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Gene: Araf (Araf proto-oncogene, serine/threonine kinase) Mus musculus
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Symbol: Araf
Name: Araf proto-oncogene, serine/threonine kinase
RGD ID: 10188
Description: Predicted to have MAP kinase kinase kinase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; regulation of TOR signaling; and regulation of cellular protein metabolic process. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and retina. Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; acute myeloid leukemia pathway; ceramide signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200013E08Rik; A-; A-Raf; A-Raf proto-oncogene serine/threonine-protein kinase; Ar; Araf1; AW495444; proto-oncogene A-Raf; raf-related oncogene; serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog 1
Orthologs:
Homo sapiens (human) : ARAF (A-Raf proto-oncogene, serine/threonine kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Araf (A-Raf proto-oncogene, serine/threonine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Araf (A-Raf proto-oncogene, serine/threonine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : ARAF (A-Raf proto-oncogene, serine/threonine kinase)
Canis lupus familiaris (dog) : ARAF (A-Raf proto-oncogene, serine/threonine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Araf (A-Raf proto-oncogene, serine/threonine kinase)
Sus scrofa (pig) : ARAF (A-Raf proto-oncogene, serine/threonine kinase)
Chlorocebus sabaeus (African green monkey) : ARAF (A-Raf proto-oncogene, serine/threonine kinase)
Heterocephalus glaber (naked mole-rat) : Araf (A-Raf proto-oncogene, serine/threonine kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 EnsemblX20,797,814 - 20,860,519 (+)EnsemblGRCm38mm10GRCm38
GRCm38X20,797,707 - 20,860,521 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X20,425,669 - 20,437,647 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X20,005,557 - 20,017,477 (+)NCBImm8
CeleraX18,979,682 - 18,991,660 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Araf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10188
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.