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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561365
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gata5
Name: GATA binding protein 5
Acc ID: CHEBI:16480
Term: nitric oxide
Definition: A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
Chemical ID: MESH:D009569
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gata5increases expressionEXP 6480464CTDNitric Oxide results in increased expression of GATA5 mRNA; Nitric Oxide results in increased expression of GATA5 proteinPMID:25726415
Gata5increases response to substanceEXP 6480464CTDGATA5 protein results in increased susceptibility to Nitric OxidePMID:25726415
Gata5multiple interactionsEXP 6480464CTDGATA5 protein promotes the reaction [Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 mRNA]]; GATA5 protein promotes the reaction [Nitric Oxide results in increased expression of BCL2L1 mRNA]; Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of GATA5 mRNA]; Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of GATA5 protein]PMID:25726415
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