Gabrb1 (gamma-aminobutyric acid type A receptor subunit beta1) - Rat Genome Database

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Gene: Gabrb1 (gamma-aminobutyric acid type A receptor subunit beta1) Rattus norvegicus
Analyze
Symbol: Gabrb1
Name: gamma-aminobutyric acid type A receptor subunit beta1
RGD ID: 2649
Description: Enables GABA receptor binding activity; GABA-A receptor activity; and ion channel activity. Involved in several processes, including cellular response to histamine; central nervous system neuron development; and response to progesterone. Located in several cellular components, including dendrite; nuclear envelope; and plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse; postsynaptic specialization membrane; and presynaptic active zone membrane. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 45. Orthologous to human GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GABA(A) receptor subunit beta-1; gamma-aminobutyric acid (GABA) A receptor, beta 1; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1; Gamma-aminobutyric acid receptor beta 1; gamma-aminobutyric acid receptor subunit beta-1; gamma-aminobutyric acid receptor, subunit beta 1; gamma-aminobutyric acid type A receptor beta 1 subunit; GARB1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Gabrb1Tn(pb-Bhr2)1Wmukf  
Is Marker For: Strains:   SD   WKY-Tg(Gabrb1Tn(pb-Bhr2)1Wmukf)  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21436,068,725 - 36,548,946 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1436,080,393 - 36,548,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1436,416,572 - 36,894,556 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01437,721,331 - 38,199,312 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01436,209,655 - 36,687,660 (-)NCBIRnor_WKY
Rnor_6.01438,631,192 - 39,112,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,643,385 - 39,112,600 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01438,453,142 - 38,924,073 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41438,530,259 - 39,005,615 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11438,532,649 - 39,008,000 (-)NCBI
Celera1435,310,585 - 35,771,142 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2,2-trifluoroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicuculline  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylparaben  (EXP)
chloral hydrate  (ISO)
Chloralose  (ISO)
chlorobutanol  (ISO)
cocaine  (EXP)
DDE  (EXP)
delta-hexachlorocyclohexane  (ISO)
dexamethasone  (EXP)
diazepam  (EXP,ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
endosulfan  (ISO)
enflurane  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ether  (ISO)
etomidate  (ISO)
felbamate  (ISO)
fipronil  (ISO)
flumazenil  (EXP)
flurotyl  (EXP)
folic acid  (ISO)
gamma-aminobutyric acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
isoflurane  (ISO)
kainic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
linuron  (EXP)
methoxyflurane  (ISO)
muscimol  (EXP)
N,N-diethyl-m-toluamide  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
pentobarbital  (EXP,ISO)
permethrin  (EXP)
picrotoxin  (ISO)
picrotoxinin  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP)
propofol  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sodium arsenite  (ISO)
tert-butanol  (ISO)
tetrachloromethane  (EXP)
toluene  (ISO)
tribromoethanol  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zaleplon  (EXP)
zolpidem  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors. Brandon NJ, etal., J Neurosci 2002 Aug 1;22(15):6353-61.
2. Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons. Cai X, etal., J Physiol 2002 May 1;540(Pt 3):743-59.
3. Subcellular localization of GABAB receptor subunits in rat globus pallidus. Chen L, etal., J Comp Neurol. 2004 Jun 28;474(3):340-52. doi: 10.1002/cne.20143.
4. Investigation of autism and GABA receptor subunit genes in multiple ethnic groups. Collins AL, etal., Neurogenetics. 2006 Jul;7(3):167-74. Epub 2006 Jun 13.
5. mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism. Fatemi SH, etal., J Autism Dev Disord. 2010 Jun;40(6):743-50.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Withdrawal from progesterone increases expression of alpha4, beta1, and delta GABA(A) receptor subunits in neurons in the periaqueductal gray matter in female Wistar rats. Griffiths J and Lovick T, J Comp Neurol. 2005 May 23;486(1):89-97.
9. GABAergic neurones in the rat periaqueductal grey matter express alpha4, beta1 and delta GABAA receptor subunits: plasticity of expression during the estrous cycle. Griffiths JL and Lovick TA, Neuroscience. 2005;136(2):457-66. Epub 2005 Oct 13.
10. Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit. Huntsman MM and Huguenard JR, J Physiol. 2006 Apr 15;572(Pt 2):459-75. doi: 10.1113/jphysiol.2006.106617. Epub 2006 Feb 9.
11. Prenatal alteration and distribution of the GABA(B1) and GABA(B2) receptor subunit mRNAs during rat central nervous system development. Li S, etal., Brain Res Dev Brain Res. 2004 Jun 21;150(2):141-50.
12. Expression of gamma-aminobutyric acid A receptor subunits alpha1, beta1, gamma2 mRNA in rats with hepatic encephalopathy. Li XQ, etal., World J Gastroenterol. 2005 Jun 7;11(21):3319-22.
13. Cloning and expression of a novel rat GABAA receptor. Lolait SJ, etal., FEBS Lett. 1989 Mar 27;246(1-2):145-8.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Identification, coassembly, and activity of gamma-aminobutyric acid receptor subunits in renal proximal tubular cells. Sarang SS, etal., J Pharmacol Exp Ther. 2008 Jan;324(1):376-82. Epub 2007 Oct 24.
20. Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. Saras A, etal., J Biol Chem. 2008 Apr 18;283(16):10470-5. doi: 10.1074/jbc.M709993200. Epub 2008 Feb 15.
21. Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptors. Sergeeva OA, etal., J Biol Chem. 2010 Jul 30;285(31):23985-93. Epub 2010 May 28.
22. Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors. Shan Q, etal., J Biol Chem 2002 Nov 22;277(47):44845-53.
23. The rat beta 1-subunit of the GABAA receptor forms a picrotoxin-sensitive anion channel open in the absence of GABA. Sigel E, etal., FEBS Lett. 1989 Nov 6;257(2):377-9.
24. GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. Ymer S, etal., EMBO J 1989 Jun;8(6):1665-70.
Additional References at PubMed
PMID:1977069   PMID:9039914   PMID:15014066   PMID:15708482   PMID:18338268   PMID:21242699   PMID:21735059   PMID:22215379   PMID:23176253   PMID:26950270   PMID:29706582   PMID:33636639  


Genomics

Comparative Map Data
Gabrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21436,068,725 - 36,548,946 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1436,080,393 - 36,548,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1436,416,572 - 36,894,556 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01437,721,331 - 38,199,312 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01436,209,655 - 36,687,660 (-)NCBIRnor_WKY
Rnor_6.01438,631,192 - 39,112,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,643,385 - 39,112,600 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01438,453,142 - 38,924,073 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41438,530,259 - 39,005,615 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11438,532,649 - 39,008,000 (-)NCBI
Celera1435,310,585 - 35,771,142 (-)NCBICelera
Cytogenetic Map14p11NCBI
GABRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38446,993,647 - 47,426,447 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl446,993,723 - 47,426,447 (+)EnsemblGRCh38hg38GRCh38
GRCh37447,033,584 - 47,428,464 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36446,728,336 - 47,123,202 (+)NCBINCBI36Build 36hg18NCBI36
Build 34446,874,506 - 47,269,373NCBI
Celera447,482,542 - 47,877,035 (+)NCBICelera
Cytogenetic Map4p12NCBI
HuRef446,352,751 - 46,747,922 (+)NCBIHuRef
CHM1_1447,032,490 - 47,427,496 (+)NCBICHM1_1
T2T-CHM13v2.0446,998,964 - 47,393,806 (+)NCBIT2T-CHM13v2.0
Gabrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39571,815,264 - 72,306,915 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl571,815,456 - 72,306,380 (+)EnsemblGRCm39 Ensembl
GRCm38571,657,921 - 72,149,572 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl571,658,113 - 72,149,037 (+)EnsemblGRCm38mm10GRCm38
MGSCv37572,091,255 - 72,528,483 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36571,979,151 - 72,416,379 (+)NCBIMGSCv36mm8
Celera568,964,933 - 69,390,319 (+)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.18NCBI
Gabrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554431,132,860 - 1,514,376 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554431,126,223 - 1,514,291 (-)NCBIChiLan1.0ChiLan1.0
GABRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1485,458,810 - 85,894,427 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl485,459,225 - 85,857,321 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0474,727,321 - 75,164,407 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GABRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11343,011,491 - 43,349,876 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1342,992,569 - 43,349,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1342,942,633 - 43,300,315 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01343,598,384 - 43,955,432 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11343,276,378 - 43,634,632 (+)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.01343,691,479 - 44,049,754 (+)NCBIUU_Cfam_GSD_1.0
Gabrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528532,699,565 - 33,078,224 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648213,220,236 - 13,586,209 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648213,219,962 - 13,593,868 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl836,978,547 - 37,355,008 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1836,978,014 - 37,354,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2839,176,670 - 39,275,449 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GABRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1272,829,385 - 3,254,292 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl272,832,450 - 3,217,326 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604748,873,122 - 49,316,579 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476119,600,946 - 20,017,278 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476119,595,802 - 20,019,368 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabrb1
2116 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:55
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000003170
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat

Markers in Region
D14Hmgc7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21436,269,082 - 36,269,300 (+)MAPPERmRatBN7.2
Rnor_6.01438,832,884 - 38,833,099NCBIRnor6.0
Rnor_5.01438,642,398 - 38,642,613UniSTSRnor5.0
RGSC_v3.41438,725,068 - 38,725,284RGDRGSC3.4
RGSC_v3.41438,725,069 - 38,725,284UniSTSRGSC3.4
Celera1435,501,589 - 35,501,804UniSTS
Cytogenetic Map14p11UniSTS
U14418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21436,080,606 - 36,080,713 (+)MAPPERmRatBN7.2
Rnor_6.01438,643,599 - 38,643,705NCBIRnor6.0
Rnor_5.01438,453,370 - 38,453,476UniSTSRnor5.0
RGSC_v3.41438,530,487 - 38,530,593UniSTSRGSC3.4
Celera1435,310,813 - 35,310,919UniSTS
Cytogenetic Map14p11UniSTS
RH94648  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21436,080,412 - 36,080,565 (+)MAPPERmRatBN7.2
Rnor_6.01438,643,405 - 38,643,557NCBIRnor6.0
Rnor_5.01438,453,176 - 38,453,328UniSTSRnor5.0
RGSC_v3.41438,530,293 - 38,530,445UniSTSRGSC3.4
Celera1435,310,619 - 35,310,771UniSTS
Cytogenetic Map14p11UniSTS
Gabrb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21436,080,435 - 36,081,128 (+)MAPPERmRatBN7.2
Rnor_6.01438,643,428 - 38,644,120NCBIRnor6.0
Rnor_5.01438,453,199 - 38,453,891UniSTSRnor5.0
RGSC_v3.41438,530,316 - 38,531,008UniSTSRGSC3.4
Celera1435,310,642 - 35,311,334UniSTS
Cytogenetic Map14p11UniSTS


Related Rat Strains
The following Strains have been annotated to Gabrb1


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23
Low 1 1 41 6
Below cutoff 25 9 4 5 4 6 7 8 17 22 7 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003170   ⟹   ENSRNOP00000003170
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1436,080,393 - 36,548,948 (-)Ensembl
Rnor_6.0 Ensembl1438,643,385 - 39,112,600 (-)Ensembl
RefSeq Acc Id: NM_012956   ⟹   NP_037088
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21436,080,380 - 36,548,946 (-)NCBI
Rnor_6.01438,643,371 - 39,112,598 (-)NCBI
Rnor_5.01438,453,142 - 38,924,073 (-)NCBI
RGSC_v3.41438,530,259 - 39,005,615 (-)RGD
Celera1435,310,585 - 35,771,142 (-)RGD
Sequence:
RefSeq Acc Id: XM_039091637   ⟹   XP_038947565
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21436,068,725 - 36,112,734 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037088 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947565 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA33493 (Get FASTA)   NCBI Sequence Viewer  
  EDL90004 (Get FASTA)   NCBI Sequence Viewer  
  P15431 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037088   ⟸   NM_012956
- Peptide Label: precursor
- UniProtKB: P15431 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003170   ⟸   ENSRNOT00000003170
RefSeq Acc Id: XP_038947565   ⟸   XM_039091637
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15431-F1-model_v2 AlphaFold P15431 1-474 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2649 AgrOrtholog
BioCyc Gene G2FUF-15842 BioCyc
Ensembl Genes ENSRNOG00000002327 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000003170 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003170 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  GABAAb_rcpt UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
KEGG Report rno:25450 UniProtKB/Swiss-Prot
NCBI Gene 25450 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PhenoGen Gabrb1 PhenoGen
PRINTS GABAARBETA UniProtKB/Swiss-Prot
  GABAARECEPTR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
TIGRFAMs LIC UniProtKB/Swiss-Prot
UniProt GBRB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Gabrb1  gamma-aminobutyric acid type A receptor beta 1 subunit  Gabrb1  gamma-aminobutyric acid (GABA) A receptor, beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabrb1  gamma-aminobutyric acid (GABA) A receptor, beta 1  Gabrb1  gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gabrb1  gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1    gamma-aminobutyric acid receptor, subunit beta 1  Name updated 1299863 APPROVED
2002-11-06 Gabrb1  gamma-aminobutyric acid receptor, subunit beta 1    Gamma-aminobutyric acid receptor beta 1  Name updated 625702 APPROVED
2002-06-10 Gabrb1  Gamma-aminobutyric acid receptor beta 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neuron cells of brain 625749
gene_process mediates in inhibitory neurotransmission in the brain 625749
gene_protein 58 kDa 625749
gene_regulation activated by C kinase (RACK-1) and protein kinase C (PKC) 625749
gene_regulation modulation of function occurs by the phosphorylation of residues within the intracellular domains of the receptor subunits by serine/threonine and tyrosine kinases 625749
gene_regulation RACK-1 increases GABA(A) receptor function in neurons by a PKC-dependent signaling pathway by way of activating the muscarinic acetylcholine receptors (mAChRs) 625749