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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snai1
Name: snail family transcriptional repressor 1
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Snai1multiple interactionsEXP 6480464CTDNiclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]PMID:28318631
Snai1decreases expressionISOSNAI1 (Homo sapiens)6480464CTDNiclosamide results in decreased expression of SNAI1 mRNA; Niclosamide results in decreased expression of SNAI1 proteinPMID:30143678
Snai1increases expressionISOSNAI1 (Homo sapiens)6480464CTDNiclosamide results in increased expression of SNAI1 mRNAPMID:36318118
Snai1multiple interactionsISOSNAI1 (Homo sapiens)6480464CTDNiclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of SNAI1 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SNAI1 protein]PMID:26643609 PMID:36870549
Snai1multiple interactionsISOSnai1 (Mus musculus)6480464CTDNiclosamide inhibits the reaction [Doxorubicin results in increased expression of SNAI1 mRNA]PMID:28318631
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