LOC103231895 (serine/threonine-protein kinase A-Raf) - Rat Genome Database

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Pathways
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Gene: LOC103231895 (serine/threonine-protein kinase A-Raf) Chlorocebus sabaeus
Analyze
Symbol: LOC103231895 (Ensembl: ARAF)
Name: serine/threonine-protein kinase A-Raf (Ensembl:A-Raf proto-oncogene, serine/threonine kinase)
RGD ID: 18436341
Description: ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Breast Neoplasms (ortholog); congenital disorder of glycosylation type IIm (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: A-Raf proto-oncogene, serine/threonine kinase; ARAF
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,738,406 - 44,748,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,740,181 - 44,748,550 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366656638,210 - 47,870 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
mitochondrion  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC103231895
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,738,406 - 44,748,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,740,181 - 44,748,550 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366656638,210 - 47,870 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ARAF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,561,205 - 47,571,908 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,561,205 - 47,571,908 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,420,604 - 47,431,307 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,305,522 - 47,316,264 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X47,176,760 - 47,187,553NCBI
CeleraX51,615,774 - 51,626,577 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX45,132,731 - 45,143,540 (+)NCBIHuRef
CHM1_1X47,451,606 - 47,462,422 (+)NCBICHM1_1
T2T-CHM13v2.0X46,971,095 - 46,981,798 (+)NCBIT2T-CHM13v2.0
Araf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,663,946 - 20,726,760 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,664,053 - 20,726,758 (+)EnsemblGRCm39 Ensembl
GRCm38X20,797,707 - 20,860,521 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,797,814 - 20,860,519 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,425,669 - 20,437,647 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,005,557 - 20,017,477 (+)NCBIMGSCv36mm8
CeleraX18,979,682 - 18,991,660 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.3NCBI
Araf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,780,932 - 3,845,919 (-)NCBIGRCr8
mRatBN7.2X1,227,392 - 1,292,356 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,227,392 - 1,239,073 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,255,531 - 1,267,209 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,731,222 - 4,742,902 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,052,386 - 1,064,071 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,369,534 - 1,391,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,379,194 - 1,390,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,194,385 - 2,206,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,556,904 - 12,568,583 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,562,471 - 12,572,791 (-)NCBI
CeleraX1,795,227 - 1,806,868 (-)NCBICelera
Cytogenetic MapXq11NCBI
Araf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516521,479 - 533,212 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516521,479 - 532,980 (-)NCBIChiLan1.0ChiLan1.0
ARAF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,187,387 - 49,198,328 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,190,579 - 49,201,699 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,997,026 - 40,007,783 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,893,153 - 47,904,643 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,893,153 - 47,904,643 (+)Ensemblpanpan1.1panPan2
ARAF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,180,082 - 41,191,579 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,180,250 - 41,191,310 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,555,116 - 15,566,605 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,314,276 - 41,325,765 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,314,438 - 41,325,764 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,301,898 - 41,313,372 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,290,159 - 41,301,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,382,798 - 41,394,286 (+)NCBIUU_Cfam_GSD_1.0
Araf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,482,616 - 33,494,254 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,323,355 - 13,335,224 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650213,323,365 - 13,335,003 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARAF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,078,206 - 42,090,250 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,078,202 - 42,090,250 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,388,650 - 47,400,702 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXp13NCBI
Araf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978100,505 - 110,646 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462497899,605 - 110,645 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 10 31
Low 10 29
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011719   ⟹   ENSCSAP00000009783
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 EnsemblX44,740,181 - 44,748,550 (+)Ensembl
RefSeq Acc Id: XM_037995862   ⟹   XP_037851790
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366656638,210 - 47,870 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037851790 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009783.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000009783   ⟸   ENSCSAT00000011719
RefSeq Acc Id: XP_037851790   ⟸   XM_037995862
- UniProtKB: A0A0D9RME4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013622 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011719.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RBD_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report csab:103231895 UniProtKB/TrEMBL
NCBI Gene ARAF ENTREZGENE
PANTHER NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE UniProtKB/TrEMBL
  SERINE-THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART RBD UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A0D9RME4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LOC103231895  serine/threonine-protein kinase A-Raf  ARAF  A-Raf proto-oncogene, serine/threonine kinase  Symbol and/or name change 5135510 APPROVED