Dusp9 (dual specificity phosphatase 9) - Rat Genome Database

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Gene: Dusp9 (dual specificity phosphatase 9) Rattus norvegicus
Analyze
Symbol: Dusp9
Name: dual specificity phosphatase 9
RGD ID: 1565535
Description: Predicted to enable MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade; positive regulation of apoptotic process; and regulation of heart growth. Predicted to be active in cytosol. Orthologous to human DUSP9 (dual specificity phosphatase 9); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dual specificity protein phosphatase 9; MGC124968
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,351,897 - 151,355,822 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,351,897 - 151,355,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,493,070 - 153,496,996 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X157,056,298 - 157,060,224 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X154,728,131 - 154,732,057 (+)NCBIRnor_WKY
Rnor_6.0X157,168,143 - 157,172,068 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,168,144 - 157,172,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,917,660 - 152,921,585 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,538,012 - 159,541,937 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1136,533,933 - 136,537,858 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11988087  


Genomics

Comparative Map Data
Dusp9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,351,897 - 151,355,822 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,351,897 - 151,355,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,493,070 - 153,496,996 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X157,056,298 - 157,060,224 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X154,728,131 - 154,732,057 (+)NCBIRnor_WKY
Rnor_6.0X157,168,143 - 157,172,068 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,168,144 - 157,172,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,917,660 - 152,921,585 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,538,012 - 159,541,937 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1136,533,933 - 136,537,858 (-)NCBICelera
Cytogenetic MapXq37NCBI
DUSP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,642,441 - 153,651,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX153,642,492 - 153,651,326 (+)EnsemblGRCh38hg38GRCh38
GRCh37X152,907,895 - 152,916,781 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,561,182 - 152,569,971 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X152,428,834 - 152,437,623NCBI
CeleraX153,141,581 - 153,150,465 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,570,975 - 141,574,303 (+)NCBIHuRef
CHM1_1X152,782,380 - 152,791,259 (+)NCBICHM1_1
T2T-CHM13v2.0X151,916,069 - 151,924,981 (+)NCBIT2T-CHM13v2.0
Dusp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,682,995 - 72,687,120 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,683,025 - 72,687,120 (+)EnsemblGRCm39 Ensembl
GRCm38X73,639,389 - 73,643,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,639,419 - 73,643,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X70,884,780 - 70,888,853 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X69,892,161 - 69,896,234 (+)NCBIMGSCv36mm8
CeleraX64,893,268 - 64,897,341 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
Dusp9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580388,850 - 391,455 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580388,277 - 392,269 (+)NCBIChiLan1.0ChiLan1.0
DUSP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,079,383 - 153,088,208 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,084,555 - 153,088,208 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,192,599 - 143,201,647 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DUSP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,460,116 - 121,472,605 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,460,895 - 121,472,608 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX106,793,901 - 106,802,632 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,605,802 - 124,614,517 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX124,603,149 - 124,614,520 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,375,515 - 120,384,229 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X122,890,508 - 122,899,220 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,652,612 - 122,661,339 (+)NCBIUU_Cfam_GSD_1.0
Dusp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X118,792,268 - 118,800,490 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809535,434 - 539,319 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936809535,434 - 538,219 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,409,289 - 124,414,212 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,404,852 - 124,414,246 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X141,973,050 - 141,976,965 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,073,548 - 128,083,169 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,079,403 - 128,083,212 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606565,935,790 - 65,944,848 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946359,377 - 366,308 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946359,273 - 366,310 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dusp9
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:118
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000024088
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
RH137156  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,355,509 - 151,355,704 (-)MAPPERmRatBN7.2
Rnor_6.0X157,168,261 - 157,168,455NCBIRnor6.0
Rnor_5.01152,917,778 - 152,917,972UniSTSRnor5.0
RGSC_v3.4X159,541,625 - 159,541,819UniSTSRGSC3.4
Celera1136,534,051 - 136,534,245UniSTS
Cytogenetic MapXq37UniSTS
Dusp9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,355,368 - 151,355,542 (-)MAPPERmRatBN7.2
Rnor_6.0X157,168,423 - 157,168,596NCBIRnor6.0
Rnor_5.01152,917,940 - 152,918,113UniSTSRnor5.0
RGSC_v3.4X159,541,484 - 159,541,657UniSTSRGSC3.4
Celera1136,534,213 - 136,534,386UniSTS
Cytogenetic MapXq37UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 12 12 12 4 16 12
Low 10 8 6 6 31 19 25 9
Below cutoff 1 7 14 7 1 7 1 1 39 2 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087962   ⟹   ENSRNOP00000070655
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,351,897 - 151,355,821 (+)Ensembl
Rnor_6.0 EnsemblX157,168,144 - 157,172,068 (-)Ensembl
RefSeq Acc Id: NM_001037973   ⟹   NP_001033062
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,351,897 - 151,355,822 (+)NCBI
Rnor_6.0X157,168,143 - 157,172,068 (-)NCBI
Rnor_5.01152,917,660 - 152,921,585 (-)NCBI
RGSC_v3.4X159,538,012 - 159,541,937 (+)RGD
Celera1136,533,933 - 136,537,858 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001033062 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI10045 (Get FASTA)   NCBI Sequence Viewer  
  EDL85040 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001033062   ⟸   NM_001037973
- UniProtKB: Q2YDV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070655   ⟸   ENSRNOT00000087962
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2YDV1-F1-model_v2 AlphaFold Q2YDV1 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565535 AgrOrtholog
BioCyc Gene G2FUF-670 BioCyc
Ensembl Genes ENSRNOG00000055185 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070655 ENTREZGENE
  ENSRNOP00000070655.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087962 ENTREZGENE
  ENSRNOT00000087962.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7462125 IMAGE-MGC_LOAD
InterPro Dual-sp/Tyr_phosphatase UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  Dual-sp_phosphatase_subgr_cat UniProtKB/TrEMBL
  MAPK_phosph UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Rhodanese-like UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/TrEMBL
KEGG Report rno:293847 UniProtKB/TrEMBL
MGC_CLONE MGC:124968 IMAGE-MGC_LOAD
NCBI Gene 293847 ENTREZGENE
Pfam DSPc UniProtKB/TrEMBL
  Rhodanese UniProtKB/TrEMBL
PhenoGen Dusp9 PhenoGen
PIRSF MAPK_Ptase UniProtKB/TrEMBL
PRINTS MAPKPHPHTASE UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
SMART DSPc UniProtKB/TrEMBL
  RHOD UniProtKB/TrEMBL
Superfamily-SCOP Rhodanese-like UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt Q2YDV1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Dusp9  dual specificity phosphatase 9      Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Dusp9  dual specificity phosphatase 9      Symbol and Name status set to provisional 70820 PROVISIONAL