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Gene: Jak3 (Janus kinase 3) Rattus norvegicus
Symbol: Jak3
Name: Janus kinase 3
RGD ID: 2940
Description: Predicted to have protein phosphatase binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of activated T cell proliferation; positive regulation of cytosolic calcium ion concentration; and positive regulation of nitric-oxide synthase biosynthetic process. Localizes to cytoplasm. Biomarker of tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; adult T-cell leukemia; juvenile myelomonocytic leukemia; and megakaryocytic leukemia. Orthologous to human JAK3 (Janus kinase 3); PARTICIPATES IN altered Jak-Stat signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH amphetamine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: JAK-3; Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; RATJAK3; tyrosine-protein kinase JAK3
Homo sapiens (human) : JAK3 (Janus kinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Jak3 (Janus kinase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jak3 (Janus kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : JAK3 (Janus kinase 3)
Canis lupus familiaris (dog) : JAK3 (Janus kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jak3 (Janus kinase 3)
Sus scrofa (pig) : JAK3 (Janus kinase 3)
Chlorocebus sabaeus (African green monkey) : JAK3 (Janus kinase 3)
Heterocephalus glaber (naked mole-rat) : Jak3 (Janus kinase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01620,107,471 - 20,120,678 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,109,200 - 20,120,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,968,486 - 19,981,132 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,878,139 - 18,889,441 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,878,136 - 18,889,439 (+)NCBI
Celera1618,589,820 - 18,601,138 (+)NCBICelera
Cytogenetic Map16p14NCBI
RH 3.4 Map16181.8RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Jak3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2940
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.