RAB3A (RAB3A, member RAS oncogene family)

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Gene: RAB3A (RAB3A, member RAS oncogene family) Chlorocebus sabaeus

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Symbol:

RAB3A

Name:

RAB3A, member RAS oncogene family

RGD ID:

18344618

Description:

ENCODES a protein that exhibits ATPase activator activity (ortholog); ATPase binding (ortholog); GDP-dissociation inhibitor binding (ortholog); INVOLVED IN axonogenesis (ortholog); lung development (ortholog); maintenance of presynaptic active zone structure (ortholog); PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH Ependymomas (ortholog); Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ortholog); FOUND IN protein-containing complex (ortholog); secretory granule (ortholog); synaptic vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ras-related protein Rab-3A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	16,671,388 - 16,678,780 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	16,670,431 - 16,678,644 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	2,699,847 - 2,707,085 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ependymomas (ISO)

Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acrosomal vesicle exocytosis (IEA)

axonogenesis (IEA,ISO)

calcium-ion regulated exocytosis (IEA)

establishment of localization in cell (IEA)

evoked neurotransmitter secretion (IEA)

exocytosis (IEA)

insulin secretion (IEA)

intracellular protein transport (IEA)

lung development (IEA,ISO)

lysosome localization (IEA)

maintenance of presynaptic active zone structure (IEA,ISO)

mitochondrion organization (IEA,ISO)

neuromuscular synaptic transmission (IEA,ISO)

plasma membrane repair (IEA)

positive regulation of regulated secretory pathway (IEA)

post-embryonic development (IEA,ISO)

protein localization to plasma membrane (IEA)

protein secretion (IEA)

protein transport (IEA)

regulated exocytosis (IEA)

regulation of dopamine secretion (ISO)

regulation of exocytosis (IEA,ISO)

regulation of plasma membrane repair (IEA)

regulation of presynaptic dense core granule exocytosis (IEA)

regulation of short-term neuronal synaptic plasticity (IEA)

regulation of synaptic vesicle exocytosis (ISO)

regulation of synaptic vesicle fusion to presynaptic active zone membrane (IEA,ISO)

regulation of synaptic vesicle priming (ISO)

respiratory system process (IEA,ISO)

response to electrical stimulus (IEA,ISO)

sensory perception of touch (IEA,ISO)

synaptic vesicle clustering (IEA)

synaptic vesicle exocytosis (IEA,ISO)

synaptic vesicle maturation (IEA,ISO)

synaptic vesicle recycling (ISO)

synaptic vesicle transport (IEA)

vesicle docking involved in exocytosis (IEA)

Cellular Component

acrosomal vesicle (IEA)

axon (IEA)

cell projection (IEA)

endosome (IEA)

lysosome (IEA)

perinuclear region of cytoplasm (IEA)

plasma membrane (IEA)

postsynapse (IEA)

presynapse (IEA)

presynaptic active zone (IEA)

protein-containing complex (ISO)

secretory granule (ISO)

synapse (IEA)

synaptic vesicle (IEA,ISO)

synaptic vesicle membrane (IEA,ISO)

terminal bouton (IEA)

transport vesicle (IEA)

vesicle (IEA)

Molecular Function

ATPase activator activity (ISO)

ATPase binding (ISO)

GDP-dissociation inhibitor binding (ISO)

GTP binding (IEA,ISO)

GTP-dependent protein binding (IEA)

GTPase activity (IEA)

myosin V binding (IEA)

protein binding (ISO)

protein-macromolecule adaptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin secretion pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

RAB3A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	16,671,388 - 16,678,780 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	16,670,431 - 16,678,644 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	2,699,847 - 2,707,085 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

RAB3A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	18,196,784 - 18,204,042 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	18,196,784 - 18,204,042 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	18,307,594 - 18,314,852 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	18,168,611 - 18,175,839 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	18,168,610 - 18,175,839	NCBI
Celera	19	18,209,348 - 18,216,613 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	17,871,059 - 17,878,307 (-)	NCBI		HuRef
CHM1_1	19	18,307,151 - 18,314,427 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	18,330,909 - 18,338,143 (-)	NCBI		T2T-CHM13v2.0

Rab3a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	71,207,258 - 71,211,276 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	71,207,328 - 71,211,323 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	70,754,703 - 70,758,608 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	70,754,679 - 70,758,677 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	73,278,578 - 73,282,585 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	73,683,712 - 73,687,666 (+)	NCBI		MGSCv36	mm8
Celera	8	73,315,980 - 73,319,984 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.15	NCBI

Rab3a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	18,718,164 - 18,722,273 (-)	NCBI		GRCr8
mRatBN7.2	16	18,684,185 - 18,688,297 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	18,684,188 - 18,688,336 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	18,726,559 - 18,730,675 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	19,859,239 - 19,863,348 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	18,779,503 - 18,783,622 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,435,098 - 20,439,206 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,435,101 - 20,439,206 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	20,292,166 - 20,296,274 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	19,189,765 - 19,193,874 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	19,189,765 - 19,193,872 (-)	NCBI
Celera	16	18,876,401 - 18,880,512 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Rab3a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	3,221,366 - 3,224,376 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	3,220,108 - 3,224,376 (+)	NCBI	ChiLan1.0	ChiLan1.0

RAB3A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	23,054,186 - 23,061,417 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	22,062,526 - 22,069,753 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	17,672,661 - 17,679,541 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	18,649,166 - 18,656,768 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	18,649,166 - 18,656,768 (-)	Ensembl	panpan1.1		panPan2

RAB3A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	44,796,740 - 44,802,224 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	44,796,895 - 44,801,692 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,710,693 - 44,716,183 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	45,282,514 - 45,288,006 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	45,282,528 - 45,287,983 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	44,519,685 - 44,525,177 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	44,930,125 - 44,935,626 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	45,205,632 - 45,211,124 (+)	NCBI		UU_Cfam_GSD_1.0

Rab3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	203,441,225 - 203,447,398 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	2,989,804 - 2,998,305 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	2,990,367 - 2,995,935 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAB3A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	59,603,117 - 59,609,767 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	59,603,090 - 59,609,773 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	59,142,410 - 59,149,077 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Rab3a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,530,312 - 1,536,129 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	1,532,857 - 1,537,159 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007995781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_007995781 ⟹ XP_007993972

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	16,671,388 - 16,678,780 (-)	NCBI
Vero_WHO_p1.0	NW_023666074	2,699,847 - 2,707,085 (+)	NCBI

Sequence:

show sequence

ATGCAAACTCTAGGCCCCGCCCCATTTGCGCGTCAATCTGCGCAGGAGCCCCGCCCCATCTGGC
TCCGCGTTCGTCAATGGGCCACATCTCTACGCGTGGCTCCGCCTCCGGATGGCGTCACGGACTT
ATCTACATGTGTGGCCCCGCCCCTCCCTTTGCAGGACGTCACCGAGGACTGCAGGGGCCTGAGC
CGCTGCCGCCGCCGCCACCGCACAGCCCCACATCAACGCACAGGGGGCCCCGTCACCGCCACCG
CCAAAAAAGTCACTGCCGCTAGGGTCGCCGTTGCATCGGTTCAGGGCAAGATGGCATCCGCCAC
AGACTCACGCTATGGGCAGAAGGAGTCCTCGGATCAGAACTTCGACTACATGTTCAAGATTCTC
ATCATCGGCAACAGCAGCGTGGGCAAGACGTCCTTCCTCTTCCGCTATGCTGACGACTCGTTCA
CGCCTGCCTTCGTCAGCACCGTGGGCATCGACTTCAAGGTCAAGACCATCTATCGCAACGACAA
GAGGATCAAGCTGCAGATCTGGGACACAGCAGGGCAAGAGCGGTACCGGACCATCACCACTGCC
TACTACCGGGGCGCTATGGGCTTCATTCTCATGTATGACATCACCAATGAGGAGTCCTTCAATG
CAGTGCAGGACTGGTCCACCCAGATCAAGACCTACTCGTGGGACAATGCCCAGGTGCTGCTGGT
AGGAAACAAGTGTGACATGGAGGATGAGCGGGTGGTGTCATCAGAACGTGGCCGGCAGCTAGCT
GACCACCTTGGGTTCGAGTTCTTTGAGGCCAGCGCCAAGGACAACATCAACGTCAAACAGACCT
TTGAGCGCCTGGTGGACGTCATCTGCGAGAAGATGTCCGAGTCGTTGGACACGGCAGACCCTGC
GGTCACAGGCGCCAAGCAGGGCCCACAGCTCAGTGACCAGCAGGTGCCACCTCACCAGGACTGC
GCCTGCTGAGAGCCACCCCACCCCCTTTCCCCTCTTCCCCGTCTTCCCCACCTTCCCCCAACTA
CCCGGGCCTGACCTGGCCCCTACCAGCCATGGGCACAAAACCCCTGCTCCTGACTTAGCCCGTC
ACCCTTATTTATTATTGTAGCTATTTATTTATTTATTGAAGATGTCCCCCAGGGGCCCGGGCTC
CCCTGCCCACCCCAAGCCCTGCCCATCCTGTACATATAGCCCTTTCCCCACTCAGCTGTGGTGT
CTCGTGGCCCTGTGAACTCACCGCTCACCCTCCTGAACCCCCTCGCCTTTTTTTTAAATTCACC
CCCAACCACAGTTCAGTTGTGAAGAGGGGGCCAGATGACACCCTAGAGCAGGCTGATCGGGCAA
TGGGAGGTGGCCAGGCCTGCCAGCCCCTCGGCTCTGCCGCGGTGGGCCGAGGCCGCTGTTGGGG
GTTTCCCTGTGCGGACCATGGGGGTCAGAGTCTGGCCTGCCGGGCTCTTCTCCCCCAGTTTTCT
CTTTTGGTGGGGGGGTGTGCTGTGGGTATTCACCACCCTGGGACCCCTCCCCCTACCCACCAGA
CCTGTTCTGACCTCATGAGTGTCAAACGTGCCCCCCAGTTCCTTAGGAGATGTCAAGACAACAC
TACACACACCCAATAAAGCGAATGGACCACGTGTGTTCCTGTGAGCACCGGGCCCTGCCCACCC
TG

hide sequence

Protein Sequences


Protein RefSeqs	XP_007993972	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000001693.1

RefSeq Acc Id:	XP_007993972 ⟸ XM_007995781
- UniProtKB:	A0A0D9QZA4 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000005381	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000003415.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Rab3	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/TrEMBL
	Small_GTPase_Rab	UniProtKB/TrEMBL
NCBI Gene	RAB3A	ENTREZGENE
PANTHER	LD44762P	UniProtKB/TrEMBL
	RAS-RELATED PROTEIN RAB-3A	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
SMART	RAB	UniProtKB/TrEMBL
	RAN	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0D9QZA4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations