Nudt18 (nudix hydrolase 18) - Rat Genome Database

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Gene: Nudt18 (nudix hydrolase 18) Rattus norvegicus
Analyze
Symbol: Nudt18
Name: nudix hydrolase 18
RGD ID: 1311802
Description: Predicted to enable 8-hydroxy-dADP phosphatase activity; 8-oxo-GDP phosphatase activity; and 8-oxo-dGDP phosphatase activity. Predicted to be involved in GDP catabolic process; dADP catabolic process; and dGDP catabolic process. Orthologous to human NUDT18 (nudix hydrolase 18); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine phosphatase; 8-oxo-dGDP phosphatase NUDT18; LOC361068; mutT homolog 3; nucleoside diphosphate-linked moiety X motif 18; nudix (nucleoside diphosphate linked moiety X)-type motif 18; nudix motif 18; RGD1311802; similar to cDNA sequence BC036718
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81552,060,297 - 52,062,822 (+)NCBIGRCr8
mRatBN7.21545,650,597 - 45,653,985 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,650,664 - 45,653,963 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,768,454 - 49,770,976 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,879,960 - 50,882,483 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,739,269 - 47,741,794 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,265,557 - 52,268,081 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,265,557 - 52,268,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,989,074 - 55,991,598 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,977,124 - 50,979,648 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,992,839 - 50,996,120 (+)NCBI
Celera1545,328,967 - 45,331,491 (+)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:22556419  


Genomics

Comparative Map Data
Nudt18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81552,060,297 - 52,062,822 (+)NCBIGRCr8
mRatBN7.21545,650,597 - 45,653,985 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,650,664 - 45,653,963 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,768,454 - 49,770,976 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,879,960 - 50,882,483 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,739,269 - 47,741,794 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,265,557 - 52,268,081 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,265,557 - 52,268,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,989,074 - 55,991,598 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,977,124 - 50,979,648 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,992,839 - 50,996,120 (+)NCBI
Celera1545,328,967 - 45,331,491 (+)NCBICelera
Cytogenetic Map15p11NCBI
NUDT18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,106,878 - 22,110,482 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,105,748 - 22,109,419 (-)EnsemblGRCh38hg38GRCh38
GRCh37821,964,389 - 21,966,932 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,020,328 - 22,022,877 (-)NCBINCBI36Build 36hg18NCBI36
Celera820,926,679 - 20,929,248 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,506,929 - 20,509,498 (-)NCBIHuRef
CHM1_1822,166,045 - 22,168,614 (-)NCBICHM1_1
T2T-CHM13v2.0822,380,831 - 22,383,394 (-)NCBIT2T-CHM13v2.0
Nudt18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,815,264 - 70,820,128 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,815,077 - 70,820,128 (+)EnsemblGRCm39 Ensembl
GRCm381470,577,824 - 70,582,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,577,637 - 70,582,688 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,977,654 - 70,982,378 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,312,927 - 69,317,651 (+)NCBIMGSCv36mm8
Celera1468,119,373 - 68,124,096 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
Nudt18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540345,598,813 - 45,601,940 (-)NCBIChiLan1.0ChiLan1.0
NUDT18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2740,608,722 - 40,611,992 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,333,178 - 16,341,718 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,351,840 - 21,356,915 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,293,555 - 18,299,540 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,293,555 - 18,297,078 (-)Ensemblpanpan1.1panPan2
NUDT18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12535,139,580 - 35,144,066 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2535,140,969 - 35,143,063 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,729,138 - 35,733,637 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02535,351,117 - 35,355,601 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2535,352,416 - 35,355,503 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12535,296,344 - 35,300,845 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02535,150,896 - 35,155,376 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02535,306,384 - 35,310,868 (+)NCBIUU_Cfam_GSD_1.0
Nudt18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,638,163 - 12,641,252 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365555,928,601 - 5,932,400 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365555,929,262 - 5,932,334 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUDT18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,377,815 - 6,381,596 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,378,987 - 6,381,712 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,814,635 - 6,817,363 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUDT18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,176,500 - 20,184,637 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605222,057,257 - 22,060,315 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nudt18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,691,803 - 17,694,945 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,691,790 - 17,695,027 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nudt18
19 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:169
Count of miRNA genes:121
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000015969
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154480677352597086Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154446544756583797Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
RH141982  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,652,702 - 45,652,900 (+)MAPPERmRatBN7.2
Rnor_6.01552,267,660 - 52,267,857NCBIRnor6.0
Rnor_5.01555,991,177 - 55,991,374UniSTSRnor5.0
RGSC_v3.41550,979,227 - 50,979,424UniSTSRGSC3.4
Celera1545,331,070 - 45,331,267UniSTS
Cytogenetic Map15p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015969   ⟹   ENSRNOP00000015969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,650,664 - 45,653,963 (+)Ensembl
Rnor_6.0 Ensembl1552,265,557 - 52,268,079 (+)Ensembl
RefSeq Acc Id: NM_001100732   ⟹   NP_001094202
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81552,060,297 - 52,062,822 (+)NCBI
mRatBN7.21545,650,597 - 45,653,124 (+)NCBI
Rnor_6.01552,265,557 - 52,268,081 (+)NCBI
Rnor_5.01555,989,074 - 55,991,598 (+)NCBI
RGSC_v3.41550,977,124 - 50,979,648 (+)RGD
Celera1545,328,967 - 45,331,491 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093515   ⟹   XP_038949443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81552,061,013 - 52,062,822 (+)NCBI
mRatBN7.21545,651,373 - 45,653,985 (+)NCBI
RefSeq Acc Id: XM_039093516   ⟹   XP_038949444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81552,060,580 - 52,062,822 (+)NCBI
mRatBN7.21545,650,888 - 45,653,985 (+)NCBI
RefSeq Acc Id: NP_001094202   ⟸   NM_001100732
- UniProtKB: Q4KM80 (UniProtKB/Swiss-Prot),   Q641Y7 (UniProtKB/Swiss-Prot),   B0BNL9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015969   ⟸   ENSRNOT00000015969
RefSeq Acc Id: XP_038949444   ⟸   XM_039093516
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949443   ⟸   XM_039093515
- Peptide Label: isoform X1
Protein Domains
Nudix hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q641Y7-F1-model_v2 AlphaFold Q641Y7 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699815
Promoter ID:EPDNEW_R10338
Type:initiation region
Name:Nudt18_1
Description:nudix hydrolase 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01552,265,552 - 52,265,612EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311802 AgrOrtholog
BioCyc Gene G2FUF-13209 BioCyc
BioCyc Pathway PWY-8061 [8-oxo-(d)GTP detoxification II] BioCyc
BioCyc Pathway Image PWY-8061 BioCyc
Ensembl Genes ENSRNOG00000011831 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015969 ENTREZGENE
  ENSRNOT00000015969.7 UniProtKB/Swiss-Prot
Gene3D-CATH Nucleoside Triphosphate Pyrophosphohydrolase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132056 IMAGE-MGC_LOAD
  IMAGE:7315261 IMAGE-MGC_LOAD
  IMAGE:7933460 IMAGE-MGC_LOAD
InterPro Nudix_hydrolase UniProtKB/Swiss-Prot
  NUDIX_hydrolase-like_dom_sf UniProtKB/Swiss-Prot
  NUDIX_hydrolase_CS UniProtKB/Swiss-Prot
  NUDIX_hydrolase_dom UniProtKB/Swiss-Prot
  NUDT18_NUDIX UniProtKB/Swiss-Prot
KEGG Report rno:361068 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112699 IMAGE-MGC_LOAD
  MGC:188538 IMAGE-MGC_LOAD
  MGC:95200 IMAGE-MGC_LOAD
NCBI Gene 361068 ENTREZGENE
PANTHER 8-OXO-DGDP PHOSPHATASE NUDT18 UniProtKB/Swiss-Prot
  MUTT/NUDIX HYDROLASE UniProtKB/Swiss-Prot
Pfam NUDIX UniProtKB/Swiss-Prot
PhenoGen Nudt18 PhenoGen
PRINTS NUDIXFAMILY UniProtKB/Swiss-Prot
PROSITE NUDIX UniProtKB/Swiss-Prot
  NUDIX_BOX UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011831 RatGTEx
Superfamily-SCOP SSF55811 UniProtKB/Swiss-Prot
UniProt B0BNL9 ENTREZGENE, UniProtKB/TrEMBL
  NUD18_RAT UniProtKB/Swiss-Prot
  Q4KM80 ENTREZGENE
  Q641Y7 ENTREZGENE
UniProt Secondary Q4KM80 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Nudt18  nudix hydrolase 18  Nudt18  nudix (nucleoside diphosphate linked moiety X)-type motif 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nudt18  nudix (nucleoside diphosphate linked moiety X)-type motif 18  RGD1311802  similar to cDNA sequence BC036718  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1311802  similar to cDNA sequence BC036718  RGD1311802_predicted  similar to cDNA sequence BC036718 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311802_predicted  similar to cDNA sequence BC036718 (predicted)  LOC361068_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361068_predicted  similar to cDNA sequence BC036718 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL