 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations |
Welcome {{ username}}
Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{gene.symbol}}: {{ gene.description }}
Save List to My RGD
| Create Name: | |
| Description: |
|
| Save what matters to you |
| {{ loginError }} |
| Sign in with your RGD account |
| Create New Account | Recover Password |
{{ watchLinkText }}
Select categories you would like to watch. Updates to this gene will be send to {{ username }}
Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
 |
Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
|
MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
|
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology AnnotationsBiological Process
|
|
Cellular Component
|
|
Molecular Function
|
|
|
Molecular Pathway Annotations
|
References - curated| 1. | Carter JG, etal., Curr Eye Res. 2011 Apr;36(4):328-35. doi: 10.3109/02713683.2010.548892. Epub 2011 Feb 10. |
| 2. | Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30. |
| 3. | Cohen-Eliav M, etal., J Pathol. 2013 Mar;229(4):630-9. doi: 10.1002/path.4129. |
| 4. | Fernandez-Nogales M, etal., Nat Med. 2014 Aug;20(8):881-5. doi: 10.1038/nm.3617. Epub 2014 Jul 20. |
| 5. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 6. | Ghigna C, etal., Cancer Res. 1998 Dec 15;58(24):5818-24. |
| 7. | GOA data from the GO Consortium |
| 8. | Iborra S, etal., Int J Gynecol Cancer. 2013 Jul;23(6):990-6. doi: 10.1097/IGC.0b013e31829783e3. |
| 9. | Jensen MA, etal., Nat Struct Mol Biol. 2014 Feb;21(2):189-97. doi: 10.1038/nsmb.2756. Epub 2014 Jan 19. |
| 10. | MGD data from the GO Consortium |
| 11. | Ni B, etal., Fertil Steril. 2014 Jun;101(6):1711-7.e1-2. doi: 10.1016/j.fertnstert.2014.02.033. Epub 2014 Mar 21. |
| 12. | Nogueira TC, etal., PLoS Genet. 2013 May;9(5):e1003532. doi: 10.1371/journal.pgen.1003532. Epub 2013 May 30. |
| 13. | Patel NA, etal., J Biol Chem. 2001 Jun 22;276(25):22648-54. Epub 2001 Mar 30. |
| 14. | Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690. |
| 15. | RGD automated data pipeline |
| 16. | RGD automated import pipeline for gene-chemical interactions |
| 17. | RGD comprehensive gene curation |
| 18. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 19. | Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009. |
| 20. | Walsh CM, etal., J Biol Chem. 2013 Jan 25;288(4):2816-28. doi: 10.1074/jbc.M112.410803. Epub 2012 Dec 11. |
References - uncuratedGenomics
Comparative Map Data| Srsf6 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SRSF6 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Srsf6 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Srsf6 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SRSF6 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SRSF6 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Srsf6 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SRSF6 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SRSF6 (Chlorocebus sabaeus - green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Srsf6 (Heterocephalus glaber - naked mole-rat) |
No map positions available. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Position Markers| AW146126 |
|
|||||||||||||||||||||||||||||||||||
| RH131453 |
|
|||||||||||||||||||||||||||||||||||
| AA874922 |
|
|||||||||||||||||||||||||||||||||||
| RH139802 |
|
QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
||||||||
Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| testis | heart | brain | ovary | uterus | skeletal muscle tissue | colon | gastrocnemius | forebrain | hindbrain | lung | spleen | liver | kidney | adrenal gland | thymus | |
| High | ||||||||||||||||
| Medium | 22 | 43 | 23 | 15 | 4 | 2 | 3 | 8 | 26 | 25 | 11 | 11 | 41 | 35 | 8 | 8 |
| Low | 1 | |||||||||||||||
| Below cutoff |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_001014185 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR07054544 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AAHX01026288 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC087121 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH474005 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FM060375 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FM081417 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ223381 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ225114 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ225849 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ227426 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ227581 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000008427 ⟹ ENSRNOP00000008427 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
|
| RefSeq Acc Id: | NM_001014185 ⟹ NP_001014207 | ||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
|
||||||||||||||||||||||||
| Sequence: |
GCTGACTCGGCCGCAGCTGCGGTGTGAGGCGCGTGTTCGGGCCTTCGCCGTCCCCGCACCCGCAhide sequence |
Protein Sequences| Protein RefSeqs | NP_001014207 | (Get FASTA) | NCBI Sequence Viewer |
| GenBank Protein | AAH87121 | (Get FASTA) | NCBI Sequence Viewer |
| EDL96600 | (Get FASTA) | NCBI Sequence Viewer | |
| EDL96601 | (Get FASTA) | NCBI Sequence Viewer | |
| EDL96602 | (Get FASTA) | NCBI Sequence Viewer | |
| G3V6S8 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_001014207 ⟸ NM_001014185 |
| - UniProtKB: | G3V6S8 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MPRVYIGRLSYNVREKDIQRFFSGYGRLLEIDLKNGYGFVEFEDSRDADDAVYELNSKELCGERhide sequence |
| RefSeq Acc Id: | ENSRNOP00000008427 ⟸ ENSRNOT00000008427 |
Protein Domains
RRM
TranscriptomePromoters| RGD ID: | 13692631 | |||||||||
| Promoter ID: | EPDNEW_R3154 | |||||||||
| Type: | multiple initiation site | |||||||||
| Name: | Srsf6_1 | |||||||||
| Description: | serine and arginine rich splicing factor 6 | |||||||||
| SO ACC ID: | SO:0000170 | |||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
| Experiment Methods: | Single-end sequencing. | |||||||||
| Position: |
|
Strain Variation
Strain Sequence Variants (Rnor 6.0)
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1359241 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000006380 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000008427 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000008427 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Gene3D-CATH | 3.30.70.330 | UniProtKB/Swiss-Prot |
| IMAGE_CLONE | IMAGE:7106749 | IMAGE-MGC_LOAD |
| InterPro | Nucleotide-bd_a/b_plait_sf | UniProtKB/Swiss-Prot |
| RBD_domain_sf | UniProtKB/Swiss-Prot | |
| RRM_dom | UniProtKB/Swiss-Prot | |
| SRSF6_RRM1 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:362264 | UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:94786 | IMAGE-MGC_LOAD |
| NCBI Gene | 362264 | ENTREZGENE |
| Pfam | RRM_1 | UniProtKB/Swiss-Prot |
| PhenoGen | Srsf6 | PhenoGen |
| PROSITE | RRM | UniProtKB/Swiss-Prot |
| SMART | RRM | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | SSF54928 | UniProtKB/Swiss-Prot |
| UniGene | Rn.3175 | ENTREZGENE |
| UniProt | G3V6S8 | ENTREZGENE, UniProtKB/Swiss-Prot |
| UniProt Secondary | Q5PQM1 | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2016-06-15 | Srsf6 | serine and arginine rich splicing factor 6 | Srsf6 | serine/arginine-rich splicing factor 6 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2011-08-01 | Srsf6 | serine/arginine-rich splicing factor 6 | Sfrs6 | splicing factor, arginine/serine-rich 6 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2011-07-22 | Sfrs6 | splicing factor, arginine/serine-rich 6 | Srsf6 | serine/arginine-rich splicing factor 6 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2011-07-13 | Srsf6 | serine/arginine-rich splicing factor 6 | Sfrs6 | splicing factor, arginine/serine-rich 6 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2010-09-20 | Sfrs6 | splicing factor, arginine/serine-rich 6 | Srsf6 | serine/arginine-rich splicing factor 6 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2010-09-14 | Srsf6 | serine/arginine-rich splicing factor 6 | Sfrs6 | splicing factor, arginine/serine-rich 6 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-03-05 | Sfrs6 | splicing factor, arginine/serine-rich 6 | LOC362264 | similar to dJ862K6.2.2 (splicing factor, arginine/serine-rich 6 (SRP55-2)(isoform 2)) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
 |
| More on Srsf6 | |
|
Alliance Gene |
|
NCBI Gene |
|
Ensembl Gene |
|
|
JBrowse: rn5 rn6 |
|
NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 1359241 |
| Created: | 2005-07-29 |
| Species: | Rattus norvegicus |
| Last Modified: | 2019-11-27 |
| Status: | ACTIVE |
