Smn1 (survival of motor neuron 1, telomeric)

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Gene: Smn1 (survival of motor neuron 1, telomeric) Rattus norvegicus

Analyze

Symbol:

Smn1

Name:

survival of motor neuron 1, telomeric

RGD ID:

620755

Description:

Exhibits fibroblast growth factor binding activity. Involved in chemical synaptic transmission. Localizes to Gemini of coiled bodies; cytoplasm; and nucleolus. Human ortholog(s) of this gene implicated in Werdnig-Hoffmann disease; adult spinal muscular atrophy; intermediate spinal muscular atrophy; juvenile spinal muscular atrophy; and spinal muscular atrophy. Orthologous to several human genes including SMN2 (survival of motor neuron 2, centromeric); PARTICIPATES IN apoptotic cell death pathway; RNA transport pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

Smn; survival motor neuron; survival motor neuron 1

RGD Orthologs

Human

Mouse

Dog

Pig

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SMN1 (survival of motor neuron 1, telomeric)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Smn1 (survival motor neuron 1)	HGNC	Treefam, EggNOG, OrthoMCL, HomoloGene, OrthoDB, Ensembl
Canis lupus familiaris (dog):	SMN (survival motor neuron)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SMN1 (survival of motor neuron 1, telomeric)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SMN2 (survival of motor neuron 2, centromeric)	HGNC	EggNOG, Ensembl, HomoloGene, OMA, OrthoDB, Treefam
Alliance orthologs ³
Homo sapiens (human):	SMN1 (survival of motor neuron 1, telomeric)	Alliance	DIOPT (HGNC\|TreeFam)
Mus musculus (house mouse):	Smn1 (survival motor neuron 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	SMN2 (survival of motor neuron 2, centromeric)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	smn1 (survival of motor neuron 1, telomeric)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	smn-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Smn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	31,490,018 - 31,501,065 (+)	NCBI
Rnor_6.0 Ensembl	2	30,360,100 - 30,371,147 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	30,360,101 - 30,371,147 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	49,519,268 - 49,530,314 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	31,147,743 - 31,159,938 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	31,068,111 - 31,080,302 (+)	NCBI
Celera	2	27,512,249 - 27,523,295 (+)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult spinal muscular atrophy (ISO)

amenorrhea (ISO)

childhood spinal muscular atrophy (ISO)

Infant Death (ISO)

intermediate spinal muscular atrophy (ISO)

juvenile spinal muscular atrophy (ISO)

Neurodevelopmental Disorders (ISO)

spinal muscular atrophy (ISO)

Werdnig-Hoffmann disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrophenol (ISO)

2,4-dinitrotoluene (EXP)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

camptothecin (ISO)

cisplatin (ISO)

clofibric acid (EXP)

cycloheximide (ISO)

dibutyl phthalate (ISO)

dichlorine (EXP)

dioxygen (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

flutamide (EXP)

glafenine (EXP)

N-nitrosodiethylamine (EXP)

ozone (EXP)

paracetamol (ISO)

paraquat (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (EXP)

retinyl acetate (ISO)

rotenone (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

WIN 55212-2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axonogenesis (IEA,ISO)

chemical synaptic transmission (IEP)

DNA-templated transcription, termination (ISO,ISS)

microtubule depolymerization (IEA,ISO)

mRNA processing (IEA)

positive regulation of RNA splicing (IEA,ISO)

regulation of neuron projection development (IEA,ISO)

spliceosomal complex assembly (ISO)

spliceosomal snRNP assembly (IBA,ISO,ISS)

Cellular Component

Cajal body (IBA,IEA,ISO,ISS)

COPI-coated vesicle (IEA,ISO)

cytoplasm (IDA,ISO)

cytoplasmic ribonucleoprotein granule (ISO,ISS)

cytosol (ISO,ISS)

Gemini of coiled bodies (IBA,IDA,ISO)

Golgi apparatus (IEA,ISO)

growth cone (IEA,ISO)

neuron projection (ISO,ISS)

nuclear body (ISO)

nucleolus (IDA)

nucleoplasm (ISO,ISS)

nucleus (IBA,ISO,ISS)

perikaryon (ISO,ISS)

SMN complex (IBA,ISO,ISS)

SMN-Sm protein complex (ISO,ISS)

Z disc (IEA)

Molecular Function

fibroblast growth factor binding (IPI)

identical protein binding (ISO)

protein binding (ISO)

RNA binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

apoptotic cell death pathway (ISS)

RNA transport pathway (IEA)

References

References - curated


1.	Andreassi C, etal., Neurogenetics 2002 Mar;4(1):29-36.
2.	Battaglia G, etal., Hum Mol Genet 1997 Oct;6(11):1961-71.
3.	Claus P, etal., J Biol Chem 2003 Jan 3;278(1):479-85.
4.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	La Bella V, etal., Eur J Neurosci 1998 Sep;10(9):2913-23.
6.	Lefebvre S, etal., Cell. 1995 Jan 13;80(1):155-65.
7.	Meister G, etal., Hum Mol Genet 2000 Aug 12;9(13):1977-86.
8.	MGD data from the GO Consortium
9.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	OMIM Disease Annotation Pipeline
11.	Pellizzoni L, etal., Science 2002 Nov 29;298(5599):1775-9.
12.	Pipeline to import KEGG annotations from KEGG into RGD
13.	RGD automated data pipeline
14.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	RGD automated import pipeline for gene-chemical interactions
16.	Schmalbruch H and Haase G, Brain Pathol 2001 Apr;11(2):231-47.
17.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18.	Young PJ, etal., Brain Res Mol Brain Res 2003 Nov 6;119(1):37-49.

Additional References at PubMed

PMID:8670859	PMID:9845364	PMID:11181573	PMID:11283611	PMID:14715275	PMID:15465016	PMID:16189514	PMID:17068332	PMID:17261814	PMID:17317728	PMID:17873296	PMID:18093976
PMID:18984161	PMID:19447967	PMID:19928837	PMID:20176735	PMID:20513430	PMID:21234798	PMID:21300694	PMID:21362474	PMID:21516116	PMID:22037760	PMID:22365833	PMID:23022347
PMID:24067532	PMID:25055867	PMID:25416956	PMID:25931508	PMID:26700805	PMID:27153795	PMID:29902268	PMID:29997244

Genomics

Comparative Map Data

Smn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	31,490,018 - 31,501,065 (+)	NCBI
Rnor_6.0 Ensembl	2	30,360,100 - 30,371,147 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	30,360,101 - 30,371,147 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	49,519,268 - 49,530,314 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	31,147,743 - 31,159,938 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	31,068,111 - 31,080,302 (+)	NCBI
Celera	2	27,512,249 - 27,523,295 (+)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

SMN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	5	70,049,638 - 70,078,522 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	5	70,049,612 - 70,078,522 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	5	70,925,030 - 70,953,942 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	5	70,924,941 - 70,953,015 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	5	70,220,768 - 70,248,842 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	70,256,524 - 70,284,593 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	5	70,256,523 - 70,284,593	NCBI
Celera	5	66,468,090 - 66,482,264 (-)	NCBI
Cytogenetic Map	5	q13.2	NCBI
HuRef	5	65,881,629 - 65,882,701 (+)	NCBI		HuRef
CHM1_1	5	69,671,936 - 69,700,004 (+)	NCBI		CHM1_1

Smn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	100,259,713 - 100,274,206 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	13	100,261,360 - 100,274,198 (+)	Ensembl
GRCm38	13	100,123,205 - 100,137,699 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	100,124,852 - 100,137,690 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	100,894,810 - 100,907,653 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	13	101,225,151 - 101,237,950 (+)	NCBI			mm8
Celera	13	103,778,421 - 103,791,262 (+)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	52.99	NCBI

SMN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	2	54,596,008 - 54,636,804 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	2	54,596,000 - 54,636,837 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

SMN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	16	47,738,776 - 47,777,381 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	51,686,212 - 51,724,263 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Position Markers

BE116734

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	2	30,359,239 - 30,359,397	NCBI	Rnor6.0
Rnor_5.0	2	49,518,406 - 49,518,564	UniSTS	Rnor5.0
RGSC_v3.4	2	31,146,881 - 31,147,039	UniSTS	RGSC3.4
Celera	2	27,511,387 - 27,511,545	UniSTS
RH 3.4 Map	2	64.2	UniSTS
Cytogenetic Map	2	q12	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631682	Bp115	Blood pressure QTL 115	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	1	35167060	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	41179397	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	3127638	105149020	Rat
9590080	Insglur4	Insulin/glucose ratio QTL 4	28.7	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	2	3686308	48686308	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	5417336	42777046	Rat
738012	Anxrr3	Anxiety related response QTL 3	3.8		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	2	7893600	52893600	Rat
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	9444679	49615930	Rat
1578671	Bmd10	Bone mineral density QTL 10	5.4		femur mineral mass (VT:0010011)	cortical volumetric bone mineral density (CMO:0001730)	2	9444679	68866454	Rat
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	10555275	55555275	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	14237830	59237830	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	16679272	245624402	Rat
1357990	Ael1	Aortic elastin QTL 1	3.1	0.00091	aorta elastin amount (VT:0003905)	aortic elastin	2	19016465	64016465	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	20276981	65276981	Rat
2300168	Bmd47	Bone mineral density QTL 47	6.6	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	2	20641371	65641371	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	22612952	67612952	Rat
10402051	Gdil2	Gastrointestinal dilation QTL 2			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	23280647	75687607	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	23837491	149614623	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	23837491	169852800	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	23837491	169852800	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	169852800	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	169852800	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	23837491	169852800	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	23837491	169852800	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	218957222	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	218957222	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	23837719	169852670	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	23837719	169852670	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	26186097	83819822	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	26186097	83819822	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26186097	83819822	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26186097	135654963	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26186097	142053534	Rat
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	26267995	43133606	Rat
1643006	Pain1	Pain QTL 1	3.63	0.005	mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	2	26267995	48676716	Rat
12879841	Cm87	Cardiac mass QTL 87		0.026	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	27161361	148295267	Rat
12879842	Cm88	Cardiac mass QTL 88		0.042	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	27161361	148295267	Rat
12879843	Am3	Aortic mass QTL 3		0.016	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	27161361	148295267	Rat
12879844	Kidm62	Kidney mass QTL 62		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27161361	148295267	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	27760301	72760301	Rat
1300160	Hrtrt3	Heart rate QTL 3	3.62		heart pumping trait (VT:2000009)	absolute change in heart rate (CMO:0000534)	2	28727867	52507805	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	55
Count of miRNA genes:	48
Interacting mature miRNAs:	55
Transcripts:	ENSRNOT00000024456
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	39	24	19	24	1	4	73	29	41	11	1
Low		9	18	17		17	7	7	1	6			7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF044910	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY876898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U75369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000024456 ⟹ ENSRNOP00000024456

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	30,360,100 - 30,371,147 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000076746

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	30,360,126 - 30,363,393 (+)	Ensembl

RefSeq Acc Id:

NM_022509 ⟹ NP_071954

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	31,490,018 - 31,501,065 (+)	NCBI
Rnor_6.0	2	30,360,101 - 30,371,147 (+)	NCBI
Rnor_5.0	2	49,519,268 - 49,530,314 (+)	NCBI
RGSC_v3.4	2	31,147,743 - 31,159,938 (+)	RGD
Celera	2	27,512,249 - 27,523,295 (+)	RGD

Sequence:

show sequence

ATTTTGGGCGAGCCCAGCCCCGTCCGTGGTAGCAGGCCATGGCGATGGGCAGCGGCGGCGGCGC
GGGCTCTGAGCAGGAAGACACCGTGCTGTTCCGGCGTGGCACCGGCCAGAGTGATGATTCTGAC
ATTTGGGATGATACAGCATTGATAAAAGCTTACGATAAAGCCGTGGCCTCCTTTAAGCATGCTC
TAAAGAACGGTGACATGTGTGAAACTTCAGATAAGCCAAAAGGCACAGCTAGAAGAAAACCTGC
TAAGAAGAATAAAAACCAAAAGAAGAATGCCACAGCTCCATTGAAACAGTGGAAAGCTGGTGAC
AAATGCTCTGCCGTTTGGTCGGAAGATGGCTGCGTTTACCCAGCTACCATCACGTCAGTTGACC
TTAAGAGAGAAACCTGTGTCGTGGTTTATACTGGATATGGAAACAAAGAGGAGCAAAACCTATC
TGATCTGCTTTCCCCGACCTGTGAAGTAGCTAACAATACAGAACAGAACACTCAGGAGAATGAA
AGCCAAGTTTCCACAGACGACAGTGAACACTCCTCCAGATCGCTCAGAAGTAAAGCACACAGCA
AGTCCAAAGCTGCTCCATGGACCTCGTTTCTCCCTCCACCTCCCCCGGTGCCCGGGGCGGGATT
AGGACCAGGAAAGCCAGGTCTAAGGTTCAGTGGGCCACCGCCGCCGCCACCTCCCCCTCCCCCG
TTCTTGCCGTGTTGGATGCCTCCGTTCCCTTCAGGACCACCAATAATTCCTCCACCCCCTCCCA
TATCTCCCGACTGTCTGGATGACACGGATGCTCTGGGCAGTATGCTAATCTCTTGGTACATGAG
TGGTTACCACACTGGTTACTATATGGGTTTCAGACAAAATAAAAAGGAGGGAAAGAAGTGCTCA
CATACAAATTAAGAAGTTCAGCTCTCTCCCAAGGAGATGGTTTGTTGGTGTCCCTGGTCGATAA
GAACAGAAGTCTCCTCGTCACCTTTGTGGACTCTTGGCTAAGTGGTGTCATCATCAGGGTCTCC
CTGTCCCGGGAGTCCATCCTGAGTCAGCAGCAGGGCATGCATAGAGCAGCAGTTGGAGGAACCG
ATCAATCGATCGATCAGTGGCAGTGTGAGTGCATGGAAGTCAGCCAAACTGTGACTGAGCACAA
ACGGACAATTGCAATTTTCTTAGAATGTCAAGATTTGTATTAATGCCTTTAAAATTAAATAAAA
CCCTTTTTTGAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_071954	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB96377	(Get FASTA)	NCBI Sequence Viewer
	AAC01747	(Get FASTA)	NCBI Sequence Viewer
	AAH62404	(Get FASTA)	NCBI Sequence Viewer
	AAX58136	(Get FASTA)	NCBI Sequence Viewer
	EDM10193	(Get FASTA)	NCBI Sequence Viewer
	EDM10194	(Get FASTA)	NCBI Sequence Viewer
	O35876	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_071954 ⟸ NM_022509

- Sequence:

show sequence

MAMGSGGGAGSEQEDTVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDMCETSDKP
KGTARRKPAKKNKNQKKNATAPLKQWKAGDKCSAVWSEDGCVYPATITSVDLKRETCVVVYTGY
GNKEEQNLSDLLSPTCEVANNTEQNTQENESQVSTDDSEHSSRSLRSKAHSKSKAAPWTSFLPP
PPPVPGAGLGPGKPGLRFSGPPPPPPPPPPFLPCWMPPFPSGPPIIPPPPPISPDCLDDTDALG
SMLISWYMSGYHTGYYMGFRQNKKEGKKCSHTN

hide sequence

RefSeq Acc Id:

ENSRNOP00000024456 ⟸ ENSRNOT00000024456

Protein Domains

Tudor

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691103

Promoter ID:

EPDNEW_R1628

Type:

multiple initiation site

Name:

Smn1_1

Description:

survival of motor neuron 1, telomeric

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	30,360,124 - 30,360,184	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620755	AgrOrtholog
Ensembl Genes	ENSRNOG00000018067	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000024456	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024456	ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5621519	IMAGE-MGC_LOAD
InterPro	Survival_motor_neuron	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tudor	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64301	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72446	IMAGE-MGC_LOAD
NCBI Gene	64301	ENTREZGENE
Pfam	SMN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Smn1	PhenoGen
PROSITE	TUDOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	TUDOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	O35876	ENTREZGENE
	Q6P684_RAT	UniProtKB/TrEMBL
	SMN_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	O55045	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-03-07	Smn1	survival of motor neuron 1, telomeric	Smn1	survival motor neuron 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-25	Smn1	survival motor neuron 1	Smn1	survival of motor neuron 1, telomeric	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-01-06	Smn1		SMN1	survival of motor neuron 1, telomeric	Symbol updated to conform to rat nomenclature guidelines	1299863	APPROVED
2004-09-10	SMN1	survival of motor neuron 1, telomeric	Smn	survival motor neuron	Symbol and Name updated	1299863	APPROVED
2002-08-07	Smn	survival motor neuron			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	32 kDa isoform is mostly soluble; 35 kDa and 45 kDa isoforms localized to a mitochondrial and microsomal fraction	634120
gene_disease	human homolog is deleted in spinal muscular atrophy, which is characterized by degeneration of spinal cord and brainstem motoneurons	634123
gene_physical_interaction	binds 23-kDa FGF-2 isoform	634122

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)