Dtl (denticleless E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Dtl (denticleless E3 ubiquitin protein ligase) Mus musculus
Analyze
Symbol: Dtl
Name: denticleless E3 ubiquitin protein ligase
RGD ID: 1551993
MGI Page MGI
Description: Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Predicted to act upstream of or within DNA replication and rhythmic process. Predicted to be located in centrosome; cytosol; and nuclear lumen. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2810047L02Rik; 5730564G15Rik; denticleless homolog; denticleless protein homolog; L2dtl; lethal(2) denticleless protein homolog; Meth A ramp; meth A retinoic acid-regulated nuclear matrix-associated protein; Ramp; retinoic acid-regulated nuclear matrix-associated protein; retinoic-acid regulated nuclear matrix-associated protein; Sarcoma antigen S35
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391191,269,468 - 191,307,656 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1191,269,468 - 191,307,656 (-)EnsemblGRCm39 Ensembl
GRCm381191,537,356 - 191,575,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,537,356 - 191,575,544 (-)EnsemblGRCm38mm10GRCm38
MGSCv371193,361,244 - 193,399,413 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,237,980 - 193,276,149 (-)NCBIMGSCv36mm8
Celera1198,486,790 - 198,526,178 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
beta-hexachlorocyclohexane  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
erastin  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
folic acid  (EXP)
folpet  (EXP)
FR900359  (ISO)
genistein  (ISO)
hexadecanoic acid  (ISO)
Lasiocarpine  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
ozone  (EXP)
paracetamol  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:16778019   PMID:17107960   PMID:17967808   PMID:18235224   PMID:18799693   PMID:20360068   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24699724   PMID:26471094   PMID:26496610  
PMID:27626380   PMID:28705898   PMID:28818995   PMID:30018073   PMID:30111536   PMID:30245026   PMID:32325033   PMID:34321999   PMID:35711069  


Genomics

Comparative Map Data
Dtl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391191,269,468 - 191,307,656 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1191,269,468 - 191,307,656 (-)EnsemblGRCm39 Ensembl
GRCm381191,537,356 - 191,575,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,537,356 - 191,575,544 (-)EnsemblGRCm38mm10GRCm38
MGSCv371193,361,244 - 193,399,413 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,237,980 - 193,276,149 (-)NCBIMGSCv36mm8
Celera1198,486,790 - 198,526,178 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.44NCBI
DTL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,035,748 - 212,105,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,035,553 - 212,107,400 (+)EnsemblGRCh38hg38GRCh38
GRCh371212,209,090 - 212,278,355 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,275,754 - 210,344,809 (+)NCBINCBI36Build 36hg18NCBI36
Celera1185,435,998 - 185,505,287 (+)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1182,885,955 - 182,955,234 (+)NCBIHuRef
CHM1_11213,481,305 - 213,550,518 (+)NCBICHM1_1
T2T-CHM13v2.01211,281,835 - 211,351,118 (+)NCBIT2T-CHM13v2.0
Dtl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,646,908 - 105,685,921 (-)NCBIGRCr8
mRatBN7.213103,115,810 - 103,155,029 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,117,186 - 103,154,890 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.013110,219,276 - 110,257,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,220,283 - 110,257,367 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,783,177 - 114,821,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,603,353 - 107,640,812 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113107,792,703 - 107,830,078 (-)NCBI
Celera13102,555,070 - 102,594,148 (-)NCBICelera
Cytogenetic Map13q27NCBI
Dtl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554065,254,558 - 5,299,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554065,256,057 - 5,299,573 (-)NCBIChiLan1.0ChiLan1.0
DTL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2137,300,460 - 37,367,503 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1137,264,941 - 37,331,990 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01187,603,600 - 187,672,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,466,408 - 192,535,071 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,466,408 - 192,535,071 (+)Ensemblpanpan1.1panPan2
DTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1710,323,842 - 10,368,529 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl710,323,559 - 10,369,560 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha79,901,494 - 9,944,363 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0710,030,330 - 10,073,724 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl710,030,370 - 10,073,719 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.179,952,445 - 9,997,665 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0710,055,386 - 10,098,331 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0710,179,868 - 10,228,472 (+)NCBIUU_Cfam_GSD_1.0
Dtl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934464,087,630 - 64,149,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365571,347,991 - 1,389,836 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365571,347,991 - 1,389,836 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9131,227,705 - 131,275,451 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19131,225,840 - 131,275,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29144,272,743 - 144,325,340 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DTL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12517,418,078 - 17,485,320 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2517,418,090 - 17,485,164 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605517,940,853 - 18,008,338 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dtl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477117,612,284 - 17,662,405 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477117,612,264 - 17,660,772 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dtl
1455 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:564
Count of miRNA genes:386
Interacting mature miRNAs:444
Transcripts:ENSMUST00000027933
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171632048192681050Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1171983110195154279Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172303451195154279Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172303451195154279Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172532197195154279Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172632197195154279Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175468817194111528Mouse
1357692Axtq1_manxiety QTL 1 (mouse)Not determined1180832317191851043Mouse
1357620Aaj1_manxiety in A/J 1 (mouse)Not determined1180832317191851043Mouse

Markers in Region
RH136036  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381191,554,836 - 191,555,037UniSTSGRCm38
MGSCv371193,378,715 - 193,378,916UniSTSGRCm37
Celera1198,504,237 - 198,504,438UniSTS
Cytogenetic Map1H6UniSTS
Dtl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H6UniSTS
cM Map1 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001305233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_029766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011238925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB095735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB095736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB841951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF898098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ715636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000027933   ⟹   ENSMUSP00000027933
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1191,269,477 - 191,307,656 (-)Ensembl
GRCm38.p6 Ensembl1191,537,365 - 191,575,544 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1191,302,933 - 191,307,625 (-)Ensembl
GRCm38.p6 Ensembl1191,570,821 - 191,575,513 (-)Ensembl
RefSeq Acc Id: ENSMUST00000193977   ⟹   ENSMUSP00000142111
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1191,281,941 - 191,307,625 (-)Ensembl
GRCm38.p6 Ensembl1191,549,829 - 191,575,513 (-)Ensembl
RefSeq Acc Id: ENSMUST00000194064
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1191,292,500 - 191,307,623 (-)Ensembl
GRCm38.p6 Ensembl1191,560,388 - 191,575,511 (-)Ensembl
RefSeq Acc Id: ENSMUST00000195650   ⟹   ENSMUSP00000141218
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1191,269,468 - 191,307,633 (-)Ensembl
GRCm38.p6 Ensembl1191,537,356 - 191,575,521 (-)Ensembl
RefSeq Acc Id: ENSMUST00000195765
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1191,271,217 - 191,307,626 (-)Ensembl
GRCm38.p6 Ensembl1191,539,105 - 191,575,514 (-)Ensembl
RefSeq Acc Id: NM_001305233   ⟹   NP_001292162
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391191,269,468 - 191,307,656 (-)NCBI
GRCm381191,537,356 - 191,575,544 (-)NCBI
Sequence:
RefSeq Acc Id: NM_029766   ⟹   NP_084042
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391191,269,468 - 191,307,656 (-)NCBI
GRCm381191,537,356 - 191,575,544 (-)NCBI
MGSCv371193,361,244 - 193,399,413 (-)RGD
Celera1198,486,790 - 198,526,178 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011238925   ⟹   XP_011237227
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391191,269,478 - 191,298,032 (-)NCBI
GRCm381191,537,366 - 191,565,892 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_084042   ⟸   NM_029766
- Peptide Label: isoform 1
- UniProtKB: Q8BW38 (UniProtKB/Swiss-Prot),   Q80WY2 (UniProtKB/Swiss-Prot),   Q80WY1 (UniProtKB/Swiss-Prot),   Q6PAN1 (UniProtKB/Swiss-Prot),   Q3TTE9 (UniProtKB/Swiss-Prot),   Q9CZ76 (UniProtKB/Swiss-Prot),   Q3TLR7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011237227   ⟸   XM_011238925
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001292162   ⟸   NM_001305233
- Peptide Label: isoform 2
- UniProtKB: Q3TLR7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027933   ⟸   ENSMUST00000027933
RefSeq Acc Id: ENSMUSP00000142111   ⟸   ENSMUST00000193977
RefSeq Acc Id: ENSMUSP00000141218   ⟸   ENSMUST00000195650

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3TLR7-F1-model_v2 AlphaFold Q3TLR7 1-729 view protein structure

Promoters
RGD ID:6876114
Promoter ID:EPDNEW_M1508
Type:initiation region
Name:Dtl_1
Description:Mus musculus denticleless E3 ubiquitin protein ligase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381191,575,512 - 191,575,572EPDNEW
RGD ID:6817619
Promoter ID:MM_KWN:3311
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:UC007ECJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361193,364,841 - 193,365,341 (-)MPROMDB
RGD ID:6817643
Promoter ID:MM_KWN:3312
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000045450,   ENSMUST00000046398,   ENSMUST00000110868,   NM_029766,   UC007ECL.1,   UC007ECM.1,   UC007ECN.1,   UC007ECO.1,   UC007ECQ.1,   UC007ECR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361193,398,306 - 193,400,117 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924093 AgrOrtholog
Ensembl Genes ENSMUSG00000037474 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027933 ENTREZGENE
  ENSMUST00000027933.11 UniProtKB/Swiss-Prot
  ENSMUST00000193977.6 UniProtKB/TrEMBL
  ENSMUST00000195650.6 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:76843 UniProtKB/Swiss-Prot
MGD MGI:1924093 ENTREZGENE
NCBI Gene 76843 ENTREZGENE
PANTHER DENTICLELESS PROTEIN HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dtl PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YVQ5_MOUSE UniProtKB/TrEMBL
  A0A0A6YXS0_MOUSE UniProtKB/TrEMBL
  DTL_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TTE9 ENTREZGENE
  Q6PAN1 ENTREZGENE
  Q80WY1 ENTREZGENE
  Q80WY2 ENTREZGENE
  Q8BW38 ENTREZGENE
  Q9CZ76 ENTREZGENE
UniProt Secondary Q3TTE9 UniProtKB/Swiss-Prot
  Q6PAN1 UniProtKB/Swiss-Prot
  Q80WY1 UniProtKB/Swiss-Prot
  Q80WY2 UniProtKB/Swiss-Prot
  Q8BW38 UniProtKB/Swiss-Prot
  Q9CZ76 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Dtl  denticleless E3 ubiquitin protein ligase    denticleless homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED