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Gene: Lrp6 (LDL receptor related protein 6) Rattus norvegicus
Symbol: Lrp6
Name: LDL receptor related protein 6
RGD ID: 1304749
Description: Predicted to have several functions, including Wnt-protein binding activity; frizzled binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of cytosolic calcium ion concentration; and response to peptide hormone. Localizes to neuronal cell body and synapse. Predicted to colocalize with Golgi apparatus and caveola. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
Also known as: LOC312781; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6
Homo sapiens (human) : LRP6 (LDL receptor related protein 6)  HGNC  Alliance
Mus musculus (house mouse) : Lrp6 (low density lipoprotein receptor-related protein 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp6 (LDL receptor related protein 6)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP6 (LDL receptor related protein 6)
Canis lupus familiaris (dog) : LRP6 (LDL receptor related protein 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp6 (LDL receptor related protein 6)
Sus scrofa (pig) : LRP6 (LDL receptor related protein 6)
Chlorocebus sabaeus (African green monkey) : LRP6 (LDL receptor related protein 6)
Heterocephalus glaber (naked mole-rat) : Lrp6 (LDL receptor related protein 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04168,194,054 - 168,323,962 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4168,194,927 - 168,323,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,475,530 - 232,606,101 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,337,114 - 171,444,932 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14171,582,253 - 171,717,580 (-)NCBI
Celera4155,870,415 - 155,972,673 (-)NCBICelera
Cytogenetic Map4q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Lrp6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1304749
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.