Gata5 (GATA binding protein 5) - Rat Genome Database

Name: Gata5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Gata5 (GATA binding protein 5) Rattus norvegicus

Analyze

Symbol:

Gata5

Name:

GATA binding protein 5

RGD ID:

1561365

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to hydrogen peroxide; cellular response to nitric oxide; and positive regulation of apoptotic DNA fragmentation. Predicted to be part of chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation (multiple); congenital heart disease (multiple); and dilated cardiomyopathy. Orthologous to human GATA5 (GATA binding protein 5); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; dimethylarsinic acid.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GATA-binding protein 5; LOC499951; similar to Transcription factor GATA-5 (GATA binding factor-5); transcription factor GATA-5

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GATA5 (GATA binding protein 5)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI
Mus musculus (house mouse):	Gata5 (GATA binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gata5 (GATA binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GATA5 (GATA binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GATA5 (GATA binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gata5 (GATA binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GATA5 (GATA binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GATA5 (GATA binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gata5 (GATA binding protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GATA5 (GATA binding protein 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gata5 (GATA binding protein 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gata5 (GATA binding protein 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	elt-2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	GAT1	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	GZF3	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	pnr	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gata5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	187,796,140 - 187,804,327 (-)	NCBI		GRCr8
mRatBN7.2	3	167,418,563 - 167,426,751 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	167,418,565 - 167,426,751 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	171,795,150 - 171,803,330 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	180,754,236 - 180,762,416 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	177,419,481 - 177,427,668 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	175,701,278 - 175,709,465 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	175,701,280 - 175,709,465 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	181,406,297 - 181,414,484 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	169,385,321 - 169,393,508 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	165,153,452 - 165,161,639 (+)	NCBI		Celera
Cytogenetic Map	3	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myocardial infarction (ISO)

aortic valve disease 1 (ISO)

ARTERIAL DISSECTION (ISO)

atrial fibrillation (ISO)

bicuspid aortic valve disease (ISO)

Colorectal Neoplasms (ISO)

Congenital Heart Defects, Multiple Types, 5 (ISO)

developmental and epileptic encephalopathy (ISO)

developmental and epileptic encephalopathy 33 (ISO)

dilated cardiomyopathy (ISO)

early infantile epileptic encephalopathy (ISO)

essential hypertension (ISO,ISS)

familial atrial fibrillation (ISO)

genetic disease (ISO)

hypertension (ISO)

neuronal ceroid lipofuscinosis (ISO)

tetralogy of Fallot (ISO)

thoracic aortic aneurysm (ISO)

ventricular septal defect (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

biguanides (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

butanal (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cytarabine (ISO)

diazinon (ISO)

dimethylarsinic acid (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

folic acid (ISO)

fonofos (ISO)

fulvestrant (ISO)

hydrogen peroxide (EXP)

lipopolysaccharide (ISO)

methimazole (EXP)

methotrexate (ISO)

niclosamide (ISO)

nitric oxide (EXP)

parathion (ISO)

pirinixic acid (ISO)

propanal (ISO)

resveratrol (ISO)

rifampicin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

terbufos (ISO)

titanium dioxide (ISO)

tributylstannane (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aortic valve morphogenesis (ISO)

cardiac jelly development (ISO)

cardiac muscle tissue development (IBA)

cell fate commitment (IBA)

cellular response to BMP stimulus (ISO)

cellular response to hydrogen peroxide (IEP)

cellular response to nitric oxide (IEP)

endocardial cushion fusion (ISO)

heart development (ISO)

heart induction (ISO)

intestinal epithelial cell differentiation (ISO)

negative regulation of cardiac muscle hypertrophy (ISO)

negative regulation of gene expression (ISO)

negative regulation of transcription by RNA polymerase II (IBA)

positive regulation of apoptotic DNA fragmentation (IMP)

positive regulation of cardiac endothelial to mesenchymal transition (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of gene expression (ISO)

positive regulation of Notch signaling pathway (ISO)

positive regulation of transcription by RNA polymerase II (IBA,ISO)

regulation of DNA-templated transcription (ISO)

Cellular Component

chromatin (ISO)

nucleus (IBA,ISO)

Molecular Function

cis-regulatory region sequence-specific DNA binding (ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Novel GATA5 loss-of-function mutations underlie familial atrial fibrillation.	Gu JY, etal., Clinics (Sao Paulo). 2012 Dec;67(12):1393-9. doi: 10.6061/clinics/2012(12)08.
3.	Loss of Gata5 in mice leads to bicuspid aortic valve.	Laforest B, etal., J Clin Invest. 2011 Jul;121(7):2876-87. doi: 10.1172/JCI44555.
4.	Endothelial Gata5 transcription factor regulates blood pressure.	Messaoudi S, etal., Nat Commun. 2015 Nov 30;6:8835. doi: 10.1038/ncomms9835.
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	GATA5 loss-of-function mutations associated with congenital bicuspid aortic valve.	Shi LM, etal., Int J Mol Med. 2014 May;33(5):1219-26. doi: 10.3892/ijmm.2014.1700. Epub 2014 Mar 14.
9.	Molecular genetic study on GATA5 gene promoter in acute myocardial infarction.	Song Z, etal., PLoS One. 2021 Mar 8;16(3):e0248203. doi: 10.1371/journal.pone.0248203. eCollection 2021.
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11.	Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development.	Thomas PS, etal., PLoS One. 2012;7(4):e35539. doi: 10.1371/journal.pone.0035539. Epub 2012 Apr 19.
12.	A novel GATA5 loss-of-function mutation underlies lone atrial fibrillation.	Wang XH, etal., Int J Mol Med. 2013 Jan;31(1):43-50. doi: 10.3892/ijmm.2012.1189. Epub 2012 Nov 20.
13.	GATA5 loss-of-function mutations underlie tetralogy of fallot.	Wei D, etal., Int J Med Sci. 2013;10(1):34-42. doi: 10.7150/ijms.5270. Epub 2012 Dec 10.
14.	GATA5 loss-of-function mutation responsible for the congenital ventriculoseptal defect.	Wei D, etal., Pediatr Cardiol. 2013 Mar;34(3):504-11. doi: 10.1007/s00246-012-0482-6. Epub 2012 Sep 9.
15.	Oxidative stress-induced apoptotic insults to rat osteoblasts are attenuated by nitric oxide pretreatment via GATA-5-involved regulation of Bcl-X L gene expression and protein translocation.	Wu GJ, etal., Arch Toxicol. 2016 Apr;90(4):905-16. doi: 10.1007/s00204-015-1491-z. Epub 2015 Mar 1.
16.	GATA5 loss-of-function mutation in familial dilated cardiomyopathy.	Zhang XL, etal., Int J Mol Med. 2015 Mar;35(3):763-70. doi: 10.3892/ijmm.2014.2050. Epub 2014 Dec 29.

Additional References at PubMed

PMID:9119112	PMID:9566909	PMID:9738004	PMID:14986113	PMID:15987774	PMID:18259093	PMID:20501701	PMID:20855530	PMID:22641149

Genomics

Comparative Map Data

Gata5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	187,796,140 - 187,804,327 (-)	NCBI		GRCr8
mRatBN7.2	3	167,418,563 - 167,426,751 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	167,418,565 - 167,426,751 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	171,795,150 - 171,803,330 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	180,754,236 - 180,762,416 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	177,419,481 - 177,427,668 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	175,701,278 - 175,709,465 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	175,701,280 - 175,709,465 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	181,406,297 - 181,414,484 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	169,385,321 - 169,393,508 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	165,153,452 - 165,161,639 (+)	NCBI		Celera
Cytogenetic Map	3	q43	NCBI

GATA5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	62,463,497 - 62,475,995 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	62,463,497 - 62,475,995 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	61,038,553 - 61,051,051 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	60,471,948 - 60,484,421 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	60,471,948 - 60,484,421	NCBI
Celera	20	57,773,808 - 57,786,309 (-)	NCBI		Celera
Cytogenetic Map	20	q13.33	NCBI
HuRef	20	57,816,177 - 57,828,255 (-)	NCBI		HuRef
CHM1_1	20	60,939,508 - 60,951,981 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	64,260,442 - 64,272,970 (-)	NCBI		T2T-CHM13v2.0

Gata5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	179,966,881 - 179,977,296 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	179,966,926 - 179,976,492 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	180,325,088 - 180,335,503 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	180,325,133 - 180,334,699 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	180,059,793 - 180,069,384 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	180,254,541 - 180,264,081 (-)	NCBI		MGSCv36	mm8
Celera	2	184,410,037 - 184,419,626 (-)	NCBI		Celera
Cytogenetic Map	2	H4	NCBI
cM Map	2	102.85	NCBI

Gata5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955528	1,595,231 - 1,604,979 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955528	1,595,231 - 1,604,979 (+)	NCBI	ChiLan1.0	ChiLan1.0

GATA5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	68,248,336 - 68,260,825 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	68,241,456 - 68,253,945 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1 Ensembl	20	60,148,359 - 60,158,886 (-)	Ensembl	panpan1.1		panPan2

GATA5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	46,417,404 - 46,427,617 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	46,417,391 - 46,429,858 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	45,668,394 - 45,678,477 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	47,288,132 - 47,298,276 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	47,288,119 - 47,298,250 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	46,389,267 - 46,399,377 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	46,512,623 - 46,522,731 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	47,266,944 - 47,277,059 (-)	NCBI		UU_Cfam_GSD_1.0

Gata5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	194,607,468 - 194,616,966 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	10,061,675 - 10,070,541 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936514	10,061,675 - 10,070,541 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GATA5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	61,824,899 - 61,834,267 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	61,824,891 - 61,834,742 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	69,233,783 - 69,243,866 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GATA5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	1,756,911 - 1,769,452 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	1,757,420 - 1,768,143 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	49,698,289 - 49,710,923 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gata5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	28,310,201 - 28,321,095 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	28,310,679 - 28,322,209 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gata5
21 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	407
Count of miRNA genes:	215
Interacting mature miRNAs:	251
Transcripts:	ENSRNOT00000007896
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
2317883	Alcrsp26	Alcohol response QTL 26	1.8	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	3	145526770	169034231	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	145956084	169034231	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	149040888	168026850	Rat
1300161	Rf10	Renal function QTL 10	3.57		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	3	161192952	169034231	Rat

Markers in Region

RH133208

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	167,418,723 - 167,418,933 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	175,701,439 - 175,701,648	NCBI	Rnor6.0
Rnor_5.0	3	181,414,114 - 181,414,323	UniSTS	Rnor5.0
RGSC_v3.4	3	169,385,482 - 169,385,691	UniSTS	RGSC3.4
Celera	3	165,161,269 - 165,161,478	UniSTS
RH 3.4 Map	3	1529.4	UniSTS
Cytogenetic Map	3	q43	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	39	4	4		4					8	6
Low	1	4	8	8		8				35	22	5
Below cutoff	1		37	23	14	23	5	6	17		5		5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC115322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000089971 ⟹ ENSRNOP00000073661

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	167,418,565 - 167,426,751 (-)	Ensembl
Rnor_6.0 Ensembl	3	175,701,280 - 175,709,465 (-)	Ensembl

RefSeq Acc Id:

NM_001024316 ⟹ NP_001019487

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	187,796,140 - 187,804,327 (-)	NCBI
mRatBN7.2	3	167,418,563 - 167,426,751 (-)	NCBI
Rnor_6.0	3	175,701,278 - 175,709,465 (-)	NCBI
Rnor_5.0	3	181,406,297 - 181,414,484 (+)	NCBI
RGSC_v3.4	3	169,385,321 - 169,393,508 (-)	RGD
Celera	3	165,153,452 - 165,161,639 (+)	RGD

Sequence:

show sequence

CTACAACCCACTGGTCACCCGCCCTGGGCCAGCGCCGCGCTTTCCTGTGAGGGTTTTGGCCGGT
GATCTCTGCTCGAAGCAAGGACCGTGTTCCTGGGGTCCTGCGCCTCATCTAACCTCTCGTTCCA
CCCGGAGAACCCCGGGACCTGTGCCGGTGAACCGACTCAGAAAAGTGGAGTGTGCAAGCCGAGC
AGCAGCACCTGCCCACGGCGAGCGCAATAGCTGATGGAGGGGGCCCAGTGATCCTGCCCTAGAC
GCCTGTCTTTCTTCTCTGCAGGTCAAGCTCGCTCAGGGAAAAATGTACCAGAGCTTGGCGCTGG
CCCAGAGCCCCGGCCAGGGTACCTACGCCGATTCTGGACCCTTTCTGCATTCTTCGGGAGCCGG
TTCCCCGGTGTTCGTGGCACCCACTCGCGTGCCCTCCATGCTGCCGTACCTGCCTTCGTGTGAG
CCGGGCTCGCAGCCTCCCGCGCTCGCCGCGCACTCTAGCTGGACGCAAGCGGTTTCCGCTGAAT
CCTCAGCCTTCGGCTCCGGAAGCCCGCACCCGCCAGCCACACACCCACCGGGAGCCACCGCCTT
CCCGTTCGCTCACAGCCCCTCGGGGTCGGGCAGCGGCGGCAGCGCGGGAGTCCGGGACGGCGCC
GCCTTCCAGAGCGCCCTGCTGGCTCGCGAACAGTATCCGACTGCGCTCGGGAGGCCCATGAGCG
CCTCGTACCCCACAACCTACCCAGCATACGTGAGTCCCGACGTAGCCCCTTCGTGGACCTCTGG
ACCCTTCGACAGCAGCATCCTGCACGGTCTGCAAGGTCGCCCTGGTGGCCTCCCTGGCCGCAGG
ACCACCTTCGTACCTGACTTCTTGGAGGAGTTCCCTGGTGAGGGCCGGGAGTGTGTCAACTGTG
GAGCCCTGTCTACACCACTGTGGCGCAGGGATGGCACCGGACACTATCTATGCAACGCCTGTGG
CCTCTATCACAAGATGAATGGGGTCAACCGACCGCTAGTGAGGCCCCAGAAGCGTCTGTCCTCA
TCCCGTCGATCTGGCCTCTGCTGTTCCAACTGCCACACTGCTACCACCACCCTCTGGAGGCGCA
ACGCAGAGGGGGAACCAGTGTGCAACGCCTGTGGCCTCTACATGAAGCTCCATGGGGTGCCAAG
GCCACTGGCGATGAAAAAGGAGAGTATCCAGACAAGAAAACGGAAGCCGAAGAACCCTGCCAAA
ATCAAGGGCTCCTCGGGATCCACAGCCAACAGCACAGCCTCTTCTCCCACTCTCCTCAACACCG
AGAGCTCAGCCACCACTTTGAAGGCAGAGTCCAGTCTGGCATCTCCAGGGTGTGCTGGACCCAC
TATCACCTCCCAGGCCTCCAGCCCAGCGGACGAATCCCTGGCCTCCAGCCATTTGGAGTTCAAG
TTCGAACCTGAAGACTTTGTCTTCACCTCCTCGTCCCTGAGCCCCCAGGCTGGTCTCAGTGGGG
TCCTACGTCAGGAGGCCTGGTGTGCCCTGGCCTTGGCCTAGGTGCTCAGGAAACTGTTACCACA
GTGTATCTCAGGAACAGAAGTTAGTTCCTGAACCAGCAGCCCCAGAGGTCCCTCACCACTGTGC
TGGGGAAACTTTTCTGTGCCAATTGCCTAGAGAAAAAAGCAGGCTGGTGGACGAAGGGTTGGAG
CCTCGGCTAGGGTAGTAATGGACTCCCCAGGCCCCTCGTGGACCTCTCTGCAGCCAAGATGACT
GGAGATACCCACCAATTACTTGAATTCAGCTCTTGACATCGATGGTCAAAATTTAAAGTTTGTA
GCAGCTGGCAACGGTTCACAGCATCCCACAGTAAAATCCGATCCAAGTGAAACAAACATAGTCC
GGGCAGGCAATAAGAAACAGGGCCTCTGGGCCCTCGAGGTCTTCATTTCTCATGTTTGACTGTG
CACAGCTTGCTTATGGACGCAGGACTGCCAGAGACCAGTGTACAGGTTGAGCACTGTACCAGGG
CACTGCCCCAAGGCAAACGCATTCCTCCAGCCGTCTTCACAGACTTCTGTATTTATTTGTATGT
TGGTTTGGGGCCAGGTAGTAAAGGGCCTTTTTCTGTCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001019487	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85855	(Get FASTA)	NCBI Sequence Viewer
	EDL88812	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000073661
	ENSRNOP00000073661.1

RefSeq Acc Id:

NP_001019487 ⟸ NM_001024316

- UniProtKB:

Q5U2V0 (UniProtKB/TrEMBL), A6KMA4 (UniProtKB/TrEMBL), A0A0G2K638 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MYQSLALAQSPGQGTYADSGPFLHSSGAGSPVFVAPTRVPSMLPYLPSCEPGSQPPALAAHSSW
TQAVSAESSAFGSGSPHPPATHPPGATAFPFAHSPSGSGSGGSAGVRDGAAFQSALLAREQYPT
ALGRPMSASYPTTYPAYVSPDVAPSWTSGPFDSSILHGLQGRPGGLPGRRTTFVPDFLEEFPGE
GRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRSGLCCSNCHTA
TTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKNPAKIKGSSGSTANSTAS
SPTLLNTESSATTLKAESSLASPGCAGPTITSQASSPADESLASSHLEFKFEPEDFVFTSSSLS
PQAGLSGVLRQEAWCALALA

hide sequence

RefSeq Acc Id:

ENSRNOP00000073661 ⟸ ENSRNOT00000089971

Protein Domains

GATA-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U2V0-F1-model_v2	AlphaFold	Q5U2V0	1-404	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692734

Promoter ID:

EPDNEW_R3259

Type:

initiation region

Name:

Gata5_1

Description:

GATA binding protein 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	175,709,468 - 175,709,528	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561365	AgrOrtholog
BioCyc Gene	G2FUF-46358	BioCyc
Ensembl Genes	ENSRNOG00000058983	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000089971	ENTREZGENE
	ENSRNOT00000089971.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.50.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7190097	IMAGE-MGC_LOAD
InterPro	GATA_N	UniProtKB/TrEMBL
	TF_GATA_4/5/6	UniProtKB/TrEMBL
	Transcription_factor_GATA	UniProtKB/TrEMBL
	Znf_GATA	UniProtKB/TrEMBL
	Znf_NHR/GATA	UniProtKB/TrEMBL
KEGG Report	rno:499951	UniProtKB/TrEMBL
MGC_CLONE	MGC:94578	IMAGE-MGC_LOAD
NCBI Gene	499951	ENTREZGENE
PANTHER	PTHR10071	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR GATA-5	UniProtKB/TrEMBL
Pfam	GATA	UniProtKB/TrEMBL
	GATA-N	UniProtKB/TrEMBL
PhenoGen	Gata5	PhenoGen
PIRSF	TF_GATA_4/5/6	UniProtKB/TrEMBL
PRINTS	GATAZNFINGER	UniProtKB/TrEMBL
PROSITE	GATA_ZN_FINGER_1	UniProtKB/TrEMBL
	GATA_ZN_FINGER_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000058983	RatGTEx
SMART	ZnF_GATA	UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/TrEMBL
UniProt	A0A0G2K638	ENTREZGENE, UniProtKB/TrEMBL
	A6KMA4	ENTREZGENE, UniProtKB/TrEMBL
	Q5U2V0	ENTREZGENE
UniProt Secondary	Q5U2V0	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-05	Gata5	GATA binding protein 5	LOC499951	similar to Transcription factor GATA-5 (GATA binding factor-5)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC499951	similar to Transcription factor GATA-5 (GATA binding factor-5)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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