Jak3 (Janus kinase 3) - Rat Genome Database

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Pathways
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Gene: Jak3 (Janus kinase 3) Heterocephalus glaber
Analyze
Symbol: Jak3
Name: Janus kinase 3
RGD ID: 18935473
Description: ENCODES a protein that exhibits protein phosphatase binding (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN B cell differentiation (ortholog); cellular response to cytokine stimulus (ortholog); cytokine-mediated signaling pathway (ortholog); PARTICIPATES IN altered Jak-Stat signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); acute megakaryocytic leukemia (ortholog); FOUND IN extrinsic component of cytoplasmic side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase JAK3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,371,595 - 1,383,879 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,371,595 - 1,383,879 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Acute Lymphoblastic Leukemia, with Lymphomatous Features  (ISO)
acute megakaryocytic leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
adenosine deaminase deficiency  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
B-cell lymphoma  (ISO)
Cd4+ Lymphocyte Deficiency  (ISO)
cerebral malaria  (ISO)
Colonic Neoplasms  (ISO)
Edema  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
hereditary spastic paraplegia  (ISO)
Hydrops Fetalis  (ISO)
Hyperalgesia  (ISO)
Hypoxia  (ISO)
juvenile myelomonocytic leukemia  (ISO)
Leukemoid Reaction  (ISO)
long QT syndrome  (ISO)
lymphopenia  (ISO)
Mediastinal Neoplasms  (ISO)
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1  (ISO)
Muscle Hypotonia  (ISO)
myeloproliferative neoplasm  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
NATURAL KILLER CELL ENTEROPATHY  (ISO)
severe combined immunodeficiency  (ISO)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive  (ISO)
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-Negative  (ISO)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
T-cell prolymphocytic leukemia  (ISO)
tongue squamous cell carcinoma  (ISO)
Trichiasis  (ISO)
Viral Bronchiolitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (ISO)
cellular response to cytokine stimulus  (ISO)
cytokine-mediated signaling pathway  (ISO)
enzyme-linked receptor protein signaling pathway  (ISO)
interleukin-15-mediated signaling pathway  (ISO)
interleukin-2-mediated signaling pathway  (ISO)
interleukin-4-mediated signaling pathway  (ISO)
interleukin-9-mediated signaling pathway  (ISO)
intracellular signal transduction  (ISO)
negative regulation of complement-dependent cytotoxicity  (ISO)
negative regulation of dendritic cell cytokine production  (ISO)
negative regulation of FasL production  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of T cell activation  (ISO)
negative regulation of T-helper 1 cell differentiation  (ISO)
negative regulation of thymocyte apoptotic process  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of dendritic cell apoptotic process  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of T cell apoptotic process  (ISO)
response to interleukin-4  (ISO)
T cell homeostasis  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Jak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,371,595 - 1,383,879 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,371,595 - 1,383,879 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,824,782 - 17,847,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,824,780 - 17,848,071 (-)EnsemblGRCh38hg38GRCh38
GRCh371917,935,591 - 17,958,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,797,961 - 17,819,800 (-)NCBINCBI36Build 36hg18NCBI36
Build 341917,797,960 - 17,819,800NCBI
Celera1917,837,310 - 17,860,555 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,500,992 - 17,524,212 (-)NCBIHuRef
CHM1_11917,935,132 - 17,958,532 (-)NCBICHM1_1
T2T-CHM13v2.01917,958,895 - 17,982,060 (-)NCBIT2T-CHM13v2.0
Jak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,129,027 - 72,143,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,128,940 - 72,143,219 (+)EnsemblGRCm39 Ensembl
GRCm38871,676,383 - 71,690,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,676,296 - 71,690,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,200,473 - 74,214,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,605,563 - 74,619,563 (+)NCBIMGSCv36mm8
Celera874,191,138 - 74,205,120 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
Jak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,418,807 - 18,432,515 (+)NCBIGRCr8
mRatBN7.21618,386,330 - 18,398,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,386,405 - 18,398,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,437,879 - 18,449,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,570,477 - 19,581,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,490,818 - 18,502,120 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,107,471 - 20,120,678 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,109,200 - 20,120,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,968,486 - 19,981,132 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,878,139 - 18,889,441 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,878,136 - 18,889,439 (+)NCBI
Celera1618,589,820 - 18,601,138 (+)NCBICelera
RH 3.4 Map16181.8RGD
Cytogenetic Map16p14NCBI
Jak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,401,642 - 3,411,643 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,399,895 - 3,412,018 (+)NCBIChiLan1.0ChiLan1.0
JAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,681,699 - 22,713,145 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,686,968 - 21,719,944 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,299,129 - 17,330,700 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,283,157 - 18,304,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,283,560 - 18,300,964 (-)Ensemblpanpan1.1panPan2
JAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,051,135 - 45,068,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,050,526 - 45,072,805 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,963,131 - 44,980,402 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,535,925 - 45,553,392 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,535,982 - 45,557,946 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,772,769 - 44,789,998 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,183,055 - 45,200,281 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,459,016 - 45,476,242 (+)NCBIUU_Cfam_GSD_1.0
Jak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,661,414 - 203,676,227 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,212,593 - 3,224,048 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,212,593 - 3,224,426 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,905,919 - 59,926,495 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,905,901 - 59,926,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,475,346 - 59,495,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,301,760 - 16,323,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,300,525 - 16,322,859 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660743,064,511 - 3,086,605 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000005358   ⟹   ENSHGLP00000005289
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249081,371,595 - 1,383,879 (-)Ensembl
RefSeq Acc Id: XM_004873327   ⟹   XP_004873384
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249081,371,880 - 1,383,879 (-)NCBI
RefSeq Acc Id: XM_013068714   ⟹   XP_012924168
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249081,371,880 - 1,383,879 (-)NCBI
RefSeq Acc Id: XM_021251173   ⟹   XP_021106832
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249081,371,595 - 1,382,502 (-)NCBI
RefSeq Acc Id: XR_002391811
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249081,371,595 - 1,382,502 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004873384 (Get FASTA)   NCBI Sequence Viewer  
  XP_012924168 (Get FASTA)   NCBI Sequence Viewer  
  XP_021106832 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000005289
Reference Protein Sequences
RefSeq Acc Id: XP_021106832   ⟸   XM_021251173
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004873384   ⟸   XM_004873327
- Peptide Label: isoform X2
RefSeq Acc Id: XP_012924168   ⟸   XM_013068714
- Peptide Label: isoform X2
RefSeq Acc Id: ENSHGLP00000005289   ⟸   ENSHGLT00000005358


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003869 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000005358 ENTREZGENE
NCBI Gene Jak3 ENTREZGENE