Dtl (denticleless E3 ubiquitin protein ligase homolog) - Rat Genome Database

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Gene: Dtl (denticleless E3 ubiquitin protein ligase homolog) Ictidomys tridecemlineatus
Analyze
Symbol: Dtl
Name: denticleless E3 ubiquitin protein ligase homolog
RGD ID: 12542971
Description: ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN DNA damage response (inferred); mitotic G2 DNA damage checkpoint signaling (inferred); positive regulation of G2/M transition of mitotic cell cycle (inferred); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); COVID-19 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN centrosome (inferred); Cul4-RING E3 ubiquitin ligase complex (inferred); Cul4A-RING E3 ubiquitin ligase complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: denticleless protein homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934464,087,630 - 64,149,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365571,347,991 - 1,389,836 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365571,347,991 - 1,389,836 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dtl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934464,087,630 - 64,149,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365571,347,991 - 1,389,836 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365571,347,991 - 1,389,836 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DTL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,035,748 - 212,105,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,035,553 - 212,107,400 (+)EnsemblGRCh38hg38GRCh38
GRCh371212,209,090 - 212,278,355 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,275,754 - 210,344,809 (+)NCBINCBI36Build 36hg18NCBI36
Celera1185,435,998 - 185,505,287 (+)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1182,885,955 - 182,955,234 (+)NCBIHuRef
CHM1_11213,481,305 - 213,550,518 (+)NCBICHM1_1
T2T-CHM13v2.01211,281,835 - 211,351,118 (+)NCBIT2T-CHM13v2.0
Dtl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391191,269,468 - 191,307,656 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1191,269,468 - 191,307,656 (-)EnsemblGRCm39 Ensembl
GRCm381191,537,356 - 191,575,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,537,356 - 191,575,544 (-)EnsemblGRCm38mm10GRCm38
MGSCv371193,361,244 - 193,399,413 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,237,980 - 193,276,149 (-)NCBIMGSCv36mm8
Celera1198,486,790 - 198,526,178 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.44NCBI
Dtl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,646,908 - 105,685,921 (-)NCBIGRCr8
mRatBN7.213103,115,810 - 103,155,029 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,117,186 - 103,154,890 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.013110,219,276 - 110,257,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,220,283 - 110,257,367 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,783,177 - 114,821,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,603,353 - 107,640,812 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113107,792,703 - 107,830,078 (-)NCBI
Celera13102,555,070 - 102,594,148 (-)NCBICelera
Cytogenetic Map13q27NCBI
Dtl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554065,254,558 - 5,299,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554065,256,057 - 5,299,573 (-)NCBIChiLan1.0ChiLan1.0
DTL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2137,300,460 - 37,367,503 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1137,264,941 - 37,331,990 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01187,603,600 - 187,672,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,466,408 - 192,535,071 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,466,408 - 192,535,071 (+)Ensemblpanpan1.1panPan2
DTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1710,323,842 - 10,368,529 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl710,323,559 - 10,369,560 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha79,901,494 - 9,944,363 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0710,030,330 - 10,073,724 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl710,030,370 - 10,073,719 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.179,952,445 - 9,997,665 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0710,055,386 - 10,098,331 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0710,179,868 - 10,228,472 (+)NCBIUU_Cfam_GSD_1.0
DTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9131,227,705 - 131,275,451 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19131,225,840 - 131,275,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29144,272,743 - 144,325,340 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DTL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12517,418,078 - 17,485,320 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2517,418,090 - 17,485,164 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605517,940,853 - 18,008,338 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dtl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477117,612,284 - 17,662,405 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477117,612,264 - 17,660,772 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000013562   ⟹   ENSSTOP00000012151
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365571,347,991 - 1,389,836 (-)Ensembl
RefSeq Acc Id: XM_005329440   ⟹   XP_005329497
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934464,106,516 - 64,149,419 (-)NCBI
SpeTri2.0NW_0049365571,347,991 - 1,389,836 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040278735   ⟹   XP_040134669
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934464,087,630 - 64,149,419 (-)NCBI
RefSeq Acc Id: XM_040278736   ⟹   XP_040134670
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934464,106,516 - 64,149,148 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005329497 (Get FASTA)   NCBI Sequence Viewer  
  XP_040134669 (Get FASTA)   NCBI Sequence Viewer  
  XP_040134670 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000012151.2
GenBank Protein KAG3258138 (Get FASTA)   NCBI Sequence Viewer  
  KAG3258139 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005329497   ⟸   XM_005329440
- Peptide Label: isoform X1
- UniProtKB: I3ML85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040134669   ⟸   XM_040278735
- Peptide Label: isoform X1
- UniProtKB: I3ML85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040134670   ⟸   XM_040278736
- Peptide Label: isoform X2
RefSeq Acc Id: ENSSTOP00000012151   ⟸   ENSSTOT00000013562


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013557 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013562.3 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene Dtl ENTREZGENE
PANTHER DENTICLELESS PROTEIN HOMOLOG UniProtKB/TrEMBL
  LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt I3ML85 ENTREZGENE, UniProtKB/TrEMBL