Jak3 (Janus kinase 3) - Rat Genome Database

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Gene: Jak3 (Janus kinase 3) Rattus norvegicus
Analyze
Symbol: Jak3 (Ensembl: Insl3)
Name: Janus kinase 3 (Ensembl:insulin-like 3)
RGD ID: 2940
Description: Predicted to enable growth hormone receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and protein phosphatase binding activity. Involved in several processes, including positive regulation of activated T cell proliferation; positive regulation of calcium ion transport; and positive regulation of nitric-oxide synthase biosynthetic process. Predicted to be located in cytoplasm; cytoskeleton; and endomembrane system. Predicted to be active in cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Used to study graft-versus-host disease. Biomarker of tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and severe combined immunodeficiency. Orthologous to human JAK3 (Janus kinase 3); PARTICIPATES IN altered Jak-Stat signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: JAK-3; Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; RATJAK3; tyrosine-protein kinase JAK3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,418,807 - 18,432,515 (+)NCBIGRCr8
mRatBN7.21618,386,330 - 18,398,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,386,405 - 18,398,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,437,879 - 18,449,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,570,477 - 19,581,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,490,818 - 18,502,120 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,107,471 - 20,120,678 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,109,200 - 20,120,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,968,486 - 19,981,132 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,878,139 - 18,889,441 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,878,136 - 18,889,439 (+)NCBI
Celera1618,589,820 - 18,601,138 (+)NCBICelera
RH 3.4 Map16181.8RGD
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Acute Lymphoblastic Leukemia, with Lymphomatous Features  (ISO)
acute megakaryocytic leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
adenosine deaminase deficiency  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
B-cell lymphoma  (ISO)
Cd4+ Lymphocyte Deficiency  (ISO)
cerebral malaria  (ISO)
Colonic Neoplasms  (IEP)
Edema  (ISO)
Experimental Arthritis  (IEP,IMP)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Diabetes Mellitus  (IEP)
genetic disease  (ISO)
graft-versus-host disease  (IMP,ISO)
hereditary spastic paraplegia  (ISO)
Hydrops Fetalis  (ISO)
Hyperalgesia  (IEP)
Hypoxia  (IEP)
juvenile myelomonocytic leukemia  (ISO)
Leukemoid Reaction  (ISO)
lymphopenia  (ISO)
Mediastinal Neoplasms  (ISO)
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1  (ISO)
Muscle Hypotonia  (ISO)
myeloproliferative neoplasm  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
NATURAL KILLER CELL ENTEROPATHY  (ISO)
severe combined immunodeficiency  (ISO)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive  (ISO)
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-Negative  (ISO)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive  (ISS)
T-cell acute lymphoblastic leukemia  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
T-cell prolymphocytic leukemia  (ISO)
tongue squamous cell carcinoma  (IEP)
Trichiasis  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
afimoxifene  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
baricitinib  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
ceritinib  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyanidin cation  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
genistein  (ISO)
hypochlorous acid  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylphenidate  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
paracetamol  (EXP,ISO)
PD 168393  (ISO)
PF-956980  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
prostaglandin E2  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (EXP)
tetraphene  (ISO)
tipifarnib  (EXP)
tofacitinib  (ISO)
trametinib  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
B cell differentiation  (ISO,ISS)
cell differentiation  (IBA)
cell surface receptor signaling pathway via JAK-STAT  (IBA)
cellular response to cytokine stimulus  (ISO)
cytokine-mediated signaling pathway  (IBA,IDA,IEA,ISO)
enzyme-linked receptor protein signaling pathway  (ISO,ISS)
growth hormone receptor signaling pathway via JAK-STAT  (IBA)
innate immune response  (IEA)
interleukin-15-mediated signaling pathway  (IEA,ISO)
interleukin-2-mediated signaling pathway  (IEA,ISO)
interleukin-4-mediated signaling pathway  (IEA,ISO)
interleukin-7-mediated signaling pathway  (ISO)
interleukin-9-mediated signaling pathway  (IEA,ISO)
intracellular signal transduction  (IBA,IEA,ISO,ISS)
negative regulation of complement-dependent cytotoxicity  (ISO)
negative regulation of dendritic cell cytokine production  (ISO,ISS)
negative regulation of FasL production  (ISO,ISS)
negative regulation of interleukin-10 production  (ISO,ISS)
negative regulation of interleukin-12 production  (ISO,ISS)
negative regulation of T cell activation  (ISO,ISS)
negative regulation of T-helper 1 cell differentiation  (ISO,ISS)
negative regulation of T-helper 17 cell lineage commitment  (ISO)
negative regulation of thymocyte apoptotic process  (ISO,ISS)
positive regulation of activated T cell proliferation  (IMP)
positive regulation of calcium ion transport  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of dendritic cell apoptotic process  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IMP)
positive regulation of T cell proliferation  (IDA)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of apoptotic process  (IBA)
regulation of T cell apoptotic process  (ISO,ISS)
response to interleukin-4  (ISO)
T cell homeostasis  (ISO,ISS)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Combined immunodeficiency evolving into predominant CD4+ lymphopenia caused by somatic chimerism in JAK3. Ban SA, etal., J Clin Immunol. 2014 Nov;34(8):941-53. doi: 10.1007/s10875-014-0088-2. Epub 2014 Sep 10.
2. Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts. Behbod F, etal., J Immunol. 2001 Mar 15;166(6):3724-32.
3. Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia. Bergmann AK, etal., Genes Chromosomes Cancer. 2014 Apr;53(4):309-16. doi: 10.1002/gcc.22141. Epub 2014 Jan 21.
4. Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. Bingisser RM, etal., J Immunol. 1998 Jun 15;160(12):5729-34.
5. Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome. Bixler GV, etal., BMC Med Genomics. 2011 May 15;4:40. doi: 10.1186/1755-8794-4-40.
6. An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria. Bongfen SE, etal., PLoS One. 2012;7(2):e31012. doi: 10.1371/journal.pone.0031012. Epub 2012 Feb 21.
7. Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Bunting KD, etal., Nat Med. 1998 Jan;4(1):58-64.
8. JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model. Degryse S, etal., Blood. 2014 Nov 13;124(20):3092-100. doi: 10.1182/blood-2014-04-566687. Epub 2014 Sep 5.
9. FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma. Elliott NE, etal., Blood. 2011 Oct 6;118(14):3911-21. doi: 10.1182/blood-2010-12-319467. Epub 2011 Aug 5.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4-nitroquinoline 1-oxide. Ge S, etal., Mol Med Rep. 2016 Mar;13(3):2561-9. doi: 10.3892/mmr.2016.4883. Epub 2016 Feb 8.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats. Kim BH, etal., Br J Pharmacol. 2011 Sep;164(1):106-18. doi: 10.1111/j.1476-5381.2011.01353.x.
14. Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase. Kirken RA, etal., J Biol Chem. 1994 Jul 22;269(29):19136-41.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Macchi P, etal., Nature. 1995 Sep 7;377(6544):65-8.
17. VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease. Mahajan S, etal., J Pharmacol Exp Ther. 2015 May;353(2):405-14. doi: 10.1124/jpet.114.221176. Epub 2015 Mar 11.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis. Milici AJ, etal., Arthritis Res Ther. 2008;10(1):R14. doi: 10.1186/ar2365. Epub 2008 Jan 30.
20. Localization of molecules involved in cytokine receptor signaling in the rat trigeminal ganglion. Mizuno M, etal., Brain Res Mol Brain Res. 1997 Feb;44(1):163-6.
21. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons. Orellana DI, etal., Neurotox Res. 2005 Nov;8(3-4):295-304.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. JAKs, STATs and Src kinases in hematopoiesis. Rane SG and Reddy EP, Oncogene 2002 May 13;21(21):3334-58.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies. Ross JA, etal., Leukemia. 2014 Apr;28(4):941-4. doi: 10.1038/leu.2013.309. Epub 2013 Oct 23.
32. Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: early target in the anticancer strategy. Saini MK, etal., Eur J Cancer Prev. 2013 May;22(3):215-28. doi: 10.1097/CEJ.0b013e3283584932.
33. Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Sakaguchi H, etal., Nat Genet. 2013 Aug;45(8):937-41. doi: 10.1038/ng.2698. Epub 2013 Jul 7.
34. Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. Stepkowski SM, etal., Blood. 2002 Jan 15;99(2):680-9.
35. Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases. Takahashi T and Shirasawa T, FEBS Lett 1994 Apr 4;342(2):124-8.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model. Uckun FM, etal., Blood. 2002 Jun 1;99(11):4192-9.
38. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Walters DK, etal., Cancer Cell. 2006 Jul;10(1):65-75.
39. Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A(2)-IIA in microvascular endothelial cells of the injured brain. Wang G, etal., J Neuroinflammation. 2012 Jul 12;9:170. doi: 10.1186/1742-2094-9-170.
40. [Changes of interleukin-6 and Janus kinases in rats with hypoxic pulmonary hypertension]. Wang GS, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2003 Nov;26(11):664-7.
41. Hemagglutinin from the H5N1 virus activates Janus kinase 3 to dysregulate innate immunity. Xu W, etal., PLoS One. 2012;7(2):e31721. doi: 10.1371/journal.pone.0031721. Epub 2012 Feb 16.
42. Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats. Yin L, etal., J Neuroimmunol. 2014 Sep 15;274(1-2):28-37. doi: 10.1016/j.jneuroim.2014.06.022. Epub 2014 Jun 28.
Additional References at PubMed
PMID:7538655   PMID:7594533   PMID:8022486   PMID:9498750   PMID:9973401   PMID:10485657   PMID:10872802   PMID:11909529   PMID:16020505   PMID:19220965   PMID:19233270   PMID:19414010  
PMID:19531027   PMID:21414324   PMID:22971540   PMID:24280217   PMID:26446793   PMID:28473442   PMID:30664158   PMID:33416962   PMID:33910370  


Genomics

Comparative Map Data
Jak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,418,807 - 18,432,515 (+)NCBIGRCr8
mRatBN7.21618,386,330 - 18,398,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,386,405 - 18,398,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,437,879 - 18,449,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,570,477 - 19,581,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,490,818 - 18,502,120 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,107,471 - 20,120,678 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,109,200 - 20,120,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,968,486 - 19,981,132 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,878,139 - 18,889,441 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,878,136 - 18,889,439 (+)NCBI
Celera1618,589,820 - 18,601,138 (+)NCBICelera
RH 3.4 Map16181.8RGD
Cytogenetic Map16p14NCBI
JAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,824,782 - 17,847,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,824,780 - 17,848,071 (-)EnsemblGRCh38hg38GRCh38
GRCh371917,935,591 - 17,958,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,797,961 - 17,819,800 (-)NCBINCBI36Build 36hg18NCBI36
Build 341917,797,960 - 17,819,800NCBI
Celera1917,837,310 - 17,860,555 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,500,992 - 17,524,212 (-)NCBIHuRef
CHM1_11917,935,132 - 17,958,532 (-)NCBICHM1_1
T2T-CHM13v2.01917,958,895 - 17,982,060 (-)NCBIT2T-CHM13v2.0
Jak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,129,027 - 72,143,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,128,940 - 72,143,219 (+)EnsemblGRCm39 Ensembl
GRCm38871,676,383 - 71,690,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,676,296 - 71,690,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,200,473 - 74,214,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,605,563 - 74,619,563 (+)NCBIMGSCv36mm8
Celera874,191,138 - 74,205,120 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
Jak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,401,642 - 3,411,643 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,399,895 - 3,412,018 (+)NCBIChiLan1.0ChiLan1.0
JAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,681,699 - 22,713,145 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,686,968 - 21,719,944 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,299,129 - 17,330,700 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,283,157 - 18,304,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,283,560 - 18,300,964 (-)Ensemblpanpan1.1panPan2
JAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,051,135 - 45,068,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,050,526 - 45,072,805 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,963,131 - 44,980,402 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,535,925 - 45,553,392 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,535,982 - 45,557,946 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,772,769 - 44,789,998 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,183,055 - 45,200,281 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,459,016 - 45,476,242 (+)NCBIUU_Cfam_GSD_1.0
Jak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,661,414 - 203,676,227 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,212,593 - 3,224,048 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,212,593 - 3,224,426 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,905,919 - 59,926,495 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,905,901 - 59,926,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,475,346 - 59,495,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,301,760 - 16,323,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,300,525 - 16,322,859 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660743,064,511 - 3,086,605 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,371,595 - 1,383,879 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,371,595 - 1,383,879 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Jak3
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:43
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000025312
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
D16Rat82  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,392,338 - 18,392,522 (+)MAPPERmRatBN7.2
Rnor_6.01620,114,475 - 20,114,658NCBIRnor6.0
Rnor_5.01619,974,929 - 19,975,112UniSTSRnor5.0
RGSC_v3.41618,883,254 - 18,883,437UniSTSRGSC3.4
RGSC_v3.41618,883,254 - 18,883,437RGDRGSC3.4
RGSC_v3.11618,883,252 - 18,883,435RGD
Celera1618,594,935 - 18,595,118UniSTS
RH 3.4 Map16186.4UniSTS
RH 3.4 Map16186.4RGD
RH 2.0 Map16165.9RGD
SHRSP x BN Map165.71RGD
Cytogenetic Map16p14UniSTS
RH142198  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map16181.8UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 8 19 8 14 4
Low 1 39 49 41 41 3 5 74 27 25 7 3
Below cutoff 5 6 2 5

Sequence


Ensembl Acc Id: ENSRNOT00000025312   ⟹   ENSRNOP00000025312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,386,405 - 18,398,536 (+)Ensembl
Rnor_6.0 Ensembl1620,110,148 - 20,120,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079784   ⟹   ENSRNOP00000071081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1620,109,200 - 20,120,446 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080146   ⟹   ENSRNOP00000073659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1620,110,148 - 20,120,662 (+)Ensembl
RefSeq Acc Id: NM_012855   ⟹   NP_036987
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,421,197 - 18,432,515 (+)NCBI
mRatBN7.21618,387,224 - 18,398,542 (+)NCBI
Rnor_6.01620,109,360 - 20,120,678 (+)NCBI
Rnor_5.01619,968,486 - 19,981,132 (+)NCBI
RGSC_v3.41618,878,139 - 18,889,441 (+)RGD
Celera1618,589,820 - 18,601,138 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771064   ⟹   XP_008769286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,418,807 - 18,432,515 (+)NCBI
mRatBN7.21618,386,330 - 18,398,542 (+)NCBI
Rnor_6.01620,107,472 - 20,120,678 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599993   ⟹   XP_017455482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,418,807 - 18,432,515 (+)NCBI
mRatBN7.21618,386,330 - 18,398,542 (+)NCBI
Rnor_6.01620,107,471 - 20,120,678 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094203   ⟹   XP_038950131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,421,297 - 18,432,515 (+)NCBI
mRatBN7.21618,387,315 - 18,398,542 (+)NCBI
RefSeq Acc Id: XM_063275068   ⟹   XP_063131138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,418,807 - 18,432,515 (+)NCBI
RefSeq Acc Id: XM_063275069   ⟹   XP_063131139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,418,807 - 18,432,515 (+)NCBI
RefSeq Acc Id: XR_005494533
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,418,807 - 18,432,116 (+)NCBI
mRatBN7.21618,386,330 - 18,398,542 (+)NCBI
RefSeq Acc Id: NP_036987   ⟸   NM_012855
- UniProtKB: Q63272 (UniProtKB/Swiss-Prot),   F1LR79 (UniProtKB/TrEMBL),   A0A8L2UK66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769286   ⟸   XM_008771064
- Peptide Label: isoform X1
- UniProtKB: Q63272 (UniProtKB/Swiss-Prot),   F1LR79 (UniProtKB/TrEMBL),   A0A8L2UK66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455482   ⟸   XM_017599993
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UK66 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073659   ⟸   ENSRNOT00000080146
Ensembl Acc Id: ENSRNOP00000071081   ⟸   ENSRNOT00000079784
Ensembl Acc Id: ENSRNOP00000025312   ⟸   ENSRNOT00000025312
RefSeq Acc Id: XP_038950131   ⟸   XM_039094203
- Peptide Label: isoform X1
- UniProtKB: Q63272 (UniProtKB/Swiss-Prot),   F1LR79 (UniProtKB/Swiss-Prot),   A0A8L2UK66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131138   ⟸   XM_063275068
- Peptide Label: isoform X1
- UniProtKB: Q63272 (UniProtKB/Swiss-Prot),   F1LR79 (UniProtKB/Swiss-Prot),   A0A8L2UK66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131139   ⟸   XM_063275069
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UK66 (UniProtKB/TrEMBL)
Protein Domains
FERM   Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63272-F1-model_v2 AlphaFold Q63272 1-1100 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2940 AgrOrtholog
BioCyc Gene G2FUF-11829 BioCyc
Ensembl Genes ENSRNOG00000018669 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055009634 UniProtKB/Swiss-Prot
  ENSRNOG00060011637 UniProtKB/Swiss-Prot
  ENSRNOG00065020890 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025312.7 UniProtKB/TrEMBL
  ENSRNOT00000080146 UniProtKB/TrEMBL
  ENSRNOT00055016295 UniProtKB/Swiss-Prot
  ENSRNOT00060019707 UniProtKB/Swiss-Prot
  ENSRNOT00065035477 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JAK1-3/TYK2_PHL_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25326 UniProtKB/Swiss-Prot
NCBI Gene 25326 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE HOPSCOTCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE JAK3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FERM_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jak1_Phl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen Jak3 PhenoGen
PIRSF TyrPK_Jak UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS JANUSKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JANUSKINASE3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018669 RatGTEx
  ENSRNOG00055009634 RatGTEx
  ENSRNOG00060011637 RatGTEx
  ENSRNOG00065020890 RatGTEx
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC231103
UniProt A0A0G2K636_RAT UniProtKB/TrEMBL
  A0A8L2UK66 ENTREZGENE, UniProtKB/TrEMBL
  F1LR79 ENTREZGENE
  JAK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LR79 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Jak3  Janus kinase 3, protein-tyrosine kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in spleen, lung, kidney and intestine 729028
gene_protein 1,100 amino acids 729028