ARAF (A-Raf proto-oncogene, serine/threonine kinase)

Gene: ARAF (A-Raf proto-oncogene, serine/threonine kinase) Canis lupus familiaris

Analyze

Symbol:

ARAF

Name:

A-Raf proto-oncogene, serine/threonine kinase

RGD ID:

12402597

Description:

ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Breast Neoplasms (ortholog); congenital disorder of glycosylation type IIm (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	41,180,082 - 41,191,579 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	41,180,250 - 41,191,310 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	15,555,116 - 15,566,605 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	41,314,276 - 41,325,765 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	41,314,438 - 41,325,764 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	41,301,898 - 41,313,372 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	41,290,159 - 41,301,648 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	41,382,798 - 41,394,286 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Breast Neoplasms (ISO)

congenital disorder of glycosylation type IIm (ISO)

genetic disease (ISO)

high grade glioma (ISO)

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (ISO)

lung adenocarcinoma (ISO)

lung non-small cell carcinoma (ISO)

neurodegeneration with brain iron accumulation 5 (ISO)

papillary renal cell carcinoma (ISO)

skin melanoma (ISO)

Sporadic Papillary Renal Cell Carcinoma (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked epilepsy with variable learning disabilities and behavior disorders (ISO)

X-linked severe congenital neutropenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of apoptotic process (IEA)

positive regulation of peptidyl-serine phosphorylation (IEA)

protein phosphorylation (ISO)

Ras protein signal transduction (IEA)

regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA)

regulation of TOR signaling (IEA)

signal transduction (IEA)

Cellular Component

cytoplasm (IEA)

mitochondrion (IEA)

Molecular Function

ATP binding (IEA)

MAP kinase kinase kinase activity (ISO)

metal ion binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein serine/threonine kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

the extracellular signal-regulated Raf/Mek/Erk signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ARAF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	41,180,082 - 41,191,579 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	41,180,250 - 41,191,310 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	15,555,116 - 15,566,605 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	41,314,276 - 41,325,765 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	41,314,438 - 41,325,764 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	41,301,898 - 41,313,372 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	41,290,159 - 41,301,648 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	41,382,798 - 41,394,286 (+)	NCBI		UU_Cfam_GSD_1.0

ARAF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	47,561,205 - 47,571,908 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	47,561,205 - 47,571,908 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	47,420,604 - 47,431,307 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	47,305,522 - 47,316,264 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	47,176,760 - 47,187,553	NCBI
Celera	X	51,615,774 - 51,626,577 (+)	NCBI		Celera
Cytogenetic Map	X	p11.3	NCBI
HuRef	X	45,132,731 - 45,143,540 (+)	NCBI		HuRef
CHM1_1	X	47,451,606 - 47,462,422 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	46,971,095 - 46,981,798 (+)	NCBI		T2T-CHM13v2.0

Araf
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	20,663,946 - 20,726,760 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	20,664,053 - 20,726,758 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	20,797,707 - 20,860,521 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	20,797,814 - 20,860,519 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	20,425,669 - 20,437,647 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	20,005,557 - 20,017,477 (+)	NCBI		MGSCv36	mm8
Celera	X	18,979,682 - 18,991,660 (+)	NCBI		Celera
Cytogenetic Map	X	A1.3	NCBI
cM Map	X	16.3	NCBI

Araf
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	3,780,932 - 3,845,919 (-)	NCBI		GRCr8
mRatBN7.2	X	1,227,392 - 1,292,356 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	1,227,392 - 1,239,073 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	1,255,531 - 1,267,209 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	4,731,222 - 4,742,902 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	1,052,386 - 1,064,071 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	1,369,534 - 1,391,603 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	1,379,194 - 1,390,873 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	2,194,385 - 2,206,064 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	12,556,904 - 12,568,583 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	12,562,471 - 12,572,791 (-)	NCBI
Celera	X	1,795,227 - 1,806,868 (-)	NCBI		Celera
Cytogenetic Map	X	q11	NCBI

Araf
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955516	521,479 - 533,212 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955516	521,479 - 532,980 (-)	NCBI	ChiLan1.0	ChiLan1.0

ARAF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	49,187,387 - 49,198,328 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	49,190,579 - 49,201,699 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	39,997,026 - 40,007,783 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	47,893,153 - 47,904,643 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	47,893,153 - 47,904,643 (+)	Ensembl	panpan1.1		panPan2

Araf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	33,482,616 - 33,494,254 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936502	13,323,355 - 13,335,224 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936502	13,323,365 - 13,335,003 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARAF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	42,078,206 - 42,090,250 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	42,078,202 - 42,090,250 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	47,388,650 - 47,400,702 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	X	p13	NCBI

LOC103231895
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	44,738,406 - 44,748,996 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	44,740,181 - 44,748,550 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666566	38,210 - 47,870 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Araf
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624978	100,505 - 110,646 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624978	99,605 - 110,645 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ARAF
61 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5	5	22	6	6	6	6	6	12		10	6
Low										8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_014111600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038449903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038523346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038587314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038651825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000039	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000024017 ⟹ ENSCAFP00000022298

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	X	41,180,250 - 41,191,310 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845054117 ⟹ ENSCAFP00845042519

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	X	41,314,438 - 41,325,749 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845054125 ⟹ ENSCAFP00845042527

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	X	41,314,443 - 41,325,764 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845054135 ⟹ ENSCAFP00845042537

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	X	41,314,505 - 41,325,762 (+)	Ensembl

RefSeq Acc Id:

XM_014111600 ⟹ XP_013967075

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	X	41,180,082 - 41,191,579 (+)	NCBI
Dog10K_Boxer_Tasha	X	15,555,116 - 15,566,605 (+)	NCBI

Sequence:

show sequence

TCAGAGCCTGACGTTTCGCGCAGCCCCTCCTGATCCGGAACACGACCCACATTCCACCGGTCCT
CCTTTGACAGGCGTGACCCTAACCAATAAGGATGGAGGGCTGAATCCGGCGGAGCCAATGGTGA
AAGTCCGAGGGGCGGCGGAGGCGGACTCTGCGAGGAAACAAGAAGACAGGCCCAAGATGGAGGC
GGCGGTGGCCGTAGCGGCGTGACAGGAGCCCCATGGCACCTGCTCAGCCCCGCCTCGGCCCGTC
TTGACAAAGTCCTAGGCTCCATGGAGCCACCACGGGGCCCCCCTGCCAACGGGGCCGAGCCGTC
CCGGGCAGTGGGCACTGTCAAAGTATACCTGCCCAACAAGCAACGCACCGTGGTGACTGTCCGG
GATGGCATGAGTGTCTACGACTCTCTTGACAAGGCCCTCAAGGTACGGGGTCTCAATCAGGATT
GCTGTGTGGTCTACCGGCTCATTGAGGGGCGAAAGACAGTCACTGCCTGGGACACAGCCATTGC
CCCCCTGGATGGAGAGGAGCTCATTGTAGAGGTCCTCGAAGACGTCCCACTGACCATGCACAAT
TTTGTACGGAAGACGTTCTTCAGCCTGGCATTCTGCGACTTCTGCCTTAAGTTTCTGTTCCATG
GCTTCCGCTGCCAAACCTGTGGCTACAAGTTCCACCAGCATTGTTCCTCCAAGGTCCCCACAGT
CTGTGTTGACATGAGTACCAACTGCCGACAGTTTTACCACAGTGTCCAGGATTTGTCCGGAGGC
TCCAGACAGCACGAAGCTCCCTCAAACCGCCCCTTGAATGAGCCGCTAACCCCTCAGGGTCCCA
GCTCCTGCACCCAGCACCGCGACCCTGAGCACTTTCCCTTCCCTGCCCCTGCCAACACCCCACT
CCAGCGCATCCGCTCCACATCCACTCCCAACGTCCATATGGTCAGCACCACAGCCCCCATGGAC
TCCAGCCTCATCCAGCTCACTGCCCAGAGTTTTAGCACCGATGCTGCTGGTAGTAGAGGTGGTG
GTGACGGAGCCCCTCGGGGGAGCCCCAGCCCGGCCAGCGTGNTCTCGGGGAGGAAGTCCCCACA
TTCCAAGTCCCCGTCAGAGCAGCGGGAGCGGAAGTCCGTGGCTGATGACAAGAAGAAAGTGAAG
AATCTGGGGTACCGGGACTCCGGCTATTACTGGGAGGTGCCACCCAGTGAGGTGCAGCTGCTGA
AGAGGATTGGGACGGGCTCGTTTGGCACTGTGTTTCGCGGGCGGTGGCATGGCGATGTGGCTGT
GAAGGTGCTCAAGGTGGCCCAGCCCACAGCTGAGCAGGCCCAGGCCTTCAAGAATGAGATGCAG
GTGCTCAGGAAGACCCGTCATGTCAACATCTTGCTGTTCATGGGTTTCATGACCCGGCCAGGAT
TTGCCATCATCACACAGTGGTGTGAGGGCTCCAGCCTCTACCACCACCTGCATGTGGCCGACAC
ACGCTTCGACATGGTCCAGCTCATTGATGTGGCCCGACAGACTGCCCAGGGCATGGACTACCTC
CATGCCAAGAACATCATCCACCGAGATCTCAAGTCTAACAACATCTTCCTACATGAGGGGCTCA
CAGTGAAGATTGGTGATTTTGGCCTGGCCACAGTGAAGACGCGGTGGAGTGGGGCCCAGCCCTT
GGAGCAGCCCTCAGGCTCTGTACTGTGGATGGCAGCTGAGGTGATCCGTATGCAGGACCCGAAC
CCCTACAGCTTCCAATCGGATGTCTACGCCTATGGGGTTGTGCTCTATGAGCTCATGACCGGCT
CACTGCCTTACAGCCACATTGGCAGCCGTGACCAGATTATCTTTATGGTGGGCCGTGGTTATCT
GTCCCCGGACCTCAGCAAAATCTCCAGCAACTGCCCCAAGGCCATGCGGCGCCTGCTGTCTGAC
TGCCTCAAGTTCCAGCGGGAGGAACGTCCCCTCTTCCCCCAGATCCTGGCCACGATTGAGCTGC
TGCAGCGGTCACTCCCCAAGATTGAGCGGAGTGCCTCCGAACCCTCCTTGCACCGCACCCAGGC
TGATGAGTTGCCCGCCTGCCTACTCAGCGCAGCCCGCCTTGTGCCTTAGGCCCTGCCCCCAGTC
ACCAGGGAACCAGTCTCAGCCTGCCATGCCAAGGAGCCCTGCCCACCAATCAGTGTTCTGTCTC
TGCCCTGATACTGCCTCAGGATCCCCCATACCCATCCTGGGAGATGGAGGTATCCCCATGTGCT
TTTCCAGTTCCTCTGGAAGCAGGGGGCCCCCAAAGACCGAGACCCCTGCTTCCTCCATAATTTG
GTTTCCTCTTGGCTTTGGGGATAACTTCTAAATCTGGGAGCTCCTCTATCTCCAAGCTGGGCTT
TGTGGCAGGGATTCCACTCAGAACCTCTCTGGAATTTGTGCCTGATGTGCCTTCCACTGGATTT
TGGGGTCCCCAGCACCCCGTGTGGATTTGGGGGGTCCCCTCTGTGTCTTCCCTACCATTCAAGG
ACTCCCCTCTTCACCAAGAAGTACAGAATTCTGCTGGGCC

hide sequence

RefSeq Acc Id:

XM_038449903 ⟹ XP_038305831

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	X	41,314,276 - 41,325,765 (+)	NCBI

RefSeq Acc Id:

XM_038523346 ⟹ XP_038379274

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	X	41,301,898 - 41,313,372 (+)	NCBI

RefSeq Acc Id:

XM_038587314 ⟹ XP_038443242

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	X	41,382,798 - 41,394,286 (+)	NCBI

RefSeq Acc Id:

XM_038651825 ⟹ XP_038507753

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	X	41,290,159 - 41,301,648 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_013967075	(Get FASTA)	NCBI Sequence Viewer
	XP_038305831	(Get FASTA)	NCBI Sequence Viewer
	XP_038379274	(Get FASTA)	NCBI Sequence Viewer
	XP_038443242	(Get FASTA)	NCBI Sequence Viewer
	XP_038507753	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000022298.4
	ENSCAFP00000067319.1
	ENSCAFP00000071017.1
	ENSCAFP00040029106.1
	ENSCAFP00040029176.1
	ENSCAFP00845042519.1
	ENSCAFP00845042527
	ENSCAFP00845042527.1
	ENSCAFP00845042537.1

RefSeq Acc Id:

XP_013967075 ⟸ XM_014111600

- UniProtKB:

A0A8C0LB93 (UniProtKB/TrEMBL), A0A8C0T3V7 (UniProtKB/TrEMBL), A0A8I3S7N0 (UniProtKB/TrEMBL), A0A8P0PLJ1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRL
IEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTC
GYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEAPSNRPLNEPLTPQGPSSCTQHR
DPEHFPFPAPANTPLQRIRSTSTPNVHMVSTTAPMDSSLIQLTAQSFSTDAAGSRGGGDGAPRG
SPSPASVXSGRKSPHSKSPSEQRERKSVADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGS
FGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQW
CEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDF
GLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHI
GSRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPK
IERSASEPSLHRTQADELPACLLSAARLVP

hide sequence

RefSeq Acc Id:

ENSCAFP00000022298 ⟸ ENSCAFT00000024017

RefSeq Acc Id:

XP_038379274 ⟸ XM_038523346

RefSeq Acc Id:

XP_038507753 ⟸ XM_038651825

RefSeq Acc Id:	XP_038305831 ⟸ XM_038449903
- UniProtKB:	A0A8C0LB93 (UniProtKB/TrEMBL), A0A8C0T3V7 (UniProtKB/TrEMBL), A0A8I3S7N0 (UniProtKB/TrEMBL), A0A8P0PLJ1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038443242 ⟸ XM_038587314
- UniProtKB:	A0A8C0LB93 (UniProtKB/TrEMBL), A0A8C0T3V7 (UniProtKB/TrEMBL), A0A8I3S7N0 (UniProtKB/TrEMBL), A0A8P0PLJ1 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845042527 ⟸ ENSCAFT00845054125

RefSeq Acc Id:

ENSCAFP00845042519 ⟸ ENSCAFT00845054117

RefSeq Acc Id:

ENSCAFP00845042537 ⟸ ENSCAFT00845054135

Protein Domains

Phorbol-ester/DAG-type Protein kinase RBD

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000015115	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00040018104	UniProtKB/TrEMBL
	ENSCAFG00845030502	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000024017.5	UniProtKB/TrEMBL
	ENSCAFT00000096615.1	UniProtKB/TrEMBL
	ENSCAFT00000104883.1	UniProtKB/TrEMBL
	ENSCAFT00040033445.1	UniProtKB/TrEMBL
	ENSCAFT00040033528.1	UniProtKB/TrEMBL
	ENSCAFT00845054117.1	UniProtKB/TrEMBL
	ENSCAFT00845054125	ENTREZGENE
	ENSCAFT00845054125.1	UniProtKB/TrEMBL
	ENSCAFT00845054135.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.60.20	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	C1-like_sf	UniProtKB/TrEMBL
	DAG/PE-bd	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	PE/DAG-bd	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	RBD_dom	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
	Ubiquitin-like_domsf	UniProtKB/TrEMBL
NCBI Gene	ARAF	ENTREZGENE
PANTHER	NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE	UniProtKB/TrEMBL
	SERINE-THREONINE PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	C1_1	UniProtKB/TrEMBL
	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL
	RBD	UniProtKB/TrEMBL
PRINTS	DAGPEDOMAIN	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
	RBD	UniProtKB/TrEMBL
	ZF_DAG_PE_1	UniProtKB/TrEMBL
	ZF_DAG_PE_2	UniProtKB/TrEMBL
SMART	RBD	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
	SM00109	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54236	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
	SSF57889	UniProtKB/TrEMBL
UniProt	A0A8C0LB93	ENTREZGENE
	A0A8C0T3V7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0Z196_CANLF	UniProtKB/TrEMBL
	A0A8I3Q3R4_CANLF	UniProtKB/TrEMBL
	A0A8I3Q6Q1_CANLF	UniProtKB/TrEMBL
	A0A8I3S7N0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NGM5_CANLF	UniProtKB/TrEMBL
	A0A8P0PLJ1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TIR3_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:38024	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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