Zbtb46 (zinc finger and BTB domain containing 46) - Rat Genome Database

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Gene: Zbtb46 (zinc finger and BTB domain containing 46) Rattus norvegicus
Analyze
Symbol: Zbtb46
Name: zinc finger and BTB domain containing 46
RGD ID: 1307408
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of leukocyte activation and regulation of leukocyte differentiation. Predicted to be active in chromatin. Orthologous to human ZBTB46 (zinc finger and BTB domain containing 46); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BTB (POZ) domain containing 4; Btbd4; LOC103691997; LOC311718; uncharacterized LOC103691997; zinc finger and BTB domain-containing protein 46
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,497,294 - 168,567,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,499,583 - 168,568,782 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,880,119 - 172,915,848 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03181,839,222 - 181,874,951 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03178,500,518 - 178,536,432 (-)NCBIRnor_WKY
Rnor_6.03176,888,502 - 176,959,009 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,890,806 - 176,958,880 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,600,938 - 180,636,854 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,531,198 - 170,567,755 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,438,230 - 170,473,765 (-)NCBI
Celera3164,051,059 - 164,086,966 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22615127  


Genomics

Comparative Map Data
Zbtb46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,497,294 - 168,567,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,499,583 - 168,568,782 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,880,119 - 172,915,848 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03181,839,222 - 181,874,951 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03178,500,518 - 178,536,432 (-)NCBIRnor_WKY
Rnor_6.03176,888,502 - 176,959,009 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,890,806 - 176,958,880 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,600,938 - 180,636,854 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,531,198 - 170,567,755 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,438,230 - 170,473,765 (-)NCBI
Celera3164,051,059 - 164,086,966 (+)NCBICelera
Cytogenetic Map3q43NCBI
ZBTB46
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,743,670 - 63,833,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2063,743,668 - 63,832,038 (-)EnsemblGRCh38hg38GRCh38
GRCh372062,375,023 - 62,462,617 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,846,322 - 61,907,300 (-)NCBINCBI36Build 36hg18NCBI36
Build 342061,846,321 - 61,907,300NCBI
Celera2059,060,148 - 59,121,043 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2059,107,402 - 59,169,665 (-)NCBIHuRef
CHM1_12062,276,804 - 62,338,651 (-)NCBICHM1_1
T2T-CHM13v2.02065,563,936 - 65,651,208 (-)NCBIT2T-CHM13v2.0
Zbtb46
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392181,012,105 - 181,134,776 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2181,029,555 - 181,101,219 (-)EnsemblGRCm39 Ensembl
GRCm382181,371,009 - 181,493,262 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,387,762 - 181,459,426 (-)EnsemblGRCm38mm10GRCm38
MGSCv372181,125,591 - 181,194,131 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,339,957 - 181,388,833 (-)NCBIMGSCv36mm8
Celera2185,473,180 - 185,541,076 (-)NCBICelera
Cytogenetic Map2H4NCBI
Zbtb46
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528438,859 - 475,543 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955528438,826 - 485,484 (+)NCBIChiLan1.0ChiLan1.0
ZBTB46
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12061,667,319 - 61,770,196 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,667,319 - 61,713,895 (-)Ensemblpanpan1.1panPan2
ZBTB46
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,290,696 - 47,329,342 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2447,292,684 - 47,329,570 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,411,808 - 46,462,963 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02448,416,755 - 48,467,877 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2448,407,272 - 48,468,318 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12447,261,648 - 47,312,709 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,386,485 - 47,437,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02448,124,616 - 48,175,799 (-)NCBIUU_Cfam_GSD_1.0
Zbtb46
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,534,424 - 195,591,233 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,987,984 - 11,027,502 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493651410,987,728 - 11,027,450 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZBTB46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,659,786 - 62,709,235 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,659,779 - 62,715,221 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZBTB46
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12397,663 - 487,145 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2398,268 - 483,923 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605047,938,412 - 48,040,753 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zbtb46
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,398,784 - 29,463,641 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,397,900 - 29,443,605 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zbtb46
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:492
Count of miRNA genes:238
Interacting mature miRNAs:294
Transcripts:ENSRNOT00000020168
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
D3Uia3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,511,823 - 168,512,098 (+)MAPPERmRatBN7.2
Rnor_6.03176,903,044 - 176,903,318NCBIRnor6.0
Rnor_5.03180,613,176 - 180,613,450UniSTSRnor5.0
RGSC_v3.43170,543,435 - 170,543,710RGDRGSC3.4
RGSC_v3.43170,543,436 - 170,543,710UniSTSRGSC3.4
RGSC_v3.13170,449,471 - 170,449,746RGD
Celera3164,074,463 - 164,074,737UniSTS
Cytogenetic Map3q43UniSTS
07.MMHAP64FLC1.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,530,840 - 168,531,009 (+)MAPPERmRatBN7.2
Rnor_6.03176,922,058 - 176,922,226NCBIRnor6.0
Rnor_5.03180,632,190 - 180,632,358UniSTSRnor5.0
RGSC_v3.43170,563,091 - 170,563,259UniSTSRGSC3.4
Celera3164,055,555 - 164,055,723UniSTS
Cytogenetic Map3q43UniSTS
RH143312  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,497,939 - 168,498,055 (+)MAPPERmRatBN7.2
Rnor_6.03176,889,163 - 176,889,278NCBIRnor6.0
Rnor_5.03180,599,295 - 180,599,410UniSTSRnor5.0
RGSC_v3.43170,529,555 - 170,529,670UniSTSRGSC3.4
Celera3164,088,494 - 164,088,609UniSTS
RH 3.4 Map31547.5UniSTS
Cytogenetic Map3q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 8 4 11 4 45 22 33 11
Low 3 39 49 37 8 37 8 11 29 13 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020168   ⟹   ENSRNOP00000020168
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,499,583 - 168,535,505 (-)Ensembl
Rnor_6.0 Ensembl3176,890,806 - 176,926,722 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078661   ⟹   ENSRNOP00000070297
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,523,434 - 168,568,782 (-)Ensembl
Rnor_6.0 Ensembl3176,891,605 - 176,958,880 (-)Ensembl
RefSeq Acc Id: NM_001107808   ⟹   NP_001101278
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,499,583 - 168,535,505 (-)NCBI
Rnor_6.03176,890,806 - 176,926,722 (-)NCBI
Rnor_5.03180,600,938 - 180,636,854 (-)NCBI
RGSC_v3.43170,531,198 - 170,567,755 (-)RGD
Celera3164,051,059 - 164,086,966 (+)RGD
Sequence:
RefSeq Acc Id: XM_008762510   ⟹   XP_008760732
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,497,294 - 168,567,799 (-)NCBI
Rnor_6.03176,888,502 - 176,959,009 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005501902
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,504,903 - 168,567,799 (-)NCBI
RefSeq Acc Id: XR_005501903
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,504,903 - 168,567,799 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101278 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760732 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88718 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101278   ⟸   NM_001107808
- UniProtKB: D3ZTY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760732   ⟸   XM_008762510
- Peptide Label: isoform X1
- UniProtKB: D3ZTY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020168   ⟸   ENSRNOT00000020168
RefSeq Acc Id: ENSRNOP00000070297   ⟸   ENSRNOT00000078661
Protein Domains
BTB   C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTY1-F1-model_v2 AlphaFold D3ZTY1 1-601 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307408 AgrOrtholog
BioCyc Gene G2FUF-46286 BioCyc
Ensembl Genes ENSRNOG00000014592 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020168 ENTREZGENE
  ENSRNOP00000020168.4 UniProtKB/TrEMBL
  ENSRNOP00000070297.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020168 ENTREZGENE
  ENSRNOT00000020168.7 UniProtKB/TrEMBL
  ENSRNOT00000078661.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.710.10 UniProtKB/TrEMBL
InterPro BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:311718 UniProtKB/TrEMBL
NCBI Gene 311718 ENTREZGENE
Pfam BTB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zbtb46 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2JXJ5_RAT UniProtKB/TrEMBL
  D3ZTY1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Zbtb46  zinc finger and BTB domain containing 46  LOC103691997  uncharacterized LOC103691997  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103691997  uncharacterized LOC103691997      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-07-13 Zbtb46  zinc finger and BTB domain containing 46   Btbd4  BTB (POZ) domain containing 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Btbd4  BTB (POZ) domain containing 4   Btbd4_predicted  BTB (POZ) domain containing 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Btbd4_predicted  BTB (POZ) domain containing 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED