Rab3a (RAB3A, member RAS oncogene family) - Rat Genome Database

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Gene: Rab3a (RAB3A, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab3a
Name: RAB3A, member RAS oncogene family
RGD ID: 3528
Description: Enables several functions, including ATPase activator activity; ATPase binding activity; and GTP binding activity. Involved in regulation of secretion by cell; regulation of synaptic vesicle priming; and synaptic vesicle cycle. Located in secretory granule; synaptic vesicle; and terminal bouton. Part of protein-containing complex. Is active in synaptic vesicle membrane. Orthologous to human RAB3A (RAB3A, member RAS oncogene family); PARTICIPATES IN insulin secretion pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: RAB3; ras-related protein Rab-3A; Ras-related small GTP binding protein 3A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,718,164 - 18,722,273 (-)NCBIGRCr8
mRatBN7.21618,684,185 - 18,688,297 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,684,188 - 18,688,336 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,726,559 - 18,730,675 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,859,239 - 19,863,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,779,503 - 18,783,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,435,098 - 20,439,206 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,435,101 - 20,439,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,292,166 - 20,296,274 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,189,765 - 19,193,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,189,765 - 19,193,872 (-)NCBI
Celera1618,876,401 - 18,880,512 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acrosomal vesicle exocytosis  (IEA,ISO)
axonogenesis  (IBA,IEA,ISO)
calcium-ion regulated exocytosis  (IBA,ISO)
establishment of localization in cell  (ISO)
evoked neurotransmitter secretion  (IEA,ISO)
exocytosis  (ISO)
insulin secretion  (IEA,ISO)
intracellular protein transport  (IEA)
lung development  (IEA,ISO)
lysosome localization  (IEA,ISO)
maintenance of presynaptic active zone structure  (IBA,IEA,ISO)
mitochondrion organization  (IEA,ISO)
neuromuscular synaptic transmission  (IEA,ISO)
plasma membrane repair  (IEA,ISO)
positive regulation of regulated secretory pathway  (IEA,ISO)
post-embryonic development  (IEA,ISO)
protein localization to plasma membrane  (IBA,IEA)
protein secretion  (IBA)
Rab protein signal transduction  (IC)
regulated exocytosis  (ISO)
regulation of dopamine secretion  (IDA)
regulation of exocytosis  (IBA,ISO)
regulation of plasma membrane repair  (IEA,ISO)
regulation of presynaptic dense core granule exocytosis  (IEA,ISO)
regulation of short-term neuronal synaptic plasticity  (IEA,ISO,ISS)
regulation of synaptic vesicle exocytosis  (IDA)
regulation of synaptic vesicle fusion to presynaptic active zone membrane  (IBA,IEA,ISO,ISS)
regulation of synaptic vesicle priming  (IDA)
respiratory system process  (IEA,ISO)
response to electrical stimulus  (IEA,ISO)
sensory perception of touch  (IEA,ISO)
synaptic vesicle clustering  (IEA,ISO)
synaptic vesicle exocytosis  (IBA,IEA,IMP,ISO)
synaptic vesicle maturation  (IEA,ISO)
synaptic vesicle recycling  (IMP)
synaptic vesicle transport  (IEA,ISO)
vesicle docking involved in exocytosis  (IBA,IEA)

Cellular Component
acrosomal vesicle  (IEA,ISO)
axon  (IBA,IDA)
cytosol  (IEA)
endosome  (IBA,IEA,ISO)
lysosome  (IEA)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IBA,IEA)
postsynapse  (IEA,ISO,ISS)
presynapse  (ISO)
presynaptic active zone  (IEA,ISO,ISS)
protein-containing complex  (IDA)
secretory granule  (IDA)
synaptic vesicle  (IBA,IDA,ISO)
synaptic vesicle membrane  (EXP,IDA,IEA,IEP,ISO)
terminal bouton  (IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. Brondyk WH, etal., Mol Cell Biol 1995 Mar;15(3):1137-43.
2. Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis. Coppola T, etal., Mol Biol Cell 2002 Jun;13(6):1906-15.
3. Rho proteins are localized with different membrane compartments involved in vesicular trafficking in anterior pituitary cells. Cussac D, etal., Mol Cell Endocrinol. 1996 May 31;119(2):195-206.
4. Rab3A Inhibition of Ca2+ -Dependent Dopamine Release From PC12 Cells Involves Interaction With Synaptotagmin I. Dai Z, etal., J Cell Biochem. 2017 Nov;118(11):3696-3705. doi: 10.1002/jcb.26016. Epub 2017 May 16.
5. The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis. de Hoop MJ, etal., Neuron. 1994 Jul;13(1):11-22.
6. Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion. Deak F, etal., EMBO J. 2006 Jun 21;25(12):2856-66. Epub 2006 Jun 8.
7. Coordinate regulation of catecholamine uptake by rab3 and phosphoinositide 3-kinase. Francis SC, etal., J Biol Chem 2002 Mar 8;277(10):7816-23.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Identification of Rab6 as an N-ethylmaleimide-sensitive fusion protein-binding protein. Han SY, etal., Biochem J 2000 Nov 15;352 Pt 1:165-73.
11. Differential dynamics of Rab3A and Rab27A on secretory granules. Handley MT, etal., J Cell Sci. 2007 Mar 15;120(Pt 6):973-84. doi: 10.1242/jcs.03406. Epub 2007 Feb 20.
12. Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1. Huang CC, etal., Traffic. 2011 Oct;12(10):1356-70. doi: 10.1111/j.1600-0854.2011.01237.x. Epub 2011 Jul 20.
13. GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. Luo HR, etal., Neuron 2001 Aug 16;31(3):439-51.
14. A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes. Maienschein V, etal., Glia. 1999 May;26(3):233-44.
15. Isolation and characterization of a dual prenylated Rab and VAMP2 receptor. Martincic I, etal., J Biol Chem 1997 Oct 24;272(43):26991-8.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. Ostermeier C and Brunger AT, Cell. 1999 Feb 5;96(3):363-74.
19. GTP binds to Rab3A in a complex with Ca2+/calmodulin. Park JB, etal., Biochem J 2002 Mar 15;362(Pt 3):651-7.
20. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
21. GOA pipeline RGD automated data pipeline
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex. Sakisaka T, etal., EMBO J 2002 Nov 15;21(22):6125-35.
24. Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras. Stahl B, etal., EMBO J. 1996 Apr 15;15(8):1799-809.
25. Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function. Star EN, etal., J Physiol. 2005 Nov 15;569(Pt 1):103-17. Epub 2005 Sep 1.
26. Localization of the small monomeric GTPases Rab3D and Rab3A in the AtT-20 rat pituitary cell line. Tabellini G, etal., Eur J Histochem 2001;45(4):347-56.
27. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
28. Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism. Tang X, etal., Int J Biol Macromol. 2017 Mar;96:736-742. doi: 10.1016/j.ijbiomac.2016.12.074. Epub 2017 Jan 3.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. Wang Z and Thurmond DC, J Cell Sci. 2009 Apr 1;122(Pt 7):893-903.
31. Complete coding sequences of the ras related rab 3 and 4 cDNAs. Zahraoui A, etal., Nucleic Acids Res 1988 Feb 11;16(3):1204.
Additional References at PubMed
PMID:2732579   PMID:3317403   PMID:9194562   PMID:10196122   PMID:10748113   PMID:10859313   PMID:11134008   PMID:11182090   PMID:11359932   PMID:11598194   PMID:12167638   PMID:12192047  
PMID:12477932   PMID:12937130   PMID:12972569   PMID:15039103   PMID:15489334   PMID:15837622   PMID:16704978   PMID:16782817   PMID:16822953   PMID:17149709   PMID:17534942   PMID:18448650  
PMID:18798275   PMID:19077034   PMID:20338242   PMID:21128978   PMID:21262767   PMID:21349835   PMID:22248876   PMID:22899725   PMID:24006491   PMID:24472545   PMID:24625528   PMID:24769233  
PMID:24891604   PMID:25002582   PMID:26024738   PMID:27325790   PMID:28634303   PMID:29476059   PMID:31686426   PMID:36587525   PMID:38253132  


Genomics

Comparative Map Data
Rab3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,718,164 - 18,722,273 (-)NCBIGRCr8
mRatBN7.21618,684,185 - 18,688,297 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,684,188 - 18,688,336 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,726,559 - 18,730,675 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,859,239 - 19,863,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,779,503 - 18,783,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,435,098 - 20,439,206 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,435,101 - 20,439,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,292,166 - 20,296,274 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,189,765 - 19,193,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,189,765 - 19,193,872 (-)NCBI
Celera1618,876,401 - 18,880,512 (-)NCBICelera
Cytogenetic Map16p14NCBI
RAB3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,196,784 - 18,204,042 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,196,784 - 18,204,042 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,307,594 - 18,314,852 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,168,611 - 18,175,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 341918,168,610 - 18,175,839NCBI
Celera1918,209,348 - 18,216,613 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,871,059 - 17,878,307 (-)NCBIHuRef
CHM1_11918,307,151 - 18,314,427 (-)NCBICHM1_1
T2T-CHM13v2.01918,330,909 - 18,338,143 (-)NCBIT2T-CHM13v2.0
Rab3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,207,258 - 71,211,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,207,328 - 71,211,323 (+)EnsemblGRCm39 Ensembl
GRCm38870,754,703 - 70,758,608 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,754,679 - 70,758,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,278,578 - 73,282,585 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,683,712 - 73,687,666 (+)NCBIMGSCv36mm8
Celera873,315,980 - 73,319,984 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Rab3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,221,366 - 3,224,376 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,220,108 - 3,224,376 (+)NCBIChiLan1.0ChiLan1.0
RAB3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,054,186 - 23,061,417 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,062,526 - 22,069,753 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,672,661 - 17,679,541 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,649,166 - 18,656,768 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,649,166 - 18,656,768 (-)Ensemblpanpan1.1panPan2
RAB3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,796,740 - 44,802,224 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,796,895 - 44,801,692 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,710,693 - 44,716,183 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,282,514 - 45,288,006 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,282,528 - 45,287,983 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,519,685 - 44,525,177 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,930,125 - 44,935,626 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,205,632 - 45,211,124 (+)NCBIUU_Cfam_GSD_1.0
Rab3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,441,225 - 203,447,398 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,989,804 - 2,998,305 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,990,367 - 2,995,935 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,603,117 - 59,609,767 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,603,090 - 59,609,773 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,142,410 - 59,149,077 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,671,388 - 16,678,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,670,431 - 16,678,644 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,699,847 - 2,707,085 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,530,312 - 1,536,129 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,532,857 - 1,537,159 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rab3a
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:58
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000026391
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

Markers in Region
RH130738  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,683,921 - 18,684,127 (+)MAPPERmRatBN7.2
Rnor_6.01620,434,835 - 20,435,040NCBIRnor6.0
Rnor_5.01620,291,903 - 20,292,108UniSTSRnor5.0
RGSC_v3.41619,189,502 - 19,189,707UniSTSRGSC3.4
Celera1618,876,138 - 18,876,343UniSTS
RH 3.4 Map16195.1UniSTS
Cytogenetic Map16p14UniSTS
RH133798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,684,256 - 18,684,416 (+)MAPPERmRatBN7.2
Rnor_6.01620,435,170 - 20,435,329NCBIRnor6.0
Rnor_5.01620,292,238 - 20,292,397UniSTSRnor5.0
RGSC_v3.41619,189,837 - 19,189,996UniSTSRGSC3.4
Celera1618,876,473 - 18,876,632UniSTS
RH 3.4 Map16196.0UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 2 2 72 25 25 5
Low 3 8 55 41 19 41 8 9 2 10 16 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000026391   ⟹   ENSRNOP00000026392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,684,188 - 18,688,336 (-)Ensembl
Rnor_6.0 Ensembl1620,435,101 - 20,439,206 (-)Ensembl
RefSeq Acc Id: NM_013018   ⟹   NP_037150
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,718,164 - 18,722,273 (-)NCBI
mRatBN7.21618,684,185 - 18,688,297 (-)NCBI
Rnor_6.01620,435,098 - 20,439,206 (-)NCBI
Rnor_5.01620,292,166 - 20,296,274 (-)NCBI
RGSC_v3.41619,189,765 - 19,193,874 (-)RGD
Celera1618,876,401 - 18,880,512 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037150 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87580 (Get FASTA)   NCBI Sequence Viewer  
  CAA30005 (Get FASTA)   NCBI Sequence Viewer  
  EDL90732 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026392
  ENSRNOP00000026392.4
GenBank Protein P63012 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037150   ⟸   NM_013018
- UniProtKB: P63012 (UniProtKB/Swiss-Prot),   A6KA05 (UniProtKB/TrEMBL),   A0A8L2QE16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026392   ⟸   ENSRNOT00000026391

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63012-F1-model_v2 AlphaFold P63012 1-220 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700018
Promoter ID:EPDNEW_R10540
Type:multiple initiation site
Name:Rab3a_1
Description:RAB3A, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,439,233 - 20,439,293EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3528 AgrOrtholog
BIND 134440
  134445
BioCyc Gene G2FUF-11805 BioCyc
Ensembl Genes ENSRNOG00000019433 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026391 ENTREZGENE
  ENSRNOT00000026391.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7314616 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rab3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25531 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105485 IMAGE-MGC_LOAD
NCBI Gene 25531 ENTREZGENE
PANTHER LD44762P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rab3a PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019433 RatGTEx
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC214203
UniProt A0A8L2QE16 ENTREZGENE, UniProtKB/TrEMBL
  A6KA05 ENTREZGENE, UniProtKB/TrEMBL
  P63012 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P05713 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Rab3a  RAB3A, member RAS oncogene family    Ras-related small GTP binding protein 3A  Name updated 629478 APPROVED
2002-06-10 Rab3a  Ras-related small GTP binding protein 3A      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference