RAB3A (RAB3A, member RAS oncogene family) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: RAB3A (RAB3A, member RAS oncogene family) Homo sapiens
Analyze
Symbol: RAB3A
Name: RAB3A, member RAS oncogene family
RGD ID: 735498
HGNC Page HGNC:9777
Description: Enables GTPase activity and myosin V binding activity. Involved in several processes, including acrosomal vesicle exocytosis; plasma membrane repair; and regulation of plasma membrane repair. Located in perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: RAS-associated protein RAB3A; ras-related protein Rab-3A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,196,784 - 18,204,042 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,196,784 - 18,204,042 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,307,594 - 18,314,852 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,168,611 - 18,175,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 341918,168,610 - 18,175,839NCBI
Celera1918,209,348 - 18,216,613 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,871,059 - 17,878,307 (-)NCBIHuRef
CHM1_11918,307,151 - 18,314,427 (-)NCBICHM1_1
T2T-CHM13v2.01918,330,909 - 18,338,143 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acrosomal vesicle exocytosis  (IDA)
axonogenesis  (IBA,IEA,ISO)
calcium-ion regulated exocytosis  (IBA,IEA)
constitutive secretory pathway  (TAS)
establishment of localization in cell  (IEA)
evoked neurotransmitter secretion  (IEA)
exocytosis  (IDA,IEA)
insulin secretion  (IEA)
intracellular protein transport  (IEA)
lung development  (IEA,ISO)
lysosome localization  (IMP)
maintenance of presynaptic active zone structure  (IEA,ISO)
mitochondrion organization  (IEA,ISO)
neuromuscular synaptic transmission  (IEA,ISO)
plasma membrane repair  (IDA)
positive regulation of exocytosis  (TAS)
positive regulation of regulated secretory pathway  (IMP)
post-embryonic development  (IEA,ISO)
protein localization to plasma membrane  (IEA)
protein secretion  (IBA,IEA)
protein transport  (IEA)
regulated exocytosis  (IMP)
regulation of dopamine secretion  (ISO)
regulation of exocytosis  (IEA,ISO)
regulation of plasma membrane repair  (IMP)
regulation of presynaptic dense core granule exocytosis  (IEA)
regulation of short-term neuronal synaptic plasticity  (IEA,ISS)
regulation of synaptic vesicle exocytosis  (ISO)
regulation of synaptic vesicle fusion to presynaptic active zone membrane  (IEA,ISO,ISS)
regulation of synaptic vesicle priming  (ISO)
respiratory system process  (IEA,ISO)
response to electrical stimulus  (IEA,ISO)
sensory perception of touch  (IEA,ISO)
synaptic vesicle clustering  (IEA)
synaptic vesicle exocytosis  (IBA,IEA,ISO,ISS)
synaptic vesicle maturation  (IEA,ISO)
synaptic vesicle recycling  (ISS)
synaptic vesicle transport  (IEA)
vesicle docking involved in exocytosis  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. Wang Z and Thurmond DC, J Cell Sci. 2009 Apr 1;122(Pt 7):893-903.
Additional References at PubMed
PMID:1648736   PMID:2493636   PMID:2501306   PMID:2687157   PMID:2732579   PMID:7532276   PMID:7991565   PMID:8071310   PMID:8226995   PMID:8294464   PMID:8432525   PMID:8636125  
PMID:8706741   PMID:8889548   PMID:9013620   PMID:9194562   PMID:9341137   PMID:10025402   PMID:10511453   PMID:10574328   PMID:10859313   PMID:11134008   PMID:11343654   PMID:11377421  
PMID:11516400   PMID:11563859   PMID:11773082   PMID:11809763   PMID:11846002   PMID:11865063   PMID:11884041   PMID:12051743   PMID:12176990   PMID:12244319   PMID:12477932   PMID:12535645  
PMID:12578829   PMID:12590134   PMID:12750892   PMID:12937130   PMID:14734538   PMID:15005721   PMID:15057824   PMID:15159548   PMID:15207266   PMID:15217342   PMID:15489334   PMID:15854772  
PMID:16099449   PMID:16584842   PMID:16722236   PMID:17625073   PMID:18029348   PMID:18559336   PMID:19546222   PMID:19923287   PMID:20029029   PMID:20360680   PMID:21163940   PMID:21349835  
PMID:21808068   PMID:21873635   PMID:22248876   PMID:22753498   PMID:22899725   PMID:23344955   PMID:24006491   PMID:24561123   PMID:24652202   PMID:24769233   PMID:24891604   PMID:24965146  
PMID:25416956   PMID:25613138   PMID:25713146   PMID:26186194   PMID:27325790   PMID:27613869   PMID:28298427   PMID:28514442   PMID:29564676   PMID:29845934   PMID:30575818   PMID:30599141  
PMID:30804014   PMID:31686426   PMID:31698103   PMID:32296183   PMID:32645484   PMID:33961781   PMID:35063084   PMID:35271311   PMID:35809645   PMID:36604567   PMID:36634849   PMID:36724073  
PMID:38512027  


Genomics

Comparative Map Data
RAB3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,196,784 - 18,204,042 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,196,784 - 18,204,042 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,307,594 - 18,314,852 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,168,611 - 18,175,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 341918,168,610 - 18,175,839NCBI
Celera1918,209,348 - 18,216,613 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,871,059 - 17,878,307 (-)NCBIHuRef
CHM1_11918,307,151 - 18,314,427 (-)NCBICHM1_1
T2T-CHM13v2.01918,330,909 - 18,338,143 (-)NCBIT2T-CHM13v2.0
Rab3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,207,258 - 71,211,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,207,328 - 71,211,323 (+)EnsemblGRCm39 Ensembl
GRCm38870,754,703 - 70,758,608 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,754,679 - 70,758,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,278,578 - 73,282,585 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,683,712 - 73,687,666 (+)NCBIMGSCv36mm8
Celera873,315,980 - 73,319,984 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Rab3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,718,164 - 18,722,273 (-)NCBIGRCr8
mRatBN7.21618,684,185 - 18,688,297 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,684,188 - 18,688,336 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,726,559 - 18,730,675 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,859,239 - 19,863,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,779,503 - 18,783,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,435,098 - 20,439,206 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,435,101 - 20,439,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,292,166 - 20,296,274 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,189,765 - 19,193,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,189,765 - 19,193,872 (-)NCBI
Celera1618,876,401 - 18,880,512 (-)NCBICelera
Cytogenetic Map16p14NCBI
Rab3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,221,366 - 3,224,376 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,220,108 - 3,224,376 (+)NCBIChiLan1.0ChiLan1.0
RAB3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,054,186 - 23,061,417 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,062,526 - 22,069,753 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,672,661 - 17,679,541 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,649,166 - 18,656,768 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,649,166 - 18,656,768 (-)Ensemblpanpan1.1panPan2
RAB3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,796,740 - 44,802,224 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,796,895 - 44,801,692 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,710,693 - 44,716,183 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,282,514 - 45,288,006 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,282,528 - 45,287,983 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,519,685 - 44,525,177 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,930,125 - 44,935,626 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,205,632 - 45,211,124 (+)NCBIUU_Cfam_GSD_1.0
Rab3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,441,225 - 203,447,398 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,989,804 - 2,998,305 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,990,367 - 2,995,935 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,603,117 - 59,609,767 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,603,090 - 59,609,773 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,142,410 - 59,149,077 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,671,388 - 16,678,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,670,431 - 16,678,644 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,699,847 - 2,707,085 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,530,312 - 1,536,129 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,532,857 - 1,537,159 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RAB3A
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.11-q13.11(chr19:17176767-34924150)x3 copy number gain See cases [RCV000050635] Chr19:17176767..34924150 [GRCh38]
Chr19:17287576..35415054 [GRCh37]
Chr19:17148576..40106894 [NCBI36]
Chr19:19p13.11-q13.11		 pathogenic
GRCh38/hg38 19p13.12-q11(chr19:13974677-27839676)x3 copy number gain See cases [RCV000052912] Chr19:13974677..27839676 [GRCh38]
Chr19:14085489..28330584 [GRCh37]
Chr19:13946489..33022424 [NCBI36]
Chr19:19p13.12-q11		 pathogenic
GRCh38/hg38 19p13.11(chr19:17922234-18463153)x1 copy number loss See cases [RCV000053946] Chr19:17922234..18463153 [GRCh38]
Chr19:18033043..18573963 [GRCh37]
Chr19:17894043..18434963 [NCBI36]
Chr19:19p13.11		 pathogenic
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19p13.12-12(chr19:15133594-24193591)x3 copy number gain See cases [RCV000136696] Chr19:15133594..24193591 [GRCh38]
Chr19:15244405..24376393 [GRCh37]
Chr19:15105405..24168233 [NCBI36]
Chr19:19p13.12-12		 pathogenic|likely pathogenic
GRCh38/hg38 19p13.11(chr19:18133970-18424117)x1 copy number loss See cases [RCV000142944] Chr19:18133970..18424117 [GRCh38]
Chr19:18244780..18534927 [GRCh37]
Chr19:18105780..18395927 [NCBI36]
Chr19:19p13.11		 uncertain significance
GRCh37/hg19 19p13.11-11(chr19:16526787-24631604)x3 copy number gain not provided [RCV000752593] Chr19:16526787..24631604 [GRCh37]
Chr19:19p13.11-11		 pathogenic
GRCh37/hg19 19p13.11(chr19:18304742-18311144)x3 copy number gain See cases [RCV000449431] Chr19:18304742..18311144 [GRCh37]
Chr19:19p13.11		 benign
GRCh37/hg19 19p13.11(chr19:18136482-19087534)x3 copy number gain See cases [RCV000449006] Chr19:18136482..19087534 [GRCh37]
Chr19:19p13.11		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
NM_002866.5(RAB3A):c.472+10C>G single nucleotide variant not provided [RCV000923777] Chr19:18198715 [GRCh38]
Chr19:18309525 [GRCh37]
Chr19:19p13.11		 likely benign
NM_002866.5(RAB3A):c.270A>G (p.Ala90=) single nucleotide variant not provided [RCV000900504] Chr19:18200404 [GRCh38]
Chr19:18311214 [GRCh37]
Chr19:19p13.11		 likely benign
GRCh37/hg19 19p13.12-12(chr19:14286624-20956753)x3 copy number gain not provided [RCV001259370] Chr19:14286624..20956753 [GRCh37]
Chr19:19p13.12-12		 pathogenic
NM_002866.5(RAB3A):c.285T>C (p.Ala95=) single nucleotide variant not provided [RCV001822058] Chr19:18200389 [GRCh38]
Chr19:18311199 [GRCh37]
Chr19:19p13.11		 benign
NC_000019.9:g.(?_17927663)_(19312528_?)dup duplication Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 [RCV003116292] Chr19:17927663..19312528 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_002866.5(RAB3A):c.464A>G (p.Asp155Gly) single nucleotide variant Inborn genetic diseases [RCV002969318] Chr19:18198733 [GRCh38]
Chr19:18309543 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_002866.5(RAB3A):c.20C>G (p.Ser7Trp) single nucleotide variant Inborn genetic diseases [RCV002841784] Chr19:18202721 [GRCh38]
Chr19:18313531 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_002866.5(RAB3A):c.585C>A (p.Asp195Glu) single nucleotide variant Inborn genetic diseases [RCV002758961] Chr19:18197548 [GRCh38]
Chr19:18308358 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_002866.5(RAB3A):c.650A>C (p.Asp217Ala) single nucleotide variant Inborn genetic diseases [RCV002648817] Chr19:18197483 [GRCh38]
Chr19:18308293 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_002866.5(RAB3A):c.427C>T (p.Arg143Trp) single nucleotide variant Inborn genetic diseases [RCV002719212] Chr19:18198770 [GRCh38]
Chr19:18309580 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_002866.5(RAB3A):c.452G>A (p.Arg151Gln) single nucleotide variant Inborn genetic diseases [RCV002965701] Chr19:18198745 [GRCh38]
Chr19:18309555 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_002866.5(RAB3A):c.514G>A (p.Val172Ile) single nucleotide variant Inborn genetic diseases [RCV002678558] Chr19:18197619 [GRCh38]
Chr19:18308429 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_002866.5(RAB3A):c.490G>A (p.Ala164Thr) single nucleotide variant Inborn genetic diseases [RCV003212180] Chr19:18197643 [GRCh38]
Chr19:18308453 [GRCh37]
Chr19:19p13.11		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1286
Count of miRNA genes:552
Interacting mature miRNAs:621
Transcripts:ENST00000222256, ENST00000464076, ENST00000481914, ENST00000515410
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH71434  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371918,308,244 - 18,308,404UniSTSGRCh37
Build 361918,169,244 - 18,169,404RGDNCBI36
Celera1918,209,979 - 18,210,139RGD
Cytogenetic Map19p13.2UniSTS
HuRef1917,871,690 - 17,871,850UniSTS
GeneMap99-GB4 RH Map19103.08UniSTS
NCBI RH Map19128.7UniSTS
RAB3A_1804  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371918,307,504 - 18,308,402UniSTSGRCh37
Build 361918,168,504 - 18,169,402RGDNCBI36
Celera1918,209,241 - 18,210,137RGD
HuRef1917,870,952 - 17,871,848UniSTS
STS-H95222  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371918,307,230 - 18,307,369UniSTSGRCh37
Build 361918,168,230 - 18,168,369RGDNCBI36
Celera1918,208,967 - 18,209,106RGD
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map19p13.11UniSTS
HuRef1917,870,678 - 17,870,817UniSTS
GeneMap99-GB4 RH Map19100.9UniSTS
NCBI RH Map19129.1UniSTS
WI-22566  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371918,307,304 - 18,307,378UniSTSGRCh37
Build 361918,168,304 - 18,168,378RGDNCBI36
Celera1918,209,041 - 18,209,115RGD
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map19p13.11UniSTS
HuRef1917,870,752 - 17,870,826UniSTS
GeneMap99-GB4 RH Map19101.45UniSTS
Whitehead-RH Map1991.7UniSTS
NCBI RH Map19159.7UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 5
Medium 528 1054 439 8 174 7 689 510 3029 92 403 147 4 1 29 396
Low 1908 1928 1272 604 1741 446 3614 1635 700 325 1055 1464 170 1165 2341 5 2
Below cutoff 3 9 15 12 30 12 53 52 2 2 2 10 51 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000222256   ⟹   ENSP00000222256
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1918,196,784 - 18,204,042 (-)Ensembl
RefSeq Acc Id: ENST00000464076   ⟹   ENSP00000474603
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1918,196,799 - 18,204,042 (-)Ensembl
RefSeq Acc Id: ENST00000481914   ⟹   ENSP00000472335
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1918,200,327 - 18,204,012 (-)Ensembl
RefSeq Acc Id: ENST00000515410
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1918,202,338 - 18,204,035 (-)Ensembl
RefSeq Acc Id: NM_002866   ⟹   NP_002857
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381918,196,784 - 18,204,042 (-)NCBI
GRCh371918,307,609 - 18,314,874 (-)NCBI
Build 361918,168,611 - 18,175,839 (-)NCBI Archive
HuRef1917,871,059 - 17,878,307 (-)ENTREZGENE
CHM1_11918,307,151 - 18,314,427 (-)NCBI
T2T-CHM13v2.01918,330,909 - 18,338,143 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_002857   ⟸   NM_002866
- UniProtKB: A8K0J4 (UniProtKB/Swiss-Prot),   Q9NYE1 (UniProtKB/Swiss-Prot),   P20336 (UniProtKB/Swiss-Prot),   A0A024R7I7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000474603   ⟸   ENST00000464076
RefSeq Acc Id: ENSP00000472335   ⟸   ENST00000481914
RefSeq Acc Id: ENSP00000222256   ⟸   ENST00000222256

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20336-F1-model_v2 AlphaFold P20336 1-220 view protein structure

Promoters
RGD ID:6814665
Promoter ID:HG_XEF:3947
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour
Transcripts:NM_001002679,   NM_001003419,   NM_001016426,   NM_001017761,   NM_001044155,   NM_001094522,   NM_001095062,   NM_001123179,   NM_001123495,   NM_001127284,   NM_001173892,   NM_013018,   NM_211707
Position:
Human AssemblyChrPosition (strand)Source
Build 361918,175,019 - 18,175,519 (-)MPROMDB
RGD ID:6795103
Promoter ID:HG_KWN:29288
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000268055,   OTTHUMT00000268056,   OTTHUMT00000268057,   OTTHUMT00000268058
Position:
Human AssemblyChrPosition (strand)Source
Build 361918,175,706 - 18,176,627 (-)MPROMDB
RGD ID:7239115
Promoter ID:EPDNEW_H25302
Type:initiation region
Name:RAB3A_1
Description:RAB3A, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381918,204,042 - 18,204,102EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9777 AgrOrtholog
COSMIC RAB3A COSMIC
Ensembl Genes ENSG00000105649 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000222256 ENTREZGENE
  ENST00000222256.9 UniProtKB/Swiss-Prot
  ENST00000464076.3 UniProtKB/TrEMBL
  ENST00000481914.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000105649 GTEx
HGNC ID HGNC:9777 ENTREZGENE
Human Proteome Map RAB3A Human Proteome Map
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rab3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5864 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5864 ENTREZGENE
OMIM 179490 OMIM
PANTHER LD44762P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34132 PharmGKB
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R7I7 ENTREZGENE, UniProtKB/TrEMBL
  A8K0J4 ENTREZGENE
  M0R257_HUMAN UniProtKB/TrEMBL
  P20336 ENTREZGENE
  Q9NYE1 ENTREZGENE
  RAB3A_HUMAN UniProtKB/Swiss-Prot
  S4R3Q3_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8K0J4 UniProtKB/Swiss-Prot
  Q9NYE1 UniProtKB/Swiss-Prot