Gene: Jak3 (Janus kinase 3) Rattus norvegicus
Analyze
Symbol:
Jak3
Name:
Janus kinase 3
RGD ID:
2940
Description:
Predicted to have protein phosphatase binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of activated T cell proliferation; positive regulation of cytosolic calcium ion concentration; and positive regulation of nitric-oxide synthase biosynthetic process. Localizes to cytoplasm. Biomarker of tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; adult T-cell leukemia; juvenile myelomonocytic leukemia; and megakaryocytic leukemia. Orthologous to human JAK3 (Janus kinase 3); PARTICIPATES IN altered Jak-Stat signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH amphetamine; bisphenol A; cadmium dichloride.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
JAK-3; Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; RATJAK3; tyrosine-protein kinase JAK3
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
JAK3 (Janus kinase 3) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):
Jak3 (Janus kinase 3) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Jak3 (Janus kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
JAK3 (Janus kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
JAK3 (Janus kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Jak3 (Janus kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
JAK3 (Janus kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
JAK3 (Janus kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Jak3 (Janus kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Jak3 (Janus kinase 3)
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER)
Homo sapiens (human):
JAK3 (Janus kinase 3)
Alliance
DIOPT (HGNC|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER)
Danio rerio (zebrafish):
jak3 (Janus kinase 3 (a protein tyrosine kinase, leukocyte))
Alliance
DIOPT (OrthoFinder|PANTHER)
Drosophila melanogaster (fruit fly):
hop
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 16 20,107,471 - 20,120,678 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 20,109,200 - 20,120,668 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 16 19,968,486 - 19,981,132 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 16 18,878,139 - 18,889,441 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 16 18,878,136 - 18,889,439 (+) NCBI Celera 16 18,589,820 - 18,601,138 (+) NCBI Celera Cytogenetic Map 16 p14 NCBI RH 3.4 Map 16 181.8 RGD
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
Acute Lung Injury ISO RGD:10824 11531100 RGD acute megakaryocytic leukemia ISO RGD:737593 11531113 RGD adult T-cell leukemia ISO RGD:737593 11531131 DNA:missense mutations: :p.L156P, p.R172Q, p.E183G (human) RGD Cd4+ Lymphocyte Deficiency ISO RGD:737593 11531127 DNA:missense mutation:exon:p.C1066R (c.3196T>C) (human) RGD cerebral malaria ISO RGD:10824 11531103 RGD Colonic Neoplasms treatment IEP 11533940 RGD Diabetes Mellitus, Experimental IEP 11533943 protein:increased expression:retina RGD Edema treatment ISO RGD:10824 11533938 associated with Hypersensitivity, Delayed RGD Experimental Arthritis treatment IMP 11533944 ; 11533938 RGD Experimental Arthritis treatment IEP 11533942 RGD Experimental Autoimmune Encephalomyelitis treatment IDA 11533939 RGD Graft vs Host Disease treatment ISO RGD:10824 11531124 RGD Graft vs Host Disease treatment IMP 1600262 RGD Hyperalgesia treatment IEP 11533942 RGD juvenile myelomonocytic leukemia disease_progression ISO RGD:737593 11069125 RGD severe combined immunodeficiency treatment ISO RGD:10824 11531109 RGD Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-Negative ISO RGD:737593 1600254 DNA:point mutation, deletion:CDS:394A>G, pY100C (human) RGD T-cell acute lymphoblastic leukemia ISO RGD:737593 11531122 RGD T-Cell Lymphoma treatment ISO RGD:737593 11531129 RGD T-Cell Prolymphocytic Leukemia ISO RGD:737593 11531125 DNA:missense mutations:exon:pM511I, p.R657Q (human) RGD tongue squamous cell carcinoma disease_progression IEP 11531126 RGD
Imported Annotations - ClinVar
Acute Lymphoblastic Leukemia, with Lymphomatous Features ISO RGD:737593 8554872 ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features ClinVar PMID:10982185 more ... Acute Lymphoblastic Leukemia, with Lymphomatous Features ISO RGD:737593 8554872 ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features ClinVar PMID:16843266 more ... acute megakaryocytic leukemia ISO RGD:737593 8554872 ClinVar Annotator: match by term: Acute megakaryoblastic leukemia ClinVar PMID:16843266 more ... acute megakaryocytic leukemia ISO RGD:737593 8554872 ClinVar Annotator: match by term: Acute megakaryoblastic leukemia ClinVar PMID:10982185 more ... acute megakaryocytic leukemia ISO RGD:737593 8554872 ClinVar Annotator: match by term: Acute megakaryoblastic leukemia ClinVar PMID:18397343 more ... acute megakaryocytic leukemia ISO RGD:737593 8554872 ClinVar Annotator: match by term: Acute megakaryoblastic leukemia ClinVar PMID:16843266 more ... acute megakaryocytic leukemia ISO RGD:737593 8554872 ClinVar Annotator: match by term: Acute megakaryoblastic leukemia ClinVar PMID:18397343 adenoid cystic carcinoma ISO RGD:737593 8554872 ClinVar Annotator: match by term: Adenoid cystic carcinoma ClinVar Hydrops Fetalis ISO RGD:737593 8554872 ClinVar Annotator: match by term: Hydrops fetalis, non-immune ClinVar PMID:25741868 , PMID:28492532 Leukemoid Reaction ISO RGD:737593 8554872 ClinVar Annotator: match by term: Leukemoid Reaction ClinVar PMID:18397343 Leukemoid Reaction ISO RGD:737593 8554872 ClinVar Annotator: match by term: Leukemoid Reaction ClinVar PMID:18397343 more ... lymphopenia ISO RGD:737593 8554872 ClinVar Annotator: match by term: Lymphocytopenia ClinVar PMID:25741868 , PMID:28492532 Muscle Hypotonia ISO RGD:737593 8554872 ClinVar Annotator: match by term: Neonatal hypotonia ClinVar PMID:25741868 , PMID:28492532 myeloproliferative neoplasm ISO RGD:737593 8554872 ClinVar Annotator: match by term: Myeloproliferative Neoplasm ClinVar PMID:16843266 more ... NATURAL KILLER CELL ENTEROPATHY ISO RGD:737593 8554872 ClinVar Annotator: match by term: Natural killer cell enteropathy ClinVar severe combined immunodeficiency ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency disease ClinVar PMID:19203666 , PMID:28492532 severe combined immunodeficiency ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency disease ClinVar PMID:17644747 more ... severe combined immunodeficiency ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe Combined Immunodeficiency ClinVar PMID:18559588 severe combined immunodeficiency ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe Combined Immunodeficiency ClinVar PMID:24033266 more ... severe combined immunodeficiency ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe Combined Immune Deficiency ClinVar PMID:28492532 severe combined immunodeficiency ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe Combined Immunodeficiency ClinVar severe combined immunodeficiency ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe Combined Immunodeficiency ClinVar PMID:10900158 more ... severe combined immunodeficiency ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe Combined Immunodeficiency ClinVar PMID:10900158 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:28492532 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:19203666 , PMID:28492532 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:10982185 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:20417861 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:16843266 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:21821710 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:19282076 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:10982185 , PMID:11668610 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ClinVar PMID:17644747 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:18397343 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:25741868 , PMID:28492532 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe immunodeficiency, autosomal recessive, T-cell negative, B-cell negative, NK cell-positive ClinVar PMID:25741868 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:24033266 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:10982185 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:11668610 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:24728327 , PMID:28492532 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:7659163 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:11741532 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:7481768 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:26915675 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:21050946 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:28492532 , PMID:29375547 severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:25741868 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:11668621 more ... severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive ISO RGD:737593 8554872 ClinVar Annotator: match by term: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-negative ClinVar PMID:11741532 , PMID:7659163 Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-Negative ISO RGD:737593 8554872 ClinVar Annotator: match by term: SCID, autosomal recessive, T-negative/B-positive type ClinVar PMID:25741868 , PMID:28492532 Trichiasis ISO RGD:737593 8554872 ClinVar Annotator: match by term: Trichiasis ClinVar PMID:25741868 , PMID:28492532
Gene-Chemical Interaction Annotations
