Araf (A-Raf proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: Araf (A-Raf proto-oncogene, serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Araf
Name: A-Raf proto-oncogene, serine/threonine kinase
RGD ID: 2148
Description: Enables MAP kinase kinase kinase activity. Involved in protein phosphorylation. Located in cytosol. Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-Raf proto-oncogene serine/threonine-protein kinase; Araf1; proto-oncogene A-Raf; proto-oncogene A-Raf-1; Raf related protein; Ras-binding protein; serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog; v-raf murine sarcoma 3611 viral oncogene homolog 1; v-raf oncogene homolog 1 (murine sarcoma 3611 virus)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X1,227,392 - 1,292,356 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,227,392 - 1,239,073 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,255,531 - 1,267,209 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X4,731,222 - 4,742,902 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X1,052,386 - 1,064,071 (-)NCBIRnor_WKY
Rnor_6.0X1,369,534 - 1,391,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,379,194 - 1,390,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,194,385 - 2,206,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,556,904 - 12,568,583 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,562,471 - 12,572,791 (-)NCBI
CeleraX1,795,227 - 1,806,868 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IDA,TAS)
mitochondrion  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK. Gruppuso PA and Boylan JM, FEBS Lett. 2000 Jan 21;466(1):200-4.
3. IGFBP2 expression predicts IDH-mutant glioma patient survival. Huang LE, etal., Oncotarget. 2017 Jan 3;8(1):191-202. doi: 10.18632/oncotarget.13329.
4. The complete primary structure of the rat A-raf cDNA coding region: conservation of the putative regulatory regions present in rat c-raf. Ishikawa F, etal., Oncogene Res 1987 Aug;1(3):243-53.
5. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. MEK1/2 dual-specificity protein kinases: Structure and regulation. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
Additional References at PubMed
PMID:3491291   PMID:8889548   PMID:9679960   PMID:12060780   PMID:12477932   PMID:12931191   PMID:17380122   PMID:17535970   PMID:19667065   PMID:22609986  


Genomics

Comparative Map Data
Araf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X1,227,392 - 1,292,356 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,227,392 - 1,239,073 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,255,531 - 1,267,209 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X4,731,222 - 4,742,902 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X1,052,386 - 1,064,071 (-)NCBIRnor_WKY
Rnor_6.0X1,369,534 - 1,391,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,379,194 - 1,390,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,194,385 - 2,206,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,556,904 - 12,568,583 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,562,471 - 12,572,791 (-)NCBI
CeleraX1,795,227 - 1,806,868 (-)NCBICelera
Cytogenetic MapXq11NCBI
ARAF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,561,205 - 47,571,908 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX47,561,205 - 47,571,908 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,420,604 - 47,431,307 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,305,522 - 47,316,264 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X47,176,760 - 47,187,553NCBI
CeleraX51,615,774 - 51,626,577 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX45,132,731 - 45,143,540 (+)NCBIHuRef
CHM1_1X47,451,606 - 47,462,422 (+)NCBICHM1_1
T2T-CHM13v2.0X46,971,095 - 46,981,798 (+)NCBIT2T-CHM13v2.0
Araf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,663,946 - 20,726,760 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,664,053 - 20,726,758 (+)EnsemblGRCm39 Ensembl
GRCm38X20,797,707 - 20,860,521 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,797,814 - 20,860,519 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,425,669 - 20,437,647 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,005,557 - 20,017,477 (+)NCBIMGSCv36mm8
CeleraX18,979,682 - 18,991,660 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.3NCBI
Araf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516521,479 - 533,212 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516521,479 - 532,980 (-)NCBIChiLan1.0ChiLan1.0
ARAF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X47,893,153 - 47,904,643 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,893,153 - 47,904,643 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X39,997,026 - 40,007,783 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ARAF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,180,082 - 41,191,579 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,180,250 - 41,191,310 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,555,116 - 15,566,605 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,314,276 - 41,325,765 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,314,438 - 41,325,764 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,301,898 - 41,313,372 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,290,159 - 41,301,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,382,798 - 41,394,286 (+)NCBIUU_Cfam_GSD_1.0
Araf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,482,616 - 33,494,254 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,323,355 - 13,335,224 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493650213,323,365 - 13,335,003 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARAF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,078,206 - 42,090,250 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,078,202 - 42,090,250 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,388,650 - 47,400,702 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXp13NCBI
LOC103231895
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,738,406 - 44,748,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,740,181 - 44,748,550 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366656638,210 - 47,870 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Araf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978100,505 - 110,646 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462497899,605 - 110,645 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Araf
99 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:518
Count of miRNA genes:273
Interacting mature miRNAs:325
Transcripts:ENSRNOT00000039911
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat

Markers in Region
RH131306  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,235,565 - 1,235,767 (+)MAPPERmRatBN7.2
Rnor_6.0X1,387,366 - 1,387,567NCBIRnor6.0
Rnor_5.0X2,202,557 - 2,202,758UniSTSRnor5.0
RGSC_v3.4X12,565,076 - 12,565,277UniSTSRGSC3.4
CeleraX1,803,361 - 1,803,562UniSTS
RH 3.4 Map18532.0UniSTS
Cytogenetic MapXq11.1UniSTS
Araf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,233,634 - 1,234,075 (+)MAPPERmRatBN7.2
Rnor_6.0X1,385,435 - 1,385,875NCBIRnor6.0
Rnor_5.0X2,200,626 - 2,201,066UniSTSRnor5.0
RGSC_v3.4X12,563,145 - 12,563,585UniSTSRGSC3.4
CeleraX1,801,430 - 1,801,870UniSTS
Cytogenetic MapXq11.1UniSTS
AW495444  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,235,675 - 1,235,783 (+)MAPPERmRatBN7.2
Rnor_6.0X1,387,476 - 1,387,583NCBIRnor6.0
Rnor_5.0X2,202,667 - 2,202,774UniSTSRnor5.0
RGSC_v3.4X12,565,186 - 12,565,293UniSTSRGSC3.4
CeleraX1,803,471 - 1,803,578UniSTS
Cytogenetic MapXq11.1UniSTS
RH141572  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,227,619 - 1,227,813 (+)MAPPERmRatBN7.2
Rnor_6.0X1,379,422 - 1,379,615NCBIRnor6.0
Rnor_5.0X2,194,613 - 2,194,806UniSTSRnor5.0
RGSC_v3.4X12,557,132 - 12,557,325UniSTSRGSC3.4
CeleraX1,795,455 - 1,795,648UniSTS
Cytogenetic MapXq11.1UniSTS
UniSTS:224356  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,227,192 - 1,227,306 (+)MAPPERmRatBN7.2
Rnor_6.0X1,378,995 - 1,379,108NCBIRnor6.0
Rnor_5.0X2,194,186 - 2,194,299UniSTSRnor5.0
RGSC_v3.4X12,556,705 - 12,556,818UniSTSRGSC3.4
CeleraX1,795,028 - 1,795,141UniSTS
Cytogenetic MapXq11.1UniSTS
Cytogenetic MapXq12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 36 11 8
Low 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB158253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI060060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI712552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG668593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO572305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV728203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000039911   ⟹   ENSRNOP00000048890
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,227,392 - 1,239,073 (-)Ensembl
Rnor_6.0 EnsemblX1,379,194 - 1,390,873 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097792   ⟹   ENSRNOP00000082142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,234,872 - 1,239,071 (-)Ensembl
RefSeq Acc Id: NM_001033663   ⟹   NP_001028835
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,234,858 - 1,239,073 (-)NCBI
Rnor_6.0X1,386,658 - 1,390,873 (-)NCBI
Rnor_5.0X2,194,385 - 2,206,064 (-)NCBI
RGSC_v3.4X12,556,904 - 12,568,583 (-)RGD
CeleraX1,802,653 - 1,806,868 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022532   ⟹   NP_071977
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,227,392 - 1,239,073 (-)NCBI
Rnor_6.0X1,379,194 - 1,390,873 (-)NCBI
Rnor_5.0X2,194,385 - 2,206,064 (-)NCBI
RGSC_v3.4X12,556,904 - 12,568,583 (-)RGD
CeleraX1,795,227 - 1,806,868 (-)RGD
Sequence:
RefSeq Acc Id: XM_039100021   ⟹   XP_038955949
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,227,392 - 1,292,356 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_071977   ⟸   NM_022532
- Peptide Label: isoform 1
- UniProtKB: P14056 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001028835   ⟸   NM_001033663
- Peptide Label: isoform 2
- UniProtKB: Q6P9W2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000048890   ⟸   ENSRNOT00000039911
RefSeq Acc Id: XP_038955949   ⟸   XM_039100021
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000082142   ⟸   ENSRNOT00000097792
Protein Domains
Phorbol-ester/DAG-type   Protein kinase   RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14056-F1-model_v2 AlphaFold P14056 1-604 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701692
Promoter ID:EPDNEW_R12216
Type:multiple initiation site
Name:Araf_1
Description:A-Raf proto-oncogene, serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X1,390,865 - 1,390,925EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2148 AgrOrtholog
BioCyc Gene G2FUF-3198 BioCyc
Ensembl Genes ENSRNOG00000010838 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000048890 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000082142 ENTREZGENE
  ENSRNOP00000082142.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039911 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000097792 ENTREZGENE
  ENSRNOT00000097792.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7930982 IMAGE-MGC_LOAD
InterPro C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RBD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64363 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124609 IMAGE-MGC_LOAD
NCBI Gene 64363 ENTREZGENE
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot
  RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Araf PhenoGen
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228361
UniProt A0A8I5ZXA9_RAT UniProtKB/TrEMBL
  ARAF_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P9W2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-09 Araf  A-Raf proto-oncogene, serine/threonine kinase  Araf  v-raf murine sarcoma 3611 viral oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Araf  v-raf murine sarcoma 3611 viral oncogene homolog  Araf1  v-raf oncogene homolog 1 (murine sarcoma 3611 virus)  Symbol and Name updated 1299863 APPROVED
2004-12-14 Araf1  v-raf oncogene homolog 1 (murine sarcoma 3611 virus)    v-raf murine sarcoma 3611 viral oncogene homolog 1  Name updated 1299863 APPROVED
2002-06-10 Araf1  v-raf murine sarcoma 3611 viral oncogene homolog 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in heart and liver throughout lifespan 70317
gene_function phosphorylates protein serine/threonine residues 70317
gene_product member of the raf protein-Ser/Thr kinase family 70317
gene_protein 67 kDa 70317