Nudt18 (nudix hydrolase 18) - Rat Genome Database

Name: Nudt18
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Nudt18 (nudix hydrolase 18) Rattus norvegicus

Analyze

Symbol:

Nudt18

Name:

nudix hydrolase 18

RGD ID:

1311802

Description:

Predicted to enable magnesium ion binding activity and nucleoside diphosphate phosphatase activity. Predicted to be involved in GDP catabolic process; dADP catabolic process; and dGDP catabolic process. Orthologous to human NUDT18 (nudix hydrolase 18); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine phosphatase; 8-oxo-dGDP phosphatase NUDT18; LOC361068; mutT homolog 3; nucleoside diphosphate-linked moiety X motif 18; nudix (nucleoside diphosphate linked moiety X)-type motif 18; nudix motif 18; RGD1311802; similar to cDNA sequence BC036718

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NUDT18 (nudix hydrolase 18)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther
Mus musculus (house mouse):	Nudt18 (nudix hydrolase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nudt18 (nudix hydrolase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NUDT18 (nudix hydrolase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NUDT18 (nudix hydrolase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nudt18 (nudix hydrolase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NUDT18 (nudix hydrolase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NUDT18 (nudix hydrolase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nudt18 (nudix hydrolase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	REST (RE1 silencing transcription factor)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Nudt18 (nudix hydrolase 18)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NUDT18 (nudix hydrolase 18)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nudt18 (nudix (nucleoside diphosphate linked moiety X)-type motif 18)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10898	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ndx-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nudt18	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	45,650,597 - 45,653,985 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	45,650,664 - 45,653,963 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	49,768,454 - 49,770,976 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	15	50,879,960 - 50,882,483 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	15	47,739,269 - 47,741,794 (+)	NCBI	Rnor_WKY
Rnor_6.0	15	52,265,557 - 52,268,081 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	52,265,557 - 52,268,079 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	55,989,074 - 55,991,598 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	50,977,124 - 50,979,648 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	50,992,839 - 50,996,120 (+)	NCBI
Celera	15	45,328,967 - 45,331,491 (+)	NCBI		Celera
Cytogenetic Map	15	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Conotruncal Cardiac Defects (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

calcitriol (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

cypermethrin (ISO)

diarsenic trioxide (ISO)

finasteride (EXP)

folic acid (ISO)

L-methionine (ISO)

paracetamol (EXP,ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

triclosan (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dADP catabolic process (ISO,ISS)

dGDP catabolic process (ISO,ISS)

GDP catabolic process (ISO,ISS)

Molecular Function

8-hydroxy-dADP phosphatase activity (ISO,ISS)

8-oxo-dGDP phosphatase activity (IBA,ISO,ISS)

8-oxo-GDP phosphatase activity (IBA,ISO,ISS)

magnesium ion binding (IBA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:22556419

Genomics

Comparative Map Data

Nudt18
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	45,650,597 - 45,653,985 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	45,650,664 - 45,653,963 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	49,768,454 - 49,770,976 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	15	50,879,960 - 50,882,483 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	15	47,739,269 - 47,741,794 (+)	NCBI	Rnor_WKY
Rnor_6.0	15	52,265,557 - 52,268,081 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	52,265,557 - 52,268,079 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	55,989,074 - 55,991,598 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	50,977,124 - 50,979,648 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	50,992,839 - 50,996,120 (+)	NCBI
Celera	15	45,328,967 - 45,331,491 (+)	NCBI		Celera
Cytogenetic Map	15	p11	NCBI

NUDT18
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	22,106,878 - 22,110,482 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	8	22,106,874 - 22,109,419 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	21,964,389 - 21,966,932 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	22,020,328 - 22,022,877 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	20,926,679 - 20,929,248 (-)	NCBI		Celera
Cytogenetic Map	8	p21.3	NCBI
HuRef	8	20,506,929 - 20,509,498 (-)	NCBI		HuRef
CHM1_1	8	22,166,045 - 22,168,614 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	22,380,831 - 22,383,394 (-)	NCBI		T2T-CHM13v2.0

Nudt18
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	70,815,264 - 70,820,128 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	70,815,077 - 70,820,128 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	70,577,824 - 70,582,688 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	70,577,637 - 70,582,688 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	70,977,654 - 70,982,378 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	69,312,927 - 69,317,651 (+)	NCBI		MGSCv36	mm8
Celera	14	68,119,373 - 68,124,096 (+)	NCBI		Celera
Cytogenetic Map	14	D2	NCBI

Nudt18
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955403	45,598,813 - 45,601,940 (-)	NCBI	ChiLan1.0	ChiLan1.0

NUDT18
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	8	16,333,178 - 16,341,718 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	21,351,840 - 21,356,915 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	18,293,555 - 18,299,540 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	18,293,555 - 18,297,078 (-)	Ensembl	panpan1.1		panPan2

NUDT18
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	35,139,580 - 35,144,066 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	35,140,969 - 35,143,063 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	35,729,138 - 35,733,637 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	35,351,117 - 35,355,601 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	35,352,416 - 35,355,503 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	35,296,344 - 35,300,845 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	35,150,896 - 35,155,376 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	35,306,384 - 35,310,868 (+)	NCBI		UU_Cfam_GSD_1.0

Nudt18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	12,638,163 - 12,641,252 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936555	5,928,601 - 5,932,400 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936555	5,929,262 - 5,932,334 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NUDT18
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	6,377,815 - 6,381,596 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	6,378,987 - 6,381,712 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	6,814,635 - 6,817,363 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NUDT18
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	20,176,500 - 20,184,637 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666052	22,057,257 - 22,060,315 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nudt18
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	17,691,803 - 17,694,945 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	17,691,790 - 17,695,027 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nudt18
6 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	169
Count of miRNA genes:	121
Interacting mature miRNAs:	136
Transcripts:	ENSRNOT00000015969
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
2293691	Bmd37	Bone mineral density QTL 37	6.6	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	15	33611058	71477291	Rat
2293686	Bmd36	Bone mineral density QTL 36	7.4	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	15	33611058	71477291	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	34054139	79054139	Rat
7411725	Strs7	Sensitivity to stroke QTL 7	3.8		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	15	40289901	49308583	Rat
2306968	Anxrr23	Anxiety related response QTL 23	4.83		reflex trait (VT:0001961)	amplitude of the acoustic startle response (CMO:0001520)	15	40631268	46187442	Rat
1300144	Rf23	Renal function QTL 23	3.61		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	15	40631268	98288169	Rat

Markers in Region

RH141982

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	45,652,702 - 45,652,900 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	52,267,660 - 52,267,857	NCBI	Rnor6.0
Rnor_5.0	15	55,991,177 - 55,991,374	UniSTS	Rnor5.0
RGSC_v3.4	15	50,979,227 - 50,979,424	UniSTS	RGSC3.4
Celera	15	45,331,070 - 45,331,267	UniSTS
Cytogenetic Map	15	p11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	20	15	10	12	10	1	4	39	27	24	11	1
Low		23	42	31	7	31	7	7	35	8	17		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093515	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC082050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC158874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000015969 ⟹ ENSRNOP00000015969

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	45,650,664 - 45,653,963 (+)	Ensembl
Rnor_6.0 Ensembl	15	52,265,557 - 52,268,079 (+)	Ensembl

RefSeq Acc Id:

NM_001100732 ⟹ NP_001094202

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	45,650,597 - 45,653,124 (+)	NCBI
Rnor_6.0	15	52,265,557 - 52,268,081 (+)	NCBI
Rnor_5.0	15	55,989,074 - 55,991,598 (+)	NCBI
RGSC_v3.4	15	50,977,124 - 50,979,648 (+)	RGD
Celera	15	45,328,967 - 45,331,491 (+)	RGD

Sequence:

show sequence

CCCACCGCAGCTCAAGTCCCTGCTGCCTGCCTCCGGGGGTCTGGCAGGTCCCGGCCTGCCACCT
CCCCGGAGACTTGATGGCCACGGAGGGCCTGGCAGGGGCGCTGGCCACCGTGCTGGGGGGGAAG
GGGTTGCTGGTGCAGAGCTGTGACTCGGAGCCGGCTGGCAAGCCGCTGTTGCCCGTGCGACTGC
GGAAGAATGTCTGCTACGTGGTGCTGGCCGTGTTCCTCAACGAGCAGGATGAGGTGTTGATGAT
CCAGGAGGCCAAGAGAGAATGCCGGGGAACATGGTACCTCCCGGCAGGAAGAATGGAACCAGGG
GAGACCATCGTGGAGGCCATGCAGCGGGAGGTGAAGGAGGAGGCTGGGCTGCTCTGTGAGCCAG
TGACACTGCTGTCTGTGGAGGAGAGGGGTGCCTCTTGGATCCGTTTTGTATTCCTTGCTCGACC
AACAGGTGGAGTTCTCAAGACTTCCAAGAATGCTGATTCTGAGTCCCTACAGGCTGGCTGGTAC
CCACGGGTCTCCCTGCCCACACCGCTTAGAGCTCATGATGTTGTGCACCTGGTAGAGCTAGGTG
CCAAATTCTGCCAACAAGCCACACACCCTCTCATTCTGCCTCAAGAGCTTCCCTGCAATATGGT
CTGCCAGCGGCTGGTGGCCACCTTTACAACAGTTCAGTCAGTGTGGGTGTTGGTGGGTACAGTG
GGGACACCTCACTTGCCCATCACTGCCTGTGGCTTTACCCCTATGGAACAAAGAGGTGGCATCA
AGGTGGCCATCTTGAGGCTACTACAAGAGTGTCTGACTCTGCACAGTTTGGCAGTGGAGACCAA
GGGGTTGCTTGGGCTGCAACATCTCGGCAGAGACCACGTGGATGGTATCTGCCTGAATGTGCTG
GTGACAGTGGCTTTTCGGAACCCAGGAATCCAAGATGAGCCCCCAAAGATTCGGGGGGAAAACT
ACTTTTGGTGGAAGGTACTGGAGGAAGACTTACAAAAACAGCTTCTACACAGACTCCAGGAATC
TTCTGTTGTCCCCCTGACCAGATAGATACCAGCAGTGACCAAAAGCTGAGCAGCCACCCTCCCT
CTGAGGCAGTGAAGAGACTGGCAGTCAGGGGTCTCATTGCACATTACTCAGGTACAGGAACTAC
ACATTGAGCCCAAAGGGAGGGTGCCATGAATCCAGTCATTCTGAGGGCACACGATGCTTCTCTT
TAAGTTTGAAAGGAGCTTTTCGAACCGTAAATGGCACCATCTTCTCTGTCCACTTTGGAAAAGG
CCGCATGTCAATCCTTCCAACCCCACAGCAATGTAGAGGGGGATGGGACAAGGGGGATGCATCC
CTCAGGGCAGAGTCCTCATTGCTGAGTAAAAAGGTGTTGCTTAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039093515 ⟹ XP_038949443

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	45,651,373 - 45,653,985 (+)	NCBI

RefSeq Acc Id:

XM_039093516 ⟹ XP_038949444

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	45,650,888 - 45,653,985 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094202	(Get FASTA)	NCBI Sequence Viewer
	XP_038949443	(Get FASTA)	NCBI Sequence Viewer
	XP_038949444	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82050	(Get FASTA)	NCBI Sequence Viewer
	AAH98710	(Get FASTA)	NCBI Sequence Viewer
	AAI58875	(Get FASTA)	NCBI Sequence Viewer
	EDM02231	(Get FASTA)	NCBI Sequence Viewer
	Q641Y7	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001094202 ⟸ NM_001100732

- UniProtKB:

Q4KM80 (UniProtKB/Swiss-Prot), Q641Y7 (UniProtKB/Swiss-Prot), B0BNL9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATEGLAGALATVLGGKGLLVQSCDSEPAGKPLLPVRLRKNVCYVVLAVFLNEQDEVLMIQEAK
RECRGTWYLPAGRMEPGETIVEAMQREVKEEAGLLCEPVTLLSVEERGASWIRFVFLARPTGGV
LKTSKNADSESLQAGWYPRVSLPTPLRAHDVVHLVELGAKFCQQATHPLILPQELPCNMVCQRL
VATFTTVQSVWVLVGTVGTPHLPITACGFTPMEQRGGIKVAILRLLQECLTLHSLAVETKGLLG
LQHLGRDHVDGICLNVLVTVAFRNPGIQDEPPKIRGENYFWWKVLEEDLQKQLLHRLQESSVVP
LTR

hide sequence

RefSeq Acc Id:

ENSRNOP00000015969 ⟸ ENSRNOT00000015969

RefSeq Acc Id:	XP_038949444 ⟸ XM_039093516
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038949443 ⟸ XM_039093515
- Peptide Label:	isoform X1

Protein Domains

Nudix hydrolase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q641Y7-F1-model_v2	AlphaFold	Q641Y7	1-323	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699815

Promoter ID:

EPDNEW_R10338

Type:

initiation region

Name:

Nudt18_1

Description:

nudix hydrolase 18

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	52,265,552 - 52,265,612	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311802	AgrOrtholog
BioCyc Gene	G2FUF-13209	BioCyc
BioCyc Pathway	PWY-8061 [8-oxo-(d)GTP detoxification II]	BioCyc
Ensembl Genes	ENSRNOG00000011831	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000015969	ENTREZGENE
	ENSRNOP00000015969.4	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000015969	ENTREZGENE
	ENSRNOT00000015969.7	UniProtKB/Swiss-Prot
Gene3D-CATH	Nucleoside Triphosphate Pyrophosphohydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7132056	IMAGE-MGC_LOAD
	IMAGE:7315261	IMAGE-MGC_LOAD
	IMAGE:7933460	IMAGE-MGC_LOAD
InterPro	Nudix_hydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUDIX_hydrolase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUDIX_hydrolase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUDIX_hydrolase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUDT18_NUDIX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:361068	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:112699	IMAGE-MGC_LOAD
	MGC:188538	IMAGE-MGC_LOAD
	MGC:95200	IMAGE-MGC_LOAD
NCBI Gene	361068	ENTREZGENE
PANTHER	8-OXO-DGDP PHOSPHATASE NUDT18	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MUTT/NUDIX HYDROLASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	NUDIX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Nudt18	PhenoGen
PRINTS	NUDIXFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	NUDIX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUDIX_BOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF55811	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	B0BNL9	ENTREZGENE, UniProtKB/TrEMBL
	NUD18_RAT	UniProtKB/Swiss-Prot
	Q4KM80	ENTREZGENE
	Q641Y7	ENTREZGENE
UniProt Secondary	Q4KM80	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-20	Nudt18	nudix hydrolase 18	Nudt18	nudix (nucleoside diphosphate linked moiety X)-type motif 18	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Nudt18	nudix (nucleoside diphosphate linked moiety X)-type motif 18	RGD1311802	similar to cDNA sequence BC036718	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1311802	similar to cDNA sequence BC036718	RGD1311802_predicted	similar to cDNA sequence BC036718 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1311802_predicted	similar to cDNA sequence BC036718 (predicted)	LOC361068_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC361068_predicted	similar to cDNA sequence BC036718 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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