JAK3 (Janus kinase 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: JAK3 (Janus kinase 3) Pan paniscus
Analyze
Symbol: JAK3
Name: Janus kinase 3
RGD ID: 11988633
Description: ENCODES a protein that exhibits ATP binding (inferred); growth hormone receptor binding (inferred); histone H2AXY142 kinase activity (inferred); INVOLVED IN B cell differentiation (ortholog); cellular response to cytokine stimulus (ortholog); cytokine-mediated signaling pathway (ortholog); PARTICIPATES IN altered Jak-Stat signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); acute megakaryocytic leukemia (ortholog); FOUND IN extrinsic component of cytoplasmic side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: INSL3; insulin like 3; insulin-like 3; tyrosine-protein kinase JAK3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,681,699 - 22,713,145 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,686,968 - 21,719,944 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,299,129 - 17,330,700 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,283,157 - 18,304,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,283,560 - 18,300,964 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Acute Lymphoblastic Leukemia, with Lymphomatous Features  (ISO)
acute megakaryocytic leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
adenosine deaminase deficiency  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
B-cell lymphoma  (ISO)
Cd4+ Lymphocyte Deficiency  (ISO)
cerebral malaria  (ISO)
Colonic Neoplasms  (ISO)
Edema  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
hereditary spastic paraplegia  (ISO)
Hydrops Fetalis  (ISO)
Hyperalgesia  (ISO)
Hypoxia  (ISO)
juvenile myelomonocytic leukemia  (ISO)
Leukemoid Reaction  (ISO)
lymphopenia  (ISO)
Mediastinal Neoplasms  (ISO)
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1  (ISO)
Muscle Hypotonia  (ISO)
myeloproliferative neoplasm  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
NATURAL KILLER CELL ENTEROPATHY  (ISO)
severe combined immunodeficiency  (ISO)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive  (ISO)
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-Negative  (ISO)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
T-cell prolymphocytic leukemia  (ISO)
tongue squamous cell carcinoma  (ISO)
Trichiasis  (ISO)
Viral Bronchiolitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (ISO)
cell differentiation  (IEA)
cell surface receptor signaling pathway via JAK-STAT  (IEA)
cellular response to cytokine stimulus  (ISO)
chromatin remodeling  (IEA)
cytokine-mediated signaling pathway  (IEA,ISO)
enzyme-linked receptor protein signaling pathway  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (IEA)
interleukin-15-mediated signaling pathway  (IEA)
interleukin-2-mediated signaling pathway  (IEA)
interleukin-4-mediated signaling pathway  (IEA)
interleukin-7-mediated signaling pathway  (IEA)
interleukin-9-mediated signaling pathway  (IEA)
intracellular signal transduction  (IEA,ISO)
negative regulation of complement-dependent cytotoxicity  (ISO)
negative regulation of dendritic cell cytokine production  (ISO)
negative regulation of FasL production  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of T cell activation  (ISO)
negative regulation of T-helper 1 cell differentiation  (ISO)
negative regulation of T-helper 17 cell lineage commitment  (IEA)
negative regulation of thymocyte apoptotic process  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of dendritic cell apoptotic process  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of apoptotic process  (IEA)
regulation of cell activation  (IEA)
regulation of cell-cell adhesion  (IEA)
regulation of T cell apoptotic process  (ISO)
response to interleukin-4  (IEA)
T cell homeostasis  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
JAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,681,699 - 22,713,145 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,686,968 - 21,719,944 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,299,129 - 17,330,700 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,283,157 - 18,304,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,283,560 - 18,300,964 (-)Ensemblpanpan1.1panPan2
JAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,824,782 - 17,847,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,824,780 - 17,848,071 (-)EnsemblGRCh38hg38GRCh38
GRCh371917,935,591 - 17,958,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,797,961 - 17,819,800 (-)NCBINCBI36Build 36hg18NCBI36
Build 341917,797,960 - 17,819,800NCBI
Celera1917,837,310 - 17,860,555 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,500,992 - 17,524,212 (-)NCBIHuRef
CHM1_11917,935,132 - 17,958,532 (-)NCBICHM1_1
T2T-CHM13v2.01917,958,895 - 17,982,060 (-)NCBIT2T-CHM13v2.0
Jak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,129,027 - 72,143,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,128,940 - 72,143,219 (+)EnsemblGRCm39 Ensembl
GRCm38871,676,383 - 71,690,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,676,296 - 71,690,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,200,473 - 74,214,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,605,563 - 74,619,563 (+)NCBIMGSCv36mm8
Celera874,191,138 - 74,205,120 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
Jak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,418,807 - 18,432,515 (+)NCBIGRCr8
mRatBN7.21618,386,330 - 18,398,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,386,405 - 18,398,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,437,879 - 18,449,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,570,477 - 19,581,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,490,818 - 18,502,120 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,107,471 - 20,120,678 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,109,200 - 20,120,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,968,486 - 19,981,132 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,878,139 - 18,889,441 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,878,136 - 18,889,439 (+)NCBI
Celera1618,589,820 - 18,601,138 (+)NCBICelera
RH 3.4 Map16181.8RGD
Cytogenetic Map16p14NCBI
Jak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,401,642 - 3,411,643 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,399,895 - 3,412,018 (+)NCBIChiLan1.0ChiLan1.0
JAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,051,135 - 45,068,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,050,526 - 45,072,805 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,963,131 - 44,980,402 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,535,925 - 45,553,392 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,535,982 - 45,557,946 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,772,769 - 44,789,998 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,183,055 - 45,200,281 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,459,016 - 45,476,242 (+)NCBIUU_Cfam_GSD_1.0
Jak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,661,414 - 203,676,227 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,212,593 - 3,224,048 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,212,593 - 3,224,426 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,905,919 - 59,926,495 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,905,901 - 59,926,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,475,346 - 59,495,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,301,760 - 16,323,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,300,525 - 16,322,859 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660743,064,511 - 3,086,605 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,371,595 - 1,383,879 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,371,595 - 1,383,879 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000059293   ⟹   ENSPPAP00000036401
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1918,283,560 - 18,300,964 (-)Ensembl
RefSeq Acc Id: XM_034944865   ⟹   XP_034800756
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22022,686,567 - 22,713,145 (-)NCBI
NHGRI_mPanPan11921,696,053 - 21,719,943 (-)NCBI
Mhudiblu_PPA_v01917,308,848 - 17,330,696 (-)NCBI
RefSeq Acc Id: XM_055104425   ⟹   XP_054960400
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22022,681,699 - 22,713,145 (-)NCBI
NHGRI_mPanPan11921,686,978 - 21,719,944 (-)NCBI
RefSeq Acc Id: XM_055104426   ⟹   XP_054960401
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22022,681,699 - 22,704,239 (-)NCBI
NHGRI_mPanPan11921,686,968 - 21,711,040 (-)NCBI
RefSeq Acc Id: XM_055104427   ⟹   XP_054960402
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22022,681,699 - 22,705,429 (-)NCBI
NHGRI_mPanPan11921,686,968 - 21,712,228 (-)NCBI
RefSeq Acc Id: XM_063600009   ⟹   XP_063456079
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22022,681,699 - 22,707,181 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034800756 (Get FASTA)   NCBI Sequence Viewer  
  XP_054960400 (Get FASTA)   NCBI Sequence Viewer  
  XP_054960401 (Get FASTA)   NCBI Sequence Viewer  
  XP_054960402 (Get FASTA)   NCBI Sequence Viewer  
  XP_063456079 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000036401.1
RefSeq Acc Id: XP_034800756   ⟸   XM_034944865
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C372 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000036401   ⟸   ENSPPAT00000059293
RefSeq Acc Id: XP_054960402   ⟸   XM_055104427
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054960401   ⟸   XM_055104426
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054960400   ⟸   XM_055104425
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063456079   ⟸   XM_063600009
- Peptide Label: isoform X3
Protein Domains
FERM   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040942 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059293.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  JAK UniProtKB/TrEMBL
  Jak1_PHL_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak3 UniProtKB/TrEMBL
NCBI Gene JAK3 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE HOPSCOTCH UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE JAK3 UniProtKB/TrEMBL
Pfam FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  Jak1_Phl UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2_1 UniProtKB/TrEMBL
PIRSF TyrPK_Jak UniProtKB/TrEMBL
PRINTS JANUSKINASE UniProtKB/TrEMBL
  JANUSKINASE3 UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9C372 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 JAK3  Janus kinase 3  INSL3  insulin like 3  Data merged from RGD:12026250 737654 PROVISIONAL