Dusp9 (dual specificity phosphatase 9)

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Gene: Dusp9 (dual specificity phosphatase 9) Rattus norvegicus

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Symbol:

Dusp9

Name:

dual specificity phosphatase 9

RGD ID:

1565535

Description:

Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and signal transduction. Predicted to act upstream of or within negative regulation of MAPK cascade. Predicted to be active in cytosol. Orthologous to human DUSP9 (dual specificity phosphatase 9); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dual specificity protein phosphatase 9; MGC124968

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DUSP9 (dual specificity phosphatase 9)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Dusp9 (dual specificity phosphatase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dusp9 (dual specificity phosphatase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DUSP9 (dual specificity phosphatase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DUSP9 (dual specificity phosphatase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dusp9 (dual specificity phosphatase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DUSP9 (dual specificity phosphatase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DUSP9 (dual specificity phosphatase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dusp9 (dual specificity phosphatase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CSTB (cystatin B)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DUSP9 (dual specificity phosphatase 9)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dusp9 (dual specificity phosphatase 9)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MSG5	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mkp3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lip-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dusp9	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	156,503,237 - 156,507,162 (+)	NCBI		GRCr8
mRatBN7.2	X	151,351,897 - 151,355,822 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	151,351,897 - 151,355,821 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	153,493,070 - 153,496,996 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,056,298 - 157,060,224 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	154,728,131 - 154,732,057 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	157,168,143 - 157,172,068 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	157,168,144 - 157,172,068 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,917,660 - 152,921,585 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	159,538,012 - 159,541,937 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	136,533,933 - 136,537,858 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

Barth syndrome (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

factor VIII deficiency (ISO)

favism (ISO)

immunodeficiency 33 (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

severe congenital encephalopathy due to MECP2 mutation (ISO)

Splenomegaly (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP)

belinostat (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

caffeine (ISO)

cefaloridine (EXP)

chlorpromazine (ISO)

choline (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

dichloroacetic acid (ISO)

ethylparaben (ISO)

fenvalerate (EXP)

folic acid (ISO)

FR900359 (ISO)

furan (EXP)

gefitinib (ISO)

genistein (ISO)

glycidyl methacrylate (ISO)

graphite (EXP)

hydrogen peroxide (ISO)

indometacin (ISO)

L-methionine (ISO)

lead(0) (ISO)

menadione (ISO)

niclosamide (ISO)

O-methyleugenol (ISO)

paracetamol (ISO)

paraquat (EXP)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

potassium dichromate (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

tert-butyl hydroperoxide (ISO)

titanium dioxide (EXP,ISO)

triclosan (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IEA)

negative regulation of ERK1 and ERK2 cascade (IBA)

negative regulation of MAPK cascade (ISO)

regulation of transcription by RNA polymerase II (IEA)

signal transduction (IBA)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (IBA)

Molecular Function

calmodulin-dependent protein phosphatase activity (IEA)

histone H2AXS140 phosphatase activity (IEA)

histone H2AXY142 phosphatase activity (IEA)

MAP kinase serine/threonine phosphatase activity (IEA)

MAP kinase tyrosine phosphatase activity (IBA)

MAP kinase tyrosine/serine/threonine phosphatase activity (IBA,ISO)

myosin phosphatase activity (IEA)

non-membrane spanning protein tyrosine phosphatase activity (IEA)

protein binding (ISO)

protein tyrosine phosphatase activity, metal-dependent (IEA)

protein tyrosine/threonine phosphatase activity (IBA)

RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

mitogen activated protein kinase signaling pathway (IEA)

p38 MAPK signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Mechanisms and functions of p38 MAPK signalling.	Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11988087

Genomics

Comparative Map Data

Dusp9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	156,503,237 - 156,507,162 (+)	NCBI		GRCr8
mRatBN7.2	X	151,351,897 - 151,355,822 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	151,351,897 - 151,355,821 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	153,493,070 - 153,496,996 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,056,298 - 157,060,224 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	154,728,131 - 154,732,057 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	157,168,143 - 157,172,068 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	157,168,144 - 157,172,068 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,917,660 - 152,921,585 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	159,538,012 - 159,541,937 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	136,533,933 - 136,537,858 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

DUSP9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	153,642,441 - 153,651,326 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	153,642,492 - 153,651,326 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	152,907,895 - 152,916,781 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	152,561,182 - 152,569,971 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	152,428,834 - 152,437,623	NCBI
Celera	X	153,141,581 - 153,150,465 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	141,570,975 - 141,574,303 (+)	NCBI		HuRef
CHM1_1	X	152,782,380 - 152,791,259 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	151,916,069 - 151,924,981 (+)	NCBI		T2T-CHM13v2.0

Dusp9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	72,682,995 - 72,687,120 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	72,683,025 - 72,687,120 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	73,639,389 - 73,643,514 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	73,639,419 - 73,643,514 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	70,884,780 - 70,888,853 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	69,892,161 - 69,896,234 (+)	NCBI		MGSCv36	mm8
Celera	X	64,893,268 - 64,897,341 (+)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.37	NCBI

Dusp9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	388,850 - 391,455 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	388,277 - 392,269 (+)	NCBI	ChiLan1.0	ChiLan1.0

DUSP9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	153,682,487 - 153,691,495 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	153,686,091 - 153,695,099 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	143,192,599 - 143,201,647 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	153,079,383 - 153,088,208 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	153,084,555 - 153,088,208 (+)	Ensembl	panpan1.1		panPan2

DUSP9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	121,460,116 - 121,472,605 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	121,460,895 - 121,472,608 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	106,793,901 - 106,802,632 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	124,605,802 - 124,614,517 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	124,603,149 - 124,614,520 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	120,375,515 - 120,384,229 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	122,890,508 - 122,899,220 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	122,652,612 - 122,661,339 (+)	NCBI		UU_Cfam_GSD_1.0

Dusp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	118,792,268 - 118,800,490 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	535,434 - 539,319 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	535,434 - 538,219 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUSP9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	124,409,289 - 124,414,212 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	124,404,852 - 124,414,246 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	141,973,050 - 141,976,965 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DUSP9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	128,073,548 - 128,083,169 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	128,079,403 - 128,083,212 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	65,935,790 - 65,944,848 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dusp9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624946	359,377 - 366,308 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624946	359,273 - 366,310 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dusp9
1 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	157
Count of miRNA genes:	118
Interacting mature miRNAs:	140
Transcripts:	ENSRNOT00000024088
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634346	Insul4	Insulin level QTL 4	0		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	X	126975089	152453651	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat

Markers in Region

RH137156

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	151,355,509 - 151,355,704 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	157,168,261 - 157,168,455	NCBI	Rnor6.0
Rnor_5.0	1	152,917,778 - 152,917,972	UniSTS	Rnor5.0
RGSC_v3.4	X	159,541,625 - 159,541,819	UniSTS	RGSC3.4
Celera	1	136,534,051 - 136,534,245	UniSTS
Cytogenetic Map	X	q37	UniSTS

Dusp9

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	151,355,368 - 151,355,542 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	157,168,423 - 157,168,596	NCBI	Rnor6.0
Rnor_5.0	1	152,917,940 - 152,918,113	UniSTS	Rnor5.0
RGSC_v3.4	X	159,541,484 - 159,541,657	UniSTS	RGSC3.4
Celera	1	136,534,213 - 136,534,386	UniSTS
Cytogenetic Map	X	q37	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
7	1	24	112	56	56	35	3	35	6	132	44	92	45	57	21

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001037973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC110044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000087962 ⟹ ENSRNOP00000070655

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	151,351,897 - 151,355,821 (+)	Ensembl
Rnor_6.0 Ensembl	X	157,168,144 - 157,172,068 (-)	Ensembl

RefSeq Acc Id:

NM_001037973 ⟹ NP_001033062

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	156,503,237 - 156,507,162 (+)	NCBI
mRatBN7.2	X	151,351,897 - 151,355,822 (+)	NCBI
Rnor_6.0	X	157,168,143 - 157,172,068 (-)	NCBI
Rnor_5.0	1	152,917,660 - 152,921,585 (-)	NCBI
RGSC_v3.4	X	159,538,012 - 159,541,937 (+)	RGD
Celera	1	136,533,933 - 136,537,858 (-)	NCBI

Sequence:

show sequence

GCGGCCAGCGCACGAGTGGCGCGAGGCTTGGCTTCCACGTGCGAGCCTGCTCCACCACCCCGCC
CTCTCTGAGCGCCGGAGCCTGGGGACTCCGTCTCCATGAACGATACCTGCGCCCTGCCTTGGCA
CTAGCTGTGGTGAGGACGTCCGCGTTTGGCCGCCTGCCTCTGGATCTCGCTCCAGCGCCCGCTG
CCCGACGTGCAGGACGCTGCGCGACCATGGAGAGTCTGAGTCGGTCATGCCTGTGGCTGCGTCA
GGAGCTGTCGTCCCCGCGCCCACAGCTTCTGATACTGGACTGCCGCAGCCGGGAGCTGTATGAG
TCGGCGCGCATCTGCGGGGCGCTGAGCGTGGCCCTGCCCTCGCTGATGCTGCGCCGCCTGCGGA
GAGGGAGCATGTTGGTGCGGTCGCTCTTGCCTGGGCCACCGGTGCAGCCTCCGCCACCGGCCCC
TGTGATCCTCTATGACCAGGGTAGTGGCCAGTGTCAGCCCGAAGCAACGGAGGCTGAAGCTAAG
GCCGAAGCGGAGGCCAAAGCCGAGGCCGAAGCGGAGGCCAAAGCCGAGGCCGAAGCGGAGGCCA
AAGCCGAGGCTAAAGAGGAAGCTGAAGAGTGGGATGCTGACTCGGTGCTGGGCATCCTGCTCCA
GAAGCTGCGGGAAGAAGGCTACCCAGCATACTACCTACAGGGCGGCTTCAGCAAATTCCAGGCC
GAGTGTCCTCACCTGTGTGAAACCAGCTTCAGTGGTCGCGCTGGCTCAGGCCTGGGCTCAATGT
CTAGCCCAGTGCCTGTGGTAGGGCTTGGTGGCCTGTGCTTGAGCACTGATTTCTCTGATGCAGA
GTCCGAGGCTGACCGAGACACCTTGAGCTGTGGCCTAGATTCTGAGAGCACCACATCCCCTCCA
GCTGGGCTGCTACCACCCTTCCCAGCCCAGATCCTGCCCAATCTCTACCTAGGCAGTGCTCGCG
ATTCAGCCAATTTGGAAAGCCTTGCCAAGCTTGGCATCCGCTATATCCTCAATGTCACCCCTAA
CCTTCCTAACCTCTTTGAGAAGAATGGTGACTTCCACTACAAGCAGATCCCCATCTCTGATCAT
TGGAGCCAGAATCTGTCTCAGTTCTTTCCGGAGGCCATTGCATTCATAGATGAGGCCTTGTCAC
AGAACTGTGGGGTGCTCGTCCACTGTCTGGCAGGGGTCAGCCGCTCTGTCACTGTCACCGTGGC
CTACCTCATGCAGAAGCTTAACCTCTCACTCAACGATGCCTACGACTTGGTCAAGCGGAAGAAG
TCTAACATCTCACCTAACTTCAACTTTATGGGGCAACTGCTAGACTTTGAACGCAGCCTGCGCC
TGGGGGAGAAGCGCTCTGGTGGGAGGGGCAGTGGGGGGCCAGAGTCCACTGTCTCAGACCCACC
TTCCTTTTTTACTACCCCCACCAGTGATGGGGTTTTTGAGCTGGATCCCACATAAAGCTGTCTG
GAGCTGCTGGGCTGGTCCTTACTTATGACCTCTAGTATTAGCAGGGATGGGATACAGCCATAAG
CAGGAAGAGGGGAAAGGGGGAAGGGGGAGGGAAAGCTCAATACCTCATGCGGGGATGGTGGAGC
AGGAACAGAGCAGAAACCTGCCCTACCCACTCAAGGCCAGCCCCAGATTCTATTACACGTGCCT
ATGGGTGGGCCCGTGGCTACGGGCCTAACCTGCACCGCTCTAGGGCGGAACCATGCTCCAGAAC
CTGCCTCTTCTGTGACTGTTACTTTATTTTTTTCAGGGTAGGATTGGGGTTGCCTATCCAAGAG
ACCATTCCAGATTGCTGCCAGGGCCCTGACCCTTCTTGGTGTTTCGTCTTTAGGAAAAGTGTAT
CATAATTTCCTGTCAAACCACAGGAACTTGCTCTTGGTCCCATACCTGTACCCAAATGTCCACC
TGTGGGAACAAACCTGACCACTTTGACTCTCTGACTAGGGCTTAGACCTTTTGGAGCTGTGGGG
TGTGGACCCAGAGACACAGTGGTTGCTCTCCACATCCACAGGGACAGCCTCTCTGGGTGGCTTT
TTGCTGGGCAGTGTCACTTGGGAGGGCATGGATCTGGGAGCCAATGAGCGAGATCCCAGCTACA
CGTCTGGTGCCCTGGCTGTTTCTTTCCTCCTCCCCCAGATGTCTTGACAGGATCACTGAGACTC
TTTGTGACTGAGGGTGGTCAAACTGCCACCGGAGAAGATGGGGTCTCAGCTCGAGAGCTAAGGG
GGAGGGAGGGAAAGATGAAGGCCTCAATTTTGCTGCTGTACGTCTCACACAGCCACTGTTGGTT
TGGGGGGCAGGGAAGGGACCAAGCTGCAGACACACATGGTCATTCATTTCAGTCCACACCCCGT
TGTAGACAGTTTGTGTATGTGTGTGTGTGTGTGTGTGTGCGCTCGTGCACGCACATGCACACTG
GCCCACTCACATACTCAGCTTGGAGCTGGCAGTACCTATGGCAGCAGGACCATCTAGTCTTTGA
ACCTGGAAAAACTTGTGCTTCTTTGTTTTTGTAATCCACATCAAAATCACTTTCTTTAATTGTT
CCTCCTGAATAAACAGTTTATTTAAGGTAAAAAAAAAAAAAAAAAAAAAA

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Protein Sequences


Protein RefSeqs	NP_001033062	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI10045	(Get FASTA)	NCBI Sequence Viewer
	EDL85040	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070655.1

RefSeq Acc Id:

NP_001033062 ⟸ NM_001037973

- UniProtKB:

Q2YDV1 (UniProtKB/TrEMBL), A0A0G2JYH3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESLSRSCLWLRQELSSPRPQLLILDCRSRELYESARICGALSVALPSLMLRRLRRGSMLVRSL
LPGPPVQPPPPAPVILYDQGSGQCQPEATEAEAKAEAEAKAEAEAEAKAEAEAEAKAEAKEEAE
EWDADSVLGILLQKLREEGYPAYYLQGGFSKFQAECPHLCETSFSGRAGSGLGSMSSPVPVVGL
GGLCLSTDFSDAESEADRDTLSCGLDSESTTSPPAGLLPPFPAQILPNLYLGSARDSANLESLA
KLGIRYILNVTPNLPNLFEKNGDFHYKQIPISDHWSQNLSQFFPEAIAFIDEALSQNCGVLVHC
LAGVSRSVTVTVAYLMQKLNLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLGEKRSGGR
GSGGPESTVSDPPSFFTTPTSDGVFELDPT

hide sequence

Ensembl Acc Id:

ENSRNOP00000070655 ⟸ ENSRNOT00000087962

Protein Domains

Rhodanese Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q2YDV1-F1-model_v2	AlphaFold	Q2YDV1	1-414	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565535	AgrOrtholog
BioCyc Gene	G2FUF-670	BioCyc
Ensembl Genes	ENSRNOG00000055185	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000087962.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.250.10	UniProtKB/TrEMBL
	3.90.190.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7462125	IMAGE-MGC_LOAD
InterPro	Dual-sp/Tyr_phosphatase	UniProtKB/TrEMBL
	Dual-sp_phosphatase_cat-dom	UniProtKB/TrEMBL
	Dual-sp_phosphatase_subgr_cat	UniProtKB/TrEMBL
	MAPK_phosph	UniProtKB/TrEMBL
	Prot-tyrosine_phosphatase-like	UniProtKB/TrEMBL
	Rhodanese-like	UniProtKB/TrEMBL
	Rhodanese-like_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:293847	UniProtKB/TrEMBL
MGC_CLONE	MGC:124968	IMAGE-MGC_LOAD
NCBI Gene	293847	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN PHOSPHATASE	UniProtKB/TrEMBL
	DUAL SPECIFICITY PROTEIN PHOSPHATASE 9	UniProtKB/TrEMBL
Pfam	DSPc	UniProtKB/TrEMBL
PhenoGen	Dusp9	PhenoGen
PIRSF	MAPK_Ptase	UniProtKB/TrEMBL
PRINTS	MAPKPHPHTASE	UniProtKB/TrEMBL
PROSITE	RHODANESE_3	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_2	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000055185	RatGTEx
SMART	DSPc	UniProtKB/TrEMBL
	RHOD	UniProtKB/TrEMBL
Superfamily-SCOP	Rhodanese-like	UniProtKB/TrEMBL
	SSF52799	UniProtKB/TrEMBL
UniProt	A0A0G2JYH3	ENTREZGENE, UniProtKB/TrEMBL
	Q2YDV1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Dusp9	dual specificity phosphatase 9			Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	Dusp9	dual specificity phosphatase 9			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)