Glb1l3 (galactosidase, beta 1-like 3) - Rat Genome Database

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Gene: Glb1l3 (galactosidase, beta 1-like 3) Rattus norvegicus
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Symbol: Glb1l3
Name: galactosidase, beta 1-like 3
RGD ID: 1561462
Description: Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be active in vacuole. Orthologous to human GLB1L3 (galactosidase beta 1 like 3); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-galactosidase-1-like protein 3; galactosidase, beta 1 like 3; LOC500961; similar to hypothetical protein BC008326
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8833,454,914 - 33,496,641 (-)NCBIGRCr8
mRatBN7.2825,179,165 - 25,220,904 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl825,179,165 - 25,220,904 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx829,237,730 - 29,279,461 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0827,532,023 - 27,573,752 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0825,395,446 - 25,437,166 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0827,865,452 - 27,907,726 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl827,865,350 - 27,907,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0827,885,459 - 27,927,733 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4826,448,446 - 26,490,267 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera826,737,742 - 26,779,469 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
vacuole  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334  


Genomics

Comparative Map Data
Glb1l3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8833,454,914 - 33,496,641 (-)NCBIGRCr8
mRatBN7.2825,179,165 - 25,220,904 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl825,179,165 - 25,220,904 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx829,237,730 - 29,279,461 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0827,532,023 - 27,573,752 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0825,395,446 - 25,437,166 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0827,865,452 - 27,907,726 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl827,865,350 - 27,907,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0827,885,459 - 27,927,733 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4826,448,446 - 26,490,267 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera826,737,742 - 26,779,469 (-)NCBICelera
Cytogenetic Map8q13NCBI
GLB1L3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811134,275,767 - 134,325,304 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11134,274,245 - 134,319,564 (+)EnsemblGRCh38hg38GRCh38
GRCh3711134,146,273 - 134,189,458 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611133,652,266 - 133,694,667 (+)NCBINCBI36Build 36hg18NCBI36
Celera11131,319,141 - 131,362,133 (+)NCBICelera
Cytogenetic Map11q25NCBI
HuRef11130,101,037 - 130,144,384 (+)NCBIHuRef
CHM1_111134,033,014 - 134,076,147 (+)NCBICHM1_1
T2T-CHM13v2.011134,314,651 - 134,366,918 (+)NCBIT2T-CHM13v2.0
Glb1l3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39926,729,249 - 26,773,394 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl926,729,249 - 26,772,186 (-)EnsemblGRCm39 Ensembl
GRCm38926,817,953 - 26,862,099 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl926,817,953 - 26,860,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv37926,625,538 - 26,668,408 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36926,567,399 - 26,610,336 (-)NCBIMGSCv36mm8
Celera924,077,263 - 24,119,785 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map911.67NCBI
GLB1L3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29134,998,067 - 135,044,186 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111136,097,272 - 136,143,364 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011129,126,472 - 129,172,535 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111132,985,554 - 133,029,890 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11132,987,384 - 133,029,890 (+)Ensemblpanpan1.1panPan2
GLB1L3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.15805,531 - 846,125 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl5805,653 - 846,126 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha5925,741 - 967,403 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.05760,724 - 802,389 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.15793,717 - 835,155 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.05795,014 - 836,740 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.05832,260 - 874,005 (-)NCBIUU_Cfam_GSD_1.0
GLB1L3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl960,918,345 - 60,940,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1960,917,137 - 60,940,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2967,540,330 - 67,560,798 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLB1L3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11125,359,514 - 125,400,427 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1125,360,454 - 125,400,409 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666043647,520 - 688,581 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Glb1l3
84 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:24
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000010045
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 4 35 72 66 65 35 20 35 3 133 71 55 18 56 30

Sequence


Ensembl Acc Id: ENSRNOT00000010045   ⟹   ENSRNOP00000010045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl825,179,165 - 25,220,904 (-)Ensembl
Rnor_6.0 Ensembl827,865,350 - 27,907,911 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118955   ⟹   ENSRNOP00000091712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl825,179,165 - 25,220,904 (-)Ensembl
RefSeq Acc Id: NM_001024358   ⟹   NP_001019529
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8833,454,914 - 33,496,641 (-)NCBI
mRatBN7.2825,179,165 - 25,220,904 (-)NCBI
Rnor_6.0827,865,452 - 27,907,726 (-)NCBI
Rnor_5.0827,885,459 - 27,927,733 (-)NCBI
RGSC_v3.4826,448,446 - 26,490,267 (-)RGD
Celera826,737,742 - 26,779,469 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001019529 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83665 (Get FASTA)   NCBI Sequence Viewer  
  EDL83349 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010045.4
  ENSRNOP00000091712.1
GenBank Protein Q5XIL5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019529   ⟸   NM_001024358
- Peptide Label: precursor
- UniProtKB: Q5XIL5 (UniProtKB/Swiss-Prot),   F1LQ73 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010045   ⟸   ENSRNOT00000010045
Ensembl Acc Id: ENSRNOP00000091712   ⟸   ENSRNOT00000118955
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIL5-F1-model_v2 AlphaFold Q5XIL5 1-631 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561462 AgrOrtholog
BioCyc Gene G2FUF-31311 BioCyc
Ensembl Genes ENSRNOG00000031469 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010045.6 UniProtKB/TrEMBL
  ENSRNOT00000118955.1 UniProtKB/TrEMBL
Gene3D-CATH Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135489 IMAGE-MGC_LOAD
InterPro B-gal_1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BetaGal1-like_ABD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BetaGal_gal-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gly_Hdrlase_35_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_35_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_Hdrlase_35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:500961 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94507 IMAGE-MGC_LOAD
NCBI Gene 500961 ENTREZGENE
PANTHER BETA-GALACTOSIDASE-1-LIKE PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23421 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BetaGal_ABD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BetaGal_gal-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Glb1l3 PhenoGen
PIRSF B-gal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLHYDRLASE35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031469 RatGTEx
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AGN4_RAT UniProtKB/TrEMBL
  F1LQ73 ENTREZGENE, UniProtKB/TrEMBL
  GLBL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Glb1l3  galactosidase, beta 1-like 3  LOC500961  similar to hypothetical protein BC008326  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500961  similar to hypothetical protein BC008326      Symbol and Name status set to provisional 70820 PROVISIONAL