAAYIWKVSMPWHPPTVLLGHSQEVTSVCWCPSDFTKIATCS
DDNTLKIWRLNRGLEEKPEGDKHSIVGWTSQKKKEVKAGPVSAPNSLSTPAKAPRSQCSPSASS
PSSARTPSCAGDLPLPSNTSTFSVKTTPVTTRSPVSRRGSSSSVSPKPPSSFKMSLRNWVTRTP
SSSPPVTPPASETKISSPRKALIPVSQKSSQADACSESRNRVKRRLDSSCLESVKQKCVKSCNC
VTELDGQVESLHLDLCCLSGTQEVLSQDSAGPTKSSKTEGTGTSISEPPSPVSPFASEGCGPLP
LPLGPCGEGSEMVGKENSSPENKNWLLAMAAKHKAENSSPRSPSSQTPSSRRQSRKTSPGPVTI
TPNSMRKICTYFRRKTQDDFCSPEHSTEL

hide sequence

Ensembl Acc Id:

ENSRNOP00000005576 ⟸ ENSRNOT00000005576

RefSeq Acc Id:	XP_038947434 ⟸ XM_039091506
- Peptide Label:	isoform X1
- UniProtKB:	A6JGZ8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947432 ⟸ XM_039091504
- Peptide Label:	isoform X1
- UniProtKB:	A6JGZ8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000083831 ⟸ ENSRNOT00000095446

RefSeq Acc Id:	NP_001414360 ⟸ NM_001427431
- UniProtKB:	A6JGZ8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128470 ⟸ XM_063272400
- Peptide Label:	isoform X1
- UniProtKB:	A6JGZ8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128469 ⟸ XM_063272399
- Peptide Label:	isoform X1
- UniProtKB:	A6JGZ8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128468 ⟸ XM_063272398
- Peptide Label:	isoform X1
- UniProtKB:	A6JGZ8 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZER4-F1-model_v2	AlphaFold	D3ZER4	1-783	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699133

Promoter ID:

EPDNEW_R9642

Type:

initiation region

Name:

Dtl_1

Description:

denticleless E3 ubiquitin protein ligase homolog

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	110,257,288 - 110,257,348	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310439	AgrOrtholog
BioCyc Gene	G2FUF-16841	BioCyc
Ensembl Genes	ENSRNOG00000004195	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005576	ENTREZGENE
	ENSRNOT00000005576.8	UniProtKB/TrEMBL
	ENSRNOT00000095446	ENTREZGENE
	ENSRNOT00000095446.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	WD-repeat_CDT2_adapter	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	305073	ENTREZGENE
PANTHER	DENTICLELESS PROTEIN HOMOLOG	UniProtKB/TrEMBL
	LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PhenoGen	Dtl	PhenoGen
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004195	RatGTEx
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	WD40_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZW16_RAT	UniProtKB/TrEMBL
	A6JGZ8	ENTREZGENE, UniProtKB/TrEMBL
	D3ZER4_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Dtl	denticleless E3 ubiquitin protein ligase homolog	LOC100909566	denticleless protein homolog	Data merged from RGD:6503029	737654	PROVISIONAL
2016-01-27	Dtl	denticleless E3 ubiquitin protein ligase homolog	Dtl	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-16	Dtl	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	Dtl	denticleless homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-05	LOC100909566	denticleless protein homolog			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-02-27	Dtl	denticleless homolog (Drosophila)	RGD1310439_predicted	similar to retinoic acid-regulated nuclear matrix-associated protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1310439_predicted	similar to retinoic acid-regulated nuclear matrix-associated protein (predicted)	LOC305073_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC305073_predicted	similar to retinoic acid-regulated nuclear matrix-associated protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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