Gene: Araf (A-Raf proto-oncogene, serine/threonine kinase) Rattus norvegicus
Symbol: Araf
Name: A-Raf proto-oncogene, serine/threonine kinase
Description: ENCODES a protein that exhibits MAP kinase kinase kinase activity; protein serine/threonine kinase activity (ortholog); INVOLVED IN protein phosphorylation; immortalization of host cell (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); lung adenocarcinoma (ortholog); Melanoma (ortholog); FOUND IN cytosol; mitochondrion (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A-Raf proto-oncogene serine/threonine-protein kinase; Araf1; proto-oncogene A-Raf; proto-oncogene A-Raf-1; Raf related protein; Ras-binding protein; serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog; v-raf murine sarcoma 3611 viral oncogene homolog 1; v-raf oncogene homolog 1 (murine sarcoma 3611 virus)
Homo sapiens (human) : ARAF (A-Raf proto-oncogene, serine/threonine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Araf (Araf proto-oncogene, serine/threonine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Araf (A-Raf proto-oncogene, serine/threonine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : ARAF (A-Raf proto-oncogene, serine/threonine kinase)
Canis lupus familiaris (dog) : ARAF (A-Raf proto-oncogene, serine/threonine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Araf (A-Raf proto-oncogene, serine/threonine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X1,369,534 - 1,391,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X2,194,385 - 2,206,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,556,904 - 12,568,583 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X12,562,471 - 12,572,791 (-)NCBI
CeleraX1,795,227 - 1,806,868 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Araf
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2148
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-02-06
Status: ACTIVE